Detection and quantification of residues and metabolites of medicinal products in environmental compartments, food commodities and workplaces. A review

Journal of Pharmaceutical and Biomedical Analysis

Volumn 106, Issue , 2015, Pages 3-24

  Bottoni, Paola ^a   Caroli, Sergio ^a,b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b Società di Scienze Farmacologiche Applicate Society of Applied Pharmacological Science   (Italy)

Author keywords

Analytical methods; Environmental media; Food; Pharmaceuticals; Workplace

Indexed keywords

DRINKING WATER; GROUND WATER; PLANT MEDICINAL PRODUCT; SURFACE WATER; VETERINARY DRUG; DRUG RESIDUE;

BIOTA; ENVIRONMENTAL IMPACT; FOOD; FOOD CONTAMINATION; FOOD INDUSTRY; HOSPITAL; METABOLITE; POLLUTANT; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SEDIMENT; SOIL ANALYSIS; WASTE; WASTE WATER; WATER CONTAMINATION; WORKPLACE; ANALYSIS; ANIMAL; ENVIRONMENTAL MONITORING; HUMAN; PROCEDURES;

ANIMALS; DRUG RESIDUES; ENVIRONMENTAL MONITORING; FOOD CONTAMINATION; HUMANS; WORKPLACE;

EID: 84923368675     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.12.019     Document Type: Review

References (189)

1. Mudgal S., De Toni A., Lockwood S., Salès K., Backhaus T., Halling Sorensen B., BIO Intelligence Service Study on the Environmental Risks of Medicinal Products, Final Report prepared for Executive Agency for Health and Consumers 2013, December 12, 310 pp.
2. Boxall A.B.A. New and Emerging Water Pollutants Arising from Agriculture 2012, COM/TAD/CA/ENV/EPOC(2010)17/FINAL, OECD, Paris, 49 pp.
3. NIOSH Alert Preventing Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings 2004, EHSD0380 (12/10), DHHS (NIOSH), Publication Number 2004-165, 58 pp. http://www.stonybrook.edu/ehs.
4. van Nuijs A.L.N. Application of hydrophilic interaction chromatography for the analysis of polar contaminants in food and environmental samples. J. Chromatogr. A 2011, 1218:5964-5974.
5. Kantiani L., Llorca M., Sanchis J., Farre M., Barceló D. Emerging food contaminants: a review. Anal. Bioanal. Chem. 2010, 398:2413-2427.
6. McGlinchey T.A., Rafter P.A., Regan F., McMahon G.P. A review of analytical methods for the determination of aminoglycoside and macrolide residues in food matrices. Anal. Chim. Acta 2008, 624:1-15.
7. Greenlees K.J., Friedlander L.G., Boxall A. Antibiotic residues in food and drinking water, and food safety regulations. Chemical Analysis of Antibiotic Residues in Food 2012, 111-123. John Wiley & Sons, Inc., Hoboken, N.J. J. Wang, J.D. MacNeil, J.F. Kay (Eds.).
8. Companyo R., Granados M., Guiteras J., Prat M.D. Antibiotics in food: legislation and validation of analytical methodologies. Anal. Bioanal. Chem. 2009, 395:877-891.
9. di Corcia A., Nazzari M. Liquid chromatographic-mass spectrometric methods for analyzing antibiotic and antibacterial agents in animal food products. J. Chromatogr. A 2002, 974:53-89.
10. Garcia-Campana A.M., Gamiz-Gracia L., Lara F.J., del Olmo Iruela M., Cruces-Blanco C. Applications of capillary electrophoresis to the determination of antibiotics in food and environmental samples. Anal. Bioanal. Chem. 2009, 395:967-986.
11. Salomon M. Pharmaceuticals in the aquatic environment. The German Environmental Advisory Council: need for action. Umweltwissenschaf. Schadstoff-Forsch. 2005, 17:50-53.
12. Special Issue: Emerging Contaminants in Biota. Anal. Bioanal. Chem. 2012, 404:2525-2773.
13. Buchberger W.W. Novel analytical procedures for screening of drug residues in water, waste water, sediment and sludge. Anal. Chim. Acta 2007, 593:129-139.
14. Buchberger W.W. Current approaches to trace analysis of pharmaceuticals and personal care products in the environment. J. Chromatogr. A 2011, 1218:603-618.
15. Touraud E., Roig B., Sumpter J.P., Coetsier C. Drug residues and endocrine disruptors in drinking water: risk for humans?. Int. J. Hyg. Environ. Health 2011, 214:437-441.
16. Radjenovic Je., Petrovic M., Barceló D. Complementary mass spectrometry and bioassays for evaluating pharmaceutical-transformation products in treatment of drinking water and wastewater. TrAC: Trends Anal. Chem. 2009, 28:562-580.
17. Reig M., Toldrá F. Veterinary drug residues in meat: concerns and rapid methods for detection. Meat Sci. 2008, 78:60-67.
18. Somsen G.W., Niessen W.M.A. Mass spectrometry: innovation and application: Part V. Capillary electrophoresis-mass spectrometry. J. Chromatogr. A 2007, 1159:1-255.
19. Celiz M.D., Tso J., Aga D.S. Pharmaceutical metabolites in the environment: analytical challenges and ecological risks. Environ. Toxicol. Chem. 2009, 28:2473-2484.
20. O'Connor S., Aga D.S. Analysis of tetracycline antibiotics in soil: advances in extraction, cleanup, and quantification. TrAC: Trends Anal. Chem. 2007, 26:456-465.
21. Silvia Diáz-Cruz M., Barceló D. Recent advances in LC-MS residue analysis of veterinary medicines in the terrestrial environment. TrAC: Trends Anal. Chem. 2007, 26:637-646.
22. García-Galán M.J., Díaz-Cruz M.S., Barceló D. Identification and determination of metabolites and degradation products of sulfonamide antibiotics. TrAC: Trends Anal. Chem. 2008, 27:1008-1022.
23. Bottoni P., Caroli S., Barra Caracciolo A. Pharmaceuticals as priority water contaminants. Toxicol. Environ. Chem. 2010, 92:549-565.
24. Cimetiere N., Soutrel I., Lemasle M., Laplanche A., Crocq A. Standard addition method for the determination of pharmaceutical residues in drinking water by SPE-LC-MS/MS. Environ. Technol. 2013, 34:3043-3053.
25. Ardsoongnearn C., Boonbanlu O., Kittijaruwattana S., Suntornsuk L. Liquid chromatography and ion trap mass spectrometry for simultaneous and multiclass analysis of antimicrobial residues in feed water. J. Chromatogr. B 2014, 945-946:31-38.
26. Kuhlmann B. Trace materials in water. Wasserwirts. Wassertechn. 2007, 31-33.
27. Cimetiere N., Soutrel I., Lemasle M., Laplanche A., Crocq A. Standard addition method for the determination of pharmaceutical residues in drinking water by SPE-LC-MS/MS. Environ. Technol. 2013, 34:3031-3041.
28. Metcalfe C.D., Chu S., Judt C., Li H., Oakes K.D., Servos M.R., Andrews D.M. Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed. Environ. Toxicol. Chem. 2010, 29:79-89.
29. Fatta-Kassinos D., Meric S., Nikolaou A. Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research. Anal. Bioanal. Chem. 2011, 399:251-275.
30. Zenker A., Cicero M.R., Prestinaci F., Bottoni P., Carere M. Bioaccumulation and biomagnification potential of pharmaceuticals with a focus to the aquatic environment. J. Environ. Manage. 2014, 133:378-387.
31. Hu R., Yang Z., Zhang L. Trace analysis of acidic pharmaceutical residues in waters with isotope dilution gas chromatography-mass spectrometry via methylation derivatization. Talanta 2011, 85:1751-1759.
32. Lin W.-C., Chen H.-C., Ding W.-H. Determination of pharmaceutical residues in waters by solid-phase extraction and large-volume on-line derivatization with gas chromatography-mass spectrometry. J. Chromatogr. A 2005, 1065:279-285.
33. Noche G.G., Fernandez Laespada M.E., Perez Pavon J.L., Cordero B.M., Muniategui Lorenzo S. Microextraction by packed sorbent for the analysis of pharmaceutical residues in environmental water samples by in situ derivatization-programmed temperature vaporizer-gas chromatography-mass spectrometry. J. Chromatogr. A 2011, 1218:9390-9396.
34. Bones J., Thomas K., Nesterenko P.N., Paull B. On-line preconcentration of pharmaceutical residues from large volume water samples using short reversed-phase monolithic cartridges coupled to LC-UV-ESI-MS. Talanta 2006, 70:1117-1128.
35. Gros M., Rodriguez-Mozaz S., Barceló D. Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry. J. Chromatogr. A 2012, 1248:104-121.
36. Lacina P., Mravcova L., Vavrova M. Application of comprehensive two-dimensional gas chromatography with mass spectrometric detection for the analysis of selected drug residues in wastewater and surface water. J. Environ. Sci. 2013, 25:204-212.
37. Iglesias A., Nebot C., Vazquez B.I., Miranda J.M., Abuin C.M.F., Cepeda A. Detection of veterinary drug residues in surface waters collected nearby farming areas in Galicia, North of Spain. Environ. Sci. Pollut. Res. 2014, 21:2367-2377.
38. Gethard K., Mitra S. Membrane distillation as an on-line concentration technique: application to determination of pharmaceutical residues in natural waters. Anal. Bioanal. Chem. 2011, 400:571-575.
39. Magner J., Filipovic M., Alsberg T. Application of a novel solid-phase-extraction sampler and ultra-performance liquid chromatography quadrupole-time-of-flight mass spectrometry for determination of pharmaceutical residues in surface sea water. Chemosphere 2010, 80:1255-1260.
40. Thompson T.S., Noot D.K., Forrest F., van den Heever J.P., Kendall J., Keenliside J. Large volume injection for the direct analysis of ionophores and avermectins in surface water by liquid chromatography-electrospray ionization tandem mass spectrometry. Anal. Chim. Acta 2009, 633:127-135.
41. Bones J., Nesterenko P., Thomas K., Paull B. Dual gradient LC method for the determination of pharmaceutical residues in environmental samples using a monolithic silica reversed phase column. J. Environ. Anal. Chem. 2006, 86:487-504.
42. Peng X., Yu Y., Tang C., Tan J., Huang Q., Wang Z. Occurrence of steroid estrogens, endocrine-disrupting phenols, and acid pharmaceutical residues in urban riverine water of the Pearl River Delta, South China. Sci. Total Environ. 2008, 397:158-166.
43. Trojanowicz M. Flow-injection analysis as a tool for determination of pharmaceutical residues in aqueous environment. Talanta 2012, 96:3-10.
44. Grujic S., Vasiljevic T., Lausevic M. Determination of multiple pharmaceutical classes in surface and ground waters by liquid chromatography-ion trap-tandem mass spectrometry. J. Chromatogr. A 2009, 1216:4989-5000.
45. Zhang Z.L., Zhou J.L. Simultaneous determination of various pharmaceutical compounds in water by solid-phase extraction-liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2007, 1154:205-213.
46. Chen H.-C., Wang P.-L., Ding W.-H. Using liquid chromatography-ion trap mass spectrometry to determine pharmaceutical residues in Taiwanese rivers and wastewaters. Chemosphere 2008, 72:863-869.
47. Sacher F., Ehmann M., Gabriel S., Graf C., Brauch H.-J. Pharmaceutical residues in the River Rhine - results of a one-decade monitoring program. J. Environ. Monit. 2008, 10:664-670.
48. Gros M., Petrovic M., Barceló D. Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 2006, 70:678-690.
49. Quintana J.B., Miro M., Estela J.M., Cerda V. Automated on-line renewable solid-phase extraction-liquid chromatography exploiting multisyringe flow injection-bead injection lab-on-valve analysis. Anal. Chem. 2006, 78:2832-2840.
50. Torres Padron M.E., Sosa Ferrera Z., Santana Rodriguez J.J. Coupling of solid-phase microextraction with micellar desorption and high performance liquid chromatography for the determination of pharmaceutical residues in environmental liquid samples. Biomed. Chromatogr. 2009, 23:1175-1185.
51. Wu J., Qian X., Yang Z., Zhang L. Study on the matrix effect in the determination of selected pharmaceutical residues in seawater by solid-phase extraction and ultra-high-performance liquid chromatography-electrospray ionization low-energy collision-induced dissociation tandem mass spectrometry. J. Chromatogr. A 2010, 1217:1471-1475.
52. Capka L., Lacina P., Vavrova M. Optimization of solid-phase extraction of selected nonsteroidal anti-inflammatory drugs by capillary zone electrophoresis. Chem. Listy 2012, 106:30-35.
53. Bosshart Ü. Drug residues in the Zurich Lake. GWA (Zurich, Switzerland) 2005, 85:23-26.
54. Lacina P., Zenatova P., Vavrova M. The assessment of contamination of selected river streams in the Czech Republic by human and veterinary drug residues with liquid and gas chromatography. Fresenius Environ. Bull. 2012, 21:3318-3324.
55. Liu W., Zhao C.B., Zhang Y.L., Lu S.X., Liu J.T., Xi R. Preparation of polyclonal antibodies to a derivative of 1-aminohydantoin (AHD) and development of an indirect competitive ELISA for the detection of nitrofurantoin residue in water. J. Agric. Food Chem. 2007, 55:6829-6834.
56. Milic N., Milanovic M., Letic N.G., Sekulic M.T., Radonic J., Mihajlovic I., Miloradov M.V. Occurrence of antibiotics as emerging contaminant substances in aquatic environment. Int. J. Environ. Health Res. 2013, 23:296-310.
57. Kern D., Lorenz W. Residues of selected pharmaceuticals in the Saale River catchment. Rückstände ausgewählter Humanarzneimittel in Oberflächenwasserkörpern im Einzugsgebiet Halle (Saale). Umweltwissenschaf. Schadstoff-Forsch. 2008, 20:97-101.
58. Edwards M., Topp E., Metcalfe C.D., Li H., Gottschall N., Bolton P., Curnoe W., Payne M., Beck A., Kleywegt S., Lapen D.R. Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field. Sci. Total Environ. 2009, 407:4220-4230.
59. Kosjek T., Heath E., Petrovic M., Barceló D. Mass spectrometry for identifying pharmaceutical biotransformation products in the environment. TrAC: Trends Anal. Chem. 2007, 26:1076-1085.
60. Borecka M., Bialk-Bielinska A., Siedlewicz G., Kornowska K., Kumirska J., Stepnowski P., Pazdro K. A new approach for the estimation of expanded uncertainty of results of an analytical method developed for determining antibiotics in seawater using solid-phase extraction disks and liquid chromatography coupled with tandem mass spectrometry technique. J. Chromatogr. A 2013, 1304:138-146.
61. Gozlan I., Rotstein A., Avisar D. Amoxicillin-degradation products formed under controlled environmental conditions: identification and determination in the aquatic environment. Chemosphere 2013, 91:985-992.
62. Rosin Ch., Jean-Sebastien P., Rimlinger N., Pallez Ch., Colin A., Munoz J.-F. National campaign to analyse drug residues in drinking water: outcome of a global approach. Environ. Risques Santé 2012, 11:287-293.
63. Chitescu C.L., Oosterink E., de Jong J., Stolker A.A.M. Accurate mass screening of pharmaceuticals and fungicides in water by U-HPLC-extractive orbitrap MS. Anal. Bioanal. Chem. 2012, 403:2997-3011.
64. Cernoch I., Franek M., Diblikova I., Hilscherova K., Randak T., Ocelka T., Blaha L. POCIS sampling in combination with ELISA: screening of sulfonamide residues in surface and waste waters. J. Environ. Monit. 2012, 14:250-257.
65. Yargeau V., Lopata A., Metcalfe C. Pharmaceuticals in the Yamaska River, Quebec, Canada. Water Quality Res. J. Can. 2007, 42:231-239.
66. Maskaoui K., Zhou J.L. Colloids as a sink for certain pharmaceuticals in the aquatic environment. Environ. Sci. Pollut. Res. 2010, 17:898-907.
67. Reh R., Licha T., Geyer T., Noedler K., Sauter M. Occurrence and spatial distribution of organic micro-pollutants in a complex hydrogeological Karst system during low flow and high flow periods, results of a two-year study. Sci. Total Environ. 2013, 443:438-445.
68. Siemens J., Huschek G., Siebe C., Kaupenjohann M. Concentrations and mobility of human pharmaceuticals in the world's largest wastewater irrigation system, Mexico City-Mezquital Valley. Water Res. 2008, 42:2124-2134.
69. Stülten D., Zühlke S., Lamshöft M., Spiteller M. Occurrence of diclofenac and selected metabolites in sewage effluents. Sci. Total Environ. 2008, 405:310-316.
70. Lacey C., McMahon G., Bones J., Barron L., Morrissey A., Tobin J.M. An LC-MS method for the determination of pharmaceutical compounds in wastewater treatment plant influent and effluent samples. Talanta 2008, 75:1089-1097.
71. Hernando M.D., Heath E., Petrovic M., Barceló D. Trace-level determination of pharmaceutical residues by LC-MS/MS in natural and treated waters. A pilot-survey study. Anal. Bioanal. Chem. 2006, 385:985-991.
72. Choi K., Kim Y., Park J., Park C.K., Kim M.Y., Kim H.S., Kim P. Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea. Sci. Total Environ. 2008, 405:120-128.
73. Kosjek T., Heath E., Krbavcic A. Determination of non-steroidal anti-inflammatory drug (NSAIDs) residues in water samples. Environ. Int. 2005, 31:679-685.
74. Li Y., Jindal R., Choi K., Kho Y.L., De Bullen P.G. Pharmaceutical residues in wastewater treatment plants and surface waters in Bangkok. J. Hazard. Tox. Radioact. Waste 2012, 16:88-91.
75. Magner J.A., Alsberg T.E., Broman D. Bag-SPE - a convenient extraction method for screening of pharmaceutical residues in influent and effluent water from sewage treatment plants. Anal. Bioanal. Chem. 2009, 395:1481-1489.
76. Zhou J.L., Zhang Z.L., Banks E., Grover D., Jiang J.Q. Pharmaceutical residues in wastewater treatment works effluents and their impact on receiving river water. J. Hazard. Mater. 2009, 166:655-661.
77. Montesdeoca Esponda S., Torres Padron M.E., Sosa Ferrera Z., Santana Rodriguez J.J. Solid-phase microextraction with micellar desorption and HPLC-fluorescence detection for the analysis of fluoroquinolones residues in water samples. Anal. Bioanal. Chem. 2009, 394:927-935.
78. Tewari S., Jindal R., Kho Y.L., Eo S., Choi K. Major pharmaceutical residues in wastewater treatment plants and receiving waters in Bangkok, Thailand and associated ecological risks. Chemosphere 2013, 697-704.
79. Togunde O.P., Cudjoe E., Oakes K.D., Mirnaghi F.S., Servos M.R., Pawliszyn J. Determination of selected pharmaceutical residues in wastewater using an automated open bed solid phase microextraction system. J. Chromatogr. A 2012, 1262:34-42.
80. Petrovic M., Skrbic B., Zivancev J., Ferrando-Climent L., Barceló D. Determination of 81 pharmaceutical drugs by high performance liquid chromatography coupled to mass spectrometry with hybrid triple quadrupole-linear ion trap in different types of water in Serbia. Sci. Total Environ. 2014, 468-469:415-428.
81. Rodriguez-Navas C., Bjoerklund E., Bak S.A., Hansen M., Krogh K., Maya F., Forteza R., Cerda V. Pollution pathways of pharmaceutical residues in the aquatic environment on the island of Mallorca, Spain. Arch. Environ. Contam. Toxicol. 2013, 65:56-66.
82. Zrelova L.V., Samylina I.A., Arzamastsev A.P., Dement'eva N.N. Use of indicator liquid chromatography for analysis of drug residues in aquatic media. Farmatsiya 2008, 16-19.
83. Ort C., Lawrence M.G., Reungoat J., Eaglesham G., Carter S., Keller J. Determining the fraction of pharmaceutical residues in wastewater originating from a hospital. Water Res. 2010, 44:605-615.
84. Mai T.D., Bomastyk B., Duong H.A., Pham H.V., Hauser P.C. Automated capillary electrophoresis with on-line preconcentration by solid phase extraction using a sequential injection manifold and contactless conductivity detection. Anal. Chim. Acta 2012, 727:1-7.
85. Woldegiorgis A., Green J., Remberger M., Kaj L., Brorström-Lundén E., Dye C., Schlabach M. Results from the Swedish screening 2006: sub report 4: pharmaceuticals, IVL Report 2007, B1751, A, B, 1-73.
86. Fang T.-H., Nan F.-H., Chin T.-S., Feng H.-M. The occurrence and distribution of pharmaceutical compounds in the effluents of a major sewage treatment plant in Northern Taiwan and the receiving coastal waters. Mar. Pollut. Bull. 2012, 64:1435-1444.
87. Salem A.A., Wasfi I.A., Al-Nassibi S.S. Trace determination of β-blockers and β2-agonists in distilled and waste-waters using liquid chromatography-tandem mass spectrometry and solid-phase extraction. J. Chromatogr. B 2012, 908:27-38.
88. Caban M., Migowska N., Stepnowski P., Kwiatkowski M., Kumirska J. Matrix effects and recovery calculations in analyses of pharmaceuticals based on the determination of β-blockers and β-agonists in environmental samples. J. Chromatogr. A 2012, 1258:117-127.
89. Lajeunesse A., Gagnon C. Determination of acidic pharmaceutical products and carbamazepine in roughly primary-treated wastewater by solid-phase extraction and gas chromatography-tandem mass spectrometry. Int. J. Environ. Anal. Chem. 2007, 87:565-578.
90. Scheurer M., Sacher F., Brauch H.-J. Occurrence of the antidiabetic drug metformin in sewage and surface waters in Germany. J. Environ. Monit. 2009, 11:1608-1613.
91. Chen Y., Yu G., Cao Q., Zhang H., Lin Q., Hong Y. Occurrence and environmental implications of pharmaceuticals in Chinese municipal sewage sludge. Chemosphere 2013, 93:1765-1772.
92. Kasai Y., Inagaki Y., Sakakibara Y., Milintawisamai M., Srilachai S., Mesak M., Sutiab S. Field survey on the removal of endocrine disrupting chemicals and pharmaceutical residues in oxidation ponds and constructed wetlands in tropical areas. J. Water Environ. Technol. 2012, 10:337-345.
93. Le Corre K.S., Keller J., Ort C. Pharmaceutical residues in municipal wastewater: are hospitals a major point source? A project investigated the contribution of six hospitals in South-East Queensland. Water (St. Leonards, Australia) 2012, 39:84-88.
94. Le Corre K.S., Ort C., Kateley D., Allen B., Escher B.I., Keller J. Consumption-based approach for assessing the contribution of hospitals towards the load of pharmaceutical residues in municipal wastewater. Environ. Int. 2012, 45:99-111.
95. Brun G.L., Bernier M., Losier R., Doe K., Jackman P., Lee H.B. Pharmaceutically active compounds in Atlantic Canadian sewage treatment plant effluents and receiving waters, and potential for environmental effects as measured by acute and chronic aquatic toxicity. Environ. Toxicol. Chem. 2006, 25:2163-2176.
96. Yu Y., Wu L. Analysis of endocrine disrupting compounds, pharmaceuticals and personal care products in sewage sludge by gas chromatography-mass spectrometry. Talanta 2012, 89:258-263.
97. Langford K., Thomas K.V. Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment. J. Environ. Monit. 2011, 13:416-421.
98. Postigo C., Lopez de Alda M., Barceló D. Evaluation of drugs of abuse use and trends in a prison through wastewater analysis. Environ. Int. 2011, 37:49-55.
99. Karolak S., Nefau T., Bailly E., Solgadi A., Levi Y. Estimation of illicit drugs consumption by wastewater analysis in Paris area (France). Forensic Sci. Int. 2010, 200:153-160.
100. Nefau T., Karolak S., Castillo L., Boireau V., Levi Y. Presence of illicit drugs and metabolites in influents and effluents of 25 sewage water treatment plants and map of drug consumption in France. Sci. Total Environ. 2013, 461/462:712-722.
101. Daghir E., Markuszewski M.J. Disposition of drugs of abuse and their metabolites in wastewater as a method of the estimation of drug consumption. Curr. Drug Metab. 2010, 11:629-638.
102. Kim S.C., Carlson K. Occurrence of ionophore antibiotics in water and sediments of a mixed-landscape watershed. Water Res. 2006, 40:2549-2560.
103. Zhou J., Broodbank N. Sediment-water interactions of pharmaceutical residues in the river environment. Water Res. 2014, 48:61-70.
104. Rodriguez Flores J., Contento Salcedo A.M., Munoz Fernandez L. Rapid HPLC method for monitoring relevant residues of pharmaceuticals products in environmental samples. Am. J. Anal. Chem. 2011, 2:18-26.
105. Ali I., Singh P., Sharma B. Chiral analysis of ibuprofen residues in water and sediment. Anal. Lett. 2009, 42:1747-1760.
106. Kunkel U., Radke M. Fate of pharmaceuticals in rivers: deriving a benchmark dataset at favorable attenuation conditions. Water Res. 2012, 46:5551-5565.
107. Biak-Bielinska A., Kumirska J., Palavinskas R., Stepnowski P. Optimization of multiple reaction monitoring mode for the trace analysis of veterinary sulfonamides by LC-MS/MS. Talanta 2009, 80:947-953.
108. Commission Decision 2002/657/EC of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results, . http://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32002D0657.
109. Minten J., Adolfsson-Erici M., Alsberg T. Extraction and analysis of pharmaceuticals in polluted sediment using liquid chromatography mass spectrometry. Int. J. Environ. Anal. Chem. 2011, 91:553-566.
110. He S., Chen Q.Y., Sun Y., Zhu Y.C., Luo L.X., Li J.Q., Cao Y.S. Determination of tobramycin in soil by HPLC with ultrasonic-assisted extraction and solid-phase extraction. J. Chromatogr. B 2011, 879:901-907.
111. Antonic J., Heath E. Determination of NSAIDs in river sediment samples. Anal. Bioanal. Chem. 2007, 387:1337-1342.
112. Barron L., Nesterenko E., Hart K., Power E., Quinn B., Kelleher B., Paull B. Holistic visualisation of the multimodal transport and fate of twelve pharmaceuticals in biosolid enriched topsoils. Anal. Bioanal. Chem. 2010, 397:287-296.
113. Hamscher G., Priess B., Nau H. A survey of the occurrence of various sulfonamides and tetracyclines in water and sediment samples originating from aquaculture systems in Northern Germany in summer 2005. Arch. Lebensmittelhyg. 2006, 57:97-101.
114. Bringolf R.B., Heltsley R.M., Newton T.J., Eads C.B., Fraley S.J., Shea D., Cope W.G. Environmental occurrence and reproductive effects of the pharmaceutical fluoxetine in native freshwater mussels. Environ. Toxicol. Chem. 2010, 29:1311-1318.
115. Huerta B., Rodriguez-Mozaz S., Pico Y., Barceló D. Pharmaceuticals in biota in the aquatic environment: analytical methods and environmental implications. Anal. Bioanal. Chem. 2012, 404:2611-2624.
116. Wang J., Gardinali P.R. Analysis of selected pharmaceuticals in fish and the fresh water bodies directly affected by reclaimed water using liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 2012, 404:2711-2720.
117. Nallani G.C., Paulos P.M., Venables B.J., Edziyie R.E., Constantine L.A., Huggett D.B. Tissue-specific uptake and bioconcentration of the oral contraceptive norethindrone in two freshwater fishes. Arch. Environ. Contam. Toxicol. 2012, 62:306-313.
118. Togunde O.P., Oakes K.D., Servos M.R., Pawliszyn J. Determination of pharmaceutical residues in fish bile by solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry (LC/MS/MS). Environ. Sci. Technol. 2012, 46:5302-5309.
119. Brozinski J.-M., Lahti M., Meierjohann A., Oikari A., Kronberg L. The anti-inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant. Environ. Sci. Technol. 2013, 47:342-348.
120. Sinigoj-Gacnik K., Cerkvenik-Flajs V., Vadnjal S. Evidence of veterinary drug residues in Slovenian freshwater fish. Bull. Environ. Contam. Toxicol. 2005, 75:109-114.
121. Meinertz J.R., Greseth S.L., Schreier T.M., Bernardy J.A., Gingerich W.H. Isoeugenol concentrations in rainbow trout (Oncorhynchus mykiss) skin-on fillet tissue after exposure to AQUI-STM at different temperatures, durations, and concentrations. Aquaculture 2006, 254:347-354.
122. Zhang X., Oakes K.D., Cui S.F., Bragg L., Servos M.R., Pawliszyn J. Tissue-specific in vivo bioconcentration of pharmaceuticals in rainbow trout (Oncorhynchus mykiss) using space-resolved solid-phase microextraction. Environ. Sci. Technol. 2010, 44:3417-3422.
123. Kallio J.M., Lahti M., Oikari A., Kronberg L. Metabolites of the aquatic pollutant diclofenac in fish bile. Environ. Sci. Technol. 2010, 44:7213-7219.
124. Huerta B., Jakimsk A., Gros M., Rodríguez-Mozaz S., Barceló D. Analysis of multi-class pharmaceuticals in fish tissues by ultra-high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2013, 1288:63-72.
125. Schultz M.M., Furlong E.T., Kolpin D.W., Werner S.L., Schönfuss H.L., Barber L.B., Blazer V.S., Norris D.O., Vajda A.M. Antidepressant pharmaceuticals in two U.S. effluent-impacted streams: occurrence and fate in water and sediment and selective uptake in fish neural tissue. Environ. Sci. Technol. 2010, 44:1918-1925.
126. Schütze A., Heberer T., Jürgensen S. Occurrence of residues of the veterinary drug malachite green in eels caught downstream from municipal sewage treatment plants. Chemosphere 2008, 72:1664-1670.
127. Chu S., Metcalfe C.D. Analysis of paroxetine, fluoxetine and norfluoxetine in fish tissues using pressurized liquid extraction, mixed mode solid phase extraction cleanup and liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2007, 1163:112-118.
128. Brooks B.W., Chambliss C.K., Stanley J.K., Ramirez A., Banks K.E., Johnson R.D., Lewis R.J. Determination of select antidepressants in fish from an effluent-dominated stream. Environ. Toxicol. Chem. 2005, 24:464-469.
129. Ramirez A.J., Brain R.A., Usenko S., Mottaleb M.A., O'Donnell J.G., Stahl L.L., Wathen J.B., Snyder B.D., Pitt J.L., Perez-Hurtado P., Dobbins L.L., Brooks B.W., Chambliss C.K. Occurrence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States. Environ. Toxicol. Chem. 2009, 28:2587-2597.
130. Lajeunesse A., Gagnon C., Gagné F., Louis S., Cejka P., Sauvé S. Distribution of antidepressants and their metabolites in brook trout exposed to municipal wastewaters before and after ozone treatment - evidence of biological effects. Chemosphere 2011, 83:564-571.
131. Togunde O.P., Oakes K.D., Servos M.R., Pawliszyn J. Optimization of solid phase microextraction for non-lethal in vivo determination of selected pharmaceuticals in fish muscle using liquid chromatography-mass spectrometry. J. Chromatogr. A 2012, 1261:99-106.
132. Companyó R., Granados M., Guiteras J., Prat M.D. Antibiotics in food: legislation and validation of analytical methodologies. Anal. Bioanal. Chem. 2009, 395:877-891.
133. Dudrikova E., Pistl J., Sokol J. Antibiotic residues in milk as risk factors of food chain-experimental tylosin treatment in cows suffering from mastitis. Dtsch. Tierarztl. Wochenschr. 2008, 115:75-77.
134. Guo Y., Wang X., Sun X. Aptamer biosensor for antibiotic residues detection in food analysis. Sens. Transd. J. 2013, 156:368-373.
135. Blasco C., Torres C.M., Pico Y. Progress in analysis of residual antibacterials in food. TrAC: Trends Anal. Chem. 2007, 26:895-913.
136. Oka H., Ito Y., Matsumoto H. Chromatographic analysis of tetracycline antibiotics in foods. J. Chromatogr. A 2000, 882:109-133.
137. Chemical Analysis of Antibiotic Residues in Food 2011, John Wiley & Sons, Inc., xxi + 353 pp. http://onlinelibrary.wiley.com/book/10.1002/97811180, J. Wang, J.D. MacNeil, J.F. Kay (Eds.).
138. Chafer-Pericas C., Maquieira A., Puchades R., Miralles J., Moreno R. Multiresidue determination of antibiotics in feed and fish samples for food safety evaluation. Comparison of immunoassay vs LC-MS-MS. Food Control 2011, 22:993-999.
139. Chen G.-L., Fang Y.-Y. The LC-MS/MS methods for the determination of specific antibiotics residues in food matrices. Meth. Mol. Biol. (Clifton, NJ) 2011, 747:309-355.
140. Gondova Z., Kozarova I. New screening tests developed for the detection of antibiotic residues in the meat and kidneys of food-producing animals. Fol. Veter. 2011, 55:21-23.
141. Freitas A., Leston S., Barbosa J., Ramos F. Liquid chromatography: review on the last developments on the detection of antibiotics in food-producing animals. Liquid Chromatography 2013, 99-139. Nova Science Publishers, Inc, Hauppauge, NY. F. Ramos (Ed.).
142. Fan Y.-B., Yin Y.-M., Jiang W.-B., Chen Y.-P., Yang J.-W., Wu J., Xie M.-X. Simultaneous determination of ten steroid hormones in animal origin food by matrix solid-phase dispersion and liquid chromatography-electrospray tandem mass spectrometry. Food Chem. 2014, 142:170-177.
143. Zeina K., Pamela A.K., Fawwak S. Quantification of antibiotic residues and determination of antimicrobial resistance profiles of microorganisms isolated from bovine milk in Lebanon. Food Nutr. Sci. 2013, 4:1-9.
144. Cañada-Cañada F., Muñoz de la Peña A., Espinosa-Mansilla A. Analysis of antibiotics in fish samples. Anal. Bioanal. Chem. 2009, 395:987-1008.
145. Ito Y., Oka H., Ikai Y., Matsumoto H., Miyazaki Y., Nagase H. Application of ion-exchange cartridge cleanup in food analysis. V. Simultaneous determination of sulfonamide antibacterials in animal liver and kidney using high-performance liquid chromatography with ultraviolet and mass spectrometric detection. J. Chromatogr. A 2000, 898:95-102.
146. Dickson L.C., Wang Jian Analysis of residues of macrolide antibiotics in animal-derived foods. Food Eng. Ingred. 2010, 35:18-21.
147. Rezende C.P., Souza L.F., Almeida M.P., Dias P.G., Diniz M.H., Garcia J.C. Optimisation and validation of a quantitative and confirmatory method for residues of macrolide antibiotics and lincomycin in kidney by liquid chromatography coupled to mass spectrometry. Food Addit. Contam. A 2012, 29:587-595.
148. Moreno-Bondi M.C., Marazuela M.D., Herranz S., Rodriguez E. An overview of sample preparation procedures for LC-MS multiclass antibiotic determination in environmental and food samples. Anal. Bioanal. Chem. 2009, 395:921-946.
149. Mi T., Wang Z., Eremin S.A., Shen J., Zhang S. Simultaneous determination of multiple (fluoro)quinolone antibiotics in food samples by a one-step fluorescence polarization immunoassay. J. Agric. Food Chem. 2013, 61:9347-9355.
150. Redo-Sanchez A., Salvatella G., Galceran R., Roldos E., Garcia-Reguero J.A., Castellari M., Tejada J. Assessment of terahertz spectroscopy to detect antibiotic residues in food and feed matrices. Analyst 2011, 136:1733-1738.
151. Rezende C.P., Almeida M.P., Brito R.B., Nonaka C.K., Leite M. Optimisation and validation of a quantitative and confirmatory LC-MS method for multi-residue analyses of β-lactam and tetracycline antibiotics in bovine muscle. Food Addit. Contam. A 2012, 29:541-549.
152. Ta L.Y., Wei L.Y., Jie C.Y., Ya H.H., Lin Y.T., Liu Y.W., Cheng Y.J., Huang H.Y. Analyses of sulfonamide antibiotics by a successive anion- and cation-selective injection coupled to microemulsion electrokinetic chromatography. Electrophoresis 2010, 31:2260-2266.
153. Mastovska K. Multiresidue analysis of antibiotics in food of animal origin using liquid chromatography-mass spectrometry. Meth. Mol. Biol. (Clifton, NJ) 2011, 747:267-307.
154. Bailon-Perez M.I., Garcia-Campana A.M., del Olmo-Iruela M., Gamiz-Gracia L., Cruces-Blanco C. Trace determination of 10 β-lactam antibiotics in environmental and food samples by capillary liquid chromatography. J. Chromatogr. A 2009, 1216:8355-8361.
155. Almeida M.P., Rezende C.P., Souza L.F., Brito R.B. Validation of a quantitative and confirmatory method for residue. Food Addit. Contam. A 2012, 29:517-525.
156. Kaufmann A., Widmer M. Quantitative analysis of polypeptide antibiotic residues in a variety of food matrices by liquid chromatography coupled to tandem mass spectrometry. Anal. Chim. Acta 2013, 797:81-88.
157. Lee J.-B., Lee K.-G., Chung H.-H., Chung Y.-H. Development of an analytical protocol for detecting antibiotic residues in various foods. Food Chem. 2007, 105:1726-1731.
158. Jank L., Hoff R.B., Tarouco P.C., Barreto F., Pizzolato T.M. β-Lactam antibiotics residues analysis in bovine milk by LC-ESI-MS/MS: a simple and fast liquid-liquid extraction method. Food Addit. Contam. A 2012, 29:497-507.
159. McEneff G., Barron L., Kelleher B., Paull B., Quinn B. The determination of pharmaceutical residues in cooked and uncooked marine bivalves using pressurised liquid extraction, solid-phase extraction and liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 2013, 405:9509-9521.
160. Hancock P., Morphet J., Rontree S., Cognard E., Ortelli D. Screening veterinary drugs products of animal origin. Food Sci. Technol. 2010, 24:47-48. 50.
161. Lan L., Yong R., Xiang Y.G., Hui H.X., Liang Z.Z., Ling Z.Z. Development of HPLC method for multiresidue determination of 12 quinolones in egg. Sci. Agric. Sin. 2008, 41:2419-2424.
162. Turnipseed S.B., Clark S.B., Storey J.M., Carr J.R. Analysis of veterinary drug residues in frog legs and other aquacultured species using liquid chromatography-quadrupole time-of-flight mass spectrometry. J. Agric. Food Chem. 2012, 60:4430-4439.
163. Chiaochan C., Koesukwiwat U., Yudthavorasit S., Leepipatpiboon N. Efficient hydrophilic interaction liquid chromatography-tandem mass spectrometry for the multiclass analysis of veterinary drugs in chicken muscle. Anal. Chim. Acta 2010, 682:117-129.
164. Brondi S.H.G., de Souza G.B., Nogueira A.R.A., de Camargo L.A., Majaron R.F. Development and validation of the QuEChERS method for the determination of veterinary drug residues in buffalo milk and meat. Quim. Nova 2013, 36:153-158.
165. Crivineanu M., Trifan V., Bartoiu A., Paraschiv G., Lupescu V. The detection of enrofloxacin residues in pork meat using HPLC analysis, Lucrai Stiintifice - Medicina Veterinara Universitatea de Stiinte Agricole si Medicina Veterinara "Ion Ionescu de la Brad". Iasi 2007, 50:380-384.
166. Martos P.A., Jayasundara F., Dolbeer J., Jin W., Spilsbury L., Mitchell M., Varilla C., Shurmer B. Multiclass, multiresidue drug analysis, including aminoglycosides, in animal tissue using liquid chromatography coupled to tandem mass spectrometry. J. Agric. Food Chem. 2010, 58:5932-5944.
167. Clark S.B., Turnipseed S.B., Madson M.R., Hurlbut J.A., Kuck L., Sofos J.N. Confirmation of sulfamethazine, sulfathiazole, and sulfadimethoxine residues in condensed milk and soft-cheese products by liquid chromatography/tandem mass spectrometry. J. AOAC Int. 2005, 88:736-743.
168. Biswas A.K., Rao G.S., Kondaiah N., Anjaneyulu A.S.R., Malik J.K. Simple multiresidue method for monitoring of trimethoprim and sulfonamide residues in buffalo meat by high-performance liquid chromatography. J. Agric. Food Chem. 2007, 55:8845-8850.
169. Tang Y.Y., Lu H.F., Lin H.Y., Shih Y.C., Hwang D.F. Multiclass analysis of 23 veterinary drugs in milk by ultraperformance liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. B 2012, 881/882:12-19.
170. Castellari M., Gratacos-Cubarsi M., Garcia-Regueiro J.A. Detection of tetracycline and oxytetracycline residues in pig and calf hair by ultra-high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2009, 1216:8096-8100.
171. Barbosa J., Galo A.J. Consumption of suine edible tissues with height levels of nandrolone: consequences for specific professional activities. Rev. Portug. Cienc. Veter. 2002, 97:23-28.
172. Aguilera-Luiz M.M., Martínez Vidal J.L., Romero-González R., Garrido Frenich A. Multiclass method for fast determination of veterinary drug residues in baby food by ultra-high-performance liquid chromatography-tandem mass spectrometry. Food Chem. 2012, 132:2171-2180.
173. Robert C., Gillard N., Brasseur P.-Y., Pierret G., Ralet N., Dubois M., Delahaut Ph. Rapid multi-residue and multi-class qualitative screening for veterinary drugs in foods of animal origin by UHPLC-MS/MS. Food Addit. Contam. A 2013, 30:443-457.
174. Freitas A., Barbosa J., Ramos F. Multi-residue and multi-class method for the determination of antibiotics in bovine muscle by ultra-high-performance liquid chromatography-tandem mass spectrometry. Meat Sci. 2014, 98:58-64.
175. Chafer-Pericas C., Maquieira A., Puchades R. Fast screening methods to detect antibiotic residues in food samples. TrAC: Trends Anal. Chem. 2010, 29:1038-1049.
176. Khor S.M., Liu G., Peterson J.R., Iyengar S.G., Gooding J.J. An electrochemical immunobiosensor for direct detection of veterinary drug residues in undiluted complex matrices. Electroanalysis 2011, 23:1797-1804.
177. Akinwumi A.O., Olatoye I.O., Odunsi A.A., Omojola A.B., Rafiu T.A. Effects of antibiotic residue on the physical qualities of beef in Oyo State, Nigeria. Int. Proc. Chem. Biol. Environ. Eng. 2012, 47:73-76.
178. Sheu S.-Y., Wang Y.-K., Tai Y.-T., Lei Y.-C., Chang T.-H., Yao C.-H., Kuo T.-F. Establishment of a competitive ELISA for detection of florfenicol antibiotic in food of animal origin. J. Immunoassay Immunochem. 2013, 34:438-452.
179. Peng J., Cheng G., Huang L., Wang Y., Hao H., Peng D., Liu Z., Yuan Z. Development of a direct ELISA based on carboxy-terminal of penicillin-binding protein BlaR for the detection of β-lactam antibiotics in foods. Anal. Bioanal. Chem. 2013, 405:8925-8933.
180. Yanga G., Jin W., Wub L., Wang Q., Shao H., Qin A., Yu B., Li D., Cai B. Development of an impedimetric immunosensor for the determination of 3-amino-2-oxazolidone residue in food samples. Anal. Chim. Acta 2011, 706:120-127.
181. Jin W., Yang G., Wu L., Wang Q., Shao H., Qin A., Yu B., Li D., Cai B. Detecting 5-morpholino-3-amino-2-oxazolidone residue in food with label-free electrochemical impedimetric immunosensor. Food Control 2011, 22:1609-1616.
182. Bürge I.J., Buser H.R., Poiger T., Müller M.D. Occurrence and fate of the cytostatic drugs cyclophosphamide and ifosfamide in wastewater and surfacewaters. Environ. Sci. Technol. 2006, 40:7242-7250.
183. Kandel-Tschiederer B., Kessler M., Schwietzer A., Michel A. Reduction of workplace contamination with platinum-containing cytostatic drugs in a veterinary hospital by introduction of a closed system. Vet. Rec. 2010, 166:822-825.
184. Siderov J., Kirsa S., McLauchlan R. Surface contamination of cytotoxic chemotherapy preparation areas in Australian hospital pharmacy departments. J. Pharm. Pract. Res. 2009, 39:117-121.
185. Akl M.A., Ahmed M.A., Ramadan A. Validation of an HPLC-UV method for the determination of ceftriaxone sodium residues on stainless steel surface of pharmaceutical manufacturing equipments. J. Pharm. Biomed. Anal. 2011, 55:247-252.
186. Todorovic Z.B., Lazic M.L., Veljkovic V.B., Milenovic D.M. Validation of an HPLC-UV method for the determination of digoxin residues on the surface of manufacturing equipment. J. Serb. Chem. Soc. 2009, 74:1143-1153.
187. Milenovic D.M., Milosevic S.P., Duric S.L., Naskovic D.C., Mitic S.S. Development and validation of an HPLC method for the determination of verapamil residues in supports of cleaning procedure. J. Anal. Chem. 2013, 68:545-551.
188. Milenovic D.M., Todorovic Z.B. Development and validation of a high-performance liquid chromatographic method for analysis of nimesulide residues on manufacturing equipment surfaces. Acta Chromatogr. 2009, 21:603-618.
189. Caroli S. Clinical chemistry and the quest for quality. Analytical Techniques for Clinical Chemistry: Methods and Applications 2012, 29-58. John Wiley & Sons, Inc., Hoboken, NJ, USA. S. Caroli, G. Záray (Eds.).