Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

Journal of Clinical Investigation

Volumn 124, Issue 8, 2014, Pages 3311-3324

  Kim, Jinyoung ^a,b   Cheon, Hwanju ^a   Jeong, Yeon Taek ^a   Quan, Wenying ^a   Kim, Kook Hwan ^a   Cho, Jae Min ^a   Lim, Yu Mi ^a   Oh, Seung Hoon ^a   Jin, Sang Man ^a   Kim, Jae Hyeon ^a   Lee, Moon Kyu ^a   Kim, Sunshin ^c   Komatsu, Masaaki ^d   Kang, Sang Wook ^e   Lee, Myung Shik ^a,b  

^a Samsung Medical Center   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c National Cancer Center   (South Korea)

^d NIIGATA UNIVERSITY   (Japan)

^e University of Ulsan   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; ATG7 PROTEIN, MOUSE; GLUCOSE BLOOD LEVEL; INSULIN; MICROTUBULE ASSOCIATED PROTEIN; RECOMBINANT PROTEIN; TREHALOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DIABETOGENESIS; DIMERIZATION; FEMALE; LIPID DIET; MACACA FASCICULARIS; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; APOPTOSIS; BLOOD; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DEFICIENCY; DIABETES MELLITUS, TYPE 2; DISEASE MODEL; DRUG EFFECTS; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; AUTOPHAGY; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLET AMYLOID POLYPEPTIDE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; TREHALOSE;

EID: 84905492806     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI69625     Document Type: Article

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