P53 licensed to kill? Operating the assassin

Journal of Cellular Biochemistry

Volumn 88, Issue 1, 2003, Pages 76-82

  Haupt, Susan ^a   Louria Hayon, Igal ^a   Haupt, Ygal ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Degradation; DNA damage; Mdm2; P53; Phosphorylation; PML; PML NBs

Indexed keywords

DNA; PROTEIN MDM2; PROTEIN P53;

CARCINOGENESIS; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENOTOXICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRESS; TUMOR SUPPRESSOR GENE;

ADP-RIBOSYLATION FACTORS; ANIMALS; DNA DAMAGE; HUMANS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037215395     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10311     Document Type: Review

References (41)

1. Appella E, Anderson CW. 2001. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 268:2764-2772.
2. Balint EE, Vousden KH. 2001. Activation and activities of the p53 tumour suppressor protein. Br J Cancer 85: 1813-1823.
3. Bartek J, Falck J, Lukas J. 2001. Milestones chk2 kinase - A busy messenger. Nat Rev Mol Cell Biol 2:877-886.
4. Bean LJ, Stark GR. 2002. Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2. J Biol Chem 18:1864-1871.
5. Bischof O, Kirsh O, Pearson M, Itahana K, Pelicci PG, Dejean A. 2002. Deconstructing PML-induced premature senescence. EMBO J 21:3358-3369.
6. Carbone R, Pearson M, Minucci S, Pelicci PG. 2002. PML NBs associate with the hMrell complex and p53 at sites of irradiation induced DNA damage. Oncogene 21:1633-1640.
7. D'orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Cohen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, Soddu S. 2001. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4:11-19.
8. Giaccia AJ, Kastan MB. 1998. The complexity of p53 modulation: Emerging patterns from divergent signals. Genes Dev 12:2973-2983.
9. Goldberg Z, Vogt Sionov R, Berger M, Zwang Y, Perets R, Van Etten RA, Oren M, Taya Y, Haupt Y. 2002. Tyrosine phosphorylation of Mdm2 by c-Abl: Implications for p53 regulation. EMBO J 21:3715-3727.
10. Gottlieb TM, Leal JF, Seger R, Taya Y, Oren M. 2002. Cross-talk between Akt, p53, and Mdm2: Possible implications for the regulation of apoptosis. Oncogene 21:1299-1303.
11. Hofmann TG, Moller A, Sirma H, Zentgraf H, Taya Y, Droge W, Will H, Scmitz LM. 2001. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 4:1-10.
12. Honda R, Tanaka H, Yasuda H. 1997. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420:25-27.
13. Hupp TR, Sparks A, Lane DP. 1995. Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 83:237-245.
14. Jack MT, Woo RA, Hirao A, Cheung A, Mak TW, Lee PW. 2002. Chk2 is dispensable for p53-mediated G1 arrest, but is required for a latent p53-mediated apoptotic response. Proc Natl Acad Sci USA 99:9825-9829.
15. Jimenez GS, Khan SH, Stommel JM, Wahl GM. 1999. p53 regulation by post-translational modification and nuclear retention in response to diverse stresses. Oncogene 18:7656-7665.
16. Kim IS, Kim DH, Han SM, Chin MU, Nam HJ, Cho HP, Choi SY, Song BJ, Kim ER, Bae YS, Moon YH. 2000. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. J Biol Chem 275:23139-23145.
17. Korgaonkar C, Zhao L, Modestou M, Quelle DE. 2002. ARF function does not require p53 stabilization or Mdm2 relocalization. Mol Cell Biol 22:196-206.
18. Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, Minucci S, Pelicci PG, Kouzarides T. 2002. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J 21:2383-2396.
19. Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, Gu W. 2002. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416:648-653.
20. Liang SH, Clarke MF. 2001. Regulation of p53 localization. Eur J Biochem 268:2779-2783.
21. Llanos S, Clark PA, Rowe J, Peters G. 2001. Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nat Cell Biol 3:445-452.
22. Lohrum MA, Woods DB, Ludwig RL, Balint EE, Vousden KH. 2001. C-terminal ubiquitination of p53 contributes to nuclear export. Mol Cell Biol 21:8521-8532.
23. Louria-Hayon I, Haupt Y. 2002. p53: An internal investigation. Cell Cycle 1:111-116.
24. Mayo LD, Donner DB. 2001. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA 98:11598-11603.
25. Mayo LD, Turchi JJ, Berberich SJ. 1997. Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res 57:5013-5016.
26. Michael D, Oren M, Young JC, Pendergast AM, Pondel M, Landau NR, Littman DR, Witte ON. 2002. The p53 and Mdm2 families in cancer. Curr Opin Genet Dev 12:53-59.
27. Okamoto K, Li H, Jensen MR, Zhang T, Taya Y, Thorgeirsson SS, Prives C. 2002. Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell 9:761-771.
28. Parant J, Chavez Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. 2001. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 29:92-95.
29. Pearson M, Carbone R, Sebastiani C, Cioce M, Fagioli M, Saito S, Higashimoto Y, Appella E, Minucci S, Pandolfi PP, Pelicci PG. 2000. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406:207-210.
30. Prives C, Manley LJ. 2001. Why Is p53 Acetylated? Cell 107:815-818.
31. ARF. Cell 103:321-330.
32. Salomoni P, Pandolfi PP. 2002. The role of PML in tumor suppression. Cell 108:165-170.
33. Sherr CJ, Weber JD. 2000. The ARF/p53 pathway. Curr Opin Genet Dev 10:94-99.
34. Stad R, Ramos YF, Little N, Grivell S, Attema J, van Der Eb AJ, Jochemsen AG. 2000. Hdmx stabilizes Mdm2 and p53. J Biol Chem 275:28039-28044.
35. Thomas M, Pim D, Banks L. 1999. The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene 18:7690-7700.
36. Tolbert D, Lu X, Yin C, Tantama M, Van Dyke T. 2002. pl9(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivob. Mol Cell Biol 22:370-377.
37. Vogt Sionov R, Hayon LI, Haupt Y. 2001. In: The Regulation of p53 Growth Suppression. Blagosklonny MV, editor. Cell cycle checkpoints and cancer. Austin Landes Bioscience;. pp 106-125.
38. Wu Z, Earle J, Saito S, Anderson CW, Appella E, Xu Y. 2002. Mutation of mouse p53 Ser23 and the response to DNA damage. Mol Cell Biol 22:2441-2449.
39. Xirodimas DP, Stephen CW, Lane DP. 2001. Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53. Exp Cell Res 270:66-77.
40. Yu ZK, Geyer RK, Maki CG. 2000. MDM2-dependent ubiquitination of nuclear and cytoplasmic P53. Oncogene 19:5892-5897.
41. Zhang Y, Xiong Y. 2001. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation. Science 292:1910-1915.