Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

Human Molecular Genetics

Volumn 14, Issue 19, 2005, Pages 2787-2799

  Menéndez Benito, Victoria ^a   Verhoef, Lisette G G C ^a   Masucci, Maria G ^b   Dantuma, Nico P ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASOME; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL POPULATION; CONFORMATIONAL DISEASE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEFECT; PROTEIN FOLDING; STRESS; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CELL NUCLEUS; CELLS, CULTURED; CYTOSOL; ENDOPLASMIC RETICULUM; HUMANS; MICE; MICE, TRANSGENIC; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEINS; THAPSIGARGIN; TUNICAMYCIN; UBIQUITIN;

MUS MUSCULUS;

EID: 26444494585     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddi312     Document Type: Article

References (45)

1. Carrell, R.W. and Lomas, D.A. (1997) Conformational disease. Lancet 350, 134-138.
2. Soto, C. (2003) Unfolding the role of protein misfolding in neurodegenerative diseases. Nat. Rev. Neurosci., 4, 49-60.
3. Ciechanover, A. and Brundin, P. (2003) The ubiquitin proteasome system in neuordegenerative diseases: Sometimes the chicken, sometimes the egg. Neuron, 40, 427-446.
4. Sherman, M.Y. and Goldberg, A.L. (2001) Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases. Neuron, 29, 15-32.
5. Hershko, A. and Ciechanover, A. (1998) The ubiquitin system. Annu. Rev. Biochem., 67, 425-479.
6. Bence, N.F., Sampat, R.M. and Kopito, R.R. (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science, 292, 1552-1555.
7. Dantuma, N.P., Lindsten, K., Glas, R., Jellne, M. and Masucci, M.G. (2000) Short-lived green fluorescent proteins for quantifying ubiquitin/ proteasome-dependent proteolysis in living cells. Nat. Biotechnol. 18, 538-543.
8. Plemper, R.K. and Wolf, D.H. (1999) Retrograde protein translocation: ERADication of secretory proteins in health and disease. Trends Biochem. Sci., 24, 266-270.
9. Sitia, R. and Braakman, I. (2003) Quality control in the endoplasmic reticulum protein factory. Nature, 426, 891-894.
10. Rutkowski, D.T. and Kaufman, R.J. (2004) A trip to the ER: Coping with stress. Trends Cell Biol., 14, 20-28.
11. Hitomi, J., Katayama, T., Eguchi, Y., Kudo, T., Taniguchi, M., Koyama, Y., Manabe, T., Yamagishi, S., Bando, Y., Imaizumi, K. et al. (2004) Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death. J. Cell Biol., 165, 347-356.
12. Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B.A. and Yuan, J. (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature, 403, 98-103.
13. Calfon, M., Zeng, H., Urano, F., Till, J.H., Hubbard, S.R., Harding, H.P., Clark, S.G. and Ron, D. (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature, 415, 92-96.
14. Reimold, A.M., Iwakoshi, N.N., Manis, J., Vallabhajosyula, P., Szomolanyi-Tsuda, E., Gravallese, E.M., Friend, D., Grusby, M.J., Alt, F. and Glimcher, L.H. (2001) Plasma cell differentiation requires the transcription factor XBP-1. Nature, 412, 300-307.
15. Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuno, Y. and Takahashi, R. (2001) An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell, 105, 891-902.
16. Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A. and Ichijo, H. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev., 16, 1345-1355.
17. Tobisawa, S., Hozumi, Y., Arawaka, S., Koyama, S., Wada, M., Nagai, M., Aoki, M., Itoyama, Y., Goto, K. and Kato, T. (2003) Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice. Biochem. Biophys. Res. Commun., 303, 496-503.
18. Hetz, C., Russelakis-Carneiro, M., Maundrell, K., Castilla, J. and Soto, C. (2003) Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J., 22, 5435-5445.
19. Lawless, M.W., Greene, C.M., Mulgrew, A., Taggart, C.C., O'Neill, S.J. and McElvaney, N.G. (2004) Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z α 1-antitrypsin deficiency. J. Immunol., 172, 5722-5726.
20. Jana, N.R., Zemskov, E.A., Wang, G. and Nukina, N. (2001) Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum. Mol. Genet. 10, 1049-1059.
21. Lam, Y.A., Pickart, C.M., Alban, A., Landon, M., Jamieson, C., Ramage, R., Mayer, R.J. and Layfield, R. (2000) Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc. Natl Acad. Sci. USA, 97, 9902-9906.
22. Lindsten, K., de Vrij, F.M., Verhoef, L.G., Fischer, D.F., van Leeuwen, F. W., Hol, E.M., Masucci, M.G. and Dantuma, N.P. (2002) Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation. J. Cell Biol., 157, 417-427.
23. de Vrij, F.M.S., Sluijs, J.A., Gregori, L., Fischer, D.F., Hermens, W.T.J.M.C., Goldgaber, D., Verhaagen, J., van Leeuwen, F.W. and Hol, E.M. (2001) Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death. FASEB J., 15, 2680-2688.
24. Lindsten, K. and Dantuma, N.P. (2003) Monitoring the ubiquitin/ proteasome system in conformational diseases. Ageing Res. Rev., 2, 433-449.
25. Yang, M., Omura, S., Bonifacino, J.S. and Weissman, A.M. (1998) Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: Importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes. J. Exp. Med., 187, 835-846.
26. Gilon, T., Chomsky, O. and Kulka, R.G. (2000) Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair. Mol. Cell. Biol., 20, 7214-7219.
27. Johnston, J.A., Ward, C.L. and Kopito, R.R. (1998) Aggresomes: A cellular response to misfolded proteins. J. Cell Biol., 143, 1883-1898.
28. Bowman, A.B., Yoo, S.Y., Dantuma, N.P. and Zoghbi, H.Y. (2005) Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation. Hum. Mol. Genet., 20, 679-691.
29. Li, X., Zhao, X., Fang, Y., Jiang, X., Duong, T., Fan, C., Huang, C.C. and Kain, S.R. (1998) Generation of destabilized green fluorescent protein as a transcription reporter. J. Biol. Chem., 273, 34970-34975.
30. Sun, X.M., Butterworth, M., MacFarlane, M., Dubiel, W., Ciechanover, A. and Cohen, G.M. (2004) Caspase activation inhibits proteasome function during apoptosis. Mol. Cell, 14, 81-93.
31. Hitomi, J., Katayama, T., Taniguchi, M., Honda, A., Imaizumi, K. and Tohyama, M. (2004) Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12. Neurosci. Lett. 357, 127-130.
32. van Leeuwen, F.W., Fischer, D.F., Kamel, D., Sluijs, J.A., Sonnemans, M.A., Benne, R., Swaab, D.F., Salehi, A. and Hol, E.M. (2000) Molecular misreading: A new type of transcript mutation expressed during aging. Neurobiol. Aging, 21, 879-891.
33. de Pril, R., Fischer, D.F., Maat-Schieman, M.L., Hobo, B., de Vos, R.A., Brunt, E.R., Hol, E.M., Roos, R.A. and van Leeuwen, F.W. (2004) Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases. Hum. Mol. Genet., 13, 1803-1813.
34. French, B.A., van Leeuwen, F., Riley, N.E., Yuan, Q.X., Bardag-Gorce, F., Gaal, K., Lue, Y.H., Marceau, N. and French, S.W. (2001) Aggresome formation in liver cells in response to different toxic mechanisms: Role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin. Exp. Mol. Pathol., 71, 241-246.
35. van Leeuwen, F.W., de Kleijn, D.P., van den Hurk, H.H., Neubauer, A., Sonnemans, M.A., Sluijs, J.A., Koycu, S., Ramdjielal, R.D., Salehi, A., Martens, G.J. et al. (1998) Frameshift mutants of β amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science, 279, 242-247.
36. Lindsten, K., Menendez-Benito, V., Masucci, M.G. and Dantuma, N.P. (2003) A transgenic mouse model of the ubiquitin/proteasome system. Nat. Biotechnol., 21, 897-902.
37. Zinszner, H., Kuroda, M., Wang, X., Batchvarova, N., Lightfoot, R.T., Remotti, H., Stevens, J.L. and Ron, D. (1998) CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev., 12, 982-995.
38. Illing, M.E., Rajan, R.S., Bence, N.F. and Kopito, R.R. (2002) A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system. J. Biol. Chem., 277, 34150-34160.
39. Petrucelli, L., O'Farrell, C., Lockhart, P.J., Baptista, M., Kehoe, K., Vink, L., Choi, P., Wolozin, B., Farrer, M., Hardy, J. et al. (2002) Parkin protects against the toxicity associated with mutant α-synuclein: Proteasome dysfunction selectively affects catecholaminergic neurons. Neuron, 36, 1007-1019.
40. Venkatraman, P., Wetzel, R., Tanaka, M., Nukina, N. and Goldberg, A.L. (2004) Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol. Cell, 14, 95-104.
41. Verhoef, L.G., Lindsten, K., Masucci, M.G. and Dantuma, N.P. (2002) Aggregate formation inhibits proteasomal degradation of polyglutamine proteins. Hum. Mol. Genet., 11, 2689-2700.
42. van Anken, E., Romijn, E.P., Maggioni, C., Mezghrani, A.. Sitia, R., Braakman, I. and Heck, A.J. (2003) Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity, 18, 243-253.
43. Shim, J., Umemura, T., Nothstein, E. and Rongo, C. (2004) The unfolded protein response regulates glutamate receptor export from the endoplasmic reticulum. Mol. Biol. Cell, 15, 4818-4828.
44. Gilon, T., Chomsky, O. and Kulka, R.G. (1998) Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae. EMBO J., 17, 2759-2766.
45. Kikkert, M., Doolman, R., Dai, M., Avner, R., Hassink, G., van Voorden, S., Thanedar, S., Roitelman, J., Chau, V. and Wiertz, E. (2004) Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J. Biol. Chem., 279, 3525-3534.