Occurrence of pharmaceuticals and personal care products in fish: Results of a national pilot study in the United States

Environmental Toxicology and Chemistry

Volumn 28, Issue 12, 2009, Pages 2587-2597

  Ramirez, Alejandro J ^a   Brain, Richard A ^a   Usenko, Sascha ^a   Mottaleb, Mohammad A ^a   O'Donnell, John G ^b   Stahl, Leanne L ^c   Wathen, John B ^c   Snyder, Blaine D ^b   Pitt, Jennifer L ^b   Perez Hurtado, Pilar ^a   Dobbins, Laura L ^a   Brooks, Bryan W ^a   Chambliss, C Kevin ^a  

^a BAYLOR UNIVERSITY   (United States)

^b TETRA TECH INC   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Accumulation; Effluent dominated sites; Fish tissue; Personal care products; Pharmaceuticals

Indexed keywords

ANTHROPOGENIC INFLUENCE; ARIZONA; BIOLOGICAL MATRIXES; CARBAMAZEPINE; CHICAGO; DILTIAZEM; DIPHENHYDRAMINE; FISH TISSUE; FLUOXETINE; GAS CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; GEMFIBROZILS; GEOGRAPHICAL AREA; ILLINOIS; LIPID CONTENT; LIVER TISSUE; NANOGRAMS; NEW MEXICO; NORFLUOXETINE; ORLANDO , FLORIDA; PENNSYLVANIA; PERSONAL CARE PRODUCTS; PHARMACEUTICALS AND PERSONAL CARE PRODUCTS; PILOT STUDIES; POSITIVE CORRELATIONS; REFERENCE CONDITION; SAMPLING LOCATION; SAMPLING SITE; SERTRALINE; TISSUE TYPES; TONALIDE; TRACE LEVEL; TRICLOSAN; WASTEWATER TREATMENT FACILITIES;

AMIDES; CHROMATOGRAPHIC ANALYSIS; CONCENTRATION (PROCESS); DRUG PRODUCTS; EFFLUENT TREATMENT; FISH; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; MASS SPECTROMETERS; MASS SPECTROMETRY; MEATS; TISSUE; TRACE ANALYSIS; WASTEWATER; WASTEWATER RECLAMATION; WASTEWATER TREATMENT; WATER TREATMENT PLANTS;

EFFLUENTS;

7 AMINOFLUNITRAZEPAM; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; ANTIHYPERTENSIVE AGENT; ATENOLOL; CARBAMAZEPINE; CODEINE; DILTIAZEM; DIPHENHYDRAMINE; FENOFIBRATE; FLUOXETINE; GALAXOLIDE; GEMFIBROZIL; IBUPROFEN; LIPID; MIREX; MUSK KETONE; MUSK XYLENE; NORFLUOXETINE; PARACETAMOL; PROPRANOLOL; SERTRALINE; TRICLOSAN; TYLOSIN;

ANTHROPOGENIC EFFECT; BIOACCUMULATION; DRUG; FISH; LIPID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; WASTE TREATMENT; WASTEWATER;

ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EFFLUENT; FISH; GEOGRAPHIC DISTRIBUTION; LIPID LIVER LEVEL; LIVER; NONHUMAN; PERSONAL HYGIENE; PILOT STUDY; PRIORITY JOURNAL; UNITED STATES; WASTE WATER TREATMENT PLANT; WATER POLLUTION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COSMETICS; FISHES; PHARMACEUTICAL PREPARATIONS; PILOT PROJECTS; QUALITY CONTROL; REGRESSION ANALYSIS; TANDEM MASS SPECTROMETRY; WASTE DISPOSAL, FLUID; WATER POLLUTANTS, CHEMICAL;

EID: 73449114997     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/08-561.1     Document Type: Article

References (47)

1. Ankley GT, Brooks BW, Hugget DB, Sumpter JS. 2007. Repeating history: Pharmaceuticals in the environment. Environ Sci Technol 41:8211-8217.
2. Daughton CG, Ternes TA. 1999. Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environ Health Perspect 107:907-938.
3. Brooks BW, Chambliss CK, Stanley JK, Ramirez AJ, Banks KE, Johnson RD, Lewis RJ. 2005. Determination of select antidipressants in fish from an effluent-dominated stream. Environ Toxicol Chem 24:464-469.
4. Brown JN, Paxéus N, Förlin L, Larsson JDG. 2007. Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma. Environ Toxicol Pharmacol 24:267-274.
5. Chu S, Metcalfe CD. 2007. Analysis of paroxetine, fluoxetine, and norfluoxetine in fish tissues using pressurized liquid extraction, mixed mode solid phase extraction cleanup and liquid chromatography-tandem mass spectrometry. J Chromatogr A 1163:112118.
6. Mottaleb MA, Usenko S, O'Donnell JG, Ramirez AJ, Brooks BW, Chambliss CK. 2009. Gas chromatography-mass spectrometry screening methods for select UV-filters, synthetic musks, alkylphenols, an antimicrobial agent, and an insect repellent in fish. J Chromatogr A 1216:815-823.
7. Nakamura Y, Yamamoto H, Sekizawa J, Kondo T, Hirai N, Tatarazako N. 2008. The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes): Acute toxicity in fish larvae and bioaccumulation in juvenile fish. Chemosphere 70:865-873.
8. Ramirez AJ, Mottaleb MA, Brooks BW, Chambhss CK. 2007. Analysis of pharmaceuticals in fish using liquid chromatography-tandem mass spectrometry. Anal Chem 79:3155-3163.
9. Wen Y, Wang Y, Feng Y-Q. 2006. Simultaneous residue monitoring of four tetracycline antibiotics in fish muscle by intube solid-phase microextraction coupled with high-performance liquid chromatography. Talanta 70:153-159.
10. Balmer ME, Buser H-R, Müller MD, Poiger T. 2005. Occurrence of some organic UV-filters in wastewater, in surface waters, and in fish from Swiss lakes. Environ Sci Technol 39:953-962.
11. Buser H-R, Balmer ME, Schmid P, Kohler M. 2006. Occurrence of UV-filters 4-methylbenzylidene camphor and octocrylene in fish from various Swiss rivers with inputs from wastewater treatment plants. Environ Sci Technol 40:1427-1431.
12. Duedahl-Olesen L, Cederberg T, Pedersen KH, Høgård A. 2005. Synthetic musk fragrances in trout from Danish fish farms and human milk. Chemosphere 61:422-431.
13. Keith TL, Snyder SA, Naylor CG, Staples CA, Summer C, Kannan K, Giesy JP. 2001. Identification and quantitation of nonylphenol ethoxylates and nonylphenol in fish tissues from Michigan. Environ Sci Technol 35:10-13.
14. Nakata H. 2005. Occurrence of synthetic musk fragrances in marine mammals and sharks from Japanese coastal waters. Environ Sci Technol 39:3430-3434.
15. Okumura T, Nishikawa Y. 1996. Gas chromatography-mass spectrometry determination of triclosans in water, sediment and fish samples via methylation with diazomethane. Anal Chim Acta 325:175-184.
16. Peck AM, Kucklick JR, Schantz MM. 2007. Synthetic musk fragrances in environmental standard reference materials. Anal Bioanal Chem 387:2381-2388.
17. Schmid P, Martin Kohler M, Gujer E, Zennegg M, Lanfranchi M. 2007. Persistent organic pollutants, brominated flame retardants and synthetic musks in fish from remote alpine lakes in Switzerland. Chemosphere 67:S16-S21.
18. Burkhardt MR, ReVello RC, Smith SG, Zaugg SD. 2005. Pressurized liquid extraction using water/isopropanol coupled with solid-phase extraction cleanup for industrial and anthropogenic waste-indicator compounds in sediment. Anal Chim Acta 534:89-100.
19. Kinney CA, Furlong ET, Zaugg SD, Burkhardt MR, Werner SL. 2006. Survey of organic wastewater contaminants in biosolids destined for land application. Environ Sci Technol 40:7207-7215.
20. Paterson G, Metcalfe CD. 2008. Uptake and depuration of the anti-depressant fluoxetine by the Japanese medaka (Oryzias latipes). Chemosphere 74:125-130.
21. Schultz M, Furlong ET, Kolpin DW, Werner SL, Shoenfuss H, Barber LB. 2008. Occurrence and distribution of antidepressant pharmaceuticals in two U.S. streams, sediments and fish brain tissue exposed to wastewater effluent. Abstracts, 5th World Congress, Society of Environmental Toxicology and Chemistry, Sydney, Australia, August 2-6, No. 3.
22. Zhou SN, Oakes KD, Servos MR, Pawliszyn J. 2008. Application of solid-phase microextraction for in vivo laboratory and field sampling of pharmaceuticals in fish. Environ Sci Technol 42:6073-6079.
23. Rüdel H, Böhmer W, Schröter-Kermani C. 2006. Retrospective monitoring of synthetic musk compounds in aquatic biota from German rivers and coastal areas. J Environ Monit 8:812-823.
24. Balmer ME, Poiger T, Droz C, Romanin K, Bergqvist P-A, Müller MD, Buser H-A. 2004. Occurrence of methyl triclosan, a transformation product of the bacericide triclosan, in fish and from various lakes in Switzerland. Environ Sci Technol 38:390-395.
25. Kinney CA, Furlong ET, Kolpin DW, Burkhardt MR, Zaugg SD, Werner SL, Bossio JP, Benotti MJ. 2008. Bioaccumulation of pharmaceuticals and other anthropogenic waste indicators in earthworms from agricultural soil amended with biosolid or swine manure. Environ Sci Technol 42:1863-1870.
26. Boyd G, Reemtsam H, Grimm D, Mitra S. 2003. Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA and Ontario, Canada. Sci Total Environ 311:135-149.
27. Heberer T. 2002. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: A review of recent research data. Toxicol Lett 131:5-17.
28. Brooks BW, Riley TM, Taylor RD. 2006. Water quality of effluent-dominated stream ecosystems: Ecotoxicological, hydrological, and management considerations. Hydrobiologia 556:365-379.
29. Daughton CG. 2002. Environmental stewardship and drugs as pollutants. Lancet 360:1035-1036.
30. Brooks BW, Foran CM, Richards SM, Weston J, Turner PK, Stanley JK, Solomon KR, Slattery M, La Point TW. 2003. Aquatic ecotoxicology of fluoxetine. Toxicol Lett 142:169-183.
31. Kolpin DK, Furlong ET, Meyer MT, Thurman ME, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance. Environ Sci Technol 36:1202-1211.
32. U.S. Environmental Protection Agency. 2000. Guidance for assessing chemical contaminant data for use in fish advisories, Vol 1 - Fish sampling and analysis, 3rd ed. EPA 823/B-00/007. Final Report. Office of Water, Washington, DC.
33. Code of Federal Regulations. 1986. Definition and procedure for the determination of the method detection limit. Title 40, Section 136, Appendix B.
34. Mimeault C, Woodhouse AJ, Miao X-S, Metcalfe CD, Moon TW, Trudeau VL. 2005. The human lipid regulator, gemfibrozil bioconcentrates and reduces testosterone in the goldfish, Carassius auratus. Aquat Toxicol 73:44-54.
35. Barber LB, Keefe SH, Antweiler RC, Taylor HE, Wass RD. 2006. Accumulation of contaminants in fish from wastewater treatment wetlands. Environ Sci Technol 40:603-611.
36. Reinert RE. 1969. Insecticides and the Great Lakes. Limnos 2:3-9.
37. Reinert RE, Stewart D, Seagran HL. 1972. Effects of dressing and cooking on DDT concentrations in certain fish from Lake Michigan. J Fish Res Board Can 29:525-529.
38. Skea JC, Simonin HA, Harris EJ, Jacking S, Spagnoli JJ, Symula J, Colquhoun JR. 1979. Reducing levels of mirex, Arochlor 1254, and DDE by trimming and cooking Lake Ontario brown trout (Salmo trutta Linnaeus) and smallmouth bass (Micropterus dolomieui Lacepede). J Gt Lakes Res 5:153-159.
39. Mackay D. 1988. Correlation of bioconcentration factors. Environ Sci Technol 16:274-278.
40. OW and tissue lipid content as predictors of chemical partitioning to fish tissues. Environ Toxicol Chem 17:1447-1455.
41. Halmelink JL, Spacie A. 1977. Fish and chemicals: The process of accumulation. Annu Rev Pharmacol Toxicol 17:167-177.
42. Valenti TW, Perez-Hurtado P, Chambliss CK, Brooks B. 2009. Aquatic toxicity of sertraline to Pimephales promelas at environmentally relevant surface water pH. Environ Toxicol Chem 28:2685-2694.
43. Nikolaou A, Meric S, Fatta D. 2007. Occurrence patterns of pharmaceuticals in water and wastewater environments. Anal Bioanal Chem 387:1225-1234.
44. Ternes T. 2001. Pharmaceuticals and metabolites as contaminants of the aquatic environment. In Daughton CG, Jones-Lepp TL, eds, Pharmaceuticals and Personal Care Products in the Environment: Scientific and Regulatory Issues. American Chemical Society, Washington, DC, p 396.
45. Richardson ML, Bowron JM. 1985. Review: The fate of pharmaceutical chemicals in the aquatic environment. J Pharmacol 37:1-12.
46. Kim SD, Cho J, Kim K, Vanderford BJ, Snyder SA. 2007. Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters. Water Res 41:1013-1021.
47. Okuda T, Kobayashi Y, Nagao R, Yamashita N, Tanaka H, Tanaka S, Fujii S, Konishi C, Houwa I. 2008. Removal efficiency of 66 pharmaceuticals during wastewater treatment process in Japan. Water Sci Technol 57:65-71.