An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation- acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-Aza-2′-deoxycytidine treatment

Journal of Biological Chemistry

Volumn 283, Issue 5, 2008, Pages 2564-2574

  Wang, Haiying ^a   Zhao, Ying ^a   Li, Lian ^a   McNutt, Michael A ^a   Wu, Lipeng ^a   Lu, Shaoli ^a   Yu, Yu ^a   Zhou, Wen ^a   Feng, Jingnan ^a   Chai, Guolin ^a   Yang, Yang ^a   Zhu, Wei Guo ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; CELL CULTURE; CHEMICAL ACTIVATION; CHROMOSOMES; MOLECULAR BIOLOGY; SIGNALING;

ATM AND RAD3-RELATED; BINDING ACTIVITIES; EXPRESSION VECTORS; HUMAN CANCER CELLS; NUCLEOSIDE ANALOGUES; POST-TRANSLATIONAL MODIFICATIONS; REPLICATION PROTEIN A; SIGNALING PATHWAYS;

PHOSPHORYLATION;

5 AZA 2' DEOXYCYTIDINE; ATR PROTEIN; AURORA A KINASE; CAFFEINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTARABINE; HISTONE ACETYLTRANSFERASE PCAF; LYSINE; MUTANT PROTEIN; PROTEIN P300; PROTEIN P53; REPLICATION FACTOR A; SERINE; THREONINE; WORTMANNIN; ATR PROTEIN, HUMAN; AZACITIDINE; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DRUG DERIVATIVE; PRIMER DNA; PROTEIN SERINE THREONINE KINASE; TP53 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CELL STRAIN HCT116; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVATION; ENZYME BINDING; EXPRESSION VECTOR; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; CELL LINE; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; SITE DIRECTED MUTAGENESIS; UBIQUITINATION;

ACETYLATION; AZACITIDINE; BASE SEQUENCE; CELL CYCLE PROTEINS; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA PRIMERS; HUMANS; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; REPLICATION PROTEIN A; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 41449118765     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M702454200     Document Type: Article

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