In vivo comparison of the effects of RHBMP-2 and RHBMP-4 in osteochondral tissue regeneration

European Cells and Materials

Volumn 20, Issue , 2010, Pages 367-378

  Lópiz Morales, Yaiza ^a   Abarrategi, Ander ^b,c   Ramos, Viviana ^c   Moreno Vicente, Carolina ^b   López Durán, Luis ^a   López Lacomba, José Luis ^b   Marco, Fernando ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c Noricum SL Departamento de I+D   (Spain)

Author keywords

Biomaterials; BMP signalling; Cartilage; In vivo; Tissue engineering

Indexed keywords

ALGINIC ACID; BMP4 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; DRUG CARRIER; GLUCURONIC ACID; HEXURONIC ACID; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; BIOSYNTHESIS; BONE REGENERATION; COMPARATIVE STUDY; DRUG EFFECT; FEMUR; GEL; HUMAN; MOUSE; PATHOLOGY; PROSTHESES AND ORTHOSES; RABBIT; TISSUE REGENERATION;

ALGINATES; ANIMALS; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; DRUG CARRIERS; FEMUR; GELS; GLUCURONIC ACID; GUIDED TISSUE REGENERATION; HEXURONIC ACIDS; HUMANS; MICE; PROSTHESES AND IMPLANTS; RABBITS; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 79953039987     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v020a30     Document Type: Article

References (48)

1. Abarrategi A., García-Cantalejo J, Moreno-Vicente C, Civantos A., Ramos V, Casado JVS, Pérez-Rial S, López-Lacomba J. L (2009) Gene expression profile on chitosan/ rhBMP-2 films: A novel osteoinductive coating for implantable materials. Acta Biomaterialia 5: 2633-2646.
2. Abarrategi A., Lópiz-Morales Y, Ramos V, Civantos A, López-Durán L, Marco F, López-Lacomba JL (2010) Chitosan scaffolds for osteochondral tissue regeneration. J Biomed Mater Res A 95: 1132-1141.
3. Buckwalter J. A, Mankin HJ (1998) Articular cartilage: Degeneration and osteoarthrosis, repair, regeneration, and transplantation. Instr Course Lect 47: 487-504.
4. Chawla K., Klein TJ, Schumacher BL, Jadin KD, Shah BH, Nakagawa K, Wong VW, Chen AC, Masuda K, Sah RL (2007) Short-term retention of labeled chondrocyte subpopulations in stratified tissue-engineered cartilaginous constructs implanted in vivo in mini-pigs. Tissue Eng.13: 1525-1537.
5. Coviello T., Matricardi P, Marianecci C, Alhaique F (2007) Polysaccharide hydrogels for modified release formulations. J Controlled Release 119: 5-24.
6. Diduch D. R, Jordan LC, Mierisch CM and Balian G. (2000) Marrow stromal cells embedded in alginate for repair of osteochondral defects. Arthroscopy 16: 571-577.
7. Erickson G. R, Gimble JM, Franklin DM, Rice HE, Awad H., Guilak F (2002) Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vitro. Biochem Biophys Res Commun 290: 763-769.
8. Fragonas E., Valente M, Pozzi-Mucelli M, Toffanin R, Rizzo R., Silvestri F, Vittur F (2000) Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate. Biomaterials 21: 795-801.
9. Gelse K., Von der Mark K, Aigner T, Park J, Schneider H (2003) Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum 48: 430-441.
10. Gombotz W. R, Wee SF (1998) Protein release from alginate matrices. Adv Drug Deliv Rev 31: 267-285.
11. Grande D. A, Halberstadt C, Naughton G, Schwartz R, Manji R. (1997) Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts. J Biomed Mater Res 34: 211-220.
12. Gründer T., Gaissmaier C, Fritz J, Stoop R, Hortschansky P., Mollenhauer J, Aicher WK (2004) Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. Osteoarthritis Cartilage 12: 559-567.
13. Hannouche D., Terai H, Fuchs JR, Terada S, Zand S, Nasseri B. A, Petite H, Sedel L, Vacanti JP (2007) Engineering of implantable cartilaginous structures from bone marrow-derived mesenchymal stem cells. Tissue Eng 13: 87-99.
14. Hyllested J., Veje K, Ostergaard J (2002) Histochemical studies of the extracellular matrix of human articular cartilage-a review. Osteoarthritis Cartilage 10: 333-343.
15. Kramer J., Hegert C, Guan K, Wobus AM, Muller PK, Rohwedel J. (2000) Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4. Mech Dev 92: 193-205.
16. Kuroda R., Usas A, Kubo S, Corsi K, Peng H, Rose T, Cummins J., Fu FH, Huard J (2006) Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum 54: 433-442.
17. Langer R., Vacanti JP (1993) Tissue engineering. Science 260: 920-926.
18. Lee K. Y, Peters MC, Mooney DJ (2003) Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice. J Controlled Release 87: 49-56.
19. Lee S. H, Shin H (2007) Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Adv Drug Deliv Rev 59: 339-359.
20. Liu W., Cui L, Cao Y (2003) A closer view of tissue engineering in China: the experience of tissue construction in immunocompetent animals. Tissue Eng.9: 17-30.
21. Luyten F. P, Chen P, Paralkar V, Reddi AH (1994) Recombinant bone morphogenetic protein-4, transforming growth factor-beta 1, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro. Exp Cell Res 210: 224-229.
22. Majumdar M. K, Wang E, Morris EA (2001) BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. J Cell Physiol 189: 275-284.
23. Malafaya P. B, Silva GA, Reis RL (2007) Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev 59: 207-233.
24. Marco F., Leon C, Lopez-Oliva F, Perez AJ, Sanchez-Barba A., Lopez-Duran Stern L (1992) Intact articular cartilage cryopreservation. In vivo evaluation. Clin Orthop Relat Res 283: 11-20.
25. Martin I., Suetterlin R, Baschong W, Heberer M, Vunjak-Novakovic G, Freed LE (2001) Enhanced cartilage tissue engineering by sequential exposure of chondrocytes to FGF-2 during 2D expansion and BMP-2 during 3D cultivation. J Cell Biochem 83: 121-128.
26. Melrose J., Chuang C, Whitelock J (2008) Tissue engineering of cartilages using biomatrices. J. Chem. Technol. Biotechnol 83: 444-463.
27. Mierisch C. M, Cohen SB, Jordan LC, Robertson PG, Balian G., Diduch DR (2002) Transforming growth factor-BBin calcium alginate beads for the treatment of articular cartilage defects in the rabbit. Arthroscopy 18: 892-900.
28. Mierisch C. M, Wilson HA, Turner MA, Milbrandt TA, Berthoux L., Hammarskjold ML, Rekosh D, Balian G, Diduch D. R (2003) Chondrocyte transplantation into articular cartilage defects with use of calcium alginate: the fate of the cells. J Bone Joint Surg Am 85-A: 1757-1767.
29. Miljkovic N. D, Cooper GM, Marra KG. (2008) Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells. Osteoarthritis Cartilage 16: 1121-1130.
30. Nesic D., Whiteside R, Brittberg M, Wendt D, Martin I, Mainil-Varlet P (2006) Cartilage tissue engineering for degenerative joint disease. Adv Drug Deliv Rev 58: 300-322. O'Driscoll SW, Marx RG, Beaton DE, Miura Y, Gallay
31. O'Driscoll SW, Marx RG, Beaton DE, Miura Y, Gallay SH, Fitzsimmons JS (2001) Validation of a simple histological-histochemical cartilage scoring system. Tissue Eng 7: 313-320.
32. Park D. J, Choi BH, Zhu SJ, Huh JY, Kim BY, Lee SH (2005) Injectable bone using chitosan-alginate gel/ mesenchymal stem cells/BMP-2 composites. J Craniomaxillofac Surg 33: 50-54.
33. Pelttari K., Steck E, Richter W (2008) The use of mesenchymal stem cells for chondrogenesis. Injury 39: 58-65.
34. Raghunath J., Salacinski HJ, Sales KM, Butler PE, Seifalian A. M (2005) Advancing cartilage tissue engineering: the application of stem cell technology. Curr Opin Biotechnol 16: 503-509.
35. Sekiya I., Larson BL, Vuoristo JT, Reger RL, Prockop DJ (2005) Comparison of effect of BMP-2,-4, and-6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell Tissue Res 320: 269-276.
36. Sellers R. S, Zhang R, Glasson SS, Kim HD, Peluso D, D'Augusta DA, Beckwith K, Morris EA (2000) Repair of articular cartilage defects one year after treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). J Bone Joint Surg Am 82: 151-160.
37. Shao X., Goh JC, Hutmacher DW, Lee EH, Zigang G (2006) Repair of large articular osteochondral defects using hybrid scaffolds and bone marrow-derived mesenchymal stem cells in a rabbit model. Tissue Eng.12: 1539-1551.
38. Sohier J., Moroni L, Van Blitterswijk C, de Groot K, Bezemer J. M (2008) Critical factors in the design of growth factor releasing scaffolds for cartilage tissue engineering. Expert Opin Drug Deliv 5: 543-566.
39. Steinert A., Weber M, Dimmler A, Julius C, Schutze N, Noth U., Cramer H, Eulert J, Zimmermann U, Hendrich C (2003) Chondrogenic differentiation of mesenchymal progenitor cells encapsulated in ultrahigh-viscosity alginate. J Orthop Res 21: 1090-1097.
40. Steinert A. F, Proffen B, Kunz M, Hendrich C, Ghivizzani S. C, Noth U, Rethwilm A, Eulert J, Evans CH (2009) Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Res Ther 11: R148.
41. Tokuhara Y., Wakitani S, Imai Y, Kawaguchi A, Fukunaga K., Kim M, Kadoya Y, Takaoka K. (2010) Repair of experimentally induced large osteochondral defects in rabbit knee with various concentrations of Escherichia coliderived recombinant human bone morphogenetic protein-2. Int Orthop 34: 761-767.
42. Tønnesen H. H, Karlsen J (2002) Alginate in drug delivery systems. Drug Dev Ind Pharm 28: 621-630.
43. Tsutsumi S., Shimazu A, Miyazaki K, Pan H, Koike C, Yoshida E., Takagishi K, Kato Y (2001) Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun 288: 413-419.
44. Valcourt U., Gouttenoire J, Moustakas A, Herbage D, Mallein-Gerin F (2002) Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes. J Biol Chem 277: 33545-33558.
45. Van den Berg WB, Van der Kraan PM, Scharstuhl A, Van Beuningen HM. (2001) Growth factors and cartilage repair. Clin. Orthop Relat Res 391 Suppl: S244-250. Van der Kraan PM, Buma P, Van Kuppevelt T, Van
46. Van der Kraan PM, Buma P, Van Kuppevelt T, Van den Berg WB (2002) Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering. Osteoarthritis Cartilage 10: 631-637.
47. Wang L., Shelton RM, Cooper PR, Lawson M, Triffitt JT, Barralet JE (2003) Evaluation of sodium alginate for bone marrow cell tissue engineering. Biomaterials 24: 3475-3481.
48. Weber M., Steinert A, Jork A, Dimmler A, Thürmer F, Schütze N., Hendrich C, Zimmermann U (2002) Formation of cartilage matrix proteins by BMP-transfected murine mesenchymal stem cells encapsulated in a novel class of alginates. Biomaterials 23: 2003-2013.