메뉴 건너뛰기




Volumn 36, Issue 1, 1999, Pages 125-141

Cyclodextrin-based controlled drug release system

Author keywords

Colon targeting; Controlled release; Cyclodextrin; Drug carrier; Drug cyclodextrin conjugate; Inclusion complex; Oral drug delivery

Indexed keywords

COMPLEXATION; CONTROLLED DRUG DELIVERY; DRUG DOSAGE; DRUG PRODUCTS;

EID: 0033104290     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(98)00058-1     Document Type: Review
Times cited : (453)

References (107)
  • 7
    • 0019779742 scopus 로고
    • Pharmaceutical applications of cyclodextrin complexations
    • K. Uekama, Pharmaceutical applications of cyclodextrin complexations, Yakugaku Zasshi 101 (1981) 857-873.
    • (1981) Yakugaku Zasshi , vol.101 , pp. 857-873
    • Uekama, K.1
  • 8
    • 0343033288 scopus 로고
    • Molecular encapsulation of drugs by cyclodextrins and congeners
    • S.D. Bruck (Ed.), CRC Press, Boca Raton, FL, Ch. 5
    • J. Pitha, L. Szente, J. Szejtli, Molecular encapsulation of drugs by cyclodextrins and congeners, in: S.D. Bruck (Ed.), Controlled Drug Delivery, Vol. I, CRC Press, Boca Raton, FL, 1983, Ch. 5.
    • (1983) Controlled Drug Delivery , vol.1
    • Pitha, J.1    Szente, L.2    Szejtli, J.3
  • 11
    • 0025810218 scopus 로고
    • Development of aqueous parenteral formulations for carbamazepine through the use of modified cyclodextrins
    • M.E. Brewster, W.R. Anderson, K.S. Estes, N. Bodor, Development of aqueous parenteral formulations for carbamazepine through the use of modified cyclodextrins, J. Pharm. Sci. 80 (1991) 380-383.
    • (1991) J. Pharm. Sci. , vol.80 , pp. 380-383
    • Brewster, M.E.1    Anderson, W.R.2    Estes, K.S.3    Bodor, N.4
  • 12
    • 0002596801 scopus 로고    scopus 로고
    • Pharmaceutical use of cyclodextrins in various drug formulations
    • J. Szejtli, T. Osa (Eds.), Pergamon, Oxford
    • K. Uekama, T. Irie, Pharmaceutical use of cyclodextrins in various drug formulations, in: J. Szejtli, T. Osa (Eds.), Cyclodextrins. Comprehensive Supramolecular Chemistry, Vol. 3, Pergamon, Oxford, 1996.
    • (1996) Cyclodextrins. Comprehensive Supramolecular Chemistry , vol.3
    • Uekama, K.1    Irie, T.2
  • 14
    • 0000117775 scopus 로고
    • Application of cyclodextrins. Drug absorption enhancement: Concepts, possibilities, limitations and trends
    • A.G. Boer (Ed.), Harwood Academic, Swizerland
    • K. Uekama, F. Hirayama, T. Irie, Application of cyclodextrins. Drug absorption enhancement: concepts, possibilities, limitations and trends, in: A.G. Boer (Ed.), Drug Targeting Delivery, Vol. 3, Harwood Academic, Swizerland, 1994, pp. 411-456.
    • (1994) Drug Targeting Delivery , vol.3 , pp. 411-456
    • Uekama, K.1    Hirayama, F.2    Irie, T.3
  • 16
    • 8244248457 scopus 로고    scopus 로고
    • Cyclodextrins: Their future in drug formulation and delivery
    • V.J. Stella, R.A. Rajewski, Cyclodextrins: their future in drug formulation and delivery, Pharm. Res. 14 (1997) 556-567.
    • (1997) Pharm. Res. , vol.14 , pp. 556-567
    • Stella, V.J.1    Rajewski, R.A.2
  • 17
    • 0031042310 scopus 로고    scopus 로고
    • Cyclodextrins-enabling excipients: Their present and future use in pharmaceuticals
    • D.O. Thompson, Cyclodextrins-enabling excipients: their present and future use in pharmaceuticals, CRC Crit. Rev. Ther. Drug Carrier Syst. 14 (1997) 1-104.
    • (1997) CRC Crit. Rev. Ther. Drug Carrier Syst. , vol.14 , pp. 1-104
    • Thompson, D.O.1
  • 18
    • 0029819323 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization
    • T. Loftsson, M.E. Brewster, Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization, J. Pharm. Sci. 85 (1996) 1017-1025.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1017-1025
    • Loftsson, T.1    Brewster, M.E.2
  • 19
    • 0029852699 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery
    • R.A. Rajewski, V.J. Stella, Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery, J. Pharm. Sci. 85 (1996) 1142-1169.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1142-1169
    • Rajewski, R.A.1    Stella, V.J.2
  • 20
    • 0031054513 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation
    • T. Irie, K. Uekama, Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation, J. Pharm. Sci. 86 (1997) 147-162.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 147-162
    • Irie, T.1    Uekama, K.2
  • 21
    • 0032119526 scopus 로고    scopus 로고
    • Cyclodextrin drug carrier systems
    • K. Uekama, F. Hirayama, T. Irie, Cyclodextrin drug carrier systems, Chem. Rev. 98 (1998) 2045-2076.
    • (1998) Chem. Rev. , vol.98 , pp. 2045-2076
    • Uekama, K.1    Hirayama, F.2    Irie, T.3
  • 22
    • 0021810514 scopus 로고
    • Amorphous water-soluble derivatives of cyclodextrins, nontoxic dissolution enhancing excipients
    • J. Pitha, J. Pitha, Amorphous water-soluble derivatives of cyclodextrins, nontoxic dissolution enhancing excipients, J. Pharm. Sci. 74 (1985) 987-990.
    • (1985) J. Pharm. Sci. , vol.74 , pp. 987-990
    • Pitha, J.1    Pitha, J.2
  • 23
    • 0021816582 scopus 로고
    • Solubilization of drugs by modified β-cyclodextrins
    • B.W. Müller, U. Brauns, Solubilization of drugs by modified β-cyclodextrins, Int. J. Pharm. 26 (1985) 77-88.
    • (1985) Int. J. Pharm. , vol.26 , pp. 77-88
    • Müller, B.W.1    Brauns, U.2
  • 24
    • 0023676038 scopus 로고
    • Pharmaceutical evaluation of hydroxyalkylethers of β-cyclodextrins
    • A. Yoshida, H. Arima, K. Uekama, J. Pitha, Pharmaceutical evaluation of hydroxyalkylethers of β-cyclodextrins, Int. J. Pharm. 46 (1988) 217-222.
    • (1988) Int. J. Pharm. , vol.46 , pp. 217-222
    • Yoshida, A.1    Arima, H.2    Uekama, K.3    Pitha, J.4
  • 26
    • 0002558849 scopus 로고
    • Isolation and characterization of branched cyclodextrins
    • K. Koizumi, T. Utamura, M. Sato, Y. Yagi, Isolation and characterization of branched cyclodextrins, Carbohydr. Res. 153 (1986) 55-67.
    • (1986) Carbohydr. Res. , vol.153 , pp. 55-67
    • Koizumi, K.1    Utamura, T.2    Sato, M.3    Yagi, Y.4
  • 27
    • 0024499690 scopus 로고
    • Some physicochemical properties of branched β-cyclodextrins and their inclusion characteristics
    • M. Yamamoto, A. Yoshida, F. Hirayama, K. Uekama, Some physicochemical properties of branched β-cyclodextrins and their inclusion characteristics, Int. J. Pharm. 49 (1989) 163-171.
    • (1989) Int. J. Pharm. , vol.49 , pp. 163-171
    • Yamamoto, M.1    Yoshida, A.2    Hirayama, F.3    Uekama, K.4
  • 28
    • 0024977229 scopus 로고
    • O-Carboxymethyl-O-ethyl-cyclomaltoheptaose as a delayed-release-type drug carrier. Improvement of the oral bioavailability of diltiazem
    • K. Uekama, Y. Horiuchi, T. Irie, F. Hirayama, O-Carboxymethyl-O-ethyl-cyclomaltoheptaose as a delayed-release-type drug carrier. Improvement of the oral bioavailability of diltiazem, Carbohydr. Res. 192 (1989) 323-330.
    • (1989) Carbohydr. Res. , vol.192 , pp. 323-330
    • Uekama, K.1    Horiuchi, Y.2    Irie, T.3    Hirayama, F.4
  • 29
    • 0025938358 scopus 로고
    • Improvement, of stability and bioavailability of 1-hexylcarbamoyl-5-fluorouracil (HCFU) by O-carboxymethyl-O-ethyl-β-cyclodextrin
    • Y. Horiuchi, F. Hirayama, K. Uekama, Improvement, of stability and bioavailability of 1-hexylcarbamoyl-5-fluorouracil (HCFU) by O-carboxymethyl-O-ethyl-β-cyclodextrin, Yakugaku Zasshi 111 (1991) 592-599.
    • (1991) Yakugaku Zasshi , vol.111 , pp. 592-599
    • Horiuchi, Y.1    Hirayama, F.2    Uekama, K.3
  • 30
    • 0025968081 scopus 로고
    • Release control of theophylline by β-cyclodextrin derivatives: Hybridizing effect of hydrophilic, hydrophobic and ionizable β-cyclodextrin complexes
    • Y. Horiuchi, K. Abe, F. Hirayama, K. Uekama, Release control of theophylline by β-cyclodextrin derivatives: hybridizing effect of hydrophilic, hydrophobic and ionizable β-cyclodextrin complexes, J. Control. Release 15 (1991) 177-183.
    • (1991) J. Control. Release , vol.15 , pp. 177-183
    • Horiuchi, Y.1    Abe, K.2    Hirayama, F.3    Uekama, K.4
  • 32
    • 0027279678 scopus 로고
    • Development and pharmaceutical evaluation of hydrophobic derivatives as modified-release drug carrier
    • F. Hirayama, Development and pharmaceutical evaluation of hydrophobic derivatives as modified-release drug carrier, Yakugaku Zasshi 113 (1993) 425-437.
    • (1993) Yakugaku Zasshi , vol.113 , pp. 425-437
    • Hirayama, F.1
  • 33
    • 0023543437 scopus 로고
    • Ethylated β-cyclodextrins as hydrophobic drug carriers: Sustained release of diltiazem in the rat
    • K. Uekama, N. Hirashima, H. Horiuchi, F. Hirayama, T. Ijitsu, M. Ueno, Ethylated β-cyclodextrins as hydrophobic drug carriers: sustained release of diltiazem in the rat, J. Pharm. Sci. 76 (1987) 660-661.
    • (1987) J. Pharm. Sci. , vol.76 , pp. 660-661
    • Uekama, K.1    Hirashima, N.2    Horiuchi, H.3    Hirayama, F.4    Ijitsu, T.5    Ueno, M.6
  • 34
    • 0027393910 scopus 로고
    • Preparation of heptakis(2,6-di-O-ethyl)-β-cyclodextrin and its nuclear magnetic resonance spectroscopic characterization
    • F. Hirayama, M. Kurihara, Y. Horiuchi, T. Utsuki, K. Uekama, M. Yamasaki, Preparation of heptakis(2,6-di-O-ethyl)-β-cyclodextrin and its nuclear magnetic resonance spectroscopic characterization, Pharm. Res. 10 (1993) 208-213.
    • (1993) Pharm. Res. , vol.10 , pp. 208-213
    • Hirayama, F.1    Kurihara, M.2    Horiuchi, Y.3    Utsuki, T.4    Uekama, K.5    Yamasaki, M.6
  • 35
    • 0024955999 scopus 로고
    • Sustained release of buserelin acetate, a luteinizing hormone-releasing hormone agonist, from the injectable oily preparation utilizing ethylated β-cyclodextrin
    • K. Uekama, H. Arima, T. Irie, K. Matsubara, K. Kuriki, Sustained release of buserelin acetate, a luteinizing hormone-releasing hormone agonist, from the injectable oily preparation utilizing ethylated β-cyclodextrin, J. Pharm. Pharmacol. 41 (1989) 874-876.
    • (1989) J. Pharm. Pharmacol. , vol.41 , pp. 874-876
    • Uekama, K.1    Arima, H.2    Irie, T.3    Matsubara, K.4    Kuriki, K.5
  • 36
    • 0028855247 scopus 로고
    • Characterization of peracylated β-cyclodextrins with different chain lengths as a novel sustained release carrier for water-soluble drugs
    • F. Hirayama, M. Yamanaka, T. Horikawa, K. Uekama, Characterization of peracylated β-cyclodextrins with different chain lengths as a novel sustained release carrier for water-soluble drugs, Chem. Pharm. Bull. 43 (1995) 130-136.
    • (1995) Chem. Pharm. Bull. , vol.43 , pp. 130-136
    • Hirayama, F.1    Yamanaka, M.2    Horikawa, T.3    Uekama, K.4
  • 37
    • 0028087996 scopus 로고
    • Controlled-release of the LHRH agonist buserelin acetate from injectable suspensions containing triacetylated cyclodextrins in an oil vehicle
    • K. Matsubara, T. Irie, K. Uekama, Controlled-release of the LHRH agonist buserelin acetate from injectable suspensions containing triacetylated cyclodextrins in an oil vehicle, J. Control. Release 31 (1994) 173-180.
    • (1994) J. Control. Release , vol.31 , pp. 173-180
    • Matsubara, K.1    Irie, T.2    Uekama, K.3
  • 38
    • 0001795431 scopus 로고    scopus 로고
    • Improvement of drug properties by cyclodextrins
    • C.G. Wermuth (Ed.), Academic Press, London, Ch. 37
    • K. Uekama, F. Hirayama, Improvement of drug properties by cyclodextrins, in: C.G. Wermuth (Ed.), The Practice of Medicinal Chemistry, Academic Press, London, 1996, Ch. 37, pp. 793-825.
    • (1996) The Practice of Medicinal Chemistry , pp. 793-825
    • Uekama, K.1    Hirayama, F.2
  • 39
    • 0019846019 scopus 로고
    • Kinetic difference between hydrolyses of γ-cyclodextrin by human salivary and pancreatic α-amylases
    • J.J. Marshall, I. Miwa, Kinetic difference between hydrolyses of γ-cyclodextrin by human salivary and pancreatic α-amylases, Biochim. Biophys. Acta 661 (1981) 142-147.
    • (1981) Biochim. Biophys. Acta , vol.661 , pp. 142-147
    • Marshall, J.J.1    Miwa, I.2
  • 40
    • 0027085845 scopus 로고
    • Acid-catalyzed hydrolysis of maltosyl-β-cyclodextrin
    • F. Hirayama, M. Yamamoto, K. Uekama, Acid-catalyzed hydrolysis of maltosyl-β-cyclodextrin, J. Pharm. Sci. 81 (1992) 913-916.
    • (1992) J. Pharm. Sci. , vol.81 , pp. 913-916
    • Hirayama, F.1    Yamamoto, M.2    Uekama, K.3
  • 41
    • 0001357555 scopus 로고
    • Biopharmaceutical evaluation of maltosyl-β-cyclodextrin as a parenteral drug carrier
    • M. Yamamoto, H. Aritomi, T. Irie, F. Hirayama, K. Uekama, Biopharmaceutical evaluation of maltosyl-β-cyclodextrin as a parenteral drug carrier, S.T.P. Pharma Sci. 1 (1991) 397-402.
    • (1991) S.T.P. Pharma Sci. , vol.1 , pp. 397-402
    • Yamamoto, M.1    Aritomi, H.2    Irie, T.3    Hirayama, F.4    Uekama, K.5
  • 42
    • 0030610609 scopus 로고    scopus 로고
    • A-amino-[(4-biphenylyl)-acetyl]-α-, β-, and γ-cyclodextrins: Potential prodrugs for colon-specific delivery
    • A-amino-[(4-biphenylyl)-acetyl]-α-, β-, and γ-cyclodextrins: potential prodrugs for colon-specific delivery, J. Med. Chem. 40 (1997) 2755-2761.
    • (1997) J. Med. Chem. , vol.40 , pp. 2755-2761
    • Uekama, K.1    Minami, K.2    Hirayama, F.3
  • 43
    • 0022639287 scopus 로고
    • Enhancement of bioavailability of cinnarizine from its β-cyclodextrin complex on oral administration with D,L-phenylalanine as a competing agent
    • T. Tokumura, M. Nambu, Y. Tsushima, K. Tatsuishi, M. Kayano, Y. Machida, T. Nagai, Enhancement of bioavailability of cinnarizine from its β-cyclodextrin complex on oral administration with D,L-phenylalanine as a competing agent, J. Pharm. Sci. 75 (1986) 391-394.
    • (1986) J. Pharm. Sci. , vol.75 , pp. 391-394
    • Tokumura, T.1    Nambu, M.2    Tsushima, Y.3    Tatsuishi, K.4    Kayano, M.5    Machida, Y.6    Nagai, T.7
  • 44
    • 0024595698 scopus 로고
    • Effect of the interaction of drug-β-cyclodextrin complex with bile salts on the drug absorption from rat small intestinal lumen
    • K. Nakanishi, M. Masada, T. Nadai, K. Miyajima, Effect of the interaction of drug-β-cyclodextrin complex with bile salts on the drug absorption from rat small intestinal lumen, Chem. Pharm. Bull. 37 (1989) 211-214.
    • (1989) Chem. Pharm. Bull. , vol.37 , pp. 211-214
    • Nakanishi, K.1    Masada, M.2    Nadai, T.3    Miyajima, K.4
  • 46
    • 0032550318 scopus 로고    scopus 로고
    • An econazole β-cyclodextrin inclusion complex: An unusual dissolution rate, supersaturation, and biological efficacy example
    • M. Pedersen, S. Bjerregaard, J. Jacobson, A.R. Larsen, A.M. Sorensen, An econazole β-cyclodextrin inclusion complex: an unusual dissolution rate, supersaturation, and biological efficacy example, Int. J. Pharm. 165 (1998) 57-68.
    • (1998) Int. J. Pharm. , vol.165 , pp. 57-68
    • Pedersen, M.1    Bjerregaard, S.2    Jacobson, J.3    Larsen, A.R.4    Sorensen, A.M.5
  • 47
    • 0344537810 scopus 로고
    • Formulation studies of a new oral cephalosporin, cefotiam hexetil hydrochloride [SCE-2174 (2HCl)]
    • S. Hirai, H. Koyama, T. Makino, N. Kitamori, H. Toguchi, Formulation studies of a new oral cephalosporin, cefotiam hexetil hydrochloride [SCE-2174 (2HCl)], Yakuzaigaku 48 (1988) 189-196.
    • (1988) Yakuzaigaku , vol.48 , pp. 189-196
    • Hirai, S.1    Koyama, H.2    Makino, T.3    Kitamori, N.4    Toguchi, H.5
  • 49
    • 85047693676 scopus 로고
    • Oral pharmacokinetics of carbamazepine in dogs from commercial tablets and a cyclodextrin complex
    • C.J. Betlach, M.A. Gonzalez, B.C. Mckiernan, C. Neff-Davis, N. Bodor, Oral pharmacokinetics of carbamazepine in dogs from commercial tablets and a cyclodextrin complex, J. Pharm. Sci. 82 (1993) 1058-1060.
    • (1993) J. Pharm. Sci. , vol.82 , pp. 1058-1060
    • Betlach, C.J.1    Gonzalez, M.A.2    Mckiernan, B.C.3    Neff-Davis, C.4    Bodor, N.5
  • 51
    • 0028920379 scopus 로고
    • β-Cyclodextrin derivatives, SBE-β-CD and HB-β-CD, increase the oral bioavailability of cinnarizine in beagle dogs
    • T. Järvinen, K. Järvinen, N. Schwarting, V.J. Stella, β-Cyclodextrin derivatives, SBE-β-CD and HB-β-CD, increase the oral bioavailability of cinnarizine in beagle dogs, J. Pharm. Sci. 84 (1995) 295-299.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 295-299
    • Järvinen, T.1    Järvinen, K.2    Schwarting, N.3    Stella, V.J.4
  • 52
    • 0031024463 scopus 로고    scopus 로고
    • Crystallization and polymorphic transition behavior of chloramphenicol palmitate in 2-hydroxypropyl-β-cyclodextrin matrix
    • F. Hirayama, M. Usami, K. Kimura, K. Uekama, Crystallization and polymorphic transition behavior of chloramphenicol palmitate in 2-hydroxypropyl-β-cyclodextrin matrix, Eur. J. Pharm. Sci. 5 (1997) 23-30.
    • (1997) Eur. J. Pharm. Sci. , vol.5 , pp. 23-30
    • Hirayama, F.1    Usami, M.2    Kimura, K.3    Uekama, K.4
  • 54
    • 0028116075 scopus 로고
    • Effect of 2-hydroxypropyl-β-cyclodextrin on crystallization and polymorphic transition of nifedipine in solid state
    • F. Hirayama, Z. Wang, K. Uekama, Effect of 2-hydroxypropyl-β-cyclodextrin on crystallization and polymorphic transition of nifedipine in solid state, Pharm. Res. 11 (1994) 1766-1770.
    • (1994) Pharm. Res. , vol.11 , pp. 1766-1770
    • Hirayama, F.1    Wang, Z.2    Uekama, K.3
  • 55
    • 0022599556 scopus 로고
    • Hydrophilic cyclodextrin derivatives enable effective oral administration of steroidal hormones
    • J. Pitha, S.M. Harman, M.E. Michel, Hydrophilic cyclodextrin derivatives enable effective oral administration of steroidal hormones, J. Pharm. Sci. 75 (1986) 165-167.
    • (1986) J. Pharm. Sci. , vol.75 , pp. 165-167
    • Pitha, J.1    Harman, S.M.2    Michel, M.E.3
  • 56
    • 0023612459 scopus 로고
    • γ-Cyclodextrin: Testosterone complex suitable for sublingual administration
    • J. Pitha, E.J. Anaissie, K. Uekama, γ-Cyclodextrin: testosterone complex suitable for sublingual administration, J. Pharm. Sci. 76 (1987) 788-790.
    • (1987) J. Pharm. Sci. , vol.76 , pp. 788-790
    • Pitha, J.1    Anaissie, E.J.2    Uekama, K.3
  • 57
    • 0024401340 scopus 로고
    • Testosterone in a cyclodextrin containing formulation: Behavioral and physiological effects of episode-like pulses in rats
    • G.T. Tayler, J. Weiss, J. Pitha, Testosterone in a cyclodextrin containing formulation: behavioral and physiological effects of episode-like pulses in rats, Pharm. Res. 6 (1989) 641-646.
    • (1989) Pharm. Res. , vol.6 , pp. 641-646
    • Tayler, G.T.1    Weiss, J.2    Pitha, J.3
  • 58
    • 0025798996 scopus 로고
    • Sublingual administration of testosterone-hydroxypropyl-β-cyclodextrin inclusion complex simulates episodic androgen release in hypogonadal men
    • C.A. Stuenkel, R.E. Dudley, S.S. Yen, Sublingual administration of testosterone-hydroxypropyl-β-cyclodextrin inclusion complex simulates episodic androgen release in hypogonadal men, J. Clin. Endocrinol. Metab. 72 (1991) 1054-1059.
    • (1991) J. Clin. Endocrinol. Metab. , vol.72 , pp. 1054-1059
    • Stuenkel, C.A.1    Dudley, R.E.2    Yen, S.S.3
  • 61
    • 0024432730 scopus 로고
    • Enhanced bioavailability of digoxin by γ-cyclodextrin complexation: Evaluation for sublingual and oral administrations in human
    • H. Seo, K. Uekama, Enhanced bioavailability of digoxin by γ-cyclodextrin complexation: evaluation for sublingual and oral administrations in human, Yakugaku Zasshi 109 (1989) 778-782.
    • (1989) Yakugaku Zasshi , vol.109 , pp. 778-782
    • Seo, H.1    Uekama, K.2
  • 62
    • 0029616701 scopus 로고
    • Evaluation of gastrointestinal behavior in the rat of amphiphilic β-cyclodextrin nanocapsules, loaded with indomethacin
    • M. Skiba, C. Morvan, D. Duchêne, F. Puisieux, D. Wouessidjewe, Evaluation of gastrointestinal behavior in the rat of amphiphilic β-cyclodextrin nanocapsules, loaded with indomethacin, Int. J. Pharm. 126 (1995) 275-279.
    • (1995) Int. J. Pharm. , vol.126 , pp. 275-279
    • Skiba, M.1    Morvan, C.2    Duchêne, D.3    Puisieux, F.4    Wouessidjewe, D.5
  • 63
    • 0027269952 scopus 로고
    • In vitro and in vivo evaluation of delayed-release behavior of diltiazem from its O-carboxymethyl-O-ethyl-β-cyclodextrin complex
    • K. Uekama, T. Horikawa, Y. Horiuchi, F. Hirayama, In vitro and in vivo evaluation of delayed-release behavior of diltiazem from its O-carboxymethyl-O-ethyl-β-cyclodextrin complex, J. Control. Release 25 (1993) 99-106.
    • (1993) J. Control. Release , vol.25 , pp. 99-106
    • Uekama, K.1    Horikawa, T.2    Horiuchi, Y.3    Hirayama, F.4
  • 64
    • 0028945752 scopus 로고
    • In-vivo and in-vitro correlation for delayed-release behavior of a molsidomine/ O-carboxymethyl-O-ethyl-β-cyclodextrin complex in gastric acidity-controlled dogs
    • T. Horikawa, F. Hirayama, K. Uekama, In-vivo and in-vitro correlation for delayed-release behavior of a molsidomine/ O-carboxymethyl-O-ethyl-β-cyclodextrin complex in gastric acidity-controlled dogs, J. Pharm. Pharmacol. 47 (1995) 124-127.
    • (1995) J. Pharm. Pharmacol. , vol.47 , pp. 124-127
    • Horikawa, T.1    Hirayama, F.2    Uekama, K.3
  • 65
    • 0025305421 scopus 로고
    • Slow-release characteristics of diltiazem from ethylated β-cyclodextrin complexes
    • Y. Horiuchi, F. Hirayama, K. Uekama, Slow-release characteristics of diltiazem from ethylated β-cyclodextrin complexes, J. Pharm. Sci. 79 (1990) 128-132.
    • (1990) J. Pharm. Sci. , vol.79 , pp. 128-132
    • Horiuchi, Y.1    Hirayama, F.2    Uekama, K.3
  • 66
    • 0023759862 scopus 로고
    • Utilization of diethyl-β-cyclodextrin as a sustained-release carrier for isosorbide dinitrate
    • F. Hirayama, N. Hirashima, K. Abe, K. Uekama, T. Ijitsu, M. Ueno, Utilization of diethyl-β-cyclodextrin as a sustained-release carrier for isosorbide dinitrate, J. Pharm. Sci. 77 (1989) 233-236.
    • (1989) J. Pharm. Sci. , vol.77 , pp. 233-236
    • Hirayama, F.1    Hirashima, N.2    Abe, K.3    Uekama, K.4    Ijitsu, T.5    Ueno, M.6
  • 68
    • 25444508474 scopus 로고    scopus 로고
    • Release-control of a water-soluble drug by film-forming trivaleryl-β-cyclodextrin
    • in press
    • M. Yamada, F. Hirayama, K. Uekama, Release-control of a water-soluble drug by film-forming trivaleryl-β-cyclodextrin, Drug Delivery System, 14, in press.
    • Drug Delivery System , pp. 14
    • Yamada, M.1    Hirayama, F.2    Uekama, K.3
  • 69
    • 0028131276 scopus 로고
    • Peracylated β-cyclodextrins as novel sustained-release carriers for a water-soluble drug, molsidomine
    • K. Uekama, T. Horikawa, M. Yamanaka, F. Hirayama, Peracylated β-cyclodextrins as novel sustained-release carriers for a water-soluble drug, molsidomine, J. Pharm. Pharmacol. 46 (1994) 714-717.
    • (1994) J. Pharm. Pharmacol. , vol.46 , pp. 714-717
    • Uekama, K.1    Horikawa, T.2    Yamanaka, M.3    Hirayama, F.4
  • 70
    • 84988148682 scopus 로고
    • Enhanced bioavailability and reduced metabolism of salbutamol by perbutanoyl-β-cyclodextrin after oral administration in dogs
    • F. Hirayama, T. Horikawa, M. Yamanaka, K. Uekama, Enhanced bioavailability and reduced metabolism of salbutamol by perbutanoyl-β-cyclodextrin after oral administration in dogs, Pharm. Sci. 1 (1995) 517-520.
    • (1995) Pharm. Sci. , vol.1 , pp. 517-520
    • Hirayama, F.1    Horikawa, T.2    Yamanaka, M.3    Uekama, K.4
  • 72
    • 0026505701 scopus 로고
    • Inhibitory effect of 2-hydroxypropyl-β-cyclodextrin on crystal-growth of nifedipine during storage: Superior dissolution and oral bioavailability compared with polyvinylpyrrolidone K-30
    • K. Uekama, K. Ikegami, Z. Wang, Y. Horiuchi, F. Hirayama, Inhibitory effect of 2-hydroxypropyl-β-cyclodextrin on crystal-growth of nifedipine during storage: superior dissolution and oral bioavailability compared with polyvinylpyrrolidone K-30, J. Pharm. Pharmacol. 44 (1992) 73-78.
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 73-78
    • Uekama, K.1    Ikegami, K.2    Wang, Z.3    Horiuchi, Y.4    Hirayama, F.5
  • 73
    • 0027380386 scopus 로고
    • Release characteristics of nifedipine from 2-hydroxypropyl-β-cyclodextrin complex during storage and its modification of hybridizing polyvinylpyrrolidone K-30
    • Z. Wang, K. Ikegami, F. Hirayama, K. Uekama, Release characteristics of nifedipine from 2-hydroxypropyl-β-cyclodextrin complex during storage and its modification of hybridizing polyvinylpyrrolidone K-30, Chem. Pharm. Bull. 41 (1993) 1822-1826.
    • (1993) Chem. Pharm. Bull. , vol.41 , pp. 1822-1826
    • Wang, Z.1    Ikegami, K.2    Hirayama, F.3    Uekama, K.4
  • 74
    • 0027441148 scopus 로고
    • Design and in-vitro evaluation of a modified-release oral dosage form of nifedipine by hybridization of hydroxypropyl-β-cyclodextrin and hydroxypropyl cellulose
    • Z. Wang, F. Hirayama, K. Uekama, Design and in-vitro evaluation of a modified-release oral dosage form of nifedipine by hybridization of hydroxypropyl-β-cyclodextrin and hydroxypropyl cellulose, J. Pharm. Pharmacol. 45 (1993) 942-946.
    • (1993) J. Pharm. Pharmacol. , vol.45 , pp. 942-946
    • Wang, Z.1    Hirayama, F.2    Uekama, K.3
  • 75
    • 0028237692 scopus 로고
    • In-vivo and in-vitro evaluations of a modified-release oral dosage form of nifedipine by hybridization of hydroxypropyl-β-cyclodextrin and hydroxypropyl celluloses in dogs
    • Z. Wang, F. Hirayama, K. Uekama, In-vivo and in-vitro evaluations of a modified-release oral dosage form of nifedipine by hybridization of hydroxypropyl-β-cyclodextrin and hydroxypropyl celluloses in dogs, J. Pharm. Pharmacol. 46 (1994) 505-507.
    • (1994) J. Pharm. Pharmacol. , vol.46 , pp. 505-507
    • Wang, Z.1    Hirayama, F.2    Uekama, K.3
  • 76
    • 0025219744 scopus 로고
    • Design and in vitro evaluation of slow-release dosage form of piretanide: Utility of β-cyclodextrin/cellulose derivative combination as a modified-release drug carrier
    • K. Uekama, K. Matsubara, K. Abe, Y. Horiuchi, F. Hirayama, N. Suzuki, Design and in vitro evaluation of slow-release dosage form of piretanide: utility of β-cyclodextrin/cellulose derivative combination as a modified-release drug carrier, J. Pharm. Sci. 79 (1990) 244-248.
    • (1990) J. Pharm. Sci. , vol.79 , pp. 244-248
    • Uekama, K.1    Matsubara, K.2    Abe, K.3    Horiuchi, Y.4    Hirayama, F.5    Suzuki, N.6
  • 77
    • 0022408524 scopus 로고
    • Osmotic flow through controlled porosity films: An approach to delivery of water-soluble compounds
    • G.M. Zentner, G.S. Rork, K.J. Himmelstein, Osmotic flow through controlled porosity films: an approach to delivery of water-soluble compounds, J. Control. Release 2 (1989) 217-229.
    • (1989) J. Control. Release , vol.2 , pp. 217-229
    • Zentner, G.M.1    Rork, G.S.2    Himmelstein, K.J.3
  • 79
    • 0030053698 scopus 로고    scopus 로고
    • The interaction of charged and uncharged drugs with neutral (HB-β-CD) and anionically charged (SBE-β-CD) β-cyclodextrins
    • K. Okimoto, R.A. Rajewski, K. Uekama, J.A. Jana, V.J. Stella, The interaction of charged and uncharged drugs with neutral (HB-β-CD) and anionically charged (SBE-β-CD) β-cyclodextrins, Pharm. Res. 13 (1996) 256-264.
    • (1996) Pharm. Res. , vol.13 , pp. 256-264
    • Okimoto, K.1    Rajewski, R.A.2    Uekama, K.3    Jana, J.A.4    Stella, V.J.5
  • 81
    • 0023632674 scopus 로고
    • Redox drug delivery systems for targeting drugs to the brain
    • N. Bodor, Redox drug delivery systems for targeting drugs to the brain, Ann. NY Acad. Sci. 507 (1987) 289-306.
    • (1987) Ann. NY Acad. Sci. , vol.507 , pp. 289-306
    • Bodor, N.1
  • 84
    • 0030009471 scopus 로고    scopus 로고
    • In-vitro evaluation of biphenylylacetic acid-β-cyclodextrin conjugates as colon-targeting prodrugs: Drug release behavior in rat biological media
    • F. Hirayama, K. Minami, K. Uekama, In-vitro evaluation of biphenylylacetic acid-β-cyclodextrin conjugates as colon-targeting prodrugs: drug release behavior in rat biological media, J. Pharm. Pharmacol. 48 (1996) 27-31.
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 27-31
    • Hirayama, F.1    Minami, K.2    Uekama, K.3
  • 85
    • 0031807470 scopus 로고    scopus 로고
    • Colon-specific drug delivery based on a cyclodextrin prodrug: Release behavior of biphenylylacetic acid from its cyclodextrin conjugates in rat intestinal tracts after oral administration
    • K. Minami, F. Hirayama, K. Uekama, Colon-specific drug delivery based on a cyclodextrin prodrug: release behavior of biphenylylacetic acid from its cyclodextrin conjugates in rat intestinal tracts after oral administration, J. Pharm. Sci. 87 (1998) 715-720.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 715-720
    • Minami, K.1    Hirayama, F.2    Uekama, K.3
  • 86
    • 0029871091 scopus 로고    scopus 로고
    • The blood-brain barrier: Principles for targeting peptides and drugs to the central nervous system
    • D.J. Begley, The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system, J. Pharm. Pharmacol. 48 (1996) 136-146.
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 136-146
    • Begley, D.J.1
  • 87
    • 0006645882 scopus 로고
    • Prodrugs versus soft drugs
    • H. Bundgaard (Ed.), Elsevier, Amsterdam, Ch. 11
    • N. Bodor, Prodrugs versus soft drugs, in: H. Bundgaard (Ed.), Design of Prodrugs. Elsevier, Amsterdam, 1985, Ch. 11, pp. 333-354.
    • (1985) Design of Prodrugs , pp. 333-354
    • Bodor, N.1
  • 88
    • 0024269519 scopus 로고
    • Improved delivery through biological membranes. XXXI: Solubilization and stabilization of an estradiol chemical delivery system by modified β-cyclodextrins
    • M.E. Brewster, K. Estes, T. Loftsson, R. Perchalski, H. Derendorf, G. Mullersman, N. Bodor, Improved delivery through biological membranes. XXXI: solubilization and stabilization of an estradiol chemical delivery system by modified β-cyclodextrins, J. Pharm. Sci. 77 (1988) 981-985.
    • (1988) J. Pharm. Sci. , vol.77 , pp. 981-985
    • Brewster, M.E.1    Estes, K.2    Loftsson, T.3    Perchalski, R.4    Derendorf, H.5    Mullersman, G.6    Bodor, N.7
  • 89
    • 0023886573 scopus 로고
    • Brain-enhanced delivery of testosterone using a chemical delivery system complexed with 2-hydoxypropyl-β-cyclodextrin
    • W.R. Anderson, J.W. Simpkins, M.E. Brewster, N. Bodor, Brain-enhanced delivery of testosterone using a chemical delivery system complexed with 2-hydoxypropyl-β-cyclodextrin, Drug Design Deliv. 2 (1988) 287-298.
    • (1988) Drug Design Deliv. , vol.2 , pp. 287-298
    • Anderson, W.R.1    Simpkins, J.W.2    Brewster, M.E.3    Bodor, N.4
  • 90
    • 0025824035 scopus 로고
    • Solubilization and stabilization of a benzylpenicillin chemical delivery system by 2-hydroxypropyl-β-cyclodextrin
    • E. Pop, T. Loftsson, N. Bodor, Solubilization and stabilization of a benzylpenicillin chemical delivery system by 2-hydroxypropyl-β-cyclodextrin, Pharm. Res. 8 (1991) 1044-1049.
    • (1991) Pharm. Res. , vol.8 , pp. 1044-1049
    • Pop, E.1    Loftsson, T.2    Bodor, N.3
  • 91
    • 0030947274 scopus 로고    scopus 로고
    • Effect of a chemical delivery system for dexamethasone (Dex-CDS) on peritumoral edema in an experimental brain tumor model
    • T. Siegal, F. Soti, A. Biegon, E. Pop, M.E. Brewster, Effect of a chemical delivery system for dexamethasone (Dex-CDS) on peritumoral edema in an experimental brain tumor model, Pharm. Res. 14 (1997) 672-675.
    • (1997) Pharm. Res. , vol.14 , pp. 672-675
    • Siegal, T.1    Soti, F.2    Biegon, A.3    Pop, E.4    Brewster, M.E.5
  • 92
    • 0027471803 scopus 로고
    • Synthesis of a new carrier: N(Leu-enkephalin)yl-6-amino-6-deoxy-cyclomaltoheptaose
    • F. Djedaini-Pilard, J. Désalos, B. Perly, Synthesis of a new carrier: N(Leu-enkephalin)yl-6-amino-6-deoxy-cyclomaltoheptaose, Tetrahedron Lett. 34 (1993) 2457-2460.
    • (1993) Tetrahedron Lett. , vol.34 , pp. 2457-2460
    • Djedaini-Pilard, F.1    Désalos, J.2    Perly, B.3
  • 95
    • 0027692111 scopus 로고
    • Synthesis of bulky β-lactams for inhibition of cell surface β-lactamase activity
    • D.N. Karunaratne, S. Farmer, R.E.W. Hancock, Synthesis of bulky β-lactams for inhibition of cell surface β-lactamase activity, Bioconjugate Chem. 4 (1993) 434-439.
    • (1993) Bioconjugate Chem. , vol.4 , pp. 434-439
    • Karunaratne, D.N.1    Farmer, S.2    Hancock, R.E.W.3
  • 96
    • 0030888946 scopus 로고    scopus 로고
    • Impermeant antitumor sulfonylurea conjugates that inhibit plasma membrane NADH oxidase and growth of HeLa cells in culture: Identification of binding proteins from sera of cancer patients
    • C. Kim, W.C. MacKellar, N. Cho, S.R. Byrn, D.J. Morre, Impermeant antitumor sulfonylurea conjugates that inhibit plasma membrane NADH oxidase and growth of HeLa cells in culture: identification of binding proteins from sera of cancer patients, Biochim. Biophys. Acta 1324 (1997) 171-181.
    • (1997) Biochim. Biophys. Acta , vol.1324 , pp. 171-181
    • Kim, C.1    MacKellar, W.C.2    Cho, N.3    Byrn, S.R.4    Morre, D.J.5
  • 98
    • 84963436258 scopus 로고
    • New β-cyclodextrin derivatives possessing biologically active saccharide antennae
    • H. Parrot-Lopez, E. Leray, A.W. Coleman, New β-cyclodextrin derivatives possessing biologically active saccharide antennae, Supramol. Chem. 3 (1993) 37-42.
    • (1993) Supramol. Chem. , vol.3 , pp. 37-42
    • Parrot-Lopez, H.1    Leray, E.2    Coleman, A.W.3
  • 99
    • 0028215921 scopus 로고
    • Synthesis of new oligosaccharidyl-thio-β-cyclodextrins (CDS): A novel family of potent drug-targeting vectors
    • L. Robertis, C. Lancelon-Pin, H. Driguez, F. Attioui, R. Bonaly, A. Marsura, Synthesis of new oligosaccharidyl-thio-β-cyclodextrins (CDS): a novel family of potent drug-targeting vectors, Bioorg. Med. Chem. Lett. 4 (1994) 1127-1130.
    • (1994) Bioorg. Med. Chem. Lett. , vol.4 , pp. 1127-1130
    • Robertis, L.1    Lancelon-Pin, C.2    Driguez, H.3    Attioui, F.4    Bonaly, R.5    Marsura, A.6
  • 100
    • 0029065414 scopus 로고
    • Chemical-enzymatic synthesis and bioactivity of mono-6-[gal-β-1,4-glcNAc-β-(1,6′)-hexyl]amido-6-deoxy- cycloheptaamylose
    • E. Leray, H. Parrot-Lopez, C. Auge, A.W. Coleman, C. Finance, R. Bonaly, Chemical-enzymatic synthesis and bioactivity of mono-6-[gal-β-1,4-glcNAc-β-(1,6′)-hexyl]amido-6-deoxy- cycloheptaamylose. J. Chem. Soc. Chem. Commun. (1995) 1019-1020.
    • (1995) J. Chem. Soc. Chem. Commun. , pp. 1019-1020
    • Leray, E.1    Parrot-Lopez, H.2    Auge, C.3    Coleman, A.W.4    Finance, C.5    Bonaly, R.6
  • 101
    • 0031014613 scopus 로고    scopus 로고
    • The specificity of association between concanavalin a and oligosaccharide-branched cyclodextrins with an optical biosensor
    • H. Imata, K. Kubota, K. Hattori, M. Aoyagi, C. Jindoh, The specificity of association between concanavalin A and oligosaccharide-branched cyclodextrins with an optical biosensor, Bioorg. Med. Chem. Lett. 7 (1997) 109-112.
    • (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 109-112
    • Imata, H.1    Kubota, K.2    Hattori, K.3    Aoyagi, M.4    Jindoh, C.5
  • 102
    • 0028673204 scopus 로고
    • Recognition ability and cytotoxicity of some oligosaccharidyl substituted β-cyclodextrins
    • F. Attioui, A. Al-Omar, E. Leray, H. Parrot-Lopez, C. Finance, R. Bonaly, Recognition ability and cytotoxicity of some oligosaccharidyl substituted β-cyclodextrins, Biol. Cell 82 (1994) 161-167.
    • (1994) Biol. Cell , vol.82 , pp. 161-167
    • Attioui, F.1    Al-Omar, A.2    Leray, E.3    Parrot-Lopez, H.4    Finance, C.5    Bonaly, R.6
  • 103
    • 0029335250 scopus 로고
    • Synthesis, hybridization properties, nuclease stability, and cellular uptake of the oligonucleotide-amino-β-cyclodextrins and adamantane conjugates
    • I. Habus, Q. Zhao, S. Agrawal, Synthesis, hybridization properties, nuclease stability, and cellular uptake of the oligonucleotide-amino-β-cyclodextrins and adamantane conjugates, Bioconjugate Chem. 6 (1995) 327-331.
    • (1995) Bioconjugate Chem. , vol.6 , pp. 327-331
    • Habus, I.1    Zhao, Q.2    Agrawal, S.3
  • 107
    • 0032558114 scopus 로고    scopus 로고
    • Cyclodextrin as carrier of peptide hormones: Conformational and biological properties of β-cyclodextrin/gastrin constructs
    • N. Schaschke, S. Fiori, E. Weyher, C. Escrieut, D. Fourmy, G. Muller, L. Moroder, Cyclodextrin as carrier of peptide hormones: conformational and biological properties of β-cyclodextrin/gastrin constructs, J. Am. Chem. Soc. 120 (1998) 7030-7038.
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 7030-7038
    • Schaschke, N.1    Fiori, S.2    Weyher, E.3    Escrieut, C.4    Fourmy, D.5    Muller, G.6    Moroder, L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.