메뉴 건너뛰기




Volumn 25, Issue 3, 2015, Pages 171-184

IQGAPs choreograph cellular signaling from the membrane to the nucleus

Author keywords

IQGAP1; IQGAP2; IQGAP3; Scaffold; Signaling

Indexed keywords

BETA ARRESTIN; CARRIER PROTEIN; G PROTEIN COUPLED RECEPTOR; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 2; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 3; MESSENGER RNA; PHOSPHATIDYLINOSITIDE; UNCLASSIFIED DRUG; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; IQGAP2 PROTEIN, HUMAN; IQGAP3 PROTEIN, HUMAN;

EID: 84923291225     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2014.12.005     Document Type: Review
Times cited : (122)

References (144)
  • 1
    • 0028033549 scopus 로고
    • Identification of a human rasGAP-related protein containing calmodulin-binding motifs
    • Weissbach L., et al. Identification of a human rasGAP-related protein containing calmodulin-binding motifs. J. Biol. Chem. 1994, 269:20517-20521.
    • (1994) J. Biol. Chem. , vol.269 , pp. 20517-20521
    • Weissbach, L.1
  • 2
    • 0029784514 scopus 로고    scopus 로고
    • The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
    • Brill S., et al. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol. Cell. Biol. 1996, 16:4869-4878.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4869-4878
    • Brill, S.1
  • 3
    • 33947319976 scopus 로고    scopus 로고
    • IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth
    • Wang S., et al. IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J. Cell Sci. 2007, 120:567-577.
    • (2007) J. Cell Sci. , vol.120 , pp. 567-577
    • Wang, S.1
  • 4
    • 0037847431 scopus 로고    scopus 로고
    • 2+, calmodulin, Cdc42 and the cytoskeleton
    • 2+, calmodulin, Cdc42 and the cytoskeleton. FEBS Lett. 2003, 542:7-11.
    • (2003) FEBS Lett. , vol.542 , pp. 7-11
    • Briggs, M.W.1    Sacks, D.B.2
  • 5
    • 0038787005 scopus 로고    scopus 로고
    • IQGAPs: integrators of the cytoskeleton, cell adhesion machinery, and signaling networks
    • Mateer S.C., et al. IQGAPs: integrators of the cytoskeleton, cell adhesion machinery, and signaling networks. Cell Motil. Cytoskeleton 2003, 55:147-155.
    • (2003) Cell Motil. Cytoskeleton , vol.55 , pp. 147-155
    • Mateer, S.C.1
  • 6
    • 0032860424 scopus 로고    scopus 로고
    • Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
    • Kaibuchi K., et al. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu. Rev. Biochem. 1999, 68:459-486.
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 459-486
    • Kaibuchi, K.1
  • 7
    • 77953395353 scopus 로고    scopus 로고
    • An emerging role for IQGAP1 in regulating protein traffic
    • Osman M. An emerging role for IQGAP1 in regulating protein traffic. Sci. World J. 2010, 10:944-953.
    • (2010) Sci. World J. , vol.10 , pp. 944-953
    • Osman, M.1
  • 8
    • 67649240282 scopus 로고    scopus 로고
    • IQGAP1 regulation and roles in cancer
    • Johnson M., et al. IQGAP1 regulation and roles in cancer. Cell. Signal. 2009, 21:1471-1478.
    • (2009) Cell. Signal. , vol.21 , pp. 1471-1478
    • Johnson, M.1
  • 9
    • 67349198476 scopus 로고    scopus 로고
    • IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis
    • White C.D., et al. IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis. FEBS Lett. 2009, 583:1817-1824.
    • (2009) FEBS Lett. , vol.583 , pp. 1817-1824
    • White, C.D.1
  • 10
    • 79952317707 scopus 로고    scopus 로고
    • IQGAP1 in microbial pathogenesis: targeting the actin cytoskeleton
    • Kim H., et al. IQGAP1 in microbial pathogenesis: targeting the actin cytoskeleton. FEBS Lett. 2011, 585:723-729.
    • (2011) FEBS Lett. , vol.585 , pp. 723-729
    • Kim, H.1
  • 11
    • 59749095198 scopus 로고    scopus 로고
    • Protein scaffolds in MAP kinase signalling
    • Brown M.D., Sacks D.B. Protein scaffolds in MAP kinase signalling. Cell. Signal. 2009, 21:462-469.
    • (2009) Cell. Signal. , vol.21 , pp. 462-469
    • Brown, M.D.1    Sacks, D.B.2
  • 12
    • 0032590071 scopus 로고    scopus 로고
    • 2+/calmodulin and Cdc42 signaling
    • 2+/calmodulin and Cdc42 signaling. J. Biol. Chem. 1999, 274:464-470.
    • (1999) J. Biol. Chem. , vol.274 , pp. 464-470
    • Ho, Y.D.1
  • 13
    • 2342424547 scopus 로고    scopus 로고
    • IQGAP1 binds ERK2 and modulates its activity
    • Roy M., et al. IQGAP1 binds ERK2 and modulates its activity. J. Biol. Chem. 2004, 279:17329-17337.
    • (2004) J. Biol. Chem. , vol.279 , pp. 17329-17337
    • Roy, M.1
  • 14
    • 24344491858 scopus 로고    scopus 로고
    • IQGAP1 is a scaffold for mitogen-activated protein kinase signaling
    • Roy M., et al. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol. Cell. Biol. 2005, 25:7940-7952.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 7940-7952
    • Roy, M.1
  • 15
    • 84883292777 scopus 로고    scopus 로고
    • Hierarchical scaffolding of an ERK1/2 activation pathway
    • Vetterkind S., et al. Hierarchical scaffolding of an ERK1/2 activation pathway. Cell Commun. Signal. 2013, 11:65.
    • (2013) Cell Commun. Signal. , vol.11 , pp. 65
    • Vetterkind, S.1
  • 16
    • 21044443326 scopus 로고    scopus 로고
    • IQGAP1: a key regulator of adhesion and migration
    • Noritake J., et al. IQGAP1: a key regulator of adhesion and migration. J. Cell Sci. 2005, 118:2085-2092.
    • (2005) J. Cell Sci. , vol.118 , pp. 2085-2092
    • Noritake, J.1
  • 17
    • 84867872264 scopus 로고    scopus 로고
    • Assembly and disassembly of cell matrix adhesions
    • Wehrle-Haller B. Assembly and disassembly of cell matrix adhesions. Curr. Opin. Cell Biol. 2012, 24:569-581.
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 569-581
    • Wehrle-Haller, B.1
  • 18
    • 84884373913 scopus 로고    scopus 로고
    • IQGAP1 links PDGF receptor-beta signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury
    • Kohno T., et al. IQGAP1 links PDGF receptor-beta signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury. Am. J. Physiol. Cell Physiol. 2013, 305:C591-C600.
    • (2013) Am. J. Physiol. Cell Physiol. , vol.305 , pp. C591-C600
    • Kohno, T.1
  • 19
    • 0032508538 scopus 로고    scopus 로고
    • MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
    • Schaeffer H.J., et al. MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 1998, 281:1668-1671.
    • (1998) Science , vol.281 , pp. 1668-1671
    • Schaeffer, H.J.1
  • 20
    • 0035911147 scopus 로고    scopus 로고
    • A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment
    • Wunderlich W., et al. A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J. Cell Biol. 2001, 152:765-776.
    • (2001) J. Cell Biol. , vol.152 , pp. 765-776
    • Wunderlich, W.1
  • 21
    • 84901808450 scopus 로고    scopus 로고
    • The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration
    • Schiefermeier N., et al. The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration. J. Cell Biol. 2014, 205:525-540.
    • (2014) J. Cell Biol. , vol.205 , pp. 525-540
    • Schiefermeier, N.1
  • 22
    • 0344305784 scopus 로고    scopus 로고
    • Cell migration: integrating signals from front to back
    • Ridley A.J., et al. Cell migration: integrating signals from front to back. Science 2003, 302:1704-1709.
    • (2003) Science , vol.302 , pp. 1704-1709
    • Ridley, A.J.1
  • 23
    • 0142103328 scopus 로고    scopus 로고
    • IQGAP1 promotes cell motility and invasion
    • Mataraza J.M., et al. IQGAP1 promotes cell motility and invasion. J. Biol. Chem. 2003, 278:41237-41245.
    • (2003) J. Biol. Chem. , vol.278 , pp. 41237-41245
    • Mataraza, J.M.1
  • 24
    • 84884365094 scopus 로고    scopus 로고
    • 1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex
    • 1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. J. Cell Biol. 2013, 202:917-935.
    • (2013) J. Cell Biol. , vol.202 , pp. 917-935
    • Jacquemet, G.1
  • 25
    • 84884381345 scopus 로고    scopus 로고
    • Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway
    • Jacquemet G., et al. Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. J. Cell Sci. 2013, 126:4121-4135.
    • (2013) J. Cell Sci. , vol.126 , pp. 4121-4135
    • Jacquemet, G.1
  • 26
    • 79959345328 scopus 로고    scopus 로고
    • Anchored protein kinase A recruitment of active Rac GTPase
    • Logue J.S., et al. Anchored protein kinase A recruitment of active Rac GTPase. J. Biol. Chem. 2011, 286:22113-22121.
    • (2011) J. Biol. Chem. , vol.286 , pp. 22113-22121
    • Logue, J.S.1
  • 27
    • 80655128129 scopus 로고    scopus 로고
    • AKAP220 protein organizes signaling elements that impact cell migration
    • Logue J.S., et al. AKAP220 protein organizes signaling elements that impact cell migration. J. Biol. Chem. 2011, 286:39269-39281.
    • (2011) J. Biol. Chem. , vol.286 , pp. 39269-39281
    • Logue, J.S.1
  • 28
    • 84889089210 scopus 로고    scopus 로고
    • AKAP signaling complexes: pointing towards the next generation of therapeutic targets?
    • Esseltine J.L., Scott J.D. AKAP signaling complexes: pointing towards the next generation of therapeutic targets?. Trends Pharmacol. Sci. 2013, 34:648-655.
    • (2013) Trends Pharmacol. Sci. , vol.34 , pp. 648-655
    • Esseltine, J.L.1    Scott, J.D.2
  • 29
    • 84901189861 scopus 로고    scopus 로고
    • A novel role for IQGAP1 protein in cell motility through cell retraction
    • Foroutannejad S., et al. A novel role for IQGAP1 protein in cell motility through cell retraction. Biochem. Biophys. Res. Commun. 2014, 448:39-44.
    • (2014) Biochem. Biophys. Res. Commun. , vol.448 , pp. 39-44
    • Foroutannejad, S.1
  • 30
    • 84884731000 scopus 로고    scopus 로고
    • Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge
    • Witze E.S., et al. Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge. Dev. Cell 2013, 26:645-657.
    • (2013) Dev. Cell , vol.26 , pp. 645-657
    • Witze, E.S.1
  • 31
    • 84893055228 scopus 로고    scopus 로고
    • Activated Cdc42-bound IQGAP1 determines the cellular endocytic site
    • Kimura T., et al. Activated Cdc42-bound IQGAP1 determines the cellular endocytic site. Mol. Cell. Biol. 2013, 33:4834-4843.
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 4834-4843
    • Kimura, T.1
  • 32
    • 33847772690 scopus 로고    scopus 로고
    • A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family
    • Heck J.N., et al. A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family. Crit. Rev. Biochem. Mol. Biol. 2007, 42:15-39.
    • (2007) Crit. Rev. Biochem. Mol. Biol. , vol.42 , pp. 15-39
    • Heck, J.N.1
  • 33
    • 32044466838 scopus 로고    scopus 로고
    • Exploiting the PI3K/AKT pathway for cancer drug discovery
    • Hennessy B.T., et al. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 2005, 4:988-1004.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 988-1004
    • Hennessy, B.T.1
  • 34
    • 84885177444 scopus 로고    scopus 로고
    • IQGAP1 is a novel phosphatidylinositol 4,5-bisphosphate effector in regulation of directional cell migration
    • Choi S., et al. IQGAP1 is a novel phosphatidylinositol 4,5-bisphosphate effector in regulation of directional cell migration. EMBO J. 2013, 32:2617-2630.
    • (2013) EMBO J. , vol.32 , pp. 2617-2630
    • Choi, S.1
  • 35
    • 84863307218 scopus 로고    scopus 로고
    • IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold
    • Dixon M.J., et al. IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. J. Biol. Chem. 2012, 287:22483-22496.
    • (2012) J. Biol. Chem. , vol.287 , pp. 22483-22496
    • Dixon, M.J.1
  • 36
    • 33947354585 scopus 로고    scopus 로고
    • Regulation of receptor tyrosine kinase signaling by GRKs and β-arrestins
    • Hupfeld C.J., Olefsky J.M. Regulation of receptor tyrosine kinase signaling by GRKs and β-arrestins. Annu. Rev. Physiol. 2007, 69:561-577.
    • (2007) Annu. Rev. Physiol. , vol.69 , pp. 561-577
    • Hupfeld, C.J.1    Olefsky, J.M.2
  • 37
    • 80052359992 scopus 로고    scopus 로고
    • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
    • Shukla A.K., et al. Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem. Sci. 2011, 36:457-469.
    • (2011) Trends Biochem. Sci. , vol.36 , pp. 457-469
    • Shukla, A.K.1
  • 38
    • 33646726750 scopus 로고    scopus 로고
    • IQGAP1 in cellular signaling: bridging the GAP
    • Brown M.D., Sacks D.B. IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol. 2006, 16:242-249.
    • (2006) Trends Cell Biol. , vol.16 , pp. 242-249
    • Brown, M.D.1    Sacks, D.B.2
  • 39
    • 79955440704 scopus 로고    scopus 로고
    • MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation
    • McNulty D.E., et al. MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation. J. Biol. Chem. 2011, 286:15010-15021.
    • (2011) J. Biol. Chem. , vol.286 , pp. 15010-15021
    • McNulty, D.E.1
  • 40
    • 70849112486 scopus 로고    scopus 로고
    • Cell signaling in space and time: where proteins come together and when they're apart
    • Scott J.D., Pawson T. Cell signaling in space and time: where proteins come together and when they're apart. Science 2009, 326:1220-1224.
    • (2009) Science , vol.326 , pp. 1220-1224
    • Scott, J.D.1    Pawson, T.2
  • 41
    • 77649337246 scopus 로고    scopus 로고
    • The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1
    • Smith M.J., et al. The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1. EMBO J. 2010, 29:884-896.
    • (2010) EMBO J. , vol.29 , pp. 884-896
    • Smith, M.J.1
  • 42
    • 84896594254 scopus 로고    scopus 로고
    • EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis
    • Banon-Rodriguez I., et al. EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis. EMBO J. 2014, 33:129-145.
    • (2014) EMBO J. , vol.33 , pp. 129-145
    • Banon-Rodriguez, I.1
  • 43
    • 84887057374 scopus 로고    scopus 로고
    • Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics
    • Foerster S., et al. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. Proteomics 2013, 13:3131-3144.
    • (2013) Proteomics , vol.13 , pp. 3131-3144
    • Foerster, S.1
  • 44
    • 84894053464 scopus 로고    scopus 로고
    • IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function
    • Matsunaga H., et al. IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function. Biochem. Biophys. Res. Commun. 2014, 444:360-364.
    • (2014) Biochem. Biophys. Res. Commun. , vol.444 , pp. 360-364
    • Matsunaga, H.1
  • 45
    • 34547548629 scopus 로고    scopus 로고
    • IQGAP1 modulates activation of B-Raf
    • Ren J.G., et al. IQGAP1 modulates activation of B-Raf. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:10465-10469.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 10465-10469
    • Ren, J.G.1
  • 46
    • 53149154520 scopus 로고    scopus 로고
    • 2+/calmodulin and B-Raf signaling
    • 2+/calmodulin and B-Raf signaling. J. Biol. Chem. 2008, 283:22972-22982.
    • (2008) J. Biol. Chem. , vol.283 , pp. 22972-22982
    • Ren, J.G.1
  • 47
    • 48649099673 scopus 로고    scopus 로고
    • IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade
    • Nojima H., et al. IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat. Cell Biol. 2008, 10:971-978.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 971-978
    • Nojima, H.1
  • 48
    • 84901309518 scopus 로고    scopus 로고
    • IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells
    • Yang Y., et al. IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. PLoS ONE 2014, 9:e97578.
    • (2014) PLoS ONE , vol.9 , pp. e97578
    • Yang, Y.1
  • 49
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • Song M.S., et al. The functions and regulation of the PTEN tumour suppressor. Nat. Rev. Mol. Cell Biol. 2012, 13:283-296.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 283-296
    • Song, M.S.1
  • 50
    • 4043148481 scopus 로고    scopus 로고
    • IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation
    • Yamaoka-Tojo M., et al. IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation. Circ. Res. 2004, 95:276-283.
    • (2004) Circ. Res. , vol.95 , pp. 276-283
    • Yamaoka-Tojo, M.1
  • 51
    • 80051932950 scopus 로고    scopus 로고
    • IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance
    • White C.D., et al. IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance. J. Biol. Chem. 2011, 286:29734-29747.
    • (2011) J. Biol. Chem. , vol.286 , pp. 29734-29747
    • White, C.D.1
  • 52
    • 77955833744 scopus 로고    scopus 로고
    • IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation
    • Chen F., et al. IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation. Exp. Mol. Med. 2010, 42:477-483.
    • (2010) Exp. Mol. Med. , vol.42 , pp. 477-483
    • Chen, F.1
  • 53
    • 78650329794 scopus 로고    scopus 로고
    • IQGAP1 plays an important role in the invasiveness of thyroid cancer
    • Liu Z., et al. IQGAP1 plays an important role in the invasiveness of thyroid cancer. Clin. Cancer Res. 2010, 16:6009-6018.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 6009-6018
    • Liu, Z.1
  • 54
    • 84858966778 scopus 로고    scopus 로고
    • IQGAP2, A candidate tumour suppressor of prostate tumorigenesis
    • Xie Y., et al. IQGAP2, A candidate tumour suppressor of prostate tumorigenesis. Biochim. Biophys. Acta 2012, 1822:875-884.
    • (2012) Biochim. Biophys. Acta , vol.1822 , pp. 875-884
    • Xie, Y.1
  • 55
    • 79955974141 scopus 로고    scopus 로고
    • Protein interactions of phosphatase and tensin homologue (PTEN) and its cancer-associated G20E mutant compared by using stable isotope labeling by amino acids in cell culture-based parallel affinity purification
    • Gunaratne J., et al. Protein interactions of phosphatase and tensin homologue (PTEN) and its cancer-associated G20E mutant compared by using stable isotope labeling by amino acids in cell culture-based parallel affinity purification. J. Biol. Chem. 2011, 286:18093-18103.
    • (2011) J. Biol. Chem. , vol.286 , pp. 18093-18103
    • Gunaratne, J.1
  • 56
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: principles and functions in development, organ regeneration and cancer
    • Trusolino L., et al. MET signalling: principles and functions in development, organ regeneration and cancer. Nat. Rev. Mol. Cell Biol. 2010, 11:834-848.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 834-848
    • Trusolino, L.1
  • 57
    • 0036315009 scopus 로고    scopus 로고
    • Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3β
    • Liu F., et al. Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3β. FASEB J. 2002, 16:950-962.
    • (2002) FASEB J. , vol.16 , pp. 950-962
    • Liu, F.1
  • 58
    • 84906070277 scopus 로고    scopus 로고
    • IQGAP1 regulates endothelial barrier function via EB1-cortactin crosstalk
    • Tian Y., et al. IQGAP1 regulates endothelial barrier function via EB1-cortactin crosstalk. Mol. Cell. Biol. 2014, 34:3546-3558.
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 3546-3558
    • Tian, Y.1
  • 59
    • 84903278256 scopus 로고    scopus 로고
    • A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions
    • Fram S., et al. A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions. Cell. Mol. Life Sci. 2014, 71:2759-2773.
    • (2014) Cell. Mol. Life Sci. , vol.71 , pp. 2759-2773
    • Fram, S.1
  • 60
    • 74349102008 scopus 로고    scopus 로고
    • The emerging importance of group II PAKs
    • Wells C.M., Jones G.E. The emerging importance of group II PAKs. Biochem. J. 2010, 425:465-473.
    • (2010) Biochem. J. , vol.425 , pp. 465-473
    • Wells, C.M.1    Jones, G.E.2
  • 61
    • 84873539187 scopus 로고    scopus 로고
    • β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1
    • Alemayehu M., et al. β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. PLoS ONE 2013, 8:e56174.
    • (2013) PLoS ONE , vol.8 , pp. e56174
    • Alemayehu, M.1
  • 62
    • 84896528786 scopus 로고    scopus 로고
    • G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion
    • Feigin M.E., et al. G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:4191-4196.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 4191-4196
    • Feigin, M.E.1
  • 63
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • Clevers H., Nusse R. Wnt/β-catenin signaling and disease. Cell 2012, 149:1192-1205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 64
    • 84870252814 scopus 로고    scopus 로고
    • The complex world of WNT receptor signalling
    • Niehrs C. The complex world of WNT receptor signalling. Nat. Rev. Mol. Cell Biol. 2012, 13:767-779.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 767-779
    • Niehrs, C.1
  • 65
    • 0036510761 scopus 로고    scopus 로고
    • IQGAP1-mediated stimulation of transcriptional co-activation by β-catenin is modulated by calmodulin
    • Briggs M.W., et al. IQGAP1-mediated stimulation of transcriptional co-activation by β-catenin is modulated by calmodulin. J. Biol. Chem. 2002, 277:7453-7465.
    • (2002) J. Biol. Chem. , vol.277 , pp. 7453-7465
    • Briggs, M.W.1
  • 66
    • 84897565798 scopus 로고    scopus 로고
    • RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling
    • Carmon K.S., et al. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:E1221-E1229.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. E1221-E1229
    • Carmon, K.S.1
  • 67
    • 84890957222 scopus 로고    scopus 로고
    • IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling
    • Goto T., et al. IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling. J. Biol. Chem. 2013, 288:36351-36360.
    • (2013) J. Biol. Chem. , vol.288 , pp. 36351-36360
    • Goto, T.1
  • 68
    • 84875930807 scopus 로고    scopus 로고
    • IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling
    • Goto T., et al. IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. PLoS ONE 2013, 8:e60865.
    • (2013) PLoS ONE , vol.8 , pp. e60865
    • Goto, T.1
  • 69
    • 77950683362 scopus 로고    scopus 로고
    • Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling
    • Heuberger J., Birchmeier W. Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb. Perspect. Biol. 2010, 2:a002915.
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2 , pp. a002915
    • Heuberger, J.1    Birchmeier, W.2
  • 70
    • 0043093686 scopus 로고    scopus 로고
    • IQGAP proteins are integral components of cytoskeletal regulation
    • Briggs M.W., Sacks D.B. IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep. 2003, 4:571-574.
    • (2003) EMBO Rep. , vol.4 , pp. 571-574
    • Briggs, M.W.1    Sacks, D.B.2
  • 71
    • 0032493903 scopus 로고    scopus 로고
    • Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion
    • Kuroda S., et al. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science 1998, 281:832-835.
    • (1998) Science , vol.281 , pp. 832-835
    • Kuroda, S.1
  • 72
    • 78650232705 scopus 로고    scopus 로고
    • IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest
    • Johnson M., et al. IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Int. J. Biochem. Cell Biol. 2011, 43:65-73.
    • (2011) Int. J. Biochem. Cell Biol. , vol.43 , pp. 65-73
    • Johnson, M.1
  • 73
    • 84897404602 scopus 로고    scopus 로고
    • IQGAP1 binds to estrogen receptor-α and modulates its function
    • Erdemir H.H., et al. IQGAP1 binds to estrogen receptor-α and modulates its function. J. Biol. Chem. 2014, 289:9100-9112.
    • (2014) J. Biol. Chem. , vol.289 , pp. 9100-9112
    • Erdemir, H.H.1
  • 74
    • 84879154874 scopus 로고    scopus 로고
    • Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2
    • Kim J.H., et al. Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2. Antioxid. Redox Signal. 2013, 19:89-101.
    • (2013) Antioxid. Redox Signal. , vol.19 , pp. 89-101
    • Kim, J.H.1
  • 75
    • 79960984904 scopus 로고    scopus 로고
    • Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex
    • Sharma S., et al. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:11381-11386.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 11381-11386
    • Sharma, S.1
  • 76
    • 84881226456 scopus 로고    scopus 로고
    • The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway
    • Cheung K.L., et al. The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway. J. Biol. Chem. 2013, 288:22378-22386.
    • (2013) J. Biol. Chem. , vol.288 , pp. 22378-22386
    • Cheung, K.L.1
  • 77
    • 12144289400 scopus 로고    scopus 로고
    • A physical and functional map of the human TNF-α/NF-κB signal transduction pathway
    • Bouwmeester T., et al. A physical and functional map of the human TNF-α/NF-κB signal transduction pathway. Nat. Cell Biol. 2004, 6:97-105.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 97-105
    • Bouwmeester, T.1
  • 78
    • 84880869807 scopus 로고    scopus 로고
    • The complexity of NF-κB signaling in inflammation and cancer
    • Hoesel B., Schmid J.A. The complexity of NF-κB signaling in inflammation and cancer. Mol. Cancer 2013, 12:86.
    • (2013) Mol. Cancer , vol.12 , pp. 86
    • Hoesel, B.1    Schmid, J.A.2
  • 79
    • 77956175013 scopus 로고    scopus 로고
    • NFAT, immunity and cancer: a transcription factor comes of age
    • Muller M.R., Rao A. NFAT, immunity and cancer: a transcription factor comes of age. Nat. Rev. Immunol. 2010, 10:645-656.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 645-656
    • Muller, M.R.1    Rao, A.2
  • 80
    • 24644481406 scopus 로고    scopus 로고
    • A strategy for probing the function of noncoding RNAs finds a repressor of NFAT
    • Willingham A.T., et al. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science 2005, 309:1570-1573.
    • (2005) Science , vol.309 , pp. 1570-1573
    • Willingham, A.T.1
  • 81
    • 2342487399 scopus 로고    scopus 로고
    • The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs
    • Villace P., et al. The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res. 2004, 32:2411-2420.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 2411-2420
    • Villace, P.1
  • 83
    • 84888617099 scopus 로고    scopus 로고
    • Organizing principles of mammalian nonsense-mediated mRNA decay
    • Popp M.W., Maquat L.E. Organizing principles of mammalian nonsense-mediated mRNA decay. Annu. Rev. Genet. 2013, 47:139-165.
    • (2013) Annu. Rev. Genet. , vol.47 , pp. 139-165
    • Popp, M.W.1    Maquat, L.E.2
  • 84
    • 79959378556 scopus 로고    scopus 로고
    • Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex
    • Takeda S., et al. Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex. Biochem. Biophys. Res. Commun. 2011, 410:29-33.
    • (2011) Biochem. Biophys. Res. Commun. , vol.410 , pp. 29-33
    • Takeda, S.1
  • 85
    • 84859918951 scopus 로고    scopus 로고
    • A new function of ROD1 in nonsense-mediated mRNA decay
    • Brazao T.F., et al. A new function of ROD1 in nonsense-mediated mRNA decay. FEBS Lett. 2012, 586:1101-1110.
    • (2012) FEBS Lett. , vol.586 , pp. 1101-1110
    • Brazao, T.F.1
  • 86
    • 10644281068 scopus 로고    scopus 로고
    • Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
    • Watanabe T., et al. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev. Cell 2004, 7:871-883.
    • (2004) Dev. Cell , vol.7 , pp. 871-883
    • Watanabe, T.1
  • 87
    • 17144372549 scopus 로고    scopus 로고
    • IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner
    • Li Z., et al. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J. Biol. Chem. 2005, 280:13871-13878.
    • (2005) J. Biol. Chem. , vol.280 , pp. 13871-13878
    • Li, Z.1
  • 88
    • 0033961250 scopus 로고    scopus 로고
    • Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1
    • Li S., et al. Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1. Mol. Cell. Biol. 2000, 20:697-701.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 697-701
    • Li, S.1
  • 89
    • 39749108409 scopus 로고    scopus 로고
    • Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent
    • Schmidt V.A., et al. Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Mol. Cell. Biol. 2008, 28:1489-1502.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 1489-1502
    • Schmidt, V.A.1
  • 90
    • 27144552768 scopus 로고    scopus 로고
    • Self-association of IQGAP1: characterization and functional sequelae
    • Ren J.G., et al. Self-association of IQGAP1: characterization and functional sequelae. J. Biol. Chem. 2005, 280:34548-34557.
    • (2005) J. Biol. Chem. , vol.280 , pp. 34548-34557
    • Ren, J.G.1
  • 91
    • 84877351889 scopus 로고    scopus 로고
    • IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors
    • Jameson K.L., et al. IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors. Nat. Med. 2013, 19:626-630.
    • (2013) Nat. Med. , vol.19 , pp. 626-630
    • Jameson, K.L.1
  • 92
    • 84881493108 scopus 로고    scopus 로고
    • -/- mouse as a model for advanced human hepatocellular carcinoma
    • -/- mouse as a model for advanced human hepatocellular carcinoma. PLoS ONE 2013, 8:e71826.
    • (2013) PLoS ONE , vol.8 , pp. e71826
    • Gnatenko, D.V.1
  • 93
    • 55249094350 scopus 로고    scopus 로고
    • Quantitative proteomic signature of liver cancer cells: tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma
    • Sun Y., et al. Quantitative proteomic signature of liver cancer cells: tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma. J. Proteome Res. 2008, 7:3847-3859.
    • (2008) J. Proteome Res. , vol.7 , pp. 3847-3859
    • Sun, Y.1
  • 94
    • 77958137062 scopus 로고    scopus 로고
    • IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma
    • White C.D., et al. IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma. BMC Gastroenterol. 2010, 10:125.
    • (2010) BMC Gastroenterol. , vol.10 , pp. 125
    • White, C.D.1
  • 95
    • 38749103163 scopus 로고    scopus 로고
    • IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells
    • Jin S.H., et al. IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Int. J. Cancer 2008, 122:1040-1046.
    • (2008) Int. J. Cancer , vol.122 , pp. 1040-1046
    • Jin, S.H.1
  • 96
    • 83255176779 scopus 로고    scopus 로고
    • Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake
    • Chiariello C.S., et al. Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake. Regul. Pept. 2011, 173:36-46.
    • (2011) Regul. Pept. , vol.173 , pp. 36-46
    • Chiariello, C.S.1
  • 97
    • 67650369692 scopus 로고    scopus 로고
    • Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development
    • Kunimoto K., et al. Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development. J. Cell. Physiol. 2009, 220:621-631.
    • (2009) J. Cell. Physiol. , vol.220 , pp. 621-631
    • Kunimoto, K.1
  • 98
    • 84861394054 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension
    • Caro-Gonzalez H.Y., et al. Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension. J. Cell Sci. 2012, 125:1247-1258.
    • (2012) J. Cell Sci. , vol.125 , pp. 1247-1258
    • Caro-Gonzalez, H.Y.1
  • 99
    • 3342994861 scopus 로고    scopus 로고
    • Actin filament binding by a monomeric IQGAP1 fragment with a single calponin homology domain
    • Mateer S.C., et al. Actin filament binding by a monomeric IQGAP1 fragment with a single calponin homology domain. Cell Motil. Cytoskeleton 2004, 58:231-241.
    • (2004) Cell Motil. Cytoskeleton , vol.58 , pp. 231-241
    • Mateer, S.C.1
  • 100
    • 77956490545 scopus 로고    scopus 로고
    • NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode
    • Umemoto R., et al. NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode. J. Biomol. NMR 2010, 48:59-64.
    • (2010) J. Biomol. NMR , vol.48 , pp. 59-64
    • Umemoto, R.1
  • 101
    • 0030943857 scopus 로고    scopus 로고
    • Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometry
    • Joyal J.L., et al. Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometry. J. Biol. Chem. 1997, 272:15419-15425.
    • (1997) J. Biol. Chem. , vol.272 , pp. 15419-15425
    • Joyal, J.L.1
  • 102
    • 79953220793 scopus 로고    scopus 로고
    • S100P is a novel interaction partner and regulator of IQGAP1
    • Heil A., et al. S100P is a novel interaction partner and regulator of IQGAP1. J. Biol. Chem. 2011, 286:7227-7238.
    • (2011) J. Biol. Chem. , vol.286 , pp. 7227-7238
    • Heil, A.1
  • 103
    • 54949133315 scopus 로고    scopus 로고
    • IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B
    • Pathmanathan S., et al. IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B. Mol. Cell. Biochem. 2008, 318:43-51.
    • (2008) Mol. Cell. Biochem. , vol.318 , pp. 43-51
    • Pathmanathan, S.1
  • 104
    • 0037423218 scopus 로고    scopus 로고
    • Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1
    • Li Z., Sacks D.B. Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J. Biol. Chem. 2003, 278:4347-4352.
    • (2003) J. Biol. Chem. , vol.278 , pp. 4347-4352
    • Li, Z.1    Sacks, D.B.2
  • 105
    • 34547103558 scopus 로고    scopus 로고
    • IQGAP1 binds Rap1 and modulates its activity
    • Jeong H.W., et al. IQGAP1 binds Rap1 and modulates its activity. J. Biol. Chem. 2007, 282:20752-20762.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20752-20762
    • Jeong, H.W.1
  • 106
    • 84856219974 scopus 로고    scopus 로고
    • IQGAP1 and its binding proteins control diverse biological functions
    • White C.D., et al. IQGAP1 and its binding proteins control diverse biological functions. Cell. Signal. 2012, 24:826-834.
    • (2012) Cell. Signal. , vol.24 , pp. 826-834
    • White, C.D.1
  • 107
    • 67649382203 scopus 로고    scopus 로고
    • Crystal structure of the GTPase-activating protein-related domain from IQGAP1
    • Kurella V.B., et al. Crystal structure of the GTPase-activating protein-related domain from IQGAP1. J. Biol. Chem. 2009, 284:14857-14865.
    • (2009) J. Biol. Chem. , vol.284 , pp. 14857-14865
    • Kurella, V.B.1
  • 108
    • 38349086370 scopus 로고    scopus 로고
    • The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes
    • Owen D., et al. The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. J. Biol. Chem. 2008, 283:1692-1704.
    • (2008) J. Biol. Chem. , vol.283 , pp. 1692-1704
    • Owen, D.1
  • 109
    • 0029891491 scopus 로고    scopus 로고
    • IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs
    • Hart M.J., et al. IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 1996, 15:2997-3005.
    • (1996) EMBO J. , vol.15 , pp. 2997-3005
    • Hart, M.J.1
  • 110
    • 79953216184 scopus 로고    scopus 로고
    • IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain
    • Atcheson E., et al. IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain. Biosci. Rep. 2011, 31:371-379.
    • (2011) Biosci. Rep. , vol.31 , pp. 371-379
    • Atcheson, E.1
  • 111
    • 0029813867 scopus 로고    scopus 로고
    • Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1
    • Kuroda S., et al. Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J. Biol. Chem. 1996, 271:23363-23367.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23363-23367
    • Kuroda, S.1
  • 112
    • 0037025333 scopus 로고    scopus 로고
    • IQGAP1 is a component of Cdc42 signaling to the cytoskeleton
    • Swart-Mataraza J.M., et al. IQGAP1 is a component of Cdc42 signaling to the cytoskeleton. J. Biol. Chem. 2002, 277:24753-24763.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24753-24763
    • Swart-Mataraza, J.M.1
  • 113
    • 0030859462 scopus 로고    scopus 로고
    • Identification of an actin cytoskeletal complex that includes IQGAP and the Cdc42 GTPase
    • Erickson J.W., et al. Identification of an actin cytoskeletal complex that includes IQGAP and the Cdc42 GTPase. J. Biol. Chem. 1997, 272:24443-24447.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24443-24447
    • Erickson, J.W.1
  • 114
    • 0030697431 scopus 로고    scopus 로고
    • Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42
    • Fukata M., et al. Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42. J. Biol. Chem. 1997, 272:29579-29583.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29579-29583
    • Fukata, M.1
  • 115
    • 0037023772 scopus 로고    scopus 로고
    • The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin
    • Mateer S.C., et al. The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin. J. Biol. Chem. 2002, 277:12324-12333.
    • (2002) J. Biol. Chem. , vol.277 , pp. 12324-12333
    • Mateer, S.C.1
  • 116
    • 0038620337 scopus 로고    scopus 로고
    • IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization
    • Schmidt V.A., et al. IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. Blood 2003, 101:3021-3028.
    • (2003) Blood , vol.101 , pp. 3021-3028
    • Schmidt, V.A.1
  • 117
    • 33947316104 scopus 로고    scopus 로고
    • IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly
    • Bensenor L.B., et al. IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. J. Cell Sci. 2007, 120:658-669.
    • (2007) J. Cell Sci. , vol.120 , pp. 658-669
    • Bensenor, L.B.1
  • 118
    • 33747423658 scopus 로고    scopus 로고
    • IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesis
    • Yamaoka-Tojo M., et al. IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesis. Arterioscler. Thromb. Vasc. Biol. 2006, 26:1991-1997.
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , pp. 1991-1997
    • Yamaoka-Tojo, M.1
  • 119
    • 84874598384 scopus 로고    scopus 로고
    • IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver
    • Liu C., et al. IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver. J. Clin. Invest. 2013, 123:1138-1156.
    • (2013) J. Clin. Invest. , vol.123 , pp. 1138-1156
    • Liu, C.1
  • 120
    • 80051856620 scopus 로고    scopus 로고
    • IQGAP1 is a novel CXCR2-interacting protein and essential component of the "chemosynapse"
    • Neel N.F., et al. IQGAP1 is a novel CXCR2-interacting protein and essential component of the "chemosynapse". PLoS ONE 2011, 6:e23813.
    • (2011) PLoS ONE , vol.6 , pp. e23813
    • Neel, N.F.1
  • 121
    • 84878428917 scopus 로고    scopus 로고
    • KISS1R induces invasiveness of estrogen receptor-negative human mammary epithelial and breast cancer cells
    • Cvetkovic D., et al. KISS1R induces invasiveness of estrogen receptor-negative human mammary epithelial and breast cancer cells. Endocrinology 2013, 154:1999-2014.
    • (2013) Endocrinology , vol.154 , pp. 1999-2014
    • Cvetkovic, D.1
  • 122
    • 80655129398 scopus 로고    scopus 로고
    • ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1
    • Sbroggio M., et al. ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1. J. Cell Sci. 2011, 124:3515-3524.
    • (2011) J. Cell Sci. , vol.124 , pp. 3515-3524
    • Sbroggio, M.1
  • 123
    • 79960791372 scopus 로고    scopus 로고
    • IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload
    • Sbroggio M., et al. IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. Cardiovasc. Res. 2011, 91:456-464.
    • (2011) Cardiovasc. Res. , vol.91 , pp. 456-464
    • Sbroggio, M.1
  • 124
    • 84863107745 scopus 로고    scopus 로고
    • A conserved role of IQGAP1 in regulating TOR complex 1
    • Tekletsadik Y.K., et al. A conserved role of IQGAP1 in regulating TOR complex 1. J. Cell Sci. 2012, 125:2041-2052.
    • (2012) J. Cell Sci. , vol.125 , pp. 2041-2052
    • Tekletsadik, Y.K.1
  • 125
    • 84862817947 scopus 로고    scopus 로고
    • DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway
    • Okada M., et al. DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway. Biochem. Biophys. Res. Commun. 2012, 420:479-484.
    • (2012) Biochem. Biophys. Res. Commun. , vol.420 , pp. 479-484
    • Okada, M.1
  • 126
    • 79961135745 scopus 로고    scopus 로고
    • Protein 4.1R regulates cell migration and IQGAP1 recruitment to the leading edge
    • Ruiz-Saenz A., et al. Protein 4.1R regulates cell migration and IQGAP1 recruitment to the leading edge. J. Cell Sci. 2011, 124:2529-2538.
    • (2011) J. Cell Sci. , vol.124 , pp. 2529-2538
    • Ruiz-Saenz, A.1
  • 127
    • 84893875999 scopus 로고    scopus 로고
    • Conserved sequence repeats of IQGAP1 mediate binding to Ezrin
    • Liu J., et al. Conserved sequence repeats of IQGAP1 mediate binding to Ezrin. J. Proteome Res. 2013, 13:1156-1166.
    • (2013) J. Proteome Res. , vol.13 , pp. 1156-1166
    • Liu, J.1
  • 128
    • 79953300492 scopus 로고    scopus 로고
    • A screen for novel phosphoinositide 3-kinase effector proteins
    • m11000317801-m11000317813
    • Dixon M.J., et al. A screen for novel phosphoinositide 3-kinase effector proteins. Mol. Cell. Proteomics 2011, 10. m11000317801-m11000317813.
    • (2011) Mol. Cell. Proteomics , vol.10
    • Dixon, M.J.1
  • 129
    • 84903549576 scopus 로고    scopus 로고
    • The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts
    • Steenblock C., et al. The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts. J. Biol. Chem. 2014, 289:18347-18359.
    • (2014) J. Biol. Chem. , vol.289 , pp. 18347-18359
    • Steenblock, C.1
  • 130
    • 84868307963 scopus 로고    scopus 로고
    • Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration
    • Casteel D.E., et al. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J. Biol. Chem. 2012, 287:38367-38378.
    • (2012) J. Biol. Chem. , vol.287 , pp. 38367-38378
    • Casteel, D.E.1
  • 131
    • 67649304855 scopus 로고    scopus 로고
    • Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells
    • Usatyuk P.V., et al. Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells. J. Biol. Chem. 2009, 284:15339-15352.
    • (2009) J. Biol. Chem. , vol.284 , pp. 15339-15352
    • Usatyuk, P.V.1
  • 132
    • 79952108946 scopus 로고    scopus 로고
    • Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line
    • Sato A., et al. Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line. FEBS J. 2010, 277:4464-4473.
    • (2010) FEBS J. , vol.277 , pp. 4464-4473
    • Sato, A.1
  • 133
    • 36749055667 scopus 로고    scopus 로고
    • Nerve growth factor receptor TrkA signaling in breast cancer cells involves Ku70 to prevent apoptosis
    • Com E., et al. Nerve growth factor receptor TrkA signaling in breast cancer cells involves Ku70 to prevent apoptosis. Mol. Cell. Proteomics 2007, 6:1842-1854.
    • (2007) Mol. Cell. Proteomics , vol.6 , pp. 1842-1854
    • Com, E.1
  • 134
    • 84885136080 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking
    • Subramani J., et al. Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking. J. Immunol. 2013, 191:3905-3912.
    • (2013) J. Immunol. , vol.191 , pp. 3905-3912
    • Subramani, J.1
  • 135
    • 84863490207 scopus 로고    scopus 로고
    • IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia
    • Bhattacharya M., et al. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am. J. Physiol. Lung Cell. Mol. Physiol. 2012, 303:L12-L19.
    • (2012) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.303 , pp. L12-L19
    • Bhattacharya, M.1
  • 136
    • 84861469119 scopus 로고    scopus 로고
    • IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro
    • Rigothier C., et al. IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro. PLoS ONE 2012, 7:e37695.
    • (2012) PLoS ONE , vol.7 , pp. e37695
    • Rigothier, C.1
  • 137
    • 34548269154 scopus 로고    scopus 로고
    • N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation
    • Schrick C., et al. N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation. Neuron 2007, 55:786-798.
    • (2007) Neuron , vol.55 , pp. 786-798
    • Schrick, C.1
  • 138
    • 79959851522 scopus 로고    scopus 로고
    • Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes
    • Routray C., et al. Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes. Am. J. Physiol. Cell Physiol. 2011, 301:C66-C74.
    • (2011) Am. J. Physiol. Cell Physiol. , vol.301 , pp. C66-C74
    • Routray, C.1
  • 139
    • 84860316904 scopus 로고    scopus 로고
    • IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer
    • Yin N., et al. IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer. Biochem. Biophys. Res. Commun. 2012, 421:64-69.
    • (2012) Biochem. Biophys. Res. Commun. , vol.421 , pp. 64-69
    • Yin, N.1
  • 140
    • 33646202857 scopus 로고    scopus 로고
    • The receptor protein tyrosine phosphatase PTPμ interacts with IQGAP1
    • Phillips-Mason P.J., et al. The receptor protein tyrosine phosphatase PTPμ interacts with IQGAP1. J. Biol. Chem. 2006, 281:4903-4910.
    • (2006) J. Biol. Chem. , vol.281 , pp. 4903-4910
    • Phillips-Mason, P.J.1
  • 141
    • 79958244544 scopus 로고    scopus 로고
    • IQGAP1 regulates NR2A signaling, spine density, and cognitive processes
    • Gao C., et al. IQGAP1 regulates NR2A signaling, spine density, and cognitive processes. J. Neurosci. 2011, 31:8533-8542.
    • (2011) J. Neurosci. , vol.31 , pp. 8533-8542
    • Gao, C.1
  • 142
    • 77954922964 scopus 로고    scopus 로고
    • Activator-mediator binding regulates mediator-cofactor interactions
    • Ebmeier C.C., Taatjes D.J. Activator-mediator binding regulates mediator-cofactor interactions. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:11283-11288.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 11283-11288
    • Ebmeier, C.C.1    Taatjes, D.J.2
  • 143
    • 84899463170 scopus 로고    scopus 로고
    • IQGAP1 is a key node within the small GTPase network
    • Jacquemet G., Humphries M.J. IQGAP1 is a key node within the small GTPase network. Small GTPases 2013, 4:199-207.
    • (2013) Small GTPases , vol.4 , pp. 199-207
    • Jacquemet, G.1    Humphries, M.J.2
  • 144
    • 84858986637 scopus 로고    scopus 로고
    • Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation
    • Li J., et al. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. J. Biol. Chem. 2012, 287:10089-10098.
    • (2012) J. Biol. Chem. , vol.287 , pp. 10089-10098
    • Li, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.