Acute overexpression of lactate dehydrogenase-A perturbs β-cell mitochondrial metasbolism and insulin secretion

Diabetes

Volumn 49, Issue 7, 2000, Pages 1149-1155

  Ainscow, Edward K ^a   Zhao, Chao ^a   Rutter, Guy A ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; GLUCOSE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; ISOPROTEIN; LACTATE DEHYDROGENASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; ENZYME ACTIVITY; GENE OVEREXPRESSION; GLUCOSE METABOLISM; INSULIN RELEASE; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0033919717     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.7.1149     Document Type: Article

References (36)

1. Prentki M, Tornheim K, Corkey BE: Signal transduction mechanisms in nutrient-induced insulin secretion. Diabetologia 40:S32-S41, 1997
2. Kennedy HJ, Pouli AE, Jouaville LS, Rizzuto R, Rutter GA: Glucose-induced ATP microdomains in single islet beta-cells. J Biol Chem 274:13281-13291, 1999
3. Detimary P, Dejonghe S, Ling ZD, Pipeleers D, Schuit F, Henquin JC: The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets. J Biol Chem 273:33905-33908, 1998
4. Aguilar-Bryan L, Clement JP, Gonzalez G, Kunjilwar K, Babenko A, Bryan J: Toward understanding the assembly and structure of K-ATP channels. Physiol Rev 78:227-245, 1998
5. Sekine N, Cirulli V, Regazzi R, Brown LJ, Gine E, Tamarit-Rodriguez J, Girotti M, Marie S, MacDonald MJ, Wollheim CB, Rutter GA: Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cell: potential role in nutrient sensing. J Biol Chem 269:4895-4902, 1994
6. Schuit F, DeVos A, Farfari S, Moens K, Pipeleers D, Brun T, Prentki M: Metabolic fate of glucose in purified islet cells: glucose-regulated anaplerosis in beta cells. J Biol Chem 272:18572-18579, 1997
7. Mertz RJ, Worley III JF, Spencer B, Johnson JH, Dukes ID: Activation of stimulus-secretion coupling in pancreatic beta-cells by specific products of glucose metabolism: evidence for privileged signaling by glycolysis. J Biol Chem 271:4838-1845, 1996
8. Liang Y, Bai G, Doliba N, Buettger C, Wang L, Berner DK, Matschinsky FM: Glucose metabolism and insulin release in mouse beta HC9 cells, as model for wild-type pancreatic beta-cells. Am J Physiol 270:E846-E857, 1996
9. Zhao C, Rutter GA: Overexpression of lactate dehydrogenase A attenuates glucose-induced insulin secretion in stable MIN-6 beta-cell lines. FEBS Lett 430:213-216, 1998
10. Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patane G, Laybutt R, Bonner-Weir S, Weir GC: Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 274:14112-14121, 1999
11. MacDonald MJ: High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide. J Biol Chem 256:8287-8290, 1981
12. Jetton TL, Magnuson MA: Heterogeneous expression of glucokinase among pancreatic beta cells. Proc Natl Acad Sci U S A 89:2619-2623, 1992
13. deVargas LM, Sobolewski J, Siegel R, Moss LG: Individual beta cells within the intact islet differentially respond to glucose. J Biol Chem 272:26573-26577, 1997
14. Ainscow E, Zhao Z, Rutter GA: Pivotal role of lactate dehydrogenase activity in the control of mitochondrial metabolism in MIN6 beta cells (Abstract). Diabetologia 42 (Suppl. 1):A140, 1999
15. Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K: Establishment of a pancreatic beta cell line that retains glucose inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127:126-132, 1990
16. 2+ concentration and insulin secretion. Biochem J 342:275-280, 1999
17. Kennedy HJ, Viollet B, Rafiq I, Kahn A, Rutter GA: Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet beta cells. J Biol Chem 272:20636-20640, 1997
18. 2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A 93:5489-5494, 1996
19. Li SSL: Human and mouse lactate dehydrogenase genes A (muscle), B (heart) and C (testis): protein structure, genomic organization, regulation of expression and molecular evolution. Proc Clin Biol Res 344:75-99, 1990
20. Aspinwall CA, Lakey JR, Kennedy RT: Insulin-stimulated insulin secretion in single pancreatic beta cells. J Biol Chem 274:6360-6365, 1999
21. 2+ in the vicinity of secretory granules. Biochem J 330:1399-1404, 1998
22. Maechler P, Wang H, Wollheim CB: Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase. FEBS Lett 422:328-332, 1998
23. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B: A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A 95:2509-2514, 1998
24. Wang H, Iynedjian PB: Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase. Proc Natl Acad Sci U S A 94:4372-4377, 1997
25. 2+ and secretion. EMBO J 9:53-60, 1990
26. Bennett BD, Jetton TL, Ying G, Magnuson MA, Piston DW: Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets. J Biol Chem 271:3647-3651, 1996
27. Eto K, Tsubamoto Y, Terauchi Y, Sugiyama T, Kishimoto T, Takahashi N, Yamauchi N, Kubota N, Murayama S, Aizawa S, Kasai H, Yazaki Y, Kadowaki T: Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283:981-985, 1999
28. Robb-Gaspers LD, Burnett P, Rutter GA, Denton RM, Rizzuto R, Thomas AP: Integrating cytosolic calcium signals into mitochondrial metabolic responses. EMBO J 17:4987-5000, 1998
29. Avi-Dor Y, Olsen JM, Doherty MD, Kaplan NO: Fluorescence of pyridine nucleotides in mitochondria. J Biol Chem 237:2377-2383, 1962
30. Sugano T, Shiota M, Tanaka T, Miyamae Y, Shimada M, Oshino N: Intracellular redox state and stimulation of gluconeogenesis by glucagon and norepinephrine in the perfused rat liver. J Biochem (Tokyo) 87:153-166, 1980
31. Denton RM, McCormack JG: On the role of the calcium transport cycle in the heart and other mammalian mitochondria. FEBS Lett 119:1-8, 1980
32. 2+ to supramicromolar levels in a pancreatic β-cell line: possible role in glucose and agonist-induced insulin secretion. J Biol Chem 268:22385-22390, 1993
33. Ishihara H, Wang H, Drewes LR, Wollheim CB: Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells. J Clin Invest 104:1621-1629, 1999
34. Alcazar O, Tiedge M, Lenzen S: Glucokinase-sensitive glucose metabolism in INS-1 cells overexpressing lactate dehydrogenase (Abstract). Diabetologia 42 (Suppl. 1):A125, 1999
35. 2+ in signal transduction in mammalian tissues. Biochim Biophys Acta 1018:287-291, 1990
36. Hattersley AT: Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity. Diabet Med 15:15-24, 1998