IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance

Journal of Biological Chemistry

Volumn 286, Issue 34, 2011, Pages 29734-29747

  White, Colin D ^a,b   Li, Zhigang ^b,c   Dillon, Deborah A ^b   Sacks, David B ^b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PARTNERS; BREAST CANCER; BREAST CARCINOMAS; EPITHELIAL CELLS; HUMAN EPIDERMAL GROWTH FACTOR; INHIBITORY EFFECT; MOLECULAR MECHANISM; PROGNOSTIC FACTORS; PROTEIN BINDS; PROTEIN INTERACTION; SCAFFOLD PROTEIN; SIGNALING PATHWAYS; TRASTUZUMAB; TUMORIGENESIS;

CELL PROLIFERATION; DISEASES; PATIENT TREATMENT; PEPTIDES; PHOSPHORYLATION; RATIONAL FUNCTIONS; SCAFFOLDS (BIOLOGY); SIGNALING; TISSUE;

MONOCLONAL ANTIBODIES;

EPIDERMAL GROWTH FACTOR RECEPTOR 2; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; PROTEIN P27; TRASTUZUMAB;

ADULT; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER SURVIVAL; CELL PROLIFERATION; CHEMOSENSITIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; UPREGULATION;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MIDDLE AGED; PHOSPHORYLATION; PROTEIN BINDING; RAS GTPASE-ACTIVATING PROTEINS; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

EID: 80051932950     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.220939     Document Type: Article

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