Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

Human Molecular Genetics

Volumn 24, Issue 5, 2015, Pages 1390-1399

  Mitchell, Ryan K ^a   Mondragon, Angeles ^a   Chen, Lingling ^b   Mcginty, James A ^b   French, Paul M ^b   Ferrer, Jorge ^a   Thorens, Bernard ^c   Hodson, David J ^a   Rutter, Guy A ^a   Da Silva Xavier, Gabriela ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; LIRAGLUTIDE; TRANSCRIPTION FACTOR 7 LIKE 2; GLP1R PROTEIN, MOUSE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON RECEPTOR; GLUCOSE BLOOD LEVEL; INS1 PROTEIN, MOUSE; INS2 PROTEIN, MOUSE; INSULIN; INTEGRASE; TCF7L2 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL COMMUNICATION; CELL FUNCTION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ASSOCIATION; GLUCAGON BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN RELEASE; INSULIN TOLERANCE TEST; LIPID DIET; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; BLOOD; C57BL MOUSE; DISEASE MODEL; GENE DELETION; GENE LOCUS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE BLOOD LEVEL; KNOCKOUT MOUSE; METABOLISM; MOLECULAR WEIGHT; PANCREAS; PATHOLOGY; PATHOPHYSIOLOGY; SECRETION (PROCESS); VETERINARY; WNT SIGNALING PATHWAY;

MURINAE; MUS;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; GENE DELETION; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; INSULIN; INSULIN-SECRETING CELLS; INTEGRASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR WEIGHT; PANCREAS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GLUCAGON; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; WNT SIGNALING PATHWAY;

EID: 84924320471     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu553     Document Type: Article

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