메뉴 건너뛰기




Volumn 46, Issue 2, 2010, Pages 504-513

Relaxin stimulates osteoclast differentiation and activation

Author keywords

Osteoclast; Osteoclastogenesis; RANK; Relaxin; RXFP1

Indexed keywords

COLONY STIMULATING FACTOR 1; F ACTIN; HORMONE RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; PROTEIN RXFP1; RELAXIN; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

EID: 74249106143     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.10.007     Document Type: Article
Times cited : (49)

References (33)
  • 1
    • 33748091739 scopus 로고    scopus 로고
    • Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics
    • Dschietzig T., Bartsch C., Baumann G., and Stangl K. Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics. Pharmacol. Ther. 112 (2006) 38-56
    • (2006) Pharmacol. Ther. , vol.112 , pp. 38-56
    • Dschietzig, T.1    Bartsch, C.2    Baumann, G.3    Stangl, K.4
  • 2
    • 38749122842 scopus 로고    scopus 로고
    • The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease
    • Samuel C.S., Lekgabe E.D., and Mookerjee I. The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease. Adv. Exp. Med. Biol. 612 (2007) 88-103
    • (2007) Adv. Exp. Med. Biol. , vol.612 , pp. 88-103
    • Samuel, C.S.1    Lekgabe, E.D.2    Mookerjee, I.3
  • 3
    • 24644449612 scopus 로고    scopus 로고
    • Novel drug development opportunity for relaxin in acute myocardial infarction: evidences from a swine model
    • Perna A.M., Masini E., Nistri S., Briganti V., Chiappini L., Stefano P., et al. Novel drug development opportunity for relaxin in acute myocardial infarction: evidences from a swine model. FASEB J. 19 (2005) 1525-1527
    • (2005) FASEB J. , vol.19 , pp. 1525-1527
    • Perna, A.M.1    Masini, E.2    Nistri, S.3    Briganti, V.4    Chiappini, L.5    Stefano, P.6
  • 4
    • 34247639085 scopus 로고    scopus 로고
    • Relaxin as a cardiovascular hormone: physiology, pathophysiology and therapeutic promises
    • Nistri S., Bigazzi M., and Bani D. Relaxin as a cardiovascular hormone: physiology, pathophysiology and therapeutic promises. Cardiovasc. Hematol. Agents Med. Chem. 5 (2007) 101-108
    • (2007) Cardiovasc. Hematol. Agents Med. Chem. , vol.5 , pp. 101-108
    • Nistri, S.1    Bigazzi, M.2    Bani, D.3
  • 6
    • 39149091073 scopus 로고    scopus 로고
    • Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction
    • Nistri S., Cinci L., Perna A.M., Masini E., Mastroianni R., and Bani D. Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction. Pharmacol. Res. 57 (2008) 43-48
    • (2008) Pharmacol. Res. , vol.57 , pp. 43-48
    • Nistri, S.1    Cinci, L.2    Perna, A.M.3    Masini, E.4    Mastroianni, R.5    Bani, D.6
  • 7
    • 38749100594 scopus 로고    scopus 로고
    • Relaxin-like ligand-receptor systems are autocrine/paracrine effectors in tumor cells and modulate cancer progression and tissue invasiveness
    • Klonisch T., Bialek J., Radestock Y., Hoang-Vu C., and Hombach-Klonisch S. Relaxin-like ligand-receptor systems are autocrine/paracrine effectors in tumor cells and modulate cancer progression and tissue invasiveness. Adv. Exp. Med. Biol. 612 (2007) 104-118
    • (2007) Adv. Exp. Med. Biol. , vol.612 , pp. 104-118
    • Klonisch, T.1    Bialek, J.2    Radestock, Y.3    Hoang-Vu, C.4    Hombach-Klonisch, S.5
  • 10
    • 0034548350 scopus 로고    scopus 로고
    • Relaxin-like factor (RLF) is differentially expressed in the normal and neoplastic human mammary gland
    • Hombach-Klonisch S., Buchmann J., Sarun S., Fischer B., and Klonisch T. Relaxin-like factor (RLF) is differentially expressed in the normal and neoplastic human mammary gland. Cancer 89 (2000) 2161-2168
    • (2000) Cancer , vol.89 , pp. 2161-2168
    • Hombach-Klonisch, S.1    Buchmann, J.2    Sarun, S.3    Fischer, B.4    Klonisch, T.5
  • 11
    • 4544357518 scopus 로고    scopus 로고
    • Elevated concentrations of serum relaxin are associated with metastatic disease in breast cancer patients
    • Binder C., Simon A., Binder L., Hagemann T., Schulz M., Emons G., et al. Elevated concentrations of serum relaxin are associated with metastatic disease in breast cancer patients. Breast Cancer Res. Treat. 87 (2004) 157-166
    • (2004) Breast Cancer Res. Treat. , vol.87 , pp. 157-166
    • Binder, C.1    Simon, A.2    Binder, L.3    Hagemann, T.4    Schulz, M.5    Emons, G.6
  • 12
    • 27944447704 scopus 로고    scopus 로고
    • H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis
    • Silvertown J.D., Ng J., Sato T., Summerlee A.J., and Medin J.A. H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. Int. J. Cancer 118 (2006) 62-73
    • (2006) Int. J. Cancer , vol.118 , pp. 62-73
    • Silvertown, J.D.1    Ng, J.2    Sato, T.3    Summerlee, A.J.4    Medin, J.A.5
  • 13
    • 33845422046 scopus 로고    scopus 로고
    • Relaxin becomes upregulated during prostate cancer progression to androgen independence and is negatively regulated by androgens
    • Thompson V.C., Morris T.G., Cochrane D.R., Cavanagh J., Wafa L.A., Hamilton T., et al. Relaxin becomes upregulated during prostate cancer progression to androgen independence and is negatively regulated by androgens. Prostate 66 (2006) 1698-1709
    • (2006) Prostate , vol.66 , pp. 1698-1709
    • Thompson, V.C.1    Morris, T.G.2    Cochrane, D.R.3    Cavanagh, J.4    Wafa, L.A.5    Hamilton, T.6
  • 14
    • 34447132814 scopus 로고    scopus 로고
    • Skeletal remodeling in health and disease
    • Zaidi M. Skeletal remodeling in health and disease. Nat. Med. 13 (2007) 791-801
    • (2007) Nat. Med. , vol.13 , pp. 791-801
    • Zaidi, M.1
  • 15
    • 42049110350 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease
    • Kearns A.E., Khosla S., and Kostenuik P.J. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr. Rev. 29 (2008) 155-192
    • (2008) Endocr. Rev. , vol.29 , pp. 155-192
    • Kearns, A.E.1    Khosla, S.2    Kostenuik, P.J.3
  • 16
    • 23644459100 scopus 로고    scopus 로고
    • Does human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?
    • Kristiansson P., Holding C., Hughes S., and Haynes D. Does human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?. Ann. N. Y. Acad. Sci. 1041 (2005) 317-319
    • (2005) Ann. N. Y. Acad. Sci. , vol.1041 , pp. 317-319
    • Kristiansson, P.1    Holding, C.2    Hughes, S.3    Haynes, D.4
  • 17
    • 33645635391 scopus 로고    scopus 로고
    • Relaxin stimulates leukocyte adhesion and migration through a relaxin receptor LGR7-dependent mechanism
    • Figueiredo K.A., Mui A.L., Nelson C.C., and Cox M.E. Relaxin stimulates leukocyte adhesion and migration through a relaxin receptor LGR7-dependent mechanism. J. Biol. Chem. 281 (2006) 3030-3039
    • (2006) J. Biol. Chem. , vol.281 , pp. 3030-3039
    • Figueiredo, K.A.1    Mui, A.L.2    Nelson, C.C.3    Cox, M.E.4
  • 20
    • 23044434673 scopus 로고    scopus 로고
    • Normal human osteoclasts formed from peripheral blood monocytes express PTH type 1 receptors and are stimulated by PTH in the absence of osteoblasts
    • Dempster D.W., Hughes-Begos C.E., Plavetic-Chee K., Brandao-Burch A., Cosman F., Nieves J., et al. Normal human osteoclasts formed from peripheral blood monocytes express PTH type 1 receptors and are stimulated by PTH in the absence of osteoblasts. J. Cell. Biochem. 95 1 (2005) 139-148
    • (2005) J. Cell. Biochem. , vol.95 , Issue.1 , pp. 139-148
    • Dempster, D.W.1    Hughes-Begos, C.E.2    Plavetic-Chee, K.3    Brandao-Burch, A.4    Cosman, F.5    Nieves, J.6
  • 21
    • 4344623297 scopus 로고    scopus 로고
    • Biology of primate relaxin: a paracrine signal in early pregnancy?
    • Hayes E.S. Biology of primate relaxin: a paracrine signal in early pregnancy?. Reprod. Biol. Endocrinol. 16 (2004) 2-36
    • (2004) Reprod. Biol. Endocrinol. , vol.16 , pp. 2-36
    • Hayes, E.S.1
  • 23
    • 33845939640 scopus 로고    scopus 로고
    • Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes
    • Halls M.L., Bathgate R.A., and Summers R.J. Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes. J. Pharmacol. Exp. Ther. 320 (2007) 281-290
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , pp. 281-290
    • Halls, M.L.1    Bathgate, R.A.2    Summers, R.J.3
  • 25
    • 33846031926 scopus 로고    scopus 로고
    • The molecular understanding of osteoclast differentiation
    • Asagiri M., and Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 40 2 (2007) 251-264
    • (2007) Bone , vol.40 , Issue.2 , pp. 251-264
    • Asagiri, M.1    Takayanagi, H.2
  • 27
    • 34547138680 scopus 로고    scopus 로고
    • Influence of receptor activator of nucleus factor (NF)-kappaB ligand (RANKL), macrophage-colony stimulating factor (M-CFS) and fetal calf serum on human osteoclast formation and activity
    • Kreja L., Liedert A., Schmidt C., Claes L., and Ignatius A. Influence of receptor activator of nucleus factor (NF)-kappaB ligand (RANKL), macrophage-colony stimulating factor (M-CFS) and fetal calf serum on human osteoclast formation and activity. J. Mol. Histol. 38 (2007) 341-345
    • (2007) J. Mol. Histol. , vol.38 , pp. 341-345
    • Kreja, L.1    Liedert, A.2    Schmidt, C.3    Claes, L.4    Ignatius, A.5
  • 28
    • 36348941863 scopus 로고    scopus 로고
    • Bone metastasis: pathogenesis and therapeutic implications
    • Clezardin P., and Teti A. Bone metastasis: pathogenesis and therapeutic implications. Clin. Exp. Metastasis 24 (2007) 599-608
    • (2007) Clin. Exp. Metastasis , vol.24 , pp. 599-608
    • Clezardin, P.1    Teti, A.2
  • 29
    • 0028828701 scopus 로고
    • Characterization of human relaxin gene regulation in the relaxin-expressing human prostate adenocarcinoma cell line LNCaP.FGC
    • Gunnersen J.M., Roche P.J., Tregear G.W., and Crawford R.J. Characterization of human relaxin gene regulation in the relaxin-expressing human prostate adenocarcinoma cell line LNCaP.FGC. J. Mol. Endocrinol. 15 (1995) 153-166
    • (1995) J. Mol. Endocrinol. , vol.15 , pp. 153-166
    • Gunnersen, J.M.1    Roche, P.J.2    Tregear, G.W.3    Crawford, R.J.4
  • 31
    • 37549070672 scopus 로고    scopus 로고
    • Cysteine cathepsin proteases as pharmacological targets in cancer
    • Palermo C., and Joyce J.A. Cysteine cathepsin proteases as pharmacological targets in cancer. Trends. Pharmacol. Sci. 29 (2008) 22-28
    • (2008) Trends. Pharmacol. Sci. , vol.29 , pp. 22-28
    • Palermo, C.1    Joyce, J.A.2
  • 32
    • 3242882918 scopus 로고    scopus 로고
    • Disparate effects of relaxin and TGFbeta1: relaxin increases, but TGFbeta1 inhibits, the relaxin receptor and the production of IGFBP-1 in human endometrial stromal/decidual cells
    • Mazella J., Tang M., and Tseng L. Disparate effects of relaxin and TGFbeta1: relaxin increases, but TGFbeta1 inhibits, the relaxin receptor and the production of IGFBP-1 in human endometrial stromal/decidual cells. Hum. Reprod. 19 (2004) 1513-1518
    • (2004) Hum. Reprod. , vol.19 , pp. 1513-1518
    • Mazella, J.1    Tang, M.2    Tseng, L.3
  • 33
    • 33645932334 scopus 로고    scopus 로고
    • The human relaxin receptor (LGR7): expression in the fetal membranes and placenta
    • Lowndes K., Amano A., Yamamoto S., and Bryant-Greenwood G.D. The human relaxin receptor (LGR7): expression in the fetal membranes and placenta. Placenta 27 (2006) 610-618
    • (2006) Placenta , vol.27 , pp. 610-618
    • Lowndes, K.1    Amano, A.2    Yamamoto, S.3    Bryant-Greenwood, G.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.