IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation

Experimental and Molecular Medicine

Volumn 42, Issue 7, 2010, Pages 477-483

  Chen, Feng ^a   Zhu, Hai Hong ^a   Zhou, Lin Fu ^a   Wu, Shan Shan ^a   Wang, Jing ^a   Chen, Zhi ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Carcinoma, Hepatocellular; IQ motif containing GTPase activating protein; mTOR protein; Oncogenes; Proto oncogene proteins c akt

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; ISOLEUCINE GLUTAMINE GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CARCINOGENICITY; CELL GROWTH; CELL INTERACTION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 77955833744     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2010.42.7.049     Document Type: Article

References (16)

1. Briggs MW, Sacks DB. IQGAP proteins are integral components of cytoskeletal regulation EMBO Rep 2003;4:571-4
2. Dong P, Nabeshima K, Nishimura N, Kawakami T, Hachisuga T, Kawarabayashi T, and Iwasaki H. Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas. Cancer Lett 2006;243:120-7
3. Dubrovska A, Kim S, Salamone RJ, Walker JR, Maria SM, García-Echeverría C, Schultz PG, Reddy VA. The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations Proc Natl Acad Sci USA 2009;106:268-73
4. Franke TF. PI3K/Akt: getting it right matters Akt signaling in animal physiology and human disease Oncogene 2008;27:6473-88
5. Jadeski L, Mataraza JM, Jeong HW, Li Z, Sacks DB. IQGAP1 Stimulates Proliferation and Enhances Tumorigenesis of Human Breast Epithelial Cells. J Biol Chem 2008;283:1008-17
6. Kuroda S, Fukata M, Nakagawa M, Fujii K, Nakamura T, Ookubo T, Izawa I, Nagase T, Nomura N, Tani H, Shoji I, Matsuura Y, Yonehara S, Kaibuchi K. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science 1998;281:832-5
7. Mateer SC, McDaniel AE, Nicolas V, Habermacher GM, Lin MJ, Cromer DA, King ME, Bloom GS. The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin. J Biol Chem 2002;277:12324-33
8. Mataraza JM, Li Z, Jeong HW, Brown MD, Sacks DB. Multiple proteins mediate IQGAP1-stimulated cell migration. Cell Signal 2007;19:1857-65
9. Nabeshima K, Shimao, Y, Inoue T, Koono M. Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. Cancer Lett 2002;176:101-9
10. Owen D, Campbell LJ, Littlefield K, Evetts KA, Li Z, Sacks DB, Lowe PN, Mott HR. The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. J Biol Chem 2008;283:1692-704
11. Roy M, Li Z, Sacks DB. IQGAP1 binds ERK2 and modulates its activity. J Biol Chem 2004;279:17329-37
12. Roy M, Li Z, Sacks DB. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol 2005;25:7940-52
13. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-101
14. Wang JB, Sonn R, Tekletsadik YK, Samorodnitsky D, Osman MA. IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway. J Cell Sci 2009;122:2024-33
15. White CD, Brown MD, Sacks DB. IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis. FEBS Lett 2009;583:1817-24
16. Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, Margolick JB, Liotta LA, Petricoin E 3rd, Zhang Y. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci USA 2007;104:16158-63