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Volumn 19, Issue 8, 2011, Pages 1066-1075

Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model

Author keywords

Bone morphogenetic protein; Cartilage healing; Computed tomography; Gene delivery; Magnetic resonance imaging

Indexed keywords

ADENOVIRUS VECTOR; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 6; GADOLINIUM; GLYCOSAMINOGLYCAN; GREEN FLUORESCENT PROTEIN;

EID: 79960323461     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2011.05.007     Document Type: Article
Times cited : (62)

References (47)
  • 1
    • 0031602467 scopus 로고    scopus 로고
    • Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation
    • Buckwalter J.A., Mankin H.J. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 1998, 47:487-504.
    • (1998) Instr Course Lect , vol.47 , pp. 487-504
    • Buckwalter, J.A.1    Mankin, H.J.2
  • 2
    • 0036083985 scopus 로고    scopus 로고
    • Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects
    • Hunziker E.B. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 2002, 10:432-463.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 432-463
    • Hunziker, E.B.1
  • 3
    • 0029715351 scopus 로고    scopus 로고
    • Arthroscopic osteochondral autograft transplantation in anterior cruciate ligament reconstruction: a preliminary clinical study
    • Bobic V. Arthroscopic osteochondral autograft transplantation in anterior cruciate ligament reconstruction: a preliminary clinical study. Knee Surg Sports Traumatol Arthrosc 1996, 3:262-264.
    • (1996) Knee Surg Sports Traumatol Arthrosc , vol.3 , pp. 262-264
    • Bobic, V.1
  • 4
    • 1242315546 scopus 로고    scopus 로고
    • The use of chondrogide membrane in autologous chondrocyte implantation
    • Haddo O., Mahroof S., Higgs D., David L., Pringle J., Bayliss M., et al. The use of chondrogide membrane in autologous chondrocyte implantation. Knee 2004, 11:51-55.
    • (2004) Knee , vol.11 , pp. 51-55
    • Haddo, O.1    Mahroof, S.2    Higgs, D.3    David, L.4    Pringle, J.5    Bayliss, M.6
  • 5
    • 0037753305 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation using a bilayer collagen membrane: a preliminary report
    • Cherubino P., Grassi F.A., Bulgheroni P., Ronga M. Autologous chondrocyte implantation using a bilayer collagen membrane: a preliminary report. J Orthop Surg (Hong Kong) 2003, 11:10-15.
    • (2003) J Orthop Surg (Hong Kong) , vol.11 , pp. 10-15
    • Cherubino, P.1    Grassi, F.A.2    Bulgheroni, P.3    Ronga, M.4
  • 6
    • 77954344675 scopus 로고    scopus 로고
    • The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage
    • Adkisson HDt, Martin J.A., Amendola R.L., Milliman C., Mauch K.A., Katwal A.B., et al. The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. Am J Sports Med 2010, 38:1324-1333.
    • (2010) Am J Sports Med , vol.38 , pp. 1324-1333
    • Adkisson, H.1    Martin, J.A.2    Amendola, R.L.3    Milliman, C.4    Mauch, K.A.5    Katwal, A.B.6
  • 7
    • 0020053076 scopus 로고
    • The response of articular cartilage to mechanical injury
    • Mankin H.J. The response of articular cartilage to mechanical injury. J Bone Joint Surg Am 1982, 64:460-466.
    • (1982) J Bone Joint Surg Am , vol.64 , pp. 460-466
    • Mankin, H.J.1
  • 8
    • 0015276042 scopus 로고
    • A comparison of the physical behavior of normal articular cartilage and the arthroplasty surface
    • Coletti J.M., Akeson W.H., Woo S.L. A comparison of the physical behavior of normal articular cartilage and the arthroplasty surface. J Bone Joint Surg Am 1972, 54:147-160.
    • (1972) J Bone Joint Surg Am , vol.54 , pp. 147-160
    • Coletti, J.M.1    Akeson, W.H.2    Woo, S.L.3
  • 9
    • 0017834521 scopus 로고
    • The role of bone changes in the degeneration of articular cartilage in osteoarthrosis
    • Radin E.L., Abernethy P.J., Townsend P.M., Rose R.M. The role of bone changes in the degeneration of articular cartilage in osteoarthrosis. Acta Orthop Belg 1978, 44:55-63.
    • (1978) Acta Orthop Belg , vol.44 , pp. 55-63
    • Radin, E.L.1    Abernethy, P.J.2    Townsend, P.M.3    Rose, R.M.4
  • 10
    • 34250699624 scopus 로고    scopus 로고
    • Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model
    • Goodrich L.R., Hidaka C., Robbins P.D., Evans C.H., Nixon A.J. Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br 2007, 89:672-685.
    • (2007) J Bone Joint Surg Br , vol.89 , pp. 672-685
    • Goodrich, L.R.1    Hidaka, C.2    Robbins, P.D.3    Evans, C.H.4    Nixon, A.J.5
  • 11
    • 0042635561 scopus 로고    scopus 로고
    • Repair of articular cartilage defects with osteogenic protein-1 (BMP-7) in dogs
    • Cook S.D., Patron L.P., Salkeld S.L., Rueger D.C. Repair of articular cartilage defects with osteogenic protein-1 (BMP-7) in dogs. J Bone Joint Surg Am 2003, 85-A(Suppl 3):116-123.
    • (2003) J Bone Joint Surg Am , Issue.SUPPL. 3 , pp. 116-123
    • Cook, S.D.1    Patron, L.P.2    Salkeld, S.L.3    Rueger, D.C.4
  • 12
    • 29744465669 scopus 로고    scopus 로고
    • Gene therapy for cartilage defects
    • Cucchiarini M., Madry H. Gene therapy for cartilage defects. J Gene Med 2005, 7:1495-1509.
    • (2005) J Gene Med , vol.7 , pp. 1495-1509
    • Cucchiarini, M.1    Madry, H.2
  • 13
    • 0033954799 scopus 로고    scopus 로고
    • Repair of articular cartilage defects one year after treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2)
    • Sellers R.S., Zhang R., Glasson S.S., Kim H.D., Peluso D., D'Augusta D.A., et al. Repair of articular cartilage defects one year after treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). J Bone Joint Surg Am 2000, 82:151-160.
    • (2000) J Bone Joint Surg Am , vol.82 , pp. 151-160
    • Sellers, R.S.1    Zhang, R.2    Glasson, S.S.3    Kim, H.D.4    Peluso, D.5    D'Augusta, D.A.6
  • 14
    • 34547113749 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated gene delivery of bone morphogenetic protein-2 in an articular fracture model
    • Zachos T., Diggs A., Weisbrode S., Bartlett J., Bertone A. Mesenchymal stem cell-mediated gene delivery of bone morphogenetic protein-2 in an articular fracture model. Mol Ther 2007, 15:1543-1550.
    • (2007) Mol Ther , vol.15 , pp. 1543-1550
    • Zachos, T.1    Diggs, A.2    Weisbrode, S.3    Bartlett, J.4    Bertone, A.5
  • 16
    • 46449095585 scopus 로고    scopus 로고
    • Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or -6 in equine osteotomy and ostectomy models
    • Ishihara A., Shields K.M., Litsky A.S., Mattoon J.S., Weisbrode S.E., Bartlett J.S., et al. Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or -6 in equine osteotomy and ostectomy models. J Orthop Res 2008, 26:764-771.
    • (2008) J Orthop Res , vol.26 , pp. 764-771
    • Ishihara, A.1    Shields, K.M.2    Litsky, A.S.3    Mattoon, J.S.4    Weisbrode, S.E.5    Bartlett, J.S.6
  • 17
    • 73949150050 scopus 로고    scopus 로고
    • Dermal fibroblast-mediated BMP2 therapy to accelerate bone healing in an equine osteotomy model
    • Ishihara A., Zekas L.J., Litsky A.S., Weisbrode S.E., Bertone A.L. Dermal fibroblast-mediated BMP2 therapy to accelerate bone healing in an equine osteotomy model. J Orthop Res 2010, 28:403-411.
    • (2010) J Orthop Res , vol.28 , pp. 403-411
    • Ishihara, A.1    Zekas, L.J.2    Litsky, A.S.3    Weisbrode, S.E.4    Bertone, A.L.5
  • 18
    • 77953479600 scopus 로고    scopus 로고
    • Comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model
    • Ishihara A., Zekas L.J., Weisbrode S.E., Bertone A.L. Comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model. Gene Ther 2010, 17:733-744.
    • (2010) Gene Ther , vol.17 , pp. 733-744
    • Ishihara, A.1    Zekas, L.J.2    Weisbrode, S.E.3    Bertone, A.L.4
  • 19
    • 73849122702 scopus 로고    scopus 로고
    • Detectable reporter gene expression following transduction of adenovirus and adeno-associated virus serotype 2 vectors within full-thickness osteoarthritic and unaffected canine cartilage in vitro and unaffected guinea pig cartilage in vivo
    • Santangelo K.S., Baker S.A., Nuovo G., Dyce J., Bartlett J.S., Bertone A.L. Detectable reporter gene expression following transduction of adenovirus and adeno-associated virus serotype 2 vectors within full-thickness osteoarthritic and unaffected canine cartilage in vitro and unaffected guinea pig cartilage in vivo. J Orthop Res 2010, 28:149-155.
    • (2010) J Orthop Res , vol.28 , pp. 149-155
    • Santangelo, K.S.1    Baker, S.A.2    Nuovo, G.3    Dyce, J.4    Bartlett, J.S.5    Bertone, A.L.6
  • 20
    • 70349251514 scopus 로고    scopus 로고
    • Subchondral fluid dynamics in a model of osteoarthritis: use of dynamic contrast-enhanced magnetic resonance imaging
    • Lee J.H., Dyke J.P., Ballon D., Ciombor D.M., Rosenwasser M.P., Aaron R.K. Subchondral fluid dynamics in a model of osteoarthritis: use of dynamic contrast-enhanced magnetic resonance imaging. Osteoarthritis Cartilage 2009, 17:1350-1355.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1350-1355
    • Lee, J.H.1    Dyke, J.P.2    Ballon, D.3    Ciombor, D.M.4    Rosenwasser, M.P.5    Aaron, R.K.6
  • 21
    • 67650669003 scopus 로고    scopus 로고
    • Measures of molecular composition and structure in osteoarthritis
    • Burstein D., Gray M., Mosher T., Dardzinski B. Measures of molecular composition and structure in osteoarthritis. Radiol Clin North Am 2009, 47:675-686.
    • (2009) Radiol Clin North Am , vol.47 , pp. 675-686
    • Burstein, D.1    Gray, M.2    Mosher, T.3    Dardzinski, B.4
  • 22
    • 77649223501 scopus 로고    scopus 로고
    • Delayed gadolinium-enhanced MRI of cartilage in the ankle at 3 T: feasibility and preliminary results after matrix-associated autologous chondrocyte implantation
    • Domayer S.E., Trattnig S., Stelzeneder D., Hirschfeld C., Quirbach S., Dorotka R., et al. Delayed gadolinium-enhanced MRI of cartilage in the ankle at 3 T: feasibility and preliminary results after matrix-associated autologous chondrocyte implantation. J Magn Reson Imaging 2010, 31:732-739.
    • (2010) J Magn Reson Imaging , vol.31 , pp. 732-739
    • Domayer, S.E.1    Trattnig, S.2    Stelzeneder, D.3    Hirschfeld, C.4    Quirbach, S.5    Dorotka, R.6
  • 23
    • 33750307965 scopus 로고    scopus 로고
    • Cartilage T2 assessment: differentiation of normal hyaline cartilage and reparative tissue after arthroscopic cartilage repair in equine subjects
    • White L.M., Sussman M.S., Hurtig M., Probyn L., Tomlinson G., Kandel R. Cartilage T2 assessment: differentiation of normal hyaline cartilage and reparative tissue after arthroscopic cartilage repair in equine subjects. Radiology 2006, 241:407-414.
    • (2006) Radiology , vol.241 , pp. 407-414
    • White, L.M.1    Sussman, M.S.2    Hurtig, M.3    Probyn, L.4    Tomlinson, G.5    Kandel, R.6
  • 24
    • 4844223862 scopus 로고    scopus 로고
    • Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model
    • Bertone A.L., Pittman D.D., Bouxsein M.L., Li J., Clancy B., Seeherman H.J. Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model. J Orthop Res 2004, 22:1261-1270.
    • (2004) J Orthop Res , vol.22 , pp. 1261-1270
    • Bertone, A.L.1    Pittman, D.D.2    Bouxsein, M.L.3    Li, J.4    Clancy, B.5    Seeherman, H.J.6
  • 25
    • 77955485475 scopus 로고    scopus 로고
    • Gene therapy for bone healing
    • Evans C.H. Gene therapy for bone healing. Expert Rev Mol Med 2010, 12:e18.
    • (2010) Expert Rev Mol Med , vol.12
    • Evans, C.H.1
  • 26
    • 33645117967 scopus 로고    scopus 로고
    • Delayed gadolinium-enhanced MR to determine glycosaminoglycan concentration in reparative cartilage after autologous chondrocyte implantation: preliminary results
    • Watanabe A., Wada Y., Obata T., Ueda T., Tamura M., Ikehira H., et al. Delayed gadolinium-enhanced MR to determine glycosaminoglycan concentration in reparative cartilage after autologous chondrocyte implantation: preliminary results. Radiology 2006, 239:201-208.
    • (2006) Radiology , vol.239 , pp. 201-208
    • Watanabe, A.1    Wada, Y.2    Obata, T.3    Ueda, T.4    Tamura, M.5    Ikehira, H.6
  • 27
    • 36348932149 scopus 로고    scopus 로고
    • Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
    • R102
    • Blaney Davidson E.N., Vitters E.L., van Lent P.L., van de Loo F.A., van den Berg W.B., van der Kraan P.M. Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling. Arthritis Res Ther 2007, 9. R102.
    • (2007) Arthritis Res Ther , vol.9
    • Blaney Davidson, E.N.1    Vitters, E.L.2    van Lent, P.L.3    van de Loo, F.A.4    van den Berg, W.B.5    van der Kraan, P.M.6
  • 28
    • 0033936593 scopus 로고    scopus 로고
    • Response of engineered cartilage tissue to biochemical agents as studied by proton magnetic resonance microscopy
    • Potter K., Butler J.J., Horton W.E., Spencer R.G. Response of engineered cartilage tissue to biochemical agents as studied by proton magnetic resonance microscopy. Arthritis Rheum 2000, 43:1580-1590.
    • (2000) Arthritis Rheum , vol.43 , pp. 1580-1590
    • Potter, K.1    Butler, J.J.2    Horton, W.E.3    Spencer, R.G.4
  • 30
    • 0030953118 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content
    • Glansbeek H.L., van Beuningen H.M., Vitters E.L., Morris E.A., van der Kraan P.M., van den Berg W.B. Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content. Arthritis Rheum 1997, 40:1020-1028.
    • (1997) Arthritis Rheum , vol.40 , pp. 1020-1028
    • Glansbeek, H.L.1    van Beuningen, H.M.2    Vitters, E.L.3    Morris, E.A.4    van der Kraan, P.M.5    van den Berg, W.B.6
  • 31
    • 3242698915 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads
    • Grunder T., Gaissmaier C., Fritz J., Stoop R., Hortschansky P., Mollenhauer J., et al. Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. Osteoarthritis Cartilage 2004, 12:559-567.
    • (2004) Osteoarthritis Cartilage , vol.12 , pp. 559-567
    • Grunder, T.1    Gaissmaier, C.2    Fritz, J.3    Stoop, R.4    Hortschansky, P.5    Mollenhauer, J.6
  • 32
    • 0346120077 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells
    • Kim D.J., Moon S.H., Kim H., Kwon U.H., Park M.S., Han K.J., et al. Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells. Spine (Phila Pa 1976) 2003, 28:2679-2684.
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 2679-2684
    • Kim, D.J.1    Moon, S.H.2    Kim, H.3    Kwon, U.H.4    Park, M.S.5    Han, K.J.6
  • 33
    • 12744261378 scopus 로고    scopus 로고
    • Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells
    • Li J., Yoon S.T., Hutton W.C. Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells. J Spinal Disord Tech 2004, 17:423-428.
    • (2004) J Spinal Disord Tech , vol.17 , pp. 423-428
    • Li, J.1    Yoon, S.T.2    Hutton, W.C.3
  • 35
    • 77952878627 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and articular cartilage: to serve and protect or a wolf in sheep clothing's?
    • van der Kraan P.M., Davidson E.N., van den Berg W.B. Bone morphogenetic proteins and articular cartilage: to serve and protect or a wolf in sheep clothing's?. Osteoarthritis Cartilage 2010, 18:735-741.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 735-741
    • van der Kraan, P.M.1    Davidson, E.N.2    van den Berg, W.B.3
  • 36
    • 1342263759 scopus 로고    scopus 로고
    • Gene-based approaches for the repair of articular cartilage
    • Trippel S.B., Ghivizzani S.C., Nixon A.J. Gene-based approaches for the repair of articular cartilage. Gene Ther 2004, 11:351-359.
    • (2004) Gene Ther , vol.11 , pp. 351-359
    • Trippel, S.B.1    Ghivizzani, S.C.2    Nixon, A.J.3
  • 37
    • 0037869555 scopus 로고    scopus 로고
    • Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7
    • Hidaka C., Goodrich L.R., Chen C.T., Warren R.F., Crystal R.G., Nixon A.J. Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7. J Orthop Res 2003, 21:573-583.
    • (2003) J Orthop Res , vol.21 , pp. 573-583
    • Hidaka, C.1    Goodrich, L.R.2    Chen, C.T.3    Warren, R.F.4    Crystal, R.G.5    Nixon, A.J.6
  • 38
    • 39749111452 scopus 로고    scopus 로고
    • Concepts in gene therapy for cartilage repair
    • Steinert A.F., Noth U., Tuan R.S. Concepts in gene therapy for cartilage repair. Injury 2008, 39(Suppl 1):S97-113.
    • (2008) Injury , vol.39 , Issue.SUPPL. 1
    • Steinert, A.F.1    Noth, U.2    Tuan, R.S.3
  • 39
    • 77957190145 scopus 로고    scopus 로고
    • Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells with BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone
    • Carpenter R.S., Goodrich L.R., Frisbie D.D., Kisiday J.D., Carbone B., McIlwraith C.W., et al. Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells with BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone. J Orthop Res 2010, 28:1330-1337.
    • (2010) J Orthop Res , vol.28 , pp. 1330-1337
    • Carpenter, R.S.1    Goodrich, L.R.2    Frisbie, D.D.3    Kisiday, J.D.4    Carbone, B.5    McIlwraith, C.W.6
  • 40
    • 33748601575 scopus 로고    scopus 로고
    • A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee
    • Frisbie D.D., Cross M.W., McIlwraith C.W. A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee. Vet Comp Orthop Traumatol 2006, 19:142-146.
    • (2006) Vet Comp Orthop Traumatol , vol.19 , pp. 142-146
    • Frisbie, D.D.1    Cross, M.W.2    McIlwraith, C.W.3
  • 41
    • 0032838154 scopus 로고    scopus 로고
    • Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites
    • Nixon A.J., Fortier L.A., Williams J., Mohammed H. Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites. J Orthop Res 1999, 17:475-487.
    • (1999) J Orthop Res , vol.17 , pp. 475-487
    • Nixon, A.J.1    Fortier, L.A.2    Williams, J.3    Mohammed, H.4
  • 42
    • 0036486699 scopus 로고    scopus 로고
    • Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1
    • Fortier L.A., Nixon A.J., Lust G. Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1. Am J Vet Res 2002, 63:301-305.
    • (2002) Am J Vet Res , vol.63 , pp. 301-305
    • Fortier, L.A.1    Nixon, A.J.2    Lust, G.3
  • 43
    • 27544505598 scopus 로고    scopus 로고
    • Biochemical and biomechanical properties of lesion and adjacent articular cartilage after chondral defect repair in an equine model
    • Strauss E.J., Goodrich L.R., Chen C.T., Hidaka C., Nixon A.J. Biochemical and biomechanical properties of lesion and adjacent articular cartilage after chondral defect repair in an equine model. Am J Sports Med 2005, 33:1647-1653.
    • (2005) Am J Sports Med , vol.33 , pp. 1647-1653
    • Strauss, E.J.1    Goodrich, L.R.2    Chen, C.T.3    Hidaka, C.4    Nixon, A.J.5
  • 44
    • 0028922224 scopus 로고
    • Chondrocyte-laden collagen scaffolds for resurfacing extensive articular cartilage defects
    • Sams A.E., Nixon A.J. Chondrocyte-laden collagen scaffolds for resurfacing extensive articular cartilage defects. Osteoarthritis Cartilage 1995, 3:47-59.
    • (1995) Osteoarthritis Cartilage , vol.3 , pp. 47-59
    • Sams, A.E.1    Nixon, A.J.2
  • 45
    • 0028395810 scopus 로고
    • Phenotype and biological activity of neonatal equine chondrocytes cultured in a three-dimensional fibrin matrix
    • Hendrickson D.A., Nixon A.J., Erb H.N., Lust G. Phenotype and biological activity of neonatal equine chondrocytes cultured in a three-dimensional fibrin matrix. Am J Vet Res 1994, 55:410-414.
    • (1994) Am J Vet Res , vol.55 , pp. 410-414
    • Hendrickson, D.A.1    Nixon, A.J.2    Erb, H.N.3    Lust, G.4
  • 46
    • 27744441368 scopus 로고    scopus 로고
    • Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage
    • Gratz K.R., Wong V.W., Chen A.C., Fortier L.A., Nixon A.J., Sah R.L. Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage. J Biomech 2006, 39:138-146.
    • (2006) J Biomech , vol.39 , pp. 138-146
    • Gratz, K.R.1    Wong, V.W.2    Chen, A.C.3    Fortier, L.A.4    Nixon, A.J.5    Sah, R.L.6
  • 47
    • 33645528770 scopus 로고    scopus 로고
    • Comparison of arthroscopic approaches and accessible anatomic structures during arthroscopy of the caudal pouches of equine femorotibial joints
    • Watts A.E., Nixon A.J. Comparison of arthroscopic approaches and accessible anatomic structures during arthroscopy of the caudal pouches of equine femorotibial joints. Vet Surg 2006, 35:219-226.
    • (2006) Vet Surg , vol.35 , pp. 219-226
    • Watts, A.E.1    Nixon, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.