Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the most efficient for tumor-specific treatment and imaging?

Journal of Controlled Release

Volumn 130, Issue 2, 2008, Pages 107-114

  Saad, Maha ^a   Garbuzenko, Olga B ^a   Ber, Elizabeth ^a   Chandna, Pooja ^a   Khandare, Jayant J ^a   Pozharov, Vitaly P ^a   Minko, Tamara ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Adverse side effects; Imaging; LHRH peptide; Nanocarriers; Tumor specific targeting

Indexed keywords

AMINES; ARCHITECTURAL DESIGN; CELL MEMBRANES; CHEMOTHERAPY; DENDRIMERS; DRUG DELIVERY; DRUG DOSAGE; HYDROGELS; LIPOSOMES; PHOSPHOLIPIDS; POLYMERS; TUMORS;

ADVERSE SIDE EFFECTS; ANTI-CANCER DRUGS; CANCER CELLS; CELLULAR INTERNALIZATION; DELIVERY SYSTEMS; DENDRIMER; IMAGING; IMAGING AGENTS; IN-VITRO; IN-VIVO; LHRH PEPTIDE; LINEAR POLYMERS; NANO-CARRIER; NANOCARRIERS; ORGAN DISTRIBUTION; PACLITAXEL; SIDE EFFECTS; TUMOR TARGETING; TUMOR-SPECIFIC TARGETING;

ENZYME INHIBITION;

CYANINE DYE; DENDRIMER; DRUG CARRIER; GONADORELIN DERIVATIVE; LIPOSOME; MACROGOL; NANOCARRIER; PACLITAXEL; POLYAMIDOAMINE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CELL MEMBRANE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG POTENTIATION; HUMAN; HUMAN CELL; IMAGING; INTERNALIZATION; LUNG CARCINOMA; MOLECULAR SIZE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBOCYANINES; CELL LINE, TUMOR; CONTRAST MEDIA; DENDRIMERS; DIAGNOSTIC IMAGING; DRUG CARRIERS; GONADOTROPIN-RELEASING HORMONE; HUMANS; LIPOSOMES; MICE; MICE, NUDE; NANOPARTICLES; NEOPLASMS; PACLITAXEL; POLYMERS; RECEPTORS, LHRH; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 49749126336     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.05.024     Document Type: Article

References (40)

1. Allen T.M., and Cullis P.R. Drug delivery systems: entering the mainstream. Science 303 5665 (2004) 1818-1822
2. Arayne M.S., and Sultana N. Review: nanoparticles in drug delivery for the treatment of cancer. Pak. J. Pharm. Sci. 19 3 (2006) 258-268
3. Duncan R. The dawning era of polymer therapeutics. Nat. Rev., Drug Discov. 2 5 (2003) 347-360
4. Duncan R. Polymer conjugates as anticancer nanomedicines. Nat. Rev., Cancer 6 9 (2006) 688-701
5. Gao X., Chung L.W., and Nie S. Quantum dots for in vivo molecular and cellular imaging. Methods Mol. Biol. 374 (2007) 135-146
6. Grodzinski P., Silver M., and Molnar L.K. Nanotechnology for cancer diagnostics: promises and challenges. Expert Rev. Mol. Diagn. 6 3 (2006) 307-318
7. Khandare J.J., Jayant S., Singh A., Chandna P., Wang Y., Vorsa N., and Minko T. Dendrimer versus linear conjugate: influence of polymeric architecture on the delivery and anticancer effect of Paclitaxel. Bioconjug. Chem. 17 6 (2006) 1464-1472
8. Malik N., Wiwattanapatapee R., Klopsch R., Lorenz K., Frey H., Weener J.W., Meijer E.W., Paulus W., and Duncan R. Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. J. Control. Release 65 1-2 (2000) 133-148
9. Majoros I.J., Myc A., Thomas T., Mehta C.B., and Baker Jr. J.R. PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality. Biomacromolecules 7 2 (2006) 572-579
10. Mitra A., Nan A., Line B.R., and Ghandehari H. Nanocarriers for nuclear imaging and radiotherapy of cancer. Curr. Pharm. Des. 12 36 (2006) 4729-4749
11. Myc A., Majoros I.J., Thomas T.P., and Baker Jr. J.R. Dendrimer-based targeted delivery of an apoptotic sensor in cancer cells. Biomacromolecules 8 1 (2007) 13-18
12. Patri A.K., Majoros I.J., and Baker J.R. Dendritic polymer macromolecular carriers for drug delivery. Curr. Opin. Chem. Biol. 6 4 (2002) 466-471
13. Popescu M.A., and Toms S.A. In vivo optical imaging using quantum dots for the management of brain tumors. Expert Rev. Mol. Diagn. 6 6 (2006) 879-890
14. Portney N.G., and Ozkan M. Nano-oncology: drug delivery, imaging, and sensing. Anal. Bioanal. Chem. 384 3 (2006) 620-630
15. Sinha R., Kim G.J., Nie S., and Shin D.M. Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery. Mol. Cancer Ther. 5 8 (2006) 1909-1917
16. Tomalia D.A., Reyna L.A., and Svenson S. Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging. Biochem. Soc. Trans. 35 Pt 1 (2007) 61-67
17. Torchilin V.P. Multifunctional nanocarriers. Adv. Drug Deliv. Rev. 58 14 (2006) 1532-1555
18. Torchilin V.P. Micellar nanocarriers: pharmaceutical perspectives. Pharm. Res. 24 1 (2007) 1-16
19. True L.D., and Gao X. Quantum dots for molecular pathology: their time has arrived. J. Mol. Diagnostics 9 1 (2007) 7-11
20. van Vlerken L.E., and Amiji M.M. Multi-functional polymeric nanoparticles for tumour-targeted drug delivery. Expert Opin. Drug Deliv. 3 2 (2006) 205-216
21. Wang D., Kopeckova J.P., Minko T., Nanayakkara V., and Kopecek J. Synthesis of starlike N-(2-hydroxypropyl)methacrylamide copolymers: potential drug carriers. Biomacromolecules 1 3 (2000) 313-319
22. Minko T., Khandare J.J., Vetcher A.A., Soldatenkov V.A., Garbuzenko O.B., Saad M., and Pozharov V.P. In: Torchilin V.P. (Ed). Multifunctional Pharmaceutical Nanocarriers (2008), Series: Fundamental Biomedical Technologies 309-335 vol. 4, Springer
23. Dharap S.S., Wang Y., Chandna P., Khandare J.J., Qiu B., Gunaseelan S., Sinko P.J., Stein S., Farmanfarmaian A., and Minko T. Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide. Proc. Natl. Acad. Sci. U. S. A. 102 36 (2005) 12962-12967
24. Khandare J.J., Chandna P., Wang Y., Pozharov V.P., and Minko T. Novel polymeric prodrug with multivalent components for cancer therapy. J. Pharmacol. Exp. Ther. 317 3 (2006) 929-937
25. Ahmed F., Pakunlu R.I., Brannan A., Bates F., Minko T., and Discher D.E. Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J. Control. Release 116 2 (2006) 150-158
26. Dharap S.S., Qiu B., Williams G.C., Sinko P., Stein S., and Minko T. Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides. J. Control. Release 91 1-2 (2003) 61-73
27. Pakunlu R.I., Wang Y., Saad M., Khandare J.J., Starovoytov V., and Minko T. In vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and anticancer drug. J. Control. Release 114 (2006) 153-162
28. Wang Y., and Minko T. A novel cancer therapy: combined liposomal hypoxia inducible factor 1 alpha antisense oligonucleotides and an anticancer drug. Biochem. Pharmacol. 68 10 (2004) 2031-2042
29. Dharap S.S., and Minko T. Targeted proapoptotic LHRH-BH3 peptide. Pharm. Res. 20 6 (2003) 889-896
30. Minko T., Kopeckova P., and Kopecek J. Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line. J. Control. Release 59 2 (1999) 133-148
31. Minko T., Kopeckova P., Pozharov V., and Kopecek J. HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line. J. Control. Release 54 2 (1998) 223-233
32. Ahmed F., Pakunlu R.I., Srinivas G., Brannan A., Bates F., Klein M.L., Minko T., and Discher D.E. Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation. Mol. Pharmacol. 3 3 (2006) 340-350
33. Geng Y., Dalhaimer P., Cai S., Tsai R., Tewari M., Minko T., and Discher D. Soft filaments circulate longer than spherical particles - shape effects in flow and drug delivery. Nature Nanotech. 2 (2007) 249-255
34. Khandare J., and Minko T. Polymer-drug conjugates: progress in polymeric prodrugs. Progr. Polym. Sci. 31 (2006) 359-397
35. Khandare J.J., and Minko T. Polymer-drug conjugates: progress in polymeric prodrugs. Progr. Polym. Sci. 31 (2006) 359-397
36. Minko T., Khandare J., and Jayant S. In: Matyjaszewski K., Gnanou Y., and Leibler L. (Eds). Macromolecular Engineering: From Precise Macromolecular Synthesis to Macroscopic Material Properties and Application. vol. 4th (2007), Wiley-VCH Verlag GmbH & Co., Weinheim 2541-2595
37. Minko T., Dharap S.S., Pakunlu R.I., and Wang Y. Molecular targeting of drug delivery systems to cancer. Curr. Drug Targets 5 4 (2004) 389-406
38. Chandna P., Saad M., Wang Y., Ber E., Khandare J., Vetcher A.A., Soldatenkov V.A., and Minko T. Targeted proapoptotic anticancer drug delivery system. Mol. Pharmacol. 4 5 (2007) 668-678
39. Burger C.W., Prinssen H.M., and Kenemans P. LHRH agonist treatment of breast cancer and gynecological malignancies: a review. Eur. J. Obstet. Gynecol. Reprod. Biol. 67 1 (1996) 27-33
40. Sharma R., Beith J., and Hamilton A. Systematic review of LHRH agonists for the adjuvant treatment of early breast cancer. Breast 14 3 (2005) 181-191