Apatite-coated collagen sponge for the delivery of bone morphogenetic protein-2 in rabbit posterolateral lumbar fusion

Artificial Organs

Volumn 38, Issue 10, 2014, Pages 893-899

  Koo, Ki Hyoung ^a   Ahn, Jung Min ^a   Lee, Jong Min ^a   Kim, Byung Soo ^b   Kim, Chang Sung ^c   Im, Gun Il ^a  

^a Dongguk University Ilsan Hospital   (South Korea)

^b Seoul National University   (South Korea)

^c Yonsei University College of Dentistry   (South Korea)

Author keywords

Apatite coated collagen sponge; Bone morphogenetic protein 2; Delivery system; Spine fusion

Indexed keywords

BIOMECHANICS; BONE; COLLAGEN; COMPUTERIZED TOMOGRAPHY; TENSILE STRENGTH;

APATITE-COATED COLLAGEN SPONGE; BONE MORPHOGENETIC PROTEIN-2; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; COLLAGEN SPONGE; CONTROL GROUPS; DELIVERY SYSTEMS; LUMBAR FUSION; RADIOGRAPHIC STUDIES; SPINE FUSION;

APATITE;

COLLAGEN SPONGE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; APATITE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; LUMBAR SPINE; MALE; NEW ZEALAND WHITE (RABBIT); NONHUMAN; OUTCOME ASSESSMENT; POSTERIOR SPINE FUSION; ANIMAL; LUMBAR VERTEBRA; PROCEDURES; RABBIT; SPINE FUSION; SURGERY; SURGICAL SPONGE;

ORYCTOLAGUS CUNICULUS;

ANIMALS; APATITES; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; LUMBAR VERTEBRAE; MALE; MODELS, ANIMAL; RABBITS; SPINAL FUSION; SURGICAL SPONGES;

EID: 84916228233     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/aor.12249     Document Type: Article

References (18)

1. Mont MA, Ragland PS, Biggins B, etal. Use of bone morphogenetic proteins for musculoskeletal applications. An overview. J Bone Joint Surg Am 2004;86:41-55.
2. McKay B, Sandhu HS. Use of recombinant human bone morphogenetic protein-2 in spinal fusion applications. Spine 2002;27:S66-85.
3. Singh K, Smucker JD, Ugbo JL, etal. rhBMP-2 enhancement of posterolateral spinal fusion in a rabbit model in the presence of concurrently administered doxorubicin. Spine J 2007;7:326-1.
4. Vaccaro AR, Whang PG, Patel T, etal. The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study. Spine J 2008;8:457-465.
5. Carragee EJ, Hurwitz EL, Weiner BK. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J 2011;6:471-491.
6. La WG, Kang SW, Yang HS, etal. The efficacy of bone morphogenetic protein-2 depends on its mode of delivery. Artif Organs 2010;34:1150-1153.
7. Koo KH, Yeo DH, Lee JS, Kim BS, Kim CS, Im GI. Lumbar posterolateral fusion using heparin-conjugated fibrin for sustained delivery of BMP-2 in rabbit model. Artif Organs 2012;36:629-634.
8. Hsu WK, Wang JC. The use of bone morphogenetic protein in spine fusion. Spine 2008;8:419-425.
9. Pek YS, Gao S, Arshad MS, Leck KJ, Ying JY. Porous collagen-apatite nanocomposite foams as bone regeneration scaffolds. Biomaterials 2008;29:4300-4305.
10. Takahashi Y, Yamamoto M, Tabata Y. Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphate. Biomaterials 2005;26:4856-4865.
11. Chung YI, Ahn KM, Jeon SH, Lee SY, Lee JH, Tae G. Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex. J Control Release 2007;121:91-99.
12. Patel VV, Zhao L, Wong P, etal. Controlling bone morphogenetic protein diffusion and bone morphogenetic protein-stimulated bone growth using fibrin glue. Spine 2007;31:1201-1206.
13. Koo KH, Lee JM, Ahn JM, etal. Controlled delivery of low-dose bone morphogenetic protein-2 using heparin-conjugated fibrin in the posterolateral lumbar fusion of rabbits. Artif Organs 2013;37:487-494.
14. Yang HS, La WG, Park J, Kim CS, Im GI, Kim BS. Efficient bone regeneration induced by bone morphogenetic protein-2 released from apatite-coated collagen scaffolds. J Biomater Sci Polym Ed 2012;23:1659-1671.
15. Yang HS, La WG, Bhang SH, Lee TJ, Lee M, Kim BS. Apatite-coated collagen scaffold for bone morphogenetic protein-2 delivery. Tissue Eng Part A 2011;17:2153-2164.
16. Konishi S, Nakamura H, Seki M, Nagayama R, Yamano Y. Hydroxyapatite granule graft combined with recombinant human bone morphogenic protein-2 for solid lumbar fusion. J Spinal Disord Tech 2002;15:237-244.
17. Visser R, Arrabal PM, Becerra J, Rinas U, Cifuentes M. The effect of an rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo. Biomaterials 2009;30:2032-2037.
18. Dmitriev AE, Lehman RA Jr, Symes AJ. Bone morphogenetic protein-2 and spinal arthrodesis: the basic science perspective on protein interaction with the nervous system. Spine J 2011;11:500-505.