Phosphodiester cleavage in ribonuclease H occurs via an associative two-metal-aided catalytic mechanism

Journal of the American Chemical Society

Volumn 130, Issue 33, 2008, Pages 10955-10962

  De Vivo, Marco ^a,c   Dal Peraro, Matteo ^b   Klein, Michael L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Chemical Engineering and Biochemistry Section   (Switzerland)

^c Rib X Pharmaceuticals Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOLOGY; CHEMOTHERAPY; CHLORINE COMPOUNDS; CLARIFICATION; CRYSTAL STRUCTURE; DNA; DRUG DELIVERY; DRUG DOSAGE; ELECTROLYSIS; ENZYMES; FOOD ADDITIVES; GENES; METAL IONS; METALS; NUCLEIC ACIDS; NUCLEOPHILES; ORGANIC ACIDS; QUANTUM CHEMISTRY; REUSABILITY; RNA; SPEED; TRACE ANALYSIS;

ACTIVE COMPLEXES; ANTI-HIV; BACILLUS HALODURANS; CATALYTIC MECHANISMS; CLASSICAL FORCE FIELDS; DNA TOPOLOGY; DRUG DESIGNS; HIGH-RESOLUTION CRYSTAL STRUCTURES; HYDROXIDE IONS; PHOSPHODIESTER; RNASE H; STRUCTURAL INFORMATIONS; TRANSFER REACTIONS; TRANSITION STATE;

IONS;

HYDROXIDE; MAGNESIUM; METAL ION; NUCLEOTIDYLTRANSFERASE; PHOSPHATE; PHOSPHODIESTERASE; PHOSPHOGLUCOMUTASE; PHOSPHORANE DERIVATIVE; RIBONUCLEASE H; WATER;

ARTICLE; CATALYSIS; CHEMICAL REACTION; MOLECULAR MECHANICS; PROTON TRANSPORT; QUANTUM MECHANICS; SOLVATION;

CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MAGNESIUM; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHORIC ACID ESTERS; QUANTUM THEORY; RIBONUCLEASE H; STEREOISOMERISM;

EID: 50249094329     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja8005786     Document Type: Article

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