Use of demineralized bone matrix in spinal fusion

World Journal of Orthopedics

Volumn 5, Issue 1, 2014, Pages 30-37

  Tilkeridis, Konstantinos ^a   Touzopoulos, Panagiotis ^b   Ververidis, Athanasios ^a   Christodoulou, Sotirios ^a   Kazakos, Konstantinos ^a   Drosos, Georgios I ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b General Hospital of Komotini   (Greece)

Author keywords

Bone grafts; Demineralized bone matrix; Scoliosis; Spinal fusion

Indexed keywords

EID: 84892956343     PISSN: None     EISSN: 22185836     Source Type: Journal    
DOI: 10.5312/wjo.v5.i1.30     Document Type: Short Survey

References (63)

1. Cowan JA, Dimick JB, Wainess R, Upchurch GR, Chandler WF, La Marca F. Changes in the utilization of spinal fusion in the United States. Neurosurgery 2006; 59: 15-20; discussion 15-20 [PMID: 16823295 DOI: 10.1227/01.NEU.0000219836.54861. CD].
2. Rajaee SS, Bae HW, Kanim LE, Delamarter RB. Spinal fusion in the United States: analysis of trends from 1998 to 2008. Spine (Phila Pa 1976) 2012; 37: 67-76 [PMID: 21311399].
3. Cammisa FP, Lowery G, Garfin SR, Geisler FH, Klara PM, McGuire RA, Sassard WR, Stubbs H, Block JE. Two-year fusion rate equivalency between Grafton DBM gel and autograft in posterolateral spine fusion: a prospective controlled trial employing a side-by-side comparison in the same patient. Spine (Phila Pa 1976) 2004; 29: 660-666 [PMID: 15014276].
4. Goldberg VM, Stevenson S. Natural history of autografts and allografts. Clin Orthop Relat Res 1987; (225): 7-16 [PMID: 3315383].
5. France JC, Yaszemski MJ, Lauerman WC, Cain JE, Glover JM, Lawson KJ, Coe JD, Topper SM. A randomized prospective study of posterolateral lumbar fusion. Outcomes with and without pedicle screw instrumentation. Spine (Phila Pa 1976) 1999; 24: 553-560 [PMID: 10101819].
6. Fischgrund JS, Mackay M, Herkowitz HN, Brower R, Montgomery DM, Kurz LT. 1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation. Spine (Phila Pa 1976) 1997; 22: 2807-2812 [PMID: 9431616].
7. Kimura I, Shingu H, Murata M, Hashiguchi H. Lumbar posterolateral fusion alone or with transpedicular instrumentation in L4-L5 degenerative spondylolisthesis. J Spinal Disord 2001; 14: 301-310 [PMID: 11481551 DOI: 10.1097/00002517-20 0108000-00004].
8. Finkemeier CG. Bone-grafting and bone-graft substitutes. J Bone Joint Surg Am 2002; 84-A: 454-464 [PMID: 11886919].
9. Kurz LT, Garfin SR, Booth RE. Harvesting autogenous iliac bone grafts. A review of complications and techniques. Spine (Phila Pa 1976) 1989; 14: 1324-1331 [PMID: 2617362].
10. Bagaria V. Bone morphogenic protein: current state of field and the road ahead. J Orthop 2005; 2: e3.
11. Biswas D, Bible JE, Whang PH, Miller CP, Jaw R, Miller S, Grauer JN. Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion. Am J Orthop (Belle Mead NJ) 2010; 39: 531-538 [PMID: 21623419].
12. Boden SD, Kang J, Sandhu H, Heller JG. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine (Phila Pa 1976) 2002; 27: 2662-2673 [PMID: 12461392].
13. Rihn JA, Kirkpatrick K, Albert TJ. Graft options in posterolateral and posterior interbody lumbar fusion. Spine (Phila Pa 1976) 2010; 35: 1629-1639 [PMID: 20628336 DOI: 10.1097/ BRS.0b013e3181d25803].
14. Vaccaro AR, Patel T, Fischgrund J, Anderson DG, Truumees E, Herkowitz HN, Phillips F, Hilibrand A, Albert TJ, Wetzel T, McCulloch JA. A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. Spine (Phila Pa 1976) 2004; 29: 1885-1892 [PMID: 15534410].
15. Boden SD, Martin GJ, Morone MA, Ugbo JL, Moskovitz PA. Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate. Spine (Phila Pa 1976) 1999; 24: 1179-1185 [PMID: 10382242].
16. Dimar JR, Glassman SD, Burkus KJ, Carreon LY. Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. Spine (Phila Pa 1976) 2006; 31: 2534-259; discussion 2540 [PMID: 17047540].
17. Dimar JR, Glassman SD, Burkus JK, Pryor PW, Hardacker JW, Carreon LY. Clinical and radiographic analysis of an optimized rhBMP-2 formulation as an autograft replacement in posterolateral lumbar spine arthrodesis. J Bone Joint Surg Am 2009; 91: 1377-1386 [PMID: 19487515 DOI: 10.2106/JBJS. H.00200].
18. Aspenberg P, Andolf E. Bone induction by fetal and adult human bone matrix in athymic rats. Acta Orthop Scand 1989; 60: 195-199 [PMID: 2728883 DOI: 10.3109/1745367890914925 3].
19. Heckman JD, Boyan BD, Aufdemorte TB, Abbott JT. The use of bone morphogenetic protein in the treatment of nonunion in a canine model. J Bone Joint Surg Am 1991; 73: 750-764 [PMID: 2045401].
20. Tiedeman JJ, Connolly JF, Strates BS, Lippiello L. Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix. An experimental study in dogs. Clin Orthop Relat Res 1991; 150: 294-302 [PMID: 2060222].
21. Urist MR. Bone: formation by autoinduction. Science 1965; 150: 893-899 [PMID: 5319761 DOI: 10.1126/science.150.3698.893].
22. Buring K, Urist MR. Effects of ionizing radiation on the bone induction principle in the matrix of bone implants. Clin Orthop Relat Res 1967; 55: 225-234 [PMID: 4230143].
23. Dubuc FL, Urist MR. The accessibility of the bone induction principle in surface-decalcified bone implants. Clin Orthop Relat Res 1967; 55: 217-223 [PMID: 4866853].
24. Urist MR, Silverman BF, Büring K, Dubuc FL, Rosenberg JM. The bone induction principle. Clin Orthop Relat Res 1967; 53: 243-283 [PMID: 4870495 DOI: 10.1097/00003086-19670700 0-00026].
25. Eriksson C. Surface energies and the bone induction principle. J Biomed Mater Res 1985; 19: 833-849 [PMID: 4077899 DOI: 10.1002/jbm.820190709].
26. Jones CB. Biological basis of fracture healing. J Orthop Trauma 2005; 19: S1-S3 [PMID: 16479215 DOI: 10.1097/00005131-2 00511101-00001].
27. Bae HW, Zhao L, Kanim LE, Wong P, Delamarter RB, Dawson EG. Intervariability and intravariability of bone morphogenetic proteins in commercially available demineralized bone matrix products. Spine (Phila Pa 1976) 2006; 31: 1299-306; discussion 1307-1308 [PMID: 16721289].
28. Han B, Tang B, Nimni ME. Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix. J Orthop Res 2003; 21: 648-654 [PMID: 12798064 DOI: 10.1016/S0736-0266(03)00005-6].
29. Oakes DA, Lee CC, Lieberman JR. An evaluation of human demineralized bone matrices in a rat femoral defect model. Clin Orthop Relat Res 2003; (413): 281-290 [PMID: 12897620 DOI: 10.1097/01.blo.0000073347.50837.16].
30. Takikawa S, Bauer TW, Kambic H, Togawa D. Comparative evaluation of the osteoinductivity of two formulations of human demineralized bone matrix. J Biomed Mater Res A 2003; 65: 37-42 [PMID: 12635152 DOI: 10.1002/jbm.a.10345].
31. Peterson B, Whang PG, Iglesias R, Wang JC, Lieberman JR. Osteoinductivity of commercially available demineralized bone matrix. Preparations in a spine fusion model. J Bone Joint Surg Am 2004; 86-A: 2243-2250 [PMID: 15466734].
32. Lee YP, Jo M, Luna M, Chien B, Lieberman JR, Wang JC. The efficacy of different commercially available demineralized bone matrix substances in an athymic rat model. J Spinal Disord Tech 2005; 18: 439-444 [PMID: 16189457 DOI: 10.1097/01. bsd.0000175696.66049.f7].
33. Wildemann B, Kadow-Romacker A, Haas NP, Schmidmaier G. Quantification of various growth factors in different demineralized bone matrix preparations. J Biomed Mater Res A 2007; 81: 437-442 [PMID: 17117475 DOI: 10.1002/jbm.a.31085].
34. Tuli SM, Singh AD. The osteoninductive property of decalcified bone matrix. An experimental study. J Bone Joint Surg Br 1978; 60: 116-123 [PMID: 342532].
35. Bos GD, Goldberg VM, Zika JM, Heiple KG, Powell AE. Immune responses of rats to frozen bone allografts. J Bone Joint Surg Am 1983; 65: 239-246 [PMID: 6337163].
36. Friedlaender GE. Immune responses to osteochondral allografts. Current knowledge and future directions. Clin Orthop Relat Res 1983; (174): 58-68 [PMID: 6339143].
37. Horowitz MC, Friedlaender GE. Immunologic aspects of bone transplantation. A rationale for future studies. Orthop Clin North Am 1987; 18: 227-233 [PMID: 2951639].
38. Friedlaender GE, Horowitz MC. Immune responses to osteochondral allografts: nature and significance. Orthopedics 1992; 15: 1171-1175 [PMID: 1409127].
39. Wright JG, Einhorn TA, Heckman JD. Grades of recommendation. J Bone Joint Surg Am 2005; 87: 1909-1910 [PMID: 16140803 DOI: 10.2106/JBJS.8709.edit].
40. OCEBM Levels of Evidence Working Group. "The Oxford 2011 Levels of Evidence". Oxford Centre for Evidence-Based Medicine. Available from: URL: http: //www.cebm.net/index. aspx?o=5653.
41. Bolander ME, Balian G. The use of demineralized bone matrix in the repair of segmental defects. Augmentation with extracted matrix proteins and a comparison with autologous grafts. J Bone Joint Surg Am 1986; 68: 1264-1274 [PMID: 3533947].
42. El Deeb M, Hosny M, Sharawy M. Osteogenesis in composite grafts of allogenic demineralized bone powder and porous hydroxylapatite. J Oral Maxillofac Surg 1989; 47: 50-56 [PMID: 2536085 DOI: 10.1016/0278-2391(89)90124-9].
43. Einhorn TA, Lane JM, Burstein AH, Kopman CR, Vigorita VJ. The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study. J Bone Joint Surg Am 1984; 66: 274-279 [PMID: 6693455].
44. Gebhart M, Lane J. A radiographical and biomechanical study of demineralized bone matrix implanted into a bone defect of rat femurs with and without bone marrow. Acta Orthop Belg 1991; 57: 130-143 [PMID: 1872156].
45. Milinković ZB, Krneta O, Milicković S, Dozić D, Curcić A. Are the additional grafts necessary? Acta Chir Iugosl 2010; 57: 69-72 [PMID: 20681203 DOI: 10.2298/ACI1001069M].
46. Wang JC, Kanim LE, Nagakawa IS, Yamane BH, Vinters HV, Dawson EG. Dose-dependent toxicity of a commercially available demineralized bone matrix material. Spine (Phila Pa 1976) 2001; 26: 1429-1435; discussion 1435-1436 [PMID: 11458146].
47. Aspenberg P, Johnsson E, Thorngren KG. Dose-dependent reduction of bone inductive properties by ethylene oxide. J Bone Joint Surg Br 1990; 72: 1036-1037 [PMID: 2123200].
48. An HS, Simpson JM, Glover JM, Stephany J. Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion. A prospective multicenter study. Spine (Phila Pa 1976) 1995; 20: 2211-2216 [PMID: 8545714].
49. Vaidya R, Carp J, Sethi A, Bartol S, Craig J, Les CM. Complications of anterior cervical discectomy and fusion using recombinant human bone morphogenetic protein-2. Eur Spine J 2007; 16: 1257-1265 [PMID: 17387522 DOI: 10.1007/ s00586-007-0351-9].
50. Topuz K, Colak A, Kaya S, Simşek H, Kutlay M, Demircan MN, Velioǧlu M. Two-level contiguous cervical disc disease treated with peek cages packed with demineralized bone matrix: results of 3-year follow-up. Eur Spine J 2009; 18: 238-243 [PMID: 19130094 DOI: 10.1007/s00586-008-0869-5].
51. Moon HJ, Kim JH, Kim JH, Kwon TH, Chung HS, Park YK. The effects of anterior cervical discectomy and fusion with stand-alone cages at two contiguous levels on cervical alignment and outcomes. Acta Neurochir (Wien) 2011; 153: 559-565 [PMID: 21132445 DOI: 10.1007/s00701-010-0879-z].
52. Park HW, Lee JK, Moon SJ, Seo SK, Lee JH, Kim SH. The efficacy of the synthetic interbody cage and Grafton for anterior cervical fusion. Spine (Phila Pa 1976) 2009; 34: E591-E595 [PMID: 19644317 DOI: 10.1097/BRS.0b013e3181ab8b9a].
53. Demircan MN, Kutlay AM, Colak A, Kaya S, Tekin T, Kibici K, Ungoren K. Multilevel cervical fusion without plates, screws or autogenous iliac crest bone graft. J Clin Neurosci 2007; 14: 723-728 [PMID: 17543528 DOI: 10.1016/ j.jocn.2006.02.026].
54. Kang J, An H, Hilibrand A, Yoon ST, Kavanagh E, Boden S. Grafton and local bone have comparable outcomes to iliac crest bone in instrumented single-level lumbar fusions. Spine (Phila Pa 1976) 2012; 37: 1083-1091 [PMID: 22076647].
55. Vaccaro AR, Stubbs HA, Block JE. Demineralized bone matrix composite grafting for posterolateral spinal fusion. Orthopedics 2007; 30: 567-570 [PMID: 17672157].
56. Sassard WR, Eidman DK, Gray PM, Block JE, Russo R, Russell JL, Taboada EM. Augmenting local bone with Grafton demineralized bone matrix for posterolateral lumbar spine fusion: avoiding second site autologous bone harvest. Orthopedics 2000; 23: 1059-1064; discussion 1064-1065 [PMID: 11045552].
57. Schizas C, Triantafyllopoulos D, Kosmopoulos V, Tzinieris N, Stafylas K. Posterolateral lumbar spine fusion using a novel demineralized bone matrix: a controlled case pilot study. Arch Orthop Trauma Surg 2008; 128: 621-625 [PMID:17978826 DOI: 10.1007/s00402-007-0495-4].
58. Epstein NE, Epstein JA. SF-36 outcomes and fusion rates after multilevel laminectomies and 1 and 2-level instrumented posterolateral fusions using lamina autograft and demineralized bone matrix. J Spinal Disord Tech 2007; 20: 139-145 [PMID: 17414983 DOI: 10.1097/01.bsd.0000211261.36120.3e].
59. Epstein NE. Fusion rates and SF-36 outcomes after multilevel laminectomy and noninstrumented lumbar fusions in a predominantly geriatric population. J Spinal Disord Tech 2008; 21: 159-164 [PMID: 18458584 DOI: 10.1097/BSD.0b013e318074ddaa].
60. Girardi FP, Cammisa FP. The effect of bone graft extenders to enhance the performance of iliac crest bone grafts in instrumented lumbar spine fusion. Orthopedics 2003; 26: s545-s548 [PMID: 12755222].
61. Thalgott JS, Giuffre JM, Klezl Z, Timlin M. Anterior lumbar interbody fusion with titanium mesh cages, coralline hydroxyapatite, and demineralized bone matrix as part of a circumferential fusion. Spine J 2002; 2: 63-69 [PMID: 14588290 DOI: 10.1016/S1529-9430(01)00155-3].
62. Thalgott JS, Giuffre JM, Fritts K, Timlin M, Klezl Z. Instrumented posterolateral lumbar fusion using coralline hydroxyapatite with or without demineralized bone matrix, as an adjunct to autologous bone. Spine J 2001; 1: 131-137 [PMID:14588393 DOI: 10.1016/S1529-9430(01)00011-0].
63. Weinzapfel B, Son-Hing JP, Armstrong DG, Blakemore LC, Poe-Kochert C, Thompson GH. Fusion rates after thoracoscopic release and bone graft substitutes in idiopathic scoliosis. Spine (Phila Pa 1976) 2008; 33: 1079-1083 [PMID: 18449041].