QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation

Chemical Communications

Volumn , Issue 35, 2005, Pages 4399-4401

  Lodola, Alessio ^a   Mor, Marco ^a   Hermann, Johannes C ^b   Tarzia, Giorgio ^c   Piomelli, Daniele ^d   Mulholland, Adrian J ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF URBINO   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID AMIDASE; HYDROLASE INHIBITOR; OLEAMIDE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; DENSITY FUNCTIONAL THEORY; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME STRUCTURE; HYDROLYSIS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR MODEL; NONHUMAN; QUANTUM MECHANICS;

EID: 25444523794     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b503887a     Document Type: Article

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