Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation

Acta Biomaterialia

Volumn 8, Issue 5, 2012, Pages 1768-1777

  Kim, Sungwoo ^a   Kang, Yunqing ^a   Krueger, Chad A ^b   Sen, Milan ^c   Holcomb, John B ^d   Chen, Di ^e   Wenke, Joseph C ^b   Yang, Yunzhi ^a  

^a STANFORD UNIVERSITY   (United States)

^b US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

BMP 2; Chitosan; Gelatin microspheres; Glyoxal; IGF 1

Indexed keywords

BONE; MICROSPHERES; PHOSPHATASES; POLYELECTROLYTES;

BONE MORPHOGENETIC PROTEIN-2; CHITOSAN GEL; DELIVERY SYSTEMS; GELATIN MICROSPHERES; GLYOXAL; INSULIN-LIKE GROWTH FACTOR-1; OSTEOBLAST DIFFERENTIATION; OSTEOBLASTIC DIFFERENTIATION; RELEASE KINETICS; SEQUENTIAL DELIVERY;

CHITOSAN;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CHITOSAN; GELATIN; GLYOXAL; MICROSPHERE; POLYELECTROLYTE; RECOMBINANT SOMATOMEDIN C; SCHIFF BASE; WATER OIL CREAM;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL STRUCTURE; COMPLEX FORMATION; CROSS LINKING; CYTOTOXICITY; DISSOLUTION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG RELEASE; ENCAPSULATION; ENZYME ACTIVITY; GEL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN STABILITY; SCANNING ELECTRON MICROSCOPY; STROMA CELL; SUSTAINED DRUG RELEASE; TEMPERATURE; THERMOSTABILITY; WETTABILITY;

EID: 84862782801     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.01.009     Document Type: Article

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