Covalent inhibitors of fatty acid amide hydrolase: A rationale for the activity of piperidine and piperazine aryl ureas

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6612-6623

  Palermo, Giulia ^a   Branduardi, Davide ^a   Masetti, Matteo ^a,b   Lodola, Alessio ^c   Mor, Marco ^c   Piomelli, Daniele ^a,d   Cavalli, Andrea ^a,b   De Vivo, Marco ^a  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; FATTY ACID AMIDASE INHIBITOR; LEAD; PIPERAZINE ARYL UREA DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; COVALENT BOND; ENZYME INHIBITION; HYDROGEN BOND; HYDROLYSIS; INFLAMMATION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PAIN; QUANTUM MECHANICS;

AMIDOHYDROLASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MOLECULAR DYNAMICS SIMULATION; PIPERAZINES; PIPERIDINES; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; WATER;

EID: 80053926122     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2004283     Document Type: Article

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