Binding, proteolytic, and crystallographic analyses of mutations at the protease - Inhibitor interface of the subtilisin BPN′/chymotrypsin inhibitor 2 complex

Biochemistry

Volumn 43, Issue 43, 2004, Pages 13648-13656

  Radisky, Evette S ^a   Kwan, Gene ^a,b   Lu, Chia Jung Karen ^a   Koshland Jr , Daniel E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOCHEMISTRY; CATALYSIS; CHEMICAL BONDS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HYDROLYSIS;

MUTATIONS; PROTEOLYTIC; SCISSILE BONDS; WATER MOLECULES;

ENZYME INHIBITION;

BPN PROTEIN; MUTANT PROTEIN; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; SUBTILISIN; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BINDING AFFINITY; CATALYSIS; CATALYST; CHEMICAL BOND; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; HYDROLYSIS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MUTATIONAL ANALYSIS; PHASE SEPARATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRUCTURE ANALYSIS; WATER ANALYSIS;

ACYLATION; BINDING SITES; CHYMOTRYPSIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; GLYCINE; HYDROLYSIS; LYSINE; METHIONINE; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; PLANT PROTEINS; PROTEIN BINDING; RECOMBINANT PROTEINS; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY; SUBTILISINS; SURFACE PROPERTIES;

EID: 7244239029     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048797k     Document Type: Article

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