Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

EMBO Molecular Medicine

Volumn 7, Issue 2, 2015, Pages 190-210

  Clarke, Julia R ^a   Lyra e Silva, Natalia M ^a   Figueiredo, Claudia P ^a   Frozza, Rudimar L ^a   Ledo, Jose H ^a   Beckman, Danielle ^a   Katashima, Carlos K ^b   Razolli, Daniela ^b   Carvalho, Bruno M ^b   Frazão, Renata ^c   Silveira, Marina A ^c   Ribeiro, Felipe C ^a   Bomfim, Theresa R ^a   Neves, Fernanda S ^a   Klein, William L ^d   Medeiros, Rodrigo ^e   Laferla, Frank M ^e   Carvalheira, Jose B ^b   Saad, Mario J ^b   Munoz, Douglas P ^f   Velloso, Licio A ^b   Ferreira, Sergio T ^a   De Felice, Fernanda G ^a   more..

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d NORTHWESTERN UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f QUEEN S UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; ER stress; Hypothalamus; Inflammation; Insulin resistance

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHOLESTEROL; EUKARYOTIC TRANSLATION INITIATION FACTOR 2ALPHA; GLUCOSE TRANSPORTER 4; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLIXIMAB; INITIATION FACTOR; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; LEPTIN; NORADRENALIN; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 1; UNCLASSIFIED DRUG; GLUCOSE; OLIGONUCLEOTIDE; TUMOR NECROSIS FACTOR;

ADIPOSE TISSUE; ADULT; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN REGION; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO; ENCEPHALITIS; ENDOPLASMIC RETICULUM STRESS; EPIDIDYMIS FAT; FEMALE; GEL PERMEATION CHROMATOGRAPHY; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HYPOTHALAMUS; HYPOTHALAMUS DISEASE; IMMUNOREACTIVITY; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LATERAL BRAIN VENTRICLE; LIPID DIET; MACACA; MALE; MEMBRANE STEADY POTENTIAL; METABOLIC DISORDER; METABOLIC REGULATION; MICROGLIA; MOUSE; MUSCLE TISSUE; NONHUMAN; NORADRENALIN BLOOD LEVEL; OLIGOMERIZATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TRANSMISSION ELECTRON MICROSCOPY; UBIQUITINATION; WESTERN BLOTTING; WHITE ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; GENETICS; HUMAN; METABOLISM; NERVE CELL; PERIPHERAL NERVE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; FEMALE; GLUCOSE; HUMANS; HYPOTHALAMUS; MACACA; MALE; MICE; MICE, INBRED C57BL; NEURONS; NF-KAPPA B; OLIGONUCLEOTIDES; PERIPHERAL NERVES; RATS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84922068640     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404183     Document Type: Article

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