Anandamide hydrolysis in FAAH reveals a dual strategy for efficient enzyme-assisted amide bond cleavage via nitrogen inversion

Journal of Physical Chemistry B

Volumn 119, Issue 3, 2015, Pages 789-801

  Palermo, Giulia ^a   Campomanes, Pablo ^b   Cavalli, Andrea ^a,c   Rothlisberger, Ursula ^b   De Vivo, Marco ^a  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b EPFL   (Switzerland)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYMES; FATTY ACIDS; HYDROLYSIS; MACHINERY; MOLECULAR DYNAMICS; NITROGEN; QUANTUM CHEMISTRY; QUANTUM THEORY; REACTION KINETICS;

ACYL-ENZYME FORMATION; CATALYTIC MECHANISMS; CLASSICAL MOLECULAR DYNAMICS; ENZYMATIC COMPLEXES; FATTY ACID AMIDE HYDROLASE; NITROGEN INVERSION; QUANTUM MECHANICAL; RATE-LIMITING STEPS;

AMIDES;

AMIDASE; AMIDE; ANANDAMIDE; ARACHIDONIC ACID DERIVATIVE; ENDOCANNABINOID; FATTY-ACID AMIDE HYDROLASE; NITROGEN;

ACYLATION; BIOCATALYSIS; CHEMISTRY; ENZYME ACTIVE SITE; HYDROLYSIS; METABOLISM; MOLECULAR DYNAMICS; QUANTUM THEORY; THERMODYNAMICS;

ACYLATION; AMIDOHYDROLASES; ARACHIDONIC ACIDS; BIOCATALYSIS; CATALYTIC DOMAIN; ENDOCANNABINOIDS; HYDROLYSIS; MOLECULAR DYNAMICS SIMULATION; NITROGEN; POLYUNSATURATED ALKAMIDES; QUANTUM THEORY; THERMODYNAMICS;

EID: 84921451189     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp5052276     Document Type: Article

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