IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest

International Journal of Biochemistry and Cell Biology

Volumn 43, Issue 1, 2011, Pages 65-73

  Johnson, Michael ^a   Sharma, Manisha ^a   Brocardo, Mariana G ^a   Henderson, Beric R ^a  

^a WESTMEAD HOSPITAL   (Australia)

Author keywords

Catenin; Cell cycle; IQGAP1; Nuclear transport; S phase

Indexed keywords

CELL RECEPTOR; CRM1 EXPORT RECEPTOR; CYCLINE; EXPORTIN 1; GLYCOGEN SYNTHASE KINASE 3BETA; IQ DOMAIN GTPASE ACTIVATING PROTEIN 1; MEMBRANE PROTEIN; REPLICATION FACTOR A; REPLICATION PROTEIN A 32; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL STRAIN 3T3; DNA REPLICATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PROTEIN LOCALIZATION; RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; DNA REPLICATION; EPITHELIAL CELLS; FIBROBLASTS; G1 PHASE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYDROXYUREA; MICE; MICROSCOPY, CONFOCAL; OSTEOSARCOMA; PROTEIN INTERACTION DOMAINS AND MOTIFS; RAS GTPASE-ACTIVATING PROTEINS; RATS; S PHASE; THYMIDINE;

EID: 78650232705     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.09.014     Document Type: Article

References (57)

1. A.M. Bashour, A.T. Fullerton, M.J. Hart, and G.S. Bloom IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments J Cell Biol 137 1997 1555 1566
2. L.B. Benseñor, H.M. Kan, N. Wang, H. Wallrabe, L.A. Davidson, and Y. Cai IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly J Cell Sci 120 2007 658 669
3. A. Bielak-Zmijewska, A. Kolano, K. Szczepanska, M. Maleszewski, and E. Borsuk Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos Dev Biol 322 2008 21 32
4. L.Y.W. Bourguignon, E. Gilad, K. Rothman, and K. Peyrollier Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression J Biol Chem 280 2005 11961 11972
5. D.T. Brandt, and R. Grosse Get to grips: steering local actin dynamics with IQGAPs EMBO Rep 8 2007 1019 1023
6. D.T. Brandt, S. Marion, G. Griffiths, T. Watanabe, K. Kaibuchi, and R. Grosse Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation J Cell Biol 178 2007 193 200
7. M.W. Briggs, Z. Li, and D.B. Sacks IQGAP1-mediated stimulation of transcriptional co-activation by β-catenin is modulated by calmodulin J Biol Chem 277 2002 7453 7465
8. 2+, calmodulin, Cdc42 and the cytoskeleton FEBS Lett 542 2003 7 11
9. M. Brocardo, and B.R. Henderson APC shuttling to the membrane, nucleus and beyond Trends Cell Biol 18 2008 587 596
10. M. Brocardo, Y. Lei, A. Tighe, S.S. Taylor, M.T.S. Mok, and B.R. Henderson Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations J Biol Chem 283 2008 5950 5959
11. M.D. Brown, and D.B. Sacks IQGAP1 in cellular signaling: bridging the GAP Trends Cell Biol 16 2006 242 249
12. V.O. Chagin, J.H. Stear, and M.C. Cardoso Organization of DNA replication Cold Spring Harb Perspect Biol 2 2010 1 13
13. C.S. Chew, C.T. Okamoto, X. Chen, and H.Y. Qin IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells Am J Physiol Gastrointest Liver Physiol 288 2005 G376 G387
14. H. Dingova, J. Fukalova, M. Maninova, V.V. Philimonenko, and P. Hozak Ultrastructural localization of actin and actin-binding proteins in the nucleus Histochem Cell Biol 131 2009 425 434
15. H.P. Easwaran, H. Leonhardt, and M.C. Cardoso Cell cycle markers for live cell analyses Cell Cycle 4 2005 453 455
16. M. Fukata, S. Kuroda, K. Fujii, T. Nakamura, I. Shoji, and Y. Matsuura Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42 J Biol Chem 272 1997 29579 29583
17. M. Fukata, S. Kuroda, M. Nakagawa, A. Kawajiri, N. Itoh, and I. Shoji Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin J Biol Chem 274 1999 26044 26050
18. M. Fukata, T. Watanabe, J. Noritake, M. Nakagawa, M. Yamaga, and S. Kuroda Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170 Cell 109 2002 873 885
19. R.S. Gieni, and M.J. Hendzel Actin dynamics and functions in the interphase nucleus: moving toward an understanding of nuclear polymeric actin Biochem Cell Biol 87 2009 283 306
20. K. Grohmanova, D. Schlaepfer, D. Hess, P. Gutierrez, M. Beck, and R. Kroschewski Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of Rho-GTPase regulator J Biol Chem 279 2004 48495 48504
21. B.R. Henderson Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover Nat Cell Biol 2 2000 653 660
22. W.A. Hofmann Cell and molecular biology of nuclear actin Int Rev Cell Mol Biol 2009 Academic Press p. 219-63 [Chapter 6]
23. W.A. Hofmann, A. Arduini, S.M. Nicol, C.J. Camacho, J.L. Lessard, and F.V. Fuller-Pace SUMOylation of nuclear actin J Cell Biol 186 2009 193 200
24. L. Jadeski, J.M. Mataraza, H.W. Jeong, Z. Li, and D.B. Sacks IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells J Biol Chem 283 2008 1008 1017
25. M. Johnson, M. Sharma, and B.R. Henderson IQGAP1 regulation and roles in cancer Cell Signal 21 2009 1471 1478
26. M. Johnson, M. Sharma, C. Jamieson, J.M. Henderson, M.T.S. Mok, and L. Bendall Regulation of beta-catenin trafficking to the membrane in living cells Cell Signal 21 2009 339 348
27. M. Kumeta, S.H. Yoshimura, M. Harata, and K. Takeyasu Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4 J Cell Sci 123 2010 1020 1030
28. S. Kuroda, M. Fukata, M. Nakagawa, K. Fujii, T. Nakamura, and T. Ookubo Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion Science 281 1998 832 835
29. C. Le Clainche, D. Schlaepfer, A. Ferrari, M. Klingauf, K. Grohmanova, and A. Veligodskiy IQGAP1 stimulates actin assembly through the N-Wasp-Arp2/3 pathway J Biol Chem 282 2007 426 435
30. J.S. Logue, and J.D. Scott AKAP220 links the cAMP signaling pathway to cell adhesion FASEB J 23 2009 530.10
31. L.M. Machesky Cytokinesis: IQGAPs find a function Curr Biol 8 1998 R202 R205
32. T. Matsuda, M. Saijo, I. Kuraoka, T. Kobayashi, Y. Nakatsu, and A. Nagai DNA repair protein XPA binds replication protein A (RPA) J Biol Chem 270 1995 4152 4157
33. S.J. McCallum, J.W. Erickson, and R.A. Cerione Characterization of the association of the actin-binding protein, IQGAP, and activated Cdc42 with Golgi membranes J Biol Chem 273 1998 22537 22544
34. K. McDonald, M. O'Sullivan, J. Parkinson, J. Shaw, C. Payne, and J. Brewer IQGAP1 and IGFBP2: valuable biomarkers for determining prognosis in glioma patients J Neuropathol Exp Neurol 66 2007 405 417
35. R.D. Meyer, D.B. Sacks, and N. Rahimi IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis PLoS ONE 3 2008 e3848
36. D. Michaelson, W. Abidi, D. Guardavaccaro, M. Zhou, I. Ahearn, and M. Pagano Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division J Cell Biol 181 2008 485 496
37. K. Nabeshima, Y. Shimao, T. Inoue, and M. Koono Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts Cancer Lett 176 2002 101 109
38. J. Noritake, T. Watanabe, K. Sato, S. Wang, and K. Kaibuchi IQGAP1: a key regulator of adhesion and migration J Cell Sci 118 2005 2085 2092
39. P. Percipalle The long journey of actin and actin-associated proteins from genes to polysomes Cell Mol Life Sci 66 2009 2151 2165
40. J.G. Ren, Z. Li, D.L. Crimmins, and D.B. Sacks Self-association of IQGAP1: characterization and functional sequelae J Biol Chem 280 2005 34548 34557
41. E.N. Rittmeyer, S. Daniel, S.C. Hsu, and M.A. Osman A dual role for IQGAP1 in regulating exocytosis J Cell Sci 121 2008 391 403
42. M. Roy, and D.B. Sacks IQGAP1 binds ERK2 and modulates its activity J Biol Chem 279 2004 17329 17337
43. K. Sandrock, H. Bielek, K. Schradi, G. Schmidt, and N. Klugbauer The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with Karyopherin α2 Traffic 11 2010 198 209
44. M. Sharma, and B.R. Henderson IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli J Biol Chem 282 2007 8545 8556
45. M. Sharma, L. Leung, M. Brocardo, J. Henderson, C. Flegg, and B.R. Henderson Membrane localization of adenomatous polyposis coli protein at cellular protrusions J Biol Chem 281 2006 17140 17149
46. M. Takaine, O. Numata, and Nakano K Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring EMBO J 28 2009 3117 3131
47. H. Takemoto, Y. Doki, H. Shiozaki, H. Imamura, T. Utsunomiya, and H. Miyata Localization of IQGAP1 is inversely correlated with intercellular adhesion mediated by e-cadherin in gastric cancers Int J Cancer 91 2001 783 788
48. A. Wada, M. Fukuda, M. Mishima, and E. Nishida Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein EMBO J 17 1998 1635 1641
49. J.B. Wang, R. Sonn, Y.K. Tekletsadik, D. Samorodnitsky, and M.A. Osman IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway J Cell Sci 122 2009 2024 2033
50. Y. Wang, A. Wang, F. Wang, M. Wang, M. Zhu, and Y. Ma IQGAP1 activates Tcf signal independent of Rac1 and Cdc42 in injury and repair of bronchial epithelial cells Exp Mol Pathol 85 2008 122 128
51. T. Watanabe, J. Noritake, M. Kakeno, T. Matsui, T. Harada, and S. Wang Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules J Cell Sci 122 2009 2969 2979
52. T. Watanabe, S. Wang, M. Kakeno, J. Usukura, and K. Kaibuchi Ultrastructural study of Rac1 and its effectors beneath the substratum-facing membrane Cell Struct Funct 33 2008 101 107
53. T. Watanabe, S. Wang, J. Noritake, K. Sato, M. Fukata, and M. Takefuji Interaction with IQGAP1 Links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration Dev Cell 7 2004 871 883
54. H. Yagisawa, M. Okadaa, Y. Naitoa, K. Sasakia, M. Yamaga, and M. Fujii Coordinated intracellular translocation of phosphoinositide-specific phospholipase C-δ with the cell cycle Biochim Biophys Acta 1761 2006 522 534
55. M. Yamaoka-Tojo, M. Ushio-Fukai, L. Hilenski, S.I. Dikalov, Y.E. Chen, and T. Tojo IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation Circ Res 95 2004 276 283
56. S. Yamashiro, T. Noguchi, and I. Mabuchi Localization of two IQGAPs in cultured cells and early embryos of Xenopus laevis Cell Motil Cytoskeleton 55 2003 36 50
57. Y. Yoo, X. Wu, and J.L. Guan A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription J Biol Chem 282 2007 7616 7623