TNF-α transiently induces endoplasmic reticulum stress and an incomplete unfolded protein response in the hypothalamus

Neuroscience

Volumn 170, Issue 4, 2010, Pages 1035-1044

  Denis, R G ^a   Arruda, A P ^a   Romanatto, T ^a   Milanski, M ^a   Coope, A ^a   Solon, C ^a   Razolli, D S ^a   Velloso, L A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Cytokine; Diabetes; Food intake; Insulin; Leptin; Obesity

Indexed keywords

INITIATION FACTOR 2ALPHA; LIPOPOLYSACCHARIDE; PROTEIN IRE1; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HYPOTHALAMUS; INFLAMMATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ENDOPLASMIC RETICULUM; HYPOTHALAMUS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; UNFOLDED PROTEIN RESPONSE;

EID: 77957155753     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.08.013     Document Type: Article

References (23)

1. Amaral M.E., Barbuio R., Milanski M., Romanatto T., Barbosa H.C., Nadruz W., Bertolo M.B., Boschero A.C., Saad M.J., Franchini K.G., Velloso L.A. Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem 2006, 98:203-212.
2. Bertelli D.F., Araujo E.P., Cesquini M., Stoppa G.R., Gasparotto-Contessotto M., Toyama M.H., Felix J.V., Carvalheira J.B., Michelini L.C., Chiavegatto S., Boschero A.C., Saad M.J., Lopes-Cendes I., Velloso L.A. Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology 2006, 147:5385-5399.
3. De Souza C.T., Araujo E.P., Bordin S., Ashimine R., Zollner R.L., Boschero A.C., Saad M.J., Velloso L.A. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005, 146:4192-4199.
4. Flier J.S. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004, 116:337-350.
5. Howard J.K., Cave B.J., Oksanen L.J., Tzameli I., Bjorbaek C., Flier J.S. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 2004, 10:734-738.
6. Hu P., Han Z., Couvillon A.D., Kaufman R.J., Exton J.H. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol 2006, 26:3071-3084.
7. Jiang C.C., Chen L.H., Gillespie S., Kiejda K.A., Mhaidat N., Wang Y.F., Thorne R., Zhang X.D., Hersey P. Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response. Cancer Res 2007, 67:5880-5888.
8. Johnson A.K., Epstein A.N. The cerebral ventricles as the avenue for the dipsogenic action of intracranial angiotensin. Brain Res 1975, 86:399-418.
9. Kleinridders A., Schenten D., Konner A.C., Belgardt B.F., Mauer J., Okamura T., Wunderlich F.T., Medzhitov R., Bruning J.C. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 2009, 10:249-259.
10. Milanski M., Degasperi G., Coope A., Morari J., Denis R., Cintra D.E., Tsukumo D.M., Anhe G., Amaral M.E., Takahashi H.K., Curi R., Oliveira H.C., Carvalheira J.B., Bordin S., Saad M.J., Velloso L.A. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 2009, 29:359-370.
11. Moraes J.C., Coope A., Morari J., Cintra D.E., Roman E.A., Pauli J.R., Romanatto T., Carvalheira J.B., Oliveira A.L., Saad M.J., Velloso L.A. High-fat diet induces apoptosis of hypothalamic neurons. PLoS One 2009, 4:e5045.
12. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., Schwartz M.W. Central nervous system control of food intake and body weight. Nature 2006, 443:289-295.
13. Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., Tuncman G., Gorgun C., Glimcher L.H., Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461.
14. Ozcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R.O., Gorgun C.Z., Hotamisligil G.S. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313:1137-1140.
15. Pfeffer K., Matsuyama T., Kundig T.M., Wakeham A., Kishihara K., Shahinian A., Wiegmann K., Ohashi P.S., Kronke M., Mak T.W. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to Lmonocytogenes infection. Cell 1993, 73:457-467.
16. Picardi P.K., Calegari V.C., Prada Pde O., Moraes J.C., Araujo E., Marcondes M.C., Ueno M., Carvalheira J.B., Velloso L.A., Saad M.J. Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology 2008, 149:3870-3880.
17. Schroder M., Kaufman R.J. ER stress and the unfolded protein response. Mutat Res 2005, 569:29-63.
18. Velloso L.A., Araujo E.P., de Souza C.T. Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation 2008, 15:189-193.
19. Wisse B.E., Schwartz M.W. Does hypothalamic inflammation cause obesity?. Cell Metab 2009, 10:241-242.
20. Xu C., Bailly-Maitre B., Reed J.C. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005, 115:2656-2664.
21. Yang L., Hotamisligil G.S. Stressing the brain, fattening the body. Cell 2008, 135:20-22.
22. Yang Q., Kim Y.S., Lin Y., Lewis J., Neckers L., Liu Z.G. Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK. EMBO Rep 2006, 7:622-627.
23. Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135:61-73.