Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid β-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): Engineering of inhibitors with altered specificities

Protein Science

Volumn 6, Issue 9, 1997, Pages 1806-1824

  Scheidig, Axel J ^a,b   Hynes, Thomas R ^a,c   Pelletier, Laura A ^a,d   Wells, James A ^a   Kossiakoff, Anthony A ^a  

^a GENENTECH INC   (United States)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c PFIZER INC   (United States)

^d AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

Kunitz inhibitors; Molecular recognition; Phage display; Protease inhibitor complexes

Indexed keywords

TRYPSIN; TRYPSIN INHIBITOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DISULFIDE BOND; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS;

ANIMALIA; BOVINAE;

EID: 0030794907     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560060902     Document Type: Article

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