Efficacy and safety of recombinant human bone morphogenetic protein-2/calcium phosphate matrix for closed tibial diaphyseal fracture a double-blind randomized controlled phase-ii/iii trial

Journal of Bone and Joint Surgery

Volumn 95, Issue 23, 2013, Pages 2088-2096

  Lyon, Thomas ^a   Scheele, Wim ^b   Bhandari, Mohit ^c   Koval, Kenneth J ^d   Sanchez, Eduardo Gomez ^e   Christensen, Jared ^b   Valentin, Alexandre ^f   Huard, Francois ^g  

^a LUTHERAN MEDICAL CENTER   (United States)

^b PFIZER INC   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d ORLANDO REGIONAL MEDICAL CENTER   (United States)

^e HOSPITAL CIVIL DE GUADALAJARA FRAY ANTONIO ALCALDE   (Mexico)

^f Coeur D́efense ^*  (United States)

^g PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM PHOSPHATE; CALCIUM PHOSPHATE MATRIX; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG; BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADJUVANT THERAPY; ADULT; ARTHRALGIA; ARTICLE; CALCIFICATION; CLOSED TIBIAL DIAPHYSEAL FRACTURE; COMPARTMENT SYNDROME; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DIAPHYSIS; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; FEMALE; FRACTURE FIXATION; FRACTURE HEALING; FRACTURE NONUNION; FRACTURE REDUCTION; HETEROTOPIC OSSIFICATION; HUMAN; INFECTION; INTRAMEDULLARY NAIL; INTRAMEDULLARY NAILING; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE BREAKAGE; MEDICAL DEVICE COMPLICATION; MEDICAL DEVICE FAILURE; MEDICAL DEVICE MALFUNCTION; MULTICENTER STUDY; PAIN; PERIPHERAL EDEMA; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PSEUDARTHROSIS; RANDOMIZED CONTROLLED TRIAL; SWELLING; TIBIA FRACTURE; TREATMENT OUTCOME; VASCULAR DISEASE; WEIGHT BEARING; BONE NAIL; CLINICAL TRIAL; DOSE RESPONSE; DRUG EFFECTS; FEASIBILITY STUDY; FRACTURES, CLOSED; INTRALESIONAL DRUG ADMINISTRATION; POSTOPERATIVE COMPLICATIONS; PROCEDURES; TIBIAL FRACTURES; TIME; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; FRACTURE; INJURY; METHODOLOGY; POSTOPERATIVE COMPLICATION;

ADULT; BONE MORPHOGENETIC PROTEIN 2; BONE NAILS; CALCIUM PHOSPHATES; DIAPHYSES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEASIBILITY STUDIES; FEMALE; FRACTURE FIXATION, INTRAMEDULLARY; FRACTURE HEALING; FRACTURES, CLOSED; HUMANS; INJECTIONS, INTRALESIONAL; MALE; POSTOPERATIVE COMPLICATIONS; RECOMBINANT PROTEINS; TIBIAL FRACTURES; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84893153887     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.L.01545     Document Type: Article

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