The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest

Cell Reports

Volumn 8, Issue 5, 2014, Pages 1545-1557

  Atkins, Katelyn M ^a   Thomas, Laura L ^b   Barroso Gonzalez, Jonathan ^b   Thomas, Laurel ^b   Auclair, Sylvain ^b   Yin, Jun ^b   Kang, Hyeog ^c   Chung, Jay H ^c   Dikeakos, Jimmy D ^d   Thomas, Gary ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; PACS 2 PROTEIN; PROTEIN; PROTEIN P21; PROTEIN P53; SELISISTAT; SIRTUIN 1; SORTING PROTEIN; UNCLASSIFIED DRUG; 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE; CARBAZOLE DERIVATIVE; CDKN1A PROTEIN, MOUSE; PACS2 PROTEIN, MOUSE; PROTEIN BINDING; SIRT1 PROTEIN, MOUSE; VESICULAR TRANSPORT PROTEIN;

ARTICLE; CATALYSIS; CELL CYCLE ARREST; CELL NUCLEUS; CONTROLLED STUDY; DEACETYLATION; DNA DAMAGE; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN TRANSPORT; THYMOCYTE; ACETYLATION; ACTIVE TRANSPORT; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CYCLE; GENETICS; HEK293 CELL LINE; METABOLISM; MOUSE; TUMOR CELL LINE;

MUS;

ACETYLATION; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CARBAZOLES; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; PROTEIN BINDING; SIRTUIN 1; THYMOCYTES; TUMOR SUPPRESSOR PROTEIN P53; VESICULAR TRANSPORT PROTEINS;

EID: 84922581149     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.07.049     Document Type: Article

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