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Volumn 1822, Issue 6, 2012, Pages 875-884

IQGAP2, A candidate tumour suppressor of prostate tumorigenesis

Author keywords

AKT; EMT; IQGAP2; Prostate cancer; Tumour suppressor

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 2; PROTEIN KINASE B; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 84858966778     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.02.019     Document Type: Article
Times cited : (52)

References (51)
  • 1
    • 0043093686 scopus 로고    scopus 로고
    • IQGAP proteins are integral components of cytoskeletal regulation
    • Briggs M.W., Sacks D.B. IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep. 2003, 4:571-574.
    • (2003) EMBO Rep. , vol.4 , pp. 571-574
    • Briggs, M.W.1    Sacks, D.B.2
  • 2
    • 67349198476 scopus 로고    scopus 로고
    • IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis
    • White C.D., Brown M.D., Sacks D.B. IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis. FEBS Lett. 2009, 583:1817-1824.
    • (2009) FEBS Lett. , vol.583 , pp. 1817-1824
    • White, C.D.1    Brown, M.D.2    Sacks, D.B.3
  • 3
    • 0029784514 scopus 로고    scopus 로고
    • The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
    • Brill S., Li S., Lyman C.W., Church D.M., Wasmuth J.J., Weissbach L., Bernards A., Snijders A.J. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol. Cell. Biol. 1996, 16:4869-4878.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4869-4878
    • Brill, S.1    Li, S.2    Lyman, C.W.3    Church, D.M.4    Wasmuth, J.J.5    Weissbach, L.6    Bernards, A.7    Snijders, A.J.8
  • 6
    • 0029891491 scopus 로고    scopus 로고
    • IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs
    • Hart M.J., Callow M.G., Souza B., Polakis P. IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 1996, 15:2997-3005.
    • (1996) EMBO J. , vol.15 , pp. 2997-3005
    • Hart, M.J.1    Callow, M.G.2    Souza, B.3    Polakis, P.4
  • 7
    • 0037025333 scopus 로고    scopus 로고
    • IQGAP1 is a component of Cdc42 signaling to the cytoskeleton
    • Swart-Mataraza J.M., Li Z., Sacks D.B. IQGAP1 is a component of Cdc42 signaling to the cytoskeleton. J. Biol. Chem. 2002, 277:24753-24763.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24753-24763
    • Swart-Mataraza, J.M.1    Li, Z.2    Sacks, D.B.3
  • 8
    • 38149036613 scopus 로고    scopus 로고
    • IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells
    • Jadeski L., Mataraza J.M., Jeong H.W., Li Z., Sacks D.B. IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells. J. Biol. Chem. 2008, 283:1008-1017.
    • (2008) J. Biol. Chem. , vol.283 , pp. 1008-1017
    • Jadeski, L.1    Mataraza, J.M.2    Jeong, H.W.3    Li, Z.4    Sacks, D.B.5
  • 9
    • 77953395353 scopus 로고    scopus 로고
    • An emerging role for IQGAP1 in regulating protein traffic
    • Osman M. An emerging role for IQGAP1 in regulating protein traffic. Sci. World J. 2010, 10:944-953.
    • (2010) Sci. World J. , vol.10 , pp. 944-953
    • Osman, M.1
  • 10
    • 38749103163 scopus 로고    scopus 로고
    • IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells
    • Jin S.H., Akiyama Y., Fukamachi H., Yanagihara K., Akashi T., Yuasa Y. IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Int. J. Cancer 2008, 122:1040-1046.
    • (2008) Int. J. Cancer , vol.122 , pp. 1040-1046
    • Jin, S.H.1    Akiyama, Y.2    Fukamachi, H.3    Yanagihara, K.4    Akashi, T.5    Yuasa, Y.6
  • 11
    • 39749108409 scopus 로고    scopus 로고
    • Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent
    • Schmidt V.A., Chiariello C.S., Capilla E., Miller F., Bahou W.F. Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Mol. Cell. Biol. 2008, 28:1489-1502.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 1489-1502
    • Schmidt, V.A.1    Chiariello, C.S.2    Capilla, E.3    Miller, F.4    Bahou, W.F.5
  • 14
    • 58149461559 scopus 로고    scopus 로고
    • Epidemiology, pathology, and genetics of prostate cancer among African Americans compared with other ethnicities
    • Williams H., Powell I.J. Epidemiology, pathology, and genetics of prostate cancer among African Americans compared with other ethnicities. Methods Mol. Biol. 2009, 472:439-453.
    • (2009) Methods Mol. Biol. , vol.472 , pp. 439-453
    • Williams, H.1    Powell, I.J.2
  • 15
    • 34548171468 scopus 로고    scopus 로고
    • The androgen receptor in prostate cancer: therapy target in search of an integrated diagnostic test
    • Ross J.S. The androgen receptor in prostate cancer: therapy target in search of an integrated diagnostic test. Adv. Anat. Pathol. 2007, 14:353-357.
    • (2007) Adv. Anat. Pathol. , vol.14 , pp. 353-357
    • Ross, J.S.1
  • 16
    • 45049086542 scopus 로고    scopus 로고
    • Current status of experimental therapeutics for prostate cancer
    • Moon C., Park J.C., Chae Y.K., Yun J.H., Kim S. Current status of experimental therapeutics for prostate cancer. Cancer Lett. 2008, 266:116-134.
    • (2008) Cancer Lett. , vol.266 , pp. 116-134
    • Moon, C.1    Park, J.C.2    Chae, Y.K.3    Yun, J.H.4    Kim, S.5
  • 17
    • 25444492850 scopus 로고    scopus 로고
    • Dual activation of pathways regulated by steroid receptors and peptide growth factors in primary prostate cancer revealed by Factor Analysis of microarray data
    • Lozano J.J., Soler M., Bermudo R., Abia D., Fernandez P.L., Thomson T.M., Ortiz A.R. Dual activation of pathways regulated by steroid receptors and peptide growth factors in primary prostate cancer revealed by Factor Analysis of microarray data. BMC Genomics 2005, 6:109.
    • (2005) BMC Genomics , vol.6 , pp. 109
    • Lozano, J.J.1    Soler, M.2    Bermudo, R.3    Abia, D.4    Fernandez, P.L.5    Thomson, T.M.6    Ortiz, A.R.7
  • 19
    • 0029202881 scopus 로고
    • Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1
    • Hayward S.W., Dahiya R., Cunha G.R., Bartek J., Deshpande N., Narayan P. Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1. In Vitro Cell. Dev. Biol. Anim. 1995, 31:14-24.
    • (1995) In Vitro Cell. Dev. Biol. Anim. , vol.31 , pp. 14-24
    • Hayward, S.W.1    Dahiya, R.2    Cunha, G.R.3    Bartek, J.4    Deshpande, N.5    Narayan, P.6
  • 22
    • 77953213657 scopus 로고    scopus 로고
    • Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells
    • He L., Ingram A., Rybak A.P., Tang D. Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. J. Clin. Invest. 2010, 120:2094-2108.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2094-2108
    • He, L.1    Ingram, A.2    Rybak, A.P.3    Tang, D.4
  • 23
    • 3943058758 scopus 로고    scopus 로고
    • Distinct PAR/IQGAP expression patterns during murine development: implications for thrombin-associated cytoskeletal reorganization
    • Cupit L.D., Schmidt V.A., Miller F., Bahou W.F. Distinct PAR/IQGAP expression patterns during murine development: implications for thrombin-associated cytoskeletal reorganization. Mamm. Genome 2004, 15:618-629.
    • (2004) Mamm. Genome , vol.15 , pp. 618-629
    • Cupit, L.D.1    Schmidt, V.A.2    Miller, F.3    Bahou, W.F.4
  • 24
    • 79955660106 scopus 로고    scopus 로고
    • Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells
    • Rybak A.P., He L., Kapoor A., Cutz J.C., Tang D. Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells. Biochim. Biophys. Acta 2011, 1813:683-694.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 683-694
    • Rybak, A.P.1    He, L.2    Kapoor, A.3    Cutz, J.C.4    Tang, D.5
  • 26
    • 34250174504 scopus 로고    scopus 로고
    • The role of epithelial-mesenchymal transition in cancer pathology
    • Guarino M., Rubino B., Ballabio G. The role of epithelial-mesenchymal transition in cancer pathology. Pathology 2007, 39:305-318.
    • (2007) Pathology , vol.39 , pp. 305-318
    • Guarino, M.1    Rubino, B.2    Ballabio, G.3
  • 27
    • 65349132693 scopus 로고    scopus 로고
    • EMT, the cytoskeleton, and cancer cell invasion
    • Yilmaz M., Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 2009, 28:15-33.
    • (2009) Cancer Metastasis Rev. , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 28
    • 76949084622 scopus 로고    scopus 로고
    • TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion
    • Wu Y., Zhou B.P. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion. Br. J. Cancer 2010, 102:639-644.
    • (2010) Br. J. Cancer , vol.102 , pp. 639-644
    • Wu, Y.1    Zhou, B.P.2
  • 29
    • 0346363757 scopus 로고    scopus 로고
    • Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
    • Peinado H., Ballestar E., Esteller M., Cano A. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell. Biol. 2004, 24:306-319.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 306-319
    • Peinado, H.1    Ballestar, E.2    Esteller, M.3    Cano, A.4
  • 30
    • 79955838431 scopus 로고    scopus 로고
    • Opposite regulation of epithelial-to- mesenchymal transition and cell invasiveness by periostin between prostate and bladder cancer cells
    • Kim C.J., Sakamoto K., Tambe Y., Inoue H. Opposite regulation of epithelial-to- mesenchymal transition and cell invasiveness by periostin between prostate and bladder cancer cells. Int. J. Oncol. 2011, 38:1759-1766.
    • (2011) Int. J. Oncol. , vol.38 , pp. 1759-1766
    • Kim, C.J.1    Sakamoto, K.2    Tambe, Y.3    Inoue, H.4
  • 31
    • 79954610504 scopus 로고    scopus 로고
    • Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β- catenin signaling
    • Kolegraff K., Nava P., Helms M.N., Parkos C.A., Nusrat A. Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β- catenin signaling. Mol. Biol. Cell 2011, 22:1121-1134.
    • (2011) Mol. Biol. Cell , vol.22 , pp. 1121-1134
    • Kolegraff, K.1    Nava, P.2    Helms, M.N.3    Parkos, C.A.4    Nusrat, A.5
  • 32
    • 79958789619 scopus 로고    scopus 로고
    • E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression
    • Lau M.T., Klausen C., Leung P.C. E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression. Oncogene 2011, 30:2753-2766.
    • (2011) Oncogene , vol.30 , pp. 2753-2766
    • Lau, M.T.1    Klausen, C.2    Leung, P.C.3
  • 33
    • 0032191393 scopus 로고    scopus 로고
    • Tumor surveillance via the ARF-p53 pathway
    • Sherr C.J. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 1998, 12:2984-2991.
    • (1998) Genes Dev. , vol.12 , pp. 2984-2991
    • Sherr, C.J.1
  • 34
    • 70350109641 scopus 로고    scopus 로고
    • ETS gene fusions in prostate cancer
    • Clark J.P., Cooper C.S. ETS gene fusions in prostate cancer. Nat. Rev. Urol. 2009, 6:429-439.
    • (2009) Nat. Rev. Urol. , vol.6 , pp. 429-439
    • Clark, J.P.1    Cooper, C.S.2
  • 35
    • 51449107401 scopus 로고    scopus 로고
    • Fusion in the ETS gene family and prostate cancer
    • Narod S.A., Seth A., Nam A. Fusion in the ETS gene family and prostate cancer. Br. J. Cancer 2008, 99:847-851.
    • (2008) Br. J. Cancer , vol.99 , pp. 847-851
    • Narod, S.A.1    Seth, A.2    Nam, A.3
  • 40
    • 77952299722 scopus 로고    scopus 로고
    • MiR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma
    • Furuta M., Kozaki K.I., Tanaka S., Arii S., Imoto I., Inazawa J. miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis 2010, 31:766-776.
    • (2010) Carcinogenesis , vol.31 , pp. 766-776
    • Furuta, M.1    Kozaki, K.I.2    Tanaka, S.3    Arii, S.4    Imoto, I.5    Inazawa, J.6
  • 42
    • 9544225039 scopus 로고    scopus 로고
    • Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2
    • McCallum S.J., Wu W.J., Cerione R.A. Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2. J. Biol. Chem. 1996, 271:21732-21737.
    • (1996) J. Biol. Chem. , vol.271 , pp. 21732-21737
    • McCallum, S.J.1    Wu, W.J.2    Cerione, R.A.3
  • 43
    • 0029784514 scopus 로고    scopus 로고
    • The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
    • Brill S., Li S., Lyman C.W., Church D.M., Wasmuth J.J., Weissbach L., Bernards A., Snijders A.J. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol. Cell. Biol. 1996, 16:4869-4878.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4869-4878
    • Brill, S.1    Li, S.2    Lyman, C.W.3    Church, D.M.4    Wasmuth, J.J.5    Weissbach, L.6    Bernards, A.7    Snijders, A.J.8
  • 45
    • 34547673530 scopus 로고    scopus 로고
    • IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos
    • Yamashiro S., Abe H., Mabuchi I. IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos. Dev. Biol. 2007, 308:485-493.
    • (2007) Dev. Biol. , vol.308 , pp. 485-493
    • Yamashiro, S.1    Abe, H.2    Mabuchi, I.3
  • 46
    • 44449173164 scopus 로고    scopus 로고
    • Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer
    • Cao J., Chiarelli C., Richman O., Zarrabi K., Kozarekar P., Zucker S. Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer. J. Biol. Chem. 2008, 283:6232-6240.
    • (2008) J. Biol. Chem. , vol.283 , pp. 6232-6240
    • Cao, J.1    Chiarelli, C.2    Richman, O.3    Zarrabi, K.4    Kozarekar, P.5    Zucker, S.6
  • 47
    • 77955833744 scopus 로고    scopus 로고
    • IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation
    • Chen F., Zhu H.H., Zhou L.F., Wu S.S., Wang J., Chen Z. IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation. Exp. Mol. Med. 2010, 42:477-483.
    • (2010) Exp. Mol. Med. , vol.42 , pp. 477-483
    • Chen, F.1    Zhu, H.H.2    Zhou, L.F.3    Wu, S.S.4    Wang, J.5    Chen, Z.6
  • 48
    • 0036873429 scopus 로고    scopus 로고
    • Rac-1 and IQGAP are potential regulators of E-cadherin catenin interactions during murine preimplantation development
    • Natale D.R., Watson A.J. Rac-1 and IQGAP are potential regulators of E-cadherin catenin interactions during murine preimplantation development. Gene Expr. Patterns 2002, 2:17-22.
    • (2002) Gene Expr. Patterns , vol.2 , pp. 17-22
    • Natale, D.R.1    Watson, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.