Enhancement of osteoinduction by continual simvastatin release from poly(lactic-co-glycolic acid)-hydroxyapatite-simvastatin nano-fibrous scaffold

Journal of Biomedical Nanotechnology

Volumn 9, Issue 11, 2013, Pages 1921-1928

  Jiang, Liming ^a   Sun, Hongchen ^a   Yuan, Anliang ^a   Zhang, Kai ^c   Li, Daowei ^a   Li, Chen ^a   Shi, Ce ^a   Li, Xiangwei ^a   Gao, Kai ^d   Zheng, Changyu ^e   Yang, Bai ^c   San, Haizhu ^a,b  

^a JILIN UNIVERSITY   (China)

^b NORTHEAST NORMAL UNIVERSITY   (China)

^c Jilin University   (China)

^d INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

^e NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Bone regeneration; Drug release; Electrospinning; Nano fibrous scaffold; Simvastatin

Indexed keywords

ALKALINE PHOSPHATASE; BONE REGENERATION; DRUG RELEASE; NANO-FIBROUS; NANOFIBROUS SCAFFOLDS; OSTEOGENIC DIFFERENTIATION; POLY LACTIC-CO-GLYCOLIC ACID; SIMVASTATIN;

BONE; CELL PROLIFERATION; COPOLYMERS; ELECTROSPINNING; NANOFIBERS; PHOSPHATASES; SCAFFOLDS (BIOLOGY);

HYDROXYAPATITE;

ALKALINE PHOSPHATASE; HYDROXYAPATITE; MOLECULAR SCAFFOLD; POLYGLACTIN; SIMVASTATIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEFECT; BONE DEVELOPMENT; BONE REGENERATION; CALVARIA; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG RELEASE; ELECTROSPINNING; FEMALE; HEALING; IN VITRO STUDY; IN VIVO STUDY; LOADING DRUG DOSE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; DELAYED-ACTION PREPARATIONS; DURAPATITE; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FEMALE; LACTIC ACID; MATERIALS TESTING; NANOCAPSULES; OSTEOGENESIS; POLYGLYCOLIC ACID; RATS; RATS, WISTAR; SIMVASTATIN; SKULL FRACTURES; TISSUE SCAFFOLDS; TREATMENT OUTCOME;

EID: 84883671359     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2013.1692     Document Type: Article

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