Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor

Journal of Biological Chemistry

Volumn 285, Issue 50, 2010, Pages 39249-39259

  McLuskey, Karen ^a   Paterson, Neil G ^a,c   Bland, Nicholas D ^b,d   Isaacs, Neil W ^a   Mottram, Jeremy C ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d MARINE BIOLOGICAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; CRYSTALLOGRAPHIC STUDIES; ENZYMATIC PROPERTIES; ENZYME ACTIVE SITES; ENZYME SUBSTRATES; HIGH RESOLUTION; INTER-DOMAIN; LEISHMANIA MAJOR; OLIGOPEPTIDES; POTENTIAL DRUG; SUBSTRATE BINDING; SUBSTRATE RECOGNITION; SUBSTRATE SPECIFICITY; THERAPEUTIC POTENTIALS; TRYPANOSOMATIDS; TWO DOMAINS; VIRULENCE FACTORS;

AMINO ACIDS; ENZYMES; HYDROGEN; HYDROGEN BONDS; SUBSTRATES;

CRYSTAL STRUCTURE;

ANTIPAIN; OLIGOPEPTIDASE B; SERINE PROTEINASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; LEISHMANIA MAJOR; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; KINETICS; LEISHMANIA MAJOR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; SWINE; TRYPANOSOMA; VIRULENCE FACTORS;

LEISHMANIA MAJOR; TRYPANOSOMATIDAE;

EID: 78649901973     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.156679     Document Type: Article

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