α-synuclein and cytosolic dopamine: Stabilizing a bad situation

Nature Medicine

Volumn 7, Issue 12, 2001, Pages 1280-1282

  Sulzer, D ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMINE OXIDASE (FLAVIN CONTAINING); DOPAMINE; NEUROMELANIN;

ALZHEIMER DISEASE; DEGENERATIVE DISEASE; DOPAMINERGIC NERVE CELL; GENE MUTATION; LEWY BODY; MOLECULAR MODEL; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FOLDING; SHORT SURVEY; SUBSTANTIA NIGRA; SYNAPTIC TRANSMISSION;

ALPHA-SYNUCLEIN; CYTOSOL; DOPAMINE; HUMANS; LEWY BODIES; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; NEURONS; PARKINSON DISEASE; SYNUCLEINS;

EID: 0035664746     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1201-1280     Document Type: Short Survey

References (11)

1. Mutation in the α-synuclein gene identified in families with Parkinson's disease
2. Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
3. The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
4. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
5. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
6. Acceleration of oligomerization, not fibrillization, is a shared property of both alphasynuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
7. β-synuclein inhibits αsynuclein aggregation: A possible role as an antiparkinsonian factor
8. Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress
9. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease
10. Vesicle permeabilization by protofibrillar alpha-synuclein: Implications for the pathogenesis and treatment of Parkinson's disease