RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate

Diabetes

Volumn 63, Issue 6, 2014, Pages 1978-1993

  Cnop, Miriam ^a,b   Abdulkarim, Baroj ^a   Bottu, Guy ^a   Cunha, Daniel A ^a   Igoillo Esteve, Mariana ^a   Masini, Matilde ^c   Turatsinze, Jean Valery ^a   Griebel, Thasso ^d   Villate, Olatz ^a   Santin, Izortze ^a   Bugliani, Marco ^c   Ladriere, Laurence ^a   Marselli, Lorella ^c   McCarthy, Mark I ^e,f   Marchetti, Piero ^c   Sammeth, Michael ^d,g   Eizirik, Décio L ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c UNIVERSITY OF PISA   (Italy)

^d Functional Bioinformatics   (Spain)

^e CHURCHILL HOSPITAL   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g LABORATÓRIO NACIONAL DE COMPUTAÇÃO CIENTÍFICA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; LONG UNTRANSLATED RNA; PALMITIC ACID; PROTEASOME; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTOME; UBIQUITIN; X BOX BINDING PROTEIN 1;

ADULT; ALTERNATIVE RNA SPLICING; ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FATTY ACID METABOLISM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN RELEASE; LIPID METABOLISM; LIPOTOXICITY; LYSOSOME; MALE; MITOCHONDRIAL DYNAMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET DISEASE; PANCREAS ISLET DYSREGULATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RNA SEQUENCE; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATION; ISLETS OF LANGERHANS; MALE; PALMITATES; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84900334812     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1383     Document Type: Article

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