As a Matter of Fat

Cell Metabolism

Volumn 10, Issue 1, 2009, Pages 9-12

  Brookheart, Rita T ^a   Michel, Carlos I ^a   Schaffer, Jean E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; FATTY ACID; LIPID; REACTIVE OXYGEN METABOLITE;

CELL DEATH; DIABETES MELLITUS; DYSLIPIDEMIA; ENDOPLASMIC RETICULUM STRESS; FATTY ACID METABOLISM; HUMAN; HYPERLIPIDEMIA; LIPID STORAGE; LIPIDOMICS; LIPOTOXICITY; MEMBRANE STRUCTURE; METABOLIC DISORDER; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL MEMBRANE; ENDOPLASMIC RETICULUM; FATTY ACIDS; LIPID METABOLISM; MITOCHONDRIA; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 67649422709     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2009.03.011     Document Type: Short Survey

References (32)

1. Borradaile N.M., Buhman K.K., Listenberger L.L., Magee C.J., Morimoto E.T., Ory D.S., and Schaffer J.E. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Mol. Biol. Cell 17 (2006) 770-778
2. Borradaile N.M., Han X., Harp J.D., Gale S.E., Ory D.S., and Schaffer J.E. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J. Lipid Res. 47 (2006) 2726-2737
3. Brookheart R.T., Michel C.I., Listenberger L.L., Ory D.S., and Schaffer J.E. The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and ER stress. J. Biol. Chem. 284 (2009) 7446-7454
4. Cacicedo J.M., Yagihashi N., Keaney Jr. J.F., Ruderman N.B., and Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 324 (2004) 1204-1209
5. Cacicedo J.M., Benjachareowong S., Chou E., Ruderman N.B., and Ido Y. Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes 54 (2005) 1838-1845
6. Chiu H.C., Kovacs A., Ford D.A., Hsu F.F., Garcia R., Herrero P., Saffitz J.E., and Schaffer J.E. A novel mouse model of lipotoxic cardiomyopathy. J. Clin. Invest. 107 (2001) 813-822
7. Cnop M., Ladriere L., Hekerman P., Ortis F., Cardozo A.K., Dogusan Z., Flamez D., Boyce M., Yuan J., and Eizirik D.L. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J. Biol. Chem. 282 (2007) 3989-3997
8. de Vries J.E., Vork M.M., Roemen T.H., de Jong Y.F., Cleutjens J.P., van der Vusse G.J., and van Bilsen M. Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. J. Lipid Res. 38 (1997) 1384-1394
9. Eitel K., Staiger H., Rieger J., Mischak H., Brandhorst H., Brendel M.D., Bretzel R.G., Haring H.U., and Kellerer M. Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes 52 (2003) 991-997
10. El-Assaad W., Buteau J., Peyot M.L., Nolan C., Roduit R., Hardy S., Joly E., Dbaibo G., Rosenberg L., and Prentki M. Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology 144 (2003) 4154-4163
11. Inoguchi T., Li P., Umeda F., Yu H.Y., Kakimoto M., Imamura M., Aoki T., Etoh T., Hashimoto T., Naruse M., et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49 (2000) 1939-1945
12. Kharroubi I., Ladriere L., Cardozo A.K., Dogusan Z., Cnop M., and Eizirik D.L. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 145 (2004) 5087-5096
13. Koves T.R., Ussher J.R., Noland R.C., Slentz D., Mosedale M., Ilkayeva O., Bain J., Stevens R., Dyck J.R., Newgard C.B., et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7 (2008) 45-56
14. Lee Y., Hirose H., Ohneda M., Johnson J.H., McGarry J.D., and Unger R.H. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc. Natl. Acad. Sci. USA 91 (1994) 10878-10882
15. Lee Y., Naseem R.H., Park B.H., Garry D.J., Richardson J.A., Schaffer J.E., and Unger R.H. Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice. Biochem. Biophys. Res. Commun. 344 (2006) 446-452
16. Listenberger L.L., Ory D.S., and Schaffer J.E. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J. Biol. Chem. 276 (2001) 14890-14895
17. Listenberger L.L., Han X., Lewis S.E., Cases S., Farese Jr. R.V., Ory D.S., and Schaffer J.E. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. USA 100 (2003) 3077-3082
18. Liu L., Zhang Y., Chen N., Shi X., Tsang B., and Yu Y.H. Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J. Clin. Invest. 117 (2007) 1679-1689
19. Maedler K., Oberholzer J., Bucher P., Spinas G.A., and Donath M.Y. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 52 (2003) 726-733
20. Moffitt J.H., Fielding B.A., Evershed R., Berstan R., Currie J.M., and Clark A. Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. Diabetologia 48 (2005) 1819-1829
21. Ostrander D.B., Sparagna G.C., Amoscato A.A., McMillin J.B., and Dowhan W. Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis. J. Biol. Chem. 276 (2001) 38061-38067
22. Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., Tuncman G., Gorgun C., Glimcher L.H., and Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306 (2004) 457-461
23. Ozcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R.O., Gorgun C.Z., and Hotamisligil G.S. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313 (2006) 1137-1140
24. Park S.Y., Cho Y.R., Kim H.J., Higashimori T., Danton C., Lee M.K., Dey A., Rothermel B., Kim Y.B., Kalinowski A., et al. Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes 54 (2005) 3530-3540
25. Sharma S., Adrogue J.V., Golfman L., Uray I., Lemm J., Youker K., Noon G.P., Frazier O.H., and Taegtmeyer H. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J. 18 (2004) 1692-1700
26. Shimabukuro M., Zhou Y.T., Levi M., and Unger R.H. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc. Natl. Acad. Sci. USA 95 (1998) 2498-2502
27. Song B., Scheuner D., Ron D., Pennathur S., and Kaufman R.J. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J. Clin. Invest. 118 (2008) 3378-3389
28. Szczepaniak L.S., Dobbins R.L., Metzger G.J., Sartoni-D'Ambrosia G., Arbique D., Vongpatanasin W., Unger R., and Victor R.G. Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn. Reson. Med. 49 (2003) 417-423
29. Wang D., Wei Y., and Pagliassotti M.J. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147 (2006) 943-951
30. Yagyu H., Chen G., Yokoyama M., Hirata K., Augustus A., Kako Y., Seo T., Hu Y., Lutz E.P., Merkel M., et al. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J. Clin. Invest. 111 (2003) 419-426
31. Ye G., Metreveli N.S., Donthi R.V., Xia S., Xu M., Carlson E.C., and Epstein P.N. Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes. Diabetes 53 (2004) 1336-1343
32. Zhou Y.T., Grayburn P., Karim A., Shimabukuro M., Higa M., Baetens D., Orci L., and Unger R.H. Lipotoxic heart disease in obese rats: implications for human obesity. Proc. Natl. Acad. Sci. USA 97 (2000) 1784-1789