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Volumn 50, Issue 4, 2012, Pages 974-982

Gentamicin and bone morphogenic protein-2 (BMP-2)-delivering heparinized-titanium implant with enhanced antibacterial activity and osteointegration

Author keywords

Antibacterial activity; Bone morphogenic protein 2; Gentamicin; Osteointegration; Titanium

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; DOPAMINE; GENTAMICIN; HEPARIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; TITANIUM;

EID: 84862794152     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.01.007     Document Type: Article
Times cited : (156)

References (33)
  • 1
    • 0034448368 scopus 로고    scopus 로고
    • Unalloyed titanium for implants in bone surgery
    • Pohler O.E. Unalloyed titanium for implants in bone surgery. Injury 2000, 31(Suppl 4):7-13.
    • (2000) Injury , vol.31 , Issue.SUPPL 4 , pp. 7-13
    • Pohler, O.E.1
  • 2
    • 0032745323 scopus 로고    scopus 로고
    • Understanding and controlling the bone-implant interface
    • Puleo D.A., Nanci A. Understanding and controlling the bone-implant interface. Biomaterials 1999, 20(23-24):2311-2321.
    • (1999) Biomaterials , vol.20 , Issue.23-24 , pp. 2311-2321
    • Puleo, D.A.1    Nanci, A.2
  • 3
    • 33645096659 scopus 로고    scopus 로고
    • Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces
    • Rupp F., Scheideler L., Olshanska N., de Wild M., Wieland M., Geis-Gerstorfer J. Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J Biomed Mater Res A 2006, 76(2):323-334.
    • (2006) J Biomed Mater Res A , vol.76 , Issue.2 , pp. 323-334
    • Rupp, F.1    Scheideler, L.2    Olshanska, N.3    de Wild, M.4    Wieland, M.5    Geis-Gerstorfer, J.6
  • 4
    • 71649095367 scopus 로고    scopus 로고
    • In vitro characterization of bioactive titanium dioxide/hydroxyapatite surfaces functionalized with BMP-2
    • Piskounova S., Forsgren J., Brohede U., Engqvist H., Stromme M. In vitro characterization of bioactive titanium dioxide/hydroxyapatite surfaces functionalized with BMP-2. J Biomed Mater Res B Appl Biomater 2009, 91(2):780-787.
    • (2009) J Biomed Mater Res B Appl Biomater , vol.91 , Issue.2 , pp. 780-787
    • Piskounova, S.1    Forsgren, J.2    Brohede, U.3    Engqvist, H.4    Stromme, M.5
  • 5
    • 67049154230 scopus 로고    scopus 로고
    • Surface functionalization of titanium with carboxymethyl chitosan and immobilized bone morphogenetic protein-2 for enhanced osseointegration
    • Shi Z., Neoh K.G., Kang E.T., Poh C.K., Wang W. Surface functionalization of titanium with carboxymethyl chitosan and immobilized bone morphogenetic protein-2 for enhanced osseointegration. Biomacromolecules 2009, 10(6):1603-1611.
    • (2009) Biomacromolecules , vol.10 , Issue.6 , pp. 1603-1611
    • Shi, Z.1    Neoh, K.G.2    Kang, E.T.3    Poh, C.K.4    Wang, W.5
  • 6
    • 58149193193 scopus 로고    scopus 로고
    • Calcification by MC3T3-E1 cells on RGD peptide immobilized on titanium through electrodeposited PEG
    • Oya K., Tanaka Y., Saito H., Kurashima K., Nogi K., Tsutsumi H., et al. Calcification by MC3T3-E1 cells on RGD peptide immobilized on titanium through electrodeposited PEG. Biomaterials 2009, 30(7):1281-1286.
    • (2009) Biomaterials , vol.30 , Issue.7 , pp. 1281-1286
    • Oya, K.1    Tanaka, Y.2    Saito, H.3    Kurashima, K.4    Nogi, K.5    Tsutsumi, H.6
  • 7
    • 33846927508 scopus 로고    scopus 로고
    • Increased osteoblast adhesion on nanograined Ti modified with KRSR
    • Balasundaram G., Webster T.J. Increased osteoblast adhesion on nanograined Ti modified with KRSR. J Biomed Mater Res A 2007, 80(3):602-611.
    • (2007) J Biomed Mater Res A , vol.80 , Issue.3 , pp. 602-611
    • Balasundaram, G.1    Webster, T.J.2
  • 8
    • 70449127058 scopus 로고    scopus 로고
    • The effect of enamel matrix proteins on the spreading, proliferation and differentiation of osteoblasts cultured on titanium surfaces
    • Miron R.J., Oates C.J., Molenberg A., Dard M., Hamilton D.W. The effect of enamel matrix proteins on the spreading, proliferation and differentiation of osteoblasts cultured on titanium surfaces. Biomaterials 2010, 31(3):449-460.
    • (2010) Biomaterials , vol.31 , Issue.3 , pp. 449-460
    • Miron, R.J.1    Oates, C.J.2    Molenberg, A.3    Dard, M.4    Hamilton, D.W.5
  • 9
    • 0031202094 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects
    • King G.N., King N., Cruchley A.T., Wozney J.M., Hughes F.J. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 1997, 76(8):1460-1470.
    • (1997) J Dent Res , vol.76 , Issue.8 , pp. 1460-1470
    • King, G.N.1    King, N.2    Cruchley, A.T.3    Wozney, J.M.4    Hughes, F.J.5
  • 10
    • 0031148699 scopus 로고    scopus 로고
    • Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects
    • Zellin G., Linde A. Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects. J Biomed Mater Res 1997, 35(2):181-190.
    • (1997) J Biomed Mater Res , vol.35 , Issue.2 , pp. 181-190
    • Zellin, G.1    Linde, A.2
  • 11
    • 33846280901 scopus 로고    scopus 로고
    • Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells
    • Kim J., Kim I.S., Cho T.H., Lee K.B., Hwang S.J., Tae G., et al. Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials 2007, 28(10):1830-1837.
    • (2007) Biomaterials , vol.28 , Issue.10 , pp. 1830-1837
    • Kim, J.1    Kim, I.S.2    Cho, T.H.3    Lee, K.B.4    Hwang, S.J.5    Tae, G.6
  • 12
    • 65349187142 scopus 로고    scopus 로고
    • Titanium with surface-grafted dextran and immobilized bone morphogenetic protein-2 for inhibition of bacterial adhesion and enhancement of osteoblast functions
    • Shi Z., Neoh K.G., Kang E.T., Poh C., Wang W. Titanium with surface-grafted dextran and immobilized bone morphogenetic protein-2 for inhibition of bacterial adhesion and enhancement of osteoblast functions. Tissue Eng Part A 2009, 15(2):417-426.
    • (2009) Tissue Eng Part A , vol.15 , Issue.2 , pp. 417-426
    • Shi, Z.1    Neoh, K.G.2    Kang, E.T.3    Poh, C.4    Wang, W.5
  • 13
    • 38549153250 scopus 로고    scopus 로고
    • Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion
    • Chua P.H., Neoh K.G., Kang E.T., Wang W. Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion. Biomaterials 2008, 29(10):1412-1421.
    • (2008) Biomaterials , vol.29 , Issue.10 , pp. 1412-1421
    • Chua, P.H.1    Neoh, K.G.2    Kang, E.T.3    Wang, W.4
  • 14
    • 32244449372 scopus 로고    scopus 로고
    • Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment
    • Lee T.C., Ho J.T., Hung K.S., Chen W.F., Chung Y.H., Yang Y.L. Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment. Neurosurgery 2006, 58(2):373-380.
    • (2006) Neurosurgery , vol.58 , Issue.2 , pp. 373-380
    • Lee, T.C.1    Ho, J.T.2    Hung, K.S.3    Chen, W.F.4    Chung, Y.H.5    Yang, Y.L.6
  • 15
    • 0002891925 scopus 로고    scopus 로고
    • On the regulation of fibroblast growth factor activity by heparin-like glycosaminoglycans
    • Sasisekharan R., Ernst S., Venkataraman G. On the regulation of fibroblast growth factor activity by heparin-like glycosaminoglycans. Angiogenesis 1997, 1(1):45-54.
    • (1997) Angiogenesis , vol.1 , Issue.1 , pp. 45-54
    • Sasisekharan, R.1    Ernst, S.2    Venkataraman, G.3
  • 17
    • 55849126671 scopus 로고    scopus 로고
    • Triple constructs consisting of nanoparticles and microspheres for bone-marrow-derived stromal-cell-delivery microscaffolds
    • Park J.S., Park K., Woo D.G., Yang H.N., Chung H.M., Park K.H. Triple constructs consisting of nanoparticles and microspheres for bone-marrow-derived stromal-cell-delivery microscaffolds. Small 2008, 4(11):1950-1955.
    • (2008) Small , vol.4 , Issue.11 , pp. 1950-1955
    • Park, J.S.1    Park, K.2    Woo, D.G.3    Yang, H.N.4    Chung, H.M.5    Park, K.H.6
  • 18
    • 78449243961 scopus 로고    scopus 로고
    • The effect of immobilization of heparin and bone morphogenic protein-2 (BMP-2) to titanium surfaces on inflammation and osteoblast function
    • Kim S.E., Song S.H., Yun Y.P., Choi B.J., Kwon I.K., Bae M.S., et al. The effect of immobilization of heparin and bone morphogenic protein-2 (BMP-2) to titanium surfaces on inflammation and osteoblast function. Biomaterials 2011, 32(2):366-373.
    • (2011) Biomaterials , vol.32 , Issue.2 , pp. 366-373
    • Kim, S.E.1    Song, S.H.2    Yun, Y.P.3    Choi, B.J.4    Kwon, I.K.5    Bae, M.S.6
  • 19
    • 29244481479 scopus 로고    scopus 로고
    • The significance of infection related to orthopedic devices and issues of antibiotic resistance
    • Campoccia D., Montanaro L., Arciola C.R. The significance of infection related to orthopedic devices and issues of antibiotic resistance. Biomaterials 2006, 27(11):2331-2339.
    • (2006) Biomaterials , vol.27 , Issue.11 , pp. 2331-2339
    • Campoccia, D.1    Montanaro, L.2    Arciola, C.R.3
  • 20
    • 12344263658 scopus 로고    scopus 로고
    • Infections associated with medical devices: pathogenesis, management and prophylaxis
    • von Eiff C., Jansen B., Kohnen W., Becker K. Infections associated with medical devices: pathogenesis, management and prophylaxis. Drugs 2005, 65(2):179-214.
    • (2005) Drugs , vol.65 , Issue.2 , pp. 179-214
    • von Eiff, C.1    Jansen, B.2    Kohnen, W.3    Becker, K.4
  • 21
    • 0033591467 scopus 로고    scopus 로고
    • Bacterial biofilms: a common cause of persistent infections
    • Costerton J.W., Stewart P.S., Greenberg E.P. Bacterial biofilms: a common cause of persistent infections. Science 1999, 284(5418):1318-1322.
    • (1999) Science , vol.284 , Issue.5418 , pp. 1318-1322
    • Costerton, J.W.1    Stewart, P.S.2    Greenberg, E.P.3
  • 22
    • 50149085523 scopus 로고    scopus 로고
    • Bacterial adhesion and osteoblast function on titanium with surface-grafted chitosan and immobilized RGD peptide
    • Shi Z., Neoh K.G., Kang E.T., Poh C., Wang W. Bacterial adhesion and osteoblast function on titanium with surface-grafted chitosan and immobilized RGD peptide. J Biomed Mater Res A 2008, 86(4):865-872.
    • (2008) J Biomed Mater Res A , vol.86 , Issue.4 , pp. 865-872
    • Shi, Z.1    Neoh, K.G.2    Kang, E.T.3    Poh, C.4    Wang, W.5
  • 23
    • 33748364766 scopus 로고    scopus 로고
    • Single-molecule mechanics of mussel adhesion
    • Lee H., Scherer N.F., Messersmith P.B. Single-molecule mechanics of mussel adhesion. Proc Natl Acad Sci USA 2006, 103(35):12999-13003.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.35 , pp. 12999-13003
    • Lee, H.1    Scherer, N.F.2    Messersmith, P.B.3
  • 24
    • 27844566629 scopus 로고    scopus 로고
    • Biomimetic anchor for surface-initiated polymerization from metal substrates
    • Fan X., Lin L., Dalsin J.L., Messersmith P.B. Biomimetic anchor for surface-initiated polymerization from metal substrates. J Am Chem Soc 2005, 127(45):15843-15847.
    • (2005) J Am Chem Soc , vol.127 , Issue.45 , pp. 15843-15847
    • Fan, X.1    Lin, L.2    Dalsin, J.L.3    Messersmith, P.B.4
  • 25
    • 35348945857 scopus 로고    scopus 로고
    • Mussel-inspired surface chemistry for multifunctional coatings
    • Lee H., Dellatore S.M., Miller W.M., Messersmith P.B. Mussel-inspired surface chemistry for multifunctional coatings. Science 2007, 318(5849):426-430.
    • (2007) Science , vol.318 , Issue.5849 , pp. 426-430
    • Lee, H.1    Dellatore, S.M.2    Miller, W.M.3    Messersmith, P.B.4
  • 26
    • 0034769224 scopus 로고    scopus 로고
    • Implant infections: a haven for opportunistic bacteria
    • Schierholz J.M., Beuth J. Implant infections: a haven for opportunistic bacteria. J Hosp Infect 2001, 49(2):87-93.
    • (2001) J Hosp Infect , vol.49 , Issue.2 , pp. 87-93
    • Schierholz, J.M.1    Beuth, J.2
  • 27
    • 33748092022 scopus 로고    scopus 로고
    • Effects of biomaterial surface chemistry on the adhesion and biofilm formation of Staphylococcus epidermidis in vitro
    • MacKintosh E.E., Patel J.D., Marchant R.E., Anderson J.M. Effects of biomaterial surface chemistry on the adhesion and biofilm formation of Staphylococcus epidermidis in vitro. J Biomed Mater Res A 2006, 78(4):836-842.
    • (2006) J Biomed Mater Res A , vol.78 , Issue.4 , pp. 836-842
    • MacKintosh, E.E.1    Patel, J.D.2    Marchant, R.E.3    Anderson, J.M.4
  • 28
    • 0023277742 scopus 로고
    • Biomaterial-centered infection: microbial adhesion versus tissue integration
    • Gristina A.G. Biomaterial-centered infection: microbial adhesion versus tissue integration. Science 1987, 237(4822):1588-1595.
    • (1987) Science , vol.237 , Issue.4822 , pp. 1588-1595
    • Gristina, A.G.1
  • 29
    • 0026630145 scopus 로고
    • Isolation of monoclonal antibodies recognizing rat bone-associated molecules in vitro and in vivo
    • Turksen K., Bhargava U., Moe H.K., Aubin J.E. Isolation of monoclonal antibodies recognizing rat bone-associated molecules in vitro and in vivo. J Histochem Cytochem 1992, 40(9):1339-1352.
    • (1992) J Histochem Cytochem , vol.40 , Issue.9 , pp. 1339-1352
    • Turksen, K.1    Bhargava, U.2    Moe, H.K.3    Aubin, J.E.4
  • 31
    • 0036791972 scopus 로고    scopus 로고
    • Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner
    • Bancroft G.N., Sikavitsas V.I., van den Dolder J., Sheffield T.L., Ambrose C.G., Jansen J.A., et al. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc Natl Acad Sci USA 2002, 99(20):12600-12605.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.20 , pp. 12600-12605
    • Bancroft, G.N.1    Sikavitsas, V.I.2    van den Dolder, J.3    Sheffield, T.L.4    Ambrose, C.G.5    Jansen, J.A.6
  • 32
    • 0034218474 scopus 로고    scopus 로고
    • Perspectives on osteoblast and osteoclast function
    • Gay C.V., Gilman V.R., Sugiyama T. Perspectives on osteoblast and osteoclast function. Poult Sci 2000 Jul, 79(7):1005-1008.
    • (2000) Poult Sci , vol.79 , Issue.7 , pp. 1005-1008
    • Gay, C.V.1    Gilman, V.R.2    Sugiyama, T.3


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