Porous beta tricalcium phosphate scaffolds used as a BMP-2 delivery system for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 92, Issue 3, 2010, Pages 1105-1114

  Sohier, Jérôme ^a   Daculsi, Guy ^a   Sourice, Sophie ^a   De Groot, Klaas ^b   Layrolle, Pierre ^a  

^a Universite de Nantes   (France)

^b UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Bone morphogenetic protein 2; Ceramic; Osteogenesis; Tricalcium phosphate

Indexed keywords

BACK MUSCLES; BETA TRICALCIUM PHOSPHATE; BONE DEFECT; BONE FORMATION; BONE MORPHOGENETIC PROTEIN-2; BONE REGENERATION; BONE TISSUE ENGINEERING; CHEMICAL ETCHING; DELIVERY SYSTEMS; HISTOLOGICAL OBSERVATIONS; HISTOMORPHOMETRY; INTERCONNECTED POROSITY; MACROPOROUS; MICROPOROUS; OSTEOGENESIS; PROTEIN LOADINGS; STATISTICAL DIFFERENCES; TRI-CALCIUM PHOSPHATES;

BONE; CERAMIC MATERIALS; DEFECTS; ETCHING; PROTEINS; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; TRANSMISSION CONTROL PROTOCOL; X RAY DIFFRACTION ANALYSIS;

SCAFFOLDS;

BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATE;

ANIMAL EXPERIMENT; ARTICLE; BONE TISSUE; CONTROLLED STUDY; DIAPHYSIS; FEMALE; HISTOLOGY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MORPHOMETRICS; NONHUMAN; RABBIT; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; TRABECULAR BONE; X RAY DIFFRACTION;

ANIMALS; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATES; FEMALE; RABBITS; SPECTROPHOTOMETRY, INFRARED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE ENGINEERING; X-RAY DIFFRACTION;

EID: 75749135292     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32467     Document Type: Article

References (57)

1. Hak DJ. The use of osteoconductive bone graft substitutes in orthopaedic trauma. J Am Acad Orthop Surg 2007;15:525-536.
2. Damron TA. Use of 3D beta-tricalcium phosphate (Vitoss) scaffolds in repairing bone defects. Nanomed 2007;2:763-775.
3. Bohner M. Physical and chemical aspects of calcium phosphates used in spinal surgery. Eur Spine J 2001;10(Suppl 2):S114-S121.
4. Passuti N, Daculsi G, Rogez JM, Martin S, Bainvel JV. Macroporous calcium phosphate ceramic performance in human spine fusion. Clin Orthop Relat Res 1989;248:169-176.
5. Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop Relat Res 1981;157:259-278.
6. de Groot K. Hydroxylapatite coated implants. J Biomed Mater Res 1989;23:1367-1371.
7. Daculsi G, LeGeros RZ, Mitre D. Crystal dissolution of biological and ceramic apatites. Calcif Tissue Int 1989;45:95-103.
8. Daculsi G, LeGeros RZ, Heughebaert M, Barbieux I. Formation of carbonate-apatite crystals after implantation of calcium phosphate ceramics. Calcif Tissue Int 1990;46:20-27.
9. Barrere F, van Blitterswijk CA, de Groot K. Bone regeneration: Molecular and cellular interactions with calcium phosphate ceramics. Int J Nanomed 2006;1:317-332.
10. G.Daculsi Rzlenklbk. Transformation of biphasic calcium phosphate ceramics in vivo: Ultrastructural and physicochemical characterization. J Biomed Mater Res 1989;23:883-894.
11. Ripamonti U. Osteoinduction in porous hydroxyapatite implanted in heterotopic sites of different animal models. Biomaterials 1996;17:31-35.
12. Yang Z, Yuan H, Tong W, Zou P, Chen W, Zhang X. Osteogenesis in extraskeletally implanted porous calcium phosphate ceramics: Variability among different kinds of animals. Biomaterials 1996;17:2131-2137.
13. Yuan H, Zou P, Yang Z, Zhang X, De Bruijn JD, De Groot K. Bone morphogenetic protein and ceramic-induced osteogenesis. J Mater Sci Mater Med 1998;9:717-721.
14. Yuan H, Yang Z, de Bruijn JD, de Groot K, Zhang X. Materialdependent bone induction by calcium phosphate ceramics: A 2.5-year study in dog. Biomaterials 2001;22:2617-2623.
15. Klein C, de Groot K, Chen W, Li Y, Zhang X. Osseous substance formation induced in porous calcium phosphate ceramics in soft tissues. Biomaterials 1994;15:31-34.
16. Yuan H, Van Den Doel M, Li S, Van Blitterswijk CA, De Groot K, De Bruijn JD. A comparison of the osteoinductive potential of two calcium phosphate ceramics implanted intramuscularly in goats. J Mater Sci Mater Med 2002;13:1271-1275.
17. Habibovic P, Yuan H, van der Valk CM, Meijer G, van Blitterswijk CA, de Groot K. 3D microenvironment as essential element for osteoinduction by biomaterials. Biomaterials 2005;26:3565-3575.
18. Ripamonti U. Bone induction in nonhuman primates. An experimental study on the baboon. Clin Orthop Relat Res 1991; 269:284-294.
19. Ripamonti U. Osteoinduction in porous hydroxyapatite implanted in heterotopic sites of different animal models. Biomaterials 1996;17:31-35.
20. Le Nihouannen D, Daculsi G, Saffarzadeh A, Gauthier O, Delplace S, Pilet P, Layrolle P. Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles. Bone 2005;36:1086-1093.
21. De Groot J. Carriers that concentrate native bone morphogenetic protein in vivo. Tissue Eng 1998;4:337-341.
22. Seeherman HJ, Azari K, Bidic S, Rogers L, Li XJ, Hollinger JO, Wozney JM. rhBMP-2 delivered in a calcium phosphate cement accelerates bridging of critical-sized defects in rabbit radii. J Bone Joint Surg Am 2006;88:1553-1565.
23. Miranda DA, Blumenthal NM, Sorensen RG, Wozney JM, Wikesjo UM. Evaluation of recombinant human bone morphogenetic protein-2 on the repair of alveolar ridge defects in baboons. J Periodontol 2005;76:210-220.
24. Seeherman HJ, Bouxsein M, Kim H, Li R, Li XJ, Aiolova M, Wozney JM. Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model. J Bone Joint Surg Am A 2004;86:1961-1972.
25. Laffargue P, Hildebrand HF, Rtaimate M, Frayssinet P, Amoureux JP, Marchandise X. Evaluation of human recombinant bone morphogenetic protein-2-loaded tricalcium phosphate implants in rabbits' bone defects. Bone 1999;25(2 Suppl):55S-58S.
26. Yuan H, De Bruijn JD, Zhang X, Van Blitterswijk CA, De Groot K. Use of an osteoinductive biomaterial as a bone morphogenetic protein carrier. J Mater Sci Mater Med 2001;12:761-766.
27. Sampath TK, Reddi AH. Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc Natl Acad Sci USA 1981;78:7599-7603.
28. Urist MR, Strates BS. Bone morphogenetic protein. J Dent Res 1971;50:1392-1406.
29. Liu Y, Hunziker EB, Valk CVD, Groot KD. Biomimetic coatings vs. collagen sponges as a carrier for BMP-2: A comparison of the osteogenic responses triggered in vivo using an ectopic rat model. Bioceramics 2003;16:619-622.
30. Otsuru S, Tamai K, Yamazaki T, Yoshikawa H, Kaneda Y. Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathway. Stem Cells 2008;26:223-234.
31. Wang EA, Rosen V, D'Alessandro JS, Bauduy M, Cordes P, Harada T, Israel DI, Hewick RM, Kerns KM, LaPan P. Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA 1990;87:2220-2224.
32. Geiger M, Li RH, Friess W. Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev 2003;55:1613-1629.
33. Cook SD. Preclinical and clinical evaluation of osteogenic protein-1 (BMP-7) in bony sites. Orthopedics 1999;22:669-671.
34. Ripamonti U. Soluble osteogenic molecular signals and the induction of bone formation. Biomaterials 2006;27:807-822.
35. Ripamonti U, Ma SS, van den Heever B, Reddi AH. Osteogenin, a bone morphogenetic protein, adsorbed on porous hydroxyapatite substrata, induces rapid bone differentiation in calvarial defects of adult primates. Plast Reconstr Surg 1992;90:382-393.
36. Li S, de Wijn JR, Li J, Layrolle P, de Groot K. Macroporous biphasic calcium phosphate scaffold with high permeability/porosity ratio. Tissue Eng 2003;9:535-548.
37. Li SH, De Wijn JR, Layrolle P, de Groot K. Synthesis of macroporous hydroxyapatite scaffolds for bone tissue engineering. J Biomed Mater Res 2002;61:109-120.
38. Hollinger JO, Leong K. Poly(alpha-hydroxy acids): Carriers for bone morphogenetic proteins. Biomaterials 1996;17:187-194.
39. Kirker-Head CA. Potential applications and delivery strategies for bone morphogenetic proteins. Adv Drug Deliv Rev 2000;43:65-92.
40. Winn SR, Uludag H, Hollinger JO. Sustained release emphasizing recombinant human bone morphogenetic protein-2. Adv Drug Deliv Rev 1998;31:303-318.
41. Yamamoto M, Takahashi Y, Tabata Y. Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials 2003;24:4375-4383.
42. Urist MR, Lietze A, Dawson E. Beta-tricalcium phosphate delivery system for bone morphogenetic protein. Clin Orthop Relat Res 1984:277-280.
43. Maeda H, Sano A, Fujioka K. Controlled release of rhBMP-2 from collagen minipellet and the relationship between release profile and ectopic bone formation. Int J Pharm 2004;275(1/2):109-122.
44. Uludag H, D'Augusta D, Golden J, Li J, Timony G, Riedel R, Wozney JM. Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: A correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model. J Biomed Mater Res 2000;50:227-238.
45. Miyamoto S, Takaoka K, Okada T, Yoshikawa H, Hashimoto J, Suzuki S, Ono K. Evaluation of polylactic acid homopolymers as carriers for bone morphogenetic protein. Clin Orthop Relat Res 1992;278:274-285.
46. Lee DD, To.ghi A, Aiolova M, Chakravarthy P, Catalano A, Majahad A, Knaack D. Alpha-BSM: A biomimetic bone substitute and drug delivery vehicle. Clin Orthop Relat Res 1999;367 Suppl:S396-S405.
47. Mickiewicz RA, Mayes AM, Knaack D. Polymer - calcium phosphate cement composites for bone substitutes. J Biomed Mater Res 2002;61:581-592.
48. Alam MI, Asahina I, Ohmamiuda K, Takahashi K, Yokota S, Enomoto S. Evaluation of ceramics composed of different hydroxyapatite to tricalcium phosphate ratios as carriers for rhBMP-2. Biomaterials 2001;22:1643-1651.
49. Long HQ, Li FB, Wang YJ, Liao WM, Wang HX. Osteogenic potential of three kinds of calcium phosphate ceramics as carriers for recombinant human morphogenetic protein-2 in vivo. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2003;17:180-184.
50. Oda S, Kinoshita A, Higuchi T, Shizuya T, Ishikawa I. Ectopic bone formation by biphasic calcium phosphate (BCP) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2). J Med Dent Sci 1997;44:53-62.
51. Liu Y, de Groot K, Hunziker EB. BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model. Bone 2005;36:745-757.
52. Liu Y, Hunziker EB, Layrolle P, De Bruijn JD, De Groot K. Bone morphogenetic protein 2 incorporated into biomimetic coatings retains its biological activity. Tissue Eng 2004;10(1/2):101-108.
53. Le Guehennec L, Goyenvalle E, Aguado E, Houchmand-Cuny M, Enkel B, Pilet P, Daculsi G, Layrolle P. Small-animal models for testing macroporous ceramic bone substitutes. J Biomed Mater Res B Appl Biomater 2005;72:69-78.
54. Lu JX, Gallur A, Flautre B, Anselme K, Descamps M, Thierry B, Hardouin P. Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits. J Biomed Mater Res 1998;42:357-367.
55. Schmitz JP, Hollinger JO. The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin Orthop Relat Res 1986;205:299-308.
56. Gautschi OP, Frey SP, Zellweger R. Bone morphogenetic proteins in clinical applications. ANZ J Surg 2007;77:626-631.
57. Garrison KR, Donell S, Ryder J, Shemilt I, Mugford M, Harvey I, Song F. Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: A systematic review. Health Technol Assess 2007;11:1-150, iii-iv.