Autophagy defends pancreatic β cells from Human islet amyloid polypeptide-induced toxicity

Journal of Clinical Investigation

Volumn 124, Issue 8, 2014, Pages 3489-3500

  Rivera, Jacqueline F ^a   Costes, Safia ^a   Gurlo, Tatyana ^a   Glabe, Charles G ^b   Butler, Peter C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; OLIGOMER; POLYPEPTIDE; AMYLIN; HEAT SHOCK PROTEIN; INSULIN; NFE2L2 PROTEIN, MOUSE; RECOMBINANT PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL PROTECTION; CELL VOLUME; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; TOXICITY; ANIMAL; CHEMISTRY; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; LYSOSOME; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE; TRANSGENIC MOUSE; TRANSGENIC RAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOPHAGY; DIABETES MELLITUS, TYPE 2; HEAT-SHOCK PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLET AMYLOID POLYPEPTIDE; LYSOSOMES; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEIN STRUCTURE, QUATERNARY; PROTEOLYSIS; RATS; RATS, TRANSGENIC; RECOMBINANT PROTEINS;

EID: 84905460026     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI71981     Document Type: Article

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