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Volumn 9, Issue 5, 2011, Pages 616-625

Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; PROTEIN P21; PROTEIN P53; PUMA PROTEIN;

EID: 79956006207     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-11-0052     Document Type: Article
Times cited : (100)

References (51)
  • 1
    • 1642580868 scopus 로고    scopus 로고
    • Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine
    • Potten CS. Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine. Radiat Res 2004;161:123-36.
    • (2004) Radiat Res , vol.161 , pp. 123-136
    • Potten, C.S.1
  • 2
    • 64549157199 scopus 로고    scopus 로고
    • Radioprotection
    • Greenberger JS. Radioprotection. In Vivo 2009;23:323-36.
    • (2009) In Vivo , vol.23 , pp. 323-336
    • Greenberger, J.S.1
  • 3
    • 0024427204 scopus 로고
    • The influence of bone marrow depletion on intestinal radiation damage
    • Terry NH, Travis EL. The influence of bone marrow depletion on intestinal radiation damage. Int J Radiat Oncol Biol Phys 1989;17:569-73.
    • (1989) Int J Radiat Oncol Biol Phys , vol.17 , pp. 569-573
    • Terry, N.H.1    Travis, E.L.2
  • 4
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell 2007;28:739-45.
    • (2007) Mol Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 5
    • 0034614576 scopus 로고    scopus 로고
    • Stem cells: Units of development, units of regeneration, and units in evolution
    • Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell 2000;100:157-68.
    • (2000) Cell , vol.100 , pp. 157-168
    • Weissman, I.L.1
  • 6
    • 0030879563 scopus 로고    scopus 로고
    • atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
    • Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet 1997;16:397-401.
    • (1997) Nat Genet , vol.16 , pp. 397-401
    • Westphal, C.H.1    Rowan, S.2    Schmaltz, C.3    Elson, A.4    Fisher, D.E.5    Leder, P.6
  • 8
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane DP, et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 1994;54:614-7.
    • (1994) Cancer Res , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6
  • 9
    • 2442681614 scopus 로고    scopus 로고
    • Dual effect of p53 on radiation sensitivity in vivo: P53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice
    • Komarova EA, Kondratov RV, Wang K, Christov K, Golovkina TV, Goldblum JR, et al. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene 2004;23:3265-71.
    • (2004) Oncogene , vol.23 , pp. 3265-3271
    • Komarova, E.A.1    Kondratov, R.V.2    Wang, K.3    Christov, K.4    Golovkina, T.V.5    Goldblum, J.R.6
  • 10
    • 0037317521 scopus 로고    scopus 로고
    • The role of p53 in determining sensitivity to radiotherapy
    • Gudkov AV, Komarova EA. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 2003;3:117-29.
    • (2003) Nat Rev Cancer , vol.3 , pp. 117-129
    • Gudkov, A.V.1    Komarova, E.A.2
  • 12
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: The growing complexity of p53
    • Vousden KH, Prives C. Blinded by the light: the growing complexity of p53. Cell 2009;137:413-31.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 13
    • 18144416611 scopus 로고    scopus 로고
    • The transcriptional targets of p53 in apoptosis control
    • Yu J, Zhang L. The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 2005;331:851-8.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 851-858
    • Yu, J.1    Zhang, L.2
  • 14
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-12.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 16
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001;7:683-94.
    • (2001) Mol Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 18
    • 33744942924 scopus 로고    scopus 로고
    • PUMA dissociates Bax and BCL-XL to induce apoptosis in colon cancer cells
    • Ming L, Wang P, Bank A, Yu J, Zhang L. PUMA dissociates Bax and BCL-XL to induce apoptosis in colon cancer cells. J Biol Chem 2006;281:16034-42.
    • (2006) J Biol Chem , vol.281 , pp. 16034-16042
    • Ming, L.1    Wang, P.2    Bank, A.3    Yu, J.4    Zhang, L.5
  • 19
    • 68149108384 scopus 로고    scopus 로고
    • PUMA, a potent killer with or without p53
    • Yu J, Zhang L. PUMA, a potent killer with or without p53. Oncogene 2008;27Suppl 1:S71-83.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Yu, J.1    Zhang, L.2
  • 21
    • 27744547091 scopus 로고    scopus 로고
    • Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    • Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, Adams JM, et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 2005;123:641-53.
    • (2005) Cell , vol.123 , pp. 641-653
    • Wu, W.S.1    Heinrichs, S.2    Xu, D.3    Garrison, S.P.4    Zambetti, G.P.5    Adams, J.M.6
  • 22
    • 77951753647 scopus 로고    scopus 로고
    • Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation
    • Yu H, Shen H, Yuan Y, XuFeng R, Hu X, Garrison SP, et al. Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood 2010;115:3472-80.
    • (2010) Blood , vol.115 , pp. 3472-3480
    • Yu, H.1    Shen, H.2    Yuan, Y.3    XuFeng, R.4    Hu, X.5    Garrison, S.P.6
  • 23
    • 77954709903 scopus 로고    scopus 로고
    • Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation
    • Shao L, Sun Y, Zhang Z, Feng W, Gao Y, Cai Z, et al. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood 2010;115:4707-14.
    • (2010) Blood , vol.115 , pp. 4707-4714
    • Shao, L.1    Sun, Y.2    Zhang, Z.3    Feng, W.4    Gao, Y.5    Cai, Z.6
  • 24
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003;4:321-8.
    • (2003) Cancer Cell , vol.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3    Yang, C.4    Wang, J.5    Brennan, J.6
  • 25
    • 34247504546 scopus 로고    scopus 로고
    • p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion
    • Wu B, Qiu W, Wang P, Yu H, Cheng T, Zambetti GP, et al. p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut 2007;56:645-54.
    • (2007) Gut , vol.56 , pp. 645-654
    • Wu, B.1    Qiu, W.2    Wang, P.3    Yu, H.4    Cheng, T.5    Zambetti, G.P.6
  • 26
  • 27
    • 77949655884 scopus 로고    scopus 로고
    • Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis
    • Qiu W, Leibowitz B, Zhang L, Yu J. Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene 2009;29:1622-32.
    • (2009) Oncogene , vol.29 , pp. 1622-1632
    • Qiu, W.1    Leibowitz, B.2    Zhang, L.3    Yu, J.4
  • 28
    • 75749114436 scopus 로고    scopus 로고
    • p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis
    • Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 2010;327:593-6.
    • (2010) Science , vol.327 , pp. 593-596
    • Kirsch, D.G.1    Santiago, P.M.2    Di Tomaso, E.3    Sullivan, J.M.4    Hou, W.S.5    Dayton, T.6
  • 30
    • 0030812174 scopus 로고    scopus 로고
    • Apoptosis in small intestinal epithelial from p53-null mice: Evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation
    • Merritt AJ, Allen TD, Potten CS, Hickman JA. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation. Oncogene 1997;14:2759-66.
    • (1997) Oncogene , vol.14 , pp. 2759-2766
    • Merritt, A.J.1    Allen, T.D.2    Potten, C.S.3    Hickman, J.A.4
  • 31
    • 70349559751 scopus 로고    scopus 로고
    • p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
    • Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, et al. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet 2009;41:1138-43.
    • (2009) Nat Genet , vol.41 , pp. 1138-1143
    • Begus-Nahrmann, Y.1    Lechel, A.2    Obenauf, A.C.3    Nalapareddy, K.4    Peit, E.5    Hoffmann, E.6
  • 32
    • 33845892109 scopus 로고    scopus 로고
    • Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
    • Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, et al. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 2007;39:99-105.
    • (2007) Nat Genet , vol.39 , pp. 99-105
    • Choudhury, A.R.1    Ju, Z.2    Djojosubroto, M.W.3    Schienke, A.4    Lechel, A.5    Schaetzlein, S.6
  • 33
    • 0031474756 scopus 로고    scopus 로고
    • Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice
    • Wang YA, Elson A, Leder P. Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc Natl Acad Sci U S A 1997;94:14590-5.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 14590-14595
    • Wang, Y.A.1    Elson, A.2    Leder, P.3
  • 34
    • 0034601420 scopus 로고    scopus 로고
    • Different impact of p53 and p21 on the radiation response of mouse tissues
    • Komarova EA, Christov K, Faerman AI, Gudkov AV. Different impact of p53 and p21 on the radiation response of mouse tissues. Oncogene 2000;19:3791-8.
    • (2000) Oncogene , vol.19 , pp. 3791-3798
    • Komarova, E.A.1    Christov, K.2    Faerman, A.I.3    Gudkov, A.V.4
  • 35
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • Waldman T, Lengauer C, Kinzler KW, Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996;381:713-16.
    • (1996) Nature , vol.381 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3    Vogelstein, B.4
  • 36
    • 37549035466 scopus 로고    scopus 로고
    • p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability
    • Payne SR, Zhang S, Tsuchiya K, Moser R, Gurley KE, Longton G, et al. p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability. Mol Cell Biol 2008;28:258-68.
    • (2008) Mol Cell Biol , vol.28 , pp. 258-268
    • Payne, S.R.1    Zhang, S.2    Tsuchiya, K.3    Moser, R.4    Gurley, K.E.5    Longton, G.6
  • 37
    • 21044450491 scopus 로고    scopus 로고
    • ATM regulates target switching to escalating doses of radiation in the intestines
    • Ch'ang HJ, Maj JG, Paris F, Xing HR, Zhang J, Truman JP, et al. ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med 2005;11:484-90.
    • (2005) Nat Med , vol.11 , pp. 484-490
    • Ch'ang, H.J.1    Maj, J.G.2    Paris, F.3    Xing, H.R.4    Zhang, J.5    Truman, J.P.6
  • 38
    • 34648819989 scopus 로고    scopus 로고
    • 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy
    • Clarke AR, Jones N, Pryde F, Adachi Y, Sansom OJ. 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. Oncogene 2007;26:6349-55.
    • (2007) Oncogene , vol.26 , pp. 6349-6355
    • Clarke, A.R.1    Jones, N.2    Pryde, F.3    Adachi, Y.4    Sansom, O.J.5
  • 39
    • 0344874229 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo
    • Ishizuka S, Martin K, Booth C, Potten CS, de Murcia G, Bürkle A, et al. Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo. Nucleic Acids Res 2003;31:6198-205.
    • (2003) Nucleic Acids Res , vol.31 , pp. 6198-6205
    • Ishizuka, S.1    Martin, K.2    Booth, C.3    Potten, C.S.4    De Murcia, G.5    Bürkle, A.6
  • 40
    • 75749146169 scopus 로고    scopus 로고
    • Coexistence of quiescent and active adult stem cells in mammals
    • Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science 2010;327:542-5.
    • (2010) Science , vol.327 , pp. 542-545
    • Li, L.1    Clevers, H.2
  • 42
    • 77956233247 scopus 로고    scopus 로고
    • A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal
    • Milyavsky M, Gan OI, Trottier M, Komosa M, Tabach O, Notta F, et al. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell 2010;7:186-97.
    • (2010) Cell Stem Cell , vol.7 , pp. 186-197
    • Milyavsky, M.1    Gan, O.I.2    Trottier, M.3    Komosa, M.4    Tabach, O.5    Notta, F.6
  • 43
  • 47
    • 77955912797 scopus 로고    scopus 로고
    • Apoptosis-promoted tumorigenesis: Gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death
    • Michalak EM, Vandenberg CJ, Delbridge AR, Wu L, Scott CL, Adams JM, et al. Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death. Genes Dev 2010;24:1608-13.
    • (2010) Genes Dev , vol.24 , pp. 1608-1613
    • Michalak, E.M.1    Vandenberg, C.J.2    Delbridge, A.R.3    Wu, L.4    Scott, C.L.5    Adams, J.M.6
  • 48
    • 77955869467 scopus 로고    scopus 로고
    • Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation
    • 20101
    • Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, et al. Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. Genes Dev 20101;24:1602-7.
    • Genes Dev , vol.24 , pp. 1602-1607
    • Labi, V.1    Erlacher, M.2    Krumschnabel, G.3    Manzl, C.4    Tzankov, A.5    Pinon, J.6
  • 49
    • 78650939212 scopus 로고    scopus 로고
    • Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death
    • Mustata G, Li M, Zevola N, Bakan A, Zhang L, Epperly M, et al. Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death. Curr Top Med Chem 2011;11:281-90.
    • (2011) Curr Top Med Chem , vol.11 , pp. 281-290
    • Mustata, G.1    Li, M.2    Zevola, N.3    Bakan, A.4    Zhang, L.5    Epperly, M.6
  • 50
    • 77954997865 scopus 로고    scopus 로고
    • Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
    • Johnson SM, Torrice CD, Bell JF, Monahan KB, Jiang Q, Wang Y, et al. Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. J Clin Invest 2010;120:2528-36.
    • (2010) J Clin Invest , vol.120 , pp. 2528-2536
    • Johnson, S.M.1    Torrice, C.D.2    Bell, J.F.3    Monahan, K.B.4    Jiang, Q.5    Wang, Y.6
  • 51
    • 0033579297 scopus 로고    scopus 로고
    • Does cancer therapy trigger cell suicide?
    • Finkel E. Does cancer therapy trigger cell suicide?Science 1999;286:2256-8.
    • (1999) Science , vol.286 , pp. 2256-2258
    • Finkel, E.1


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