IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors

Nature Medicine

Volumn 19, Issue 5, 2013, Pages 626-630

  Jameson, Katherine L ^a   Mazur, Pawel K ^a   Zehnder, Ashley M ^a   Zhang, Jiajing ^a   Zarnegar, Brian ^a   Sage, Julien ^a   Khavari, Paul A ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MOLECULAR SCAFFOLD; RAS PROTEIN; VEMURAFENIB;

ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL VIABILITY; DISEASE PREDISPOSITION; ENZYME INHIBITION; GENE; LIFESPAN; MELANOMA; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, NEOPLASM; HUMANS; INDOLES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM TRANSPLANTATION; NEOPLASMS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS B-RAF; RAS GTPASE-ACTIVATING PROTEINS; RAS PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SULFONAMIDES; WOUND HEALING;

MAMMALIA; MUS;

EID: 84877351889     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3165     Document Type: Article

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