Effect of a novel nonviral gene delivery of BMP-2 on bone healing

The Scientific World Journal

Volumn 2012, Issue , 2012, Pages

  Schwabe, P ^a   Greiner, S ^a   Ganzert, R ^a   Eberhart, J ^a   Dahn K ^a   Stemberger, A ^b   Plank, C ^b   Schmidmaier, G ^c   Wildemann, B ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RNA; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALLUS; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; FEMALE; FRACTURE HEALING; IN VITRO STUDY; IN VIVO STUDY; MORPHOMETRICS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAFETY; TIBIA FRACTURE; ANIMAL; DRUG EFFECT; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; METHODOLOGY; MICROCAPSULE; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; SYNTHESIS; TREATMENT OUTCOME; VIRAL PHENOMENA AND FUNCTIONS;

RATTUS;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CAPSULES; DNA; FEMALE; FRACTURE HEALING; GENETIC THERAPY; RATS; RATS, SPRAGUE-DAWLEY; TIBIAL FRACTURES; TRANSFECTION; TREATMENT OUTCOME; VIRUS PHYSIOLOGICAL PHENOMENA;

EID: 84871386329     PISSN: 1537744X     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2012/560142     Document Type: Article

References (39)

1. Urist M. R., McLean F. C., Calcification and Ossification I. Calcification in the callus in healing fractures in normal rats. The Journal of Bone & Joint Surgery 1941 23 1 16
2. Alt V., Donell S. T., Chhabra A., Bentley A., Eicher A., Schnettler R., A health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Germany, and France. Injury 2009 40 12 1269 1275 2-s2.0-70449700270 10.1016/j.injury.2009.02.007
3. Govender S., Csimma C., Genant H. K., Valentin-Opran A., Amit Y., Arbel R., Aro H., Atar D., Bishay M., Börner M. G., Chiron P., Choong P., Cinats J., Courtenay B., Feibel R., Geulette B., Govender S., Gravel C., Haas N., Raschke M., Hammacher E., Van der Velde D., Hardy P., Holt M., Josten C., Ketterl R. L., Lindeque B., Lob G., Mathevon H., McCoy G., Marsh D., Miller R., Munting E., Oevre S., Nordsletten L., Patel A., Pohl A., Rennie W., Reynders P., Rommens P. M., Rondia J., Rossouw W. C., Daneel P. J., Ruff S., Rüter A., Santavirtal S., Schidhauer T. A., Gekle C., Schnettler R., Segal D., Seiler H., Snowdowne R. B., Stapert J., Taglang G., Verdonik R., Vogels L., Weckbach A., Wentzensen A., Wisriewsk T., Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures a prospective, controlled, randomized study of four hundred and fifty patients. Journal of Bone and Joint Surgery A 2002 84 12 2123 2134 2-s2.0-0036899744 (Pubitemid 35417689)
4. Valentin-Opran A., Wozney J., Csimma C., Lilly L., Riedel G. E., Clinical evaluation of recombinant human bone morphogenetic protein-2. Clinical Orthopaedics and Related Research 2002 395 110 120 2-s2.0-0036166542 (Pubitemid 34136661)
5. Vaccaro A. R., Anderson D. G., Patel T., Fischgrund J., Truumees E., Herkowitz H. N., Phillips F., Hilibrand A., Albert T. J., Wetzel T., McCulloch J. A., Comparison of OP-1 putty (rhBMP-7) to iliac crest autograft for posterolateral lumbar arthrodesis: a minimum 2-year follow-up pilot study. Spine 2005 30 24 2709 2716 2-s2.0-29444440588 10.1097/01.brs.0000190812.08447.ba (Pubitemid 43011029)
6. Virk M. S., Conduah A., Park S. H., Liu N., Sugiyama O., Cuomo A., Kang C., Lieberman J. R., Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model. Bone 2008 42 5 921 931 2-s2.0-41949123855 10.1016/j.bone.2007.12.216
7. Bonadio J., Smiley E., Patil P., Goldstein S., Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nature Medicine 1999 5 7 753 759 2-s2.0-0033021062 10.1038/10473 (Pubitemid 29318608)
8. Otani K., Nita I., Macaulay W., Georgescu H. I., Robbins P. D., Evans C. H., Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. Journal of Immunology 1996 156 9 3558 3562 2-s2.0-0029967052 (Pubitemid 26123574)
9. Okubo Y., Bessho K., Fujimura K., Iizuka T., Miyatake S. I., In vitro and in vivo studies of a bone morphogenetic protein-2 expressing adenoviral vector. Journal of Bone and Joint Surgery A 2001 83 supplement 1, part 2 S99 S104 2-s2.0-0002058087
10. Musgrave D. S., Bosch P., Ghivizzani S., Robbins P. D., Evans C. H., Huard J., Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone. Bone 1999 24 6 541 547 2-s2.0-0032904745 10.1016/S8756-3282(99)00086-1 (Pubitemid 29234066)
11. Baltzer A. W. A., Lattermann C., Whalen J. D., Wooley P., Weiss K., Grimm M., Ghivizzani S. C., Robbins P. D., Evans C. H., Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Therapy 2000 7 9 734 739 2-s2.0-0034114692 10.1038/sj/gt/3301166 (Pubitemid 30255754)
12. Egermann M., Lill C. A., Griesbeck K., Evans C. H., Robbins P. D., Schneider E., Baltzer A. W., Effect of BMP-2 gene transfer on bone healing in sheep. Gene Therapy 2006 13 17 1290 1299 2-s2.0-33747586304 10.1038/sj.gt. 3302785 (Pubitemid 44264083)
13. Betz O. B., Betz V. M., Nazarian A., Pilapil C. G., Vrahas M. S., Bouxsein M. L., Gerstenfeld L. C., Einhorn T. A., Evans C. H., Direct percutaneous gene delivery to enhance healing of segmental bone defects. Journal of Bone and Joint Surgery A 2006 88 2 355 365 2-s2.0-31844454557 10.2106/JBJS.E.00464 (Pubitemid 43185138)
14. Pelled G., Ben-Arav A., Hock C., Reynolds D. G., Yazici C., Zilberman Y., Gazit Z., Awad H., Gazit D., Schwarz E. M., Direct gene therapy for bone regeneration: gene gelivery, animal models, and outcome measures. Tissue Engineering B 2010 16 1 13 20 2-s2.0-76749092694 10.1089/ten.teb.2009.0156
15. Crystal R. G., Transfer of genes to humans: early lessons and obstacles to success. Science 1995 270 5235 404 410 2-s2.0-0028875936
16. Anderson W. F., Human gene therapy. Nature 1998 392 6679 25 30 2-s2.0-0032580348 (Pubitemid 28215190)
17. Wilson J. M., Molecular medicine: adenoviruses as gene-delivery vehicles. The New England Journal of Medicine 1996 334 18 1185 1187 2-s2.0-0030563195 10.1056/NEJM199605023341809 (Pubitemid 26137980)
18. Herweijer H., Wolff J. A., Progress and prospects: naked DNA gene transfer and therapy. Gene Therapy 2003 10 6 453 458 2-s2.0-0037348748 10.1038/sj.gt.3301983 (Pubitemid 36395262)
19. Audouy S. A. L., de Leij L. F. M. H., Hoekstra D., Molema G., In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. Pharmaceutical Research 2002 19 11 1599 1605 2-s2.0-0036844766 10.1023/A:1020989709019 (Pubitemid 35305510)
20. Ono I., Yamashita T., Jin H. Y., Ito Y., Hamada H., Akasaka Y., Nakasu M., Ogawa T., Jimbow K., Combination of porous hydroxyapatite and cationic liposomes as a vector for BMP-2 gene therapy. Biomaterials 2004 25 19 4709 4718 2-s2.0-2342431481 10.1016/j.biomaterials.2003.11.038 (Pubitemid 38561158)
21. Wells D. J., Gene therapy progress and prospects: electroporation and other physical methods. Gene Therapy 2004 11 18 1363 1369 2-s2.0-4644371368 10.1038/sj.gt.3302337 (Pubitemid 39263889)
22. Carofino B. C., Lieberman J. R., Gene therapy applications for fracture-healing. Journal of Bone and Joint Surgery A 2008 90 supplement 1 99 110 2-s2.0-40149095754 10.2106/JBJS.G.01546 (Pubitemid 351329128)
23. Hannallah D., Peterson B., Lieberman J. R., Fu F. H., Huard J., Gene therapy in orthopaedic surgery. Journal of Bone and Joint Surgery A 2002 84 6 1046 1061 2-s2.0-0036600101
24. Schillinger U., Wexel G., Hacker C., Kullmer M., Koch C., Gerg M., Vogt S., Ueblacker P., Tischer T., Hensler D., Wilisch J., Aigner J., Walch A., Stemberger A., Plank C., A fibrin glue composition as carrier for nucleic acid vectors. Pharmaceutical Research 2008 25 12 2946 2962 2-s2.0-57149127981 10.1007/s11095-008-9719-8
25. Scherer F., Schillinger U., Putz U., Stemberger A., Plank C., Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo. Journal of Gene Medicine 2002 4 6 634 643 2-s2.0-0041768521 10.1002/jgm.298 (Pubitemid 40277187)
26. Finsinger D., Remy J. S., Erbacher P., Koch C., Plank C., Protective copolymers for nonviral gene vectors: synthesis, vector characterization and application in gene delivery. Gene Therapy 2000 7 14 1183 1192 2-s2.0-0033912738 (Pubitemid 30488765)
27. Schmidmaier G., Wildemann B., Stemberger A., Haas N. P., Raschke M., Biodegradable poly(D,L-lactide) coating of implants for continuous release of growth factors. Journal of Biomedical Materials Research 2001 58 4 449 455 2-s2.0-0034952967 10.1002/jbm.1040 (Pubitemid 32643194)
28. Wetterwald A., Hofstetter W., Cecchini M. G., Lanske B., Wagner C., Fleisch H., Atkinson M., Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone 1996 18 2 125 132 2-s2.0-0029881460 10.1016/8756-3282(95)00457-2 (Pubitemid 26092592)
29. Schmidmaier G., Wildemann B., Melis B., Krummrey G., Einhorn T. A., Haas N. P., Raschke M., Development and characterization of a standard closed tibial fracture model in the rat. European Journal of Trauma 2004 30 1 35 42 2-s2.0-1542358870 10.1007/s00068-004-1322-z (Pubitemid 38313497)
30. Parfitt A. M., Drezner M. K., Glorieux F. H., Kanis J. A., Malluche H., Meunier P. J., Ott S. M., Recker R. R., Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. Journal of Bone and Mineral Research 1987 2 6 595 610 2-s2.0-0023488581
31. Friedlaender G. E., Perry C. R., Cole J. D., Cook S. D., Cierny G., Muschler G. F., Zych G. A., Calhoun J. H., LaForte A. J., Yin S., Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions: a prospective, randomized clinical trial comparing rhOP-1 with fresh bone autograft. Journal of Bone and Joint Surgery A 2001 83 supplement 1, part 2 S1151 S1158 2-s2.0-18544392333 (Pubitemid 32298359)
32. Lieberman J. R., Daluiski A., Einhorn T. A., The role of growth factors in the repair of bone biology and clinical applications. Journal of Bone and Joint Surgery A 2002 84 6 1032 1044 2-s2.0-0036599845
33. Gamradt S. C., Abe N., Bahamonde M. E., Lee Y. P., Nelson S. D., Lyons K. M., Lieberman J. R., Tracking expression of virally mediated BMP-2 in gene therapy for bone repair. Clinical Orthopaedics and Related Research 2006 450 238 245 2-s2.0-33748413784 10.1097/01.blo.0000223989.49400.a8 (Pubitemid 44342141)
34. Franceschi R. T., Wang D., Krebsbach P. H., Rutherford R. B., Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. Journal of Cellular Biochemistry 2000 78 476 486 (Pubitemid 30491075)
35. Barry M. E., Pinto-González D., Orson F. M., McKenzie G. J., Petry G. R., Barry M. A., Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection. Human Gene Therapy 1999 10 15 2461 2480 2-s2.0-2442761730 10.1089/10430349950016816 (Pubitemid 29489721)
36. Fang J., Zhu Y. Y., Smiley E., Bonadio J., Rouleau J. P., Goldstein S. A., Mccauley L. K., Davidson B. L., Roessler B. J., Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Proceedings of the National Academy of Sciences of the United States of America 1996 93 12 5753 5758 2-s2.0-0029994334 10.1073/pnas.93.12.5753 (Pubitemid 26190752)
37. Ishihara A., Shields K. M., Litsky A. S., Mattoon J. S., Weisbrode S. E., Bartlett J. S., Bertone A. L., Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or -6 in equine osteotomy and ostectomy models. Journal of Orthopaedic Research 2008 26 6 764 771 2-s2.0-46449095585 10.1002/jor.20585
38. Baltzer A. W., Lattermann C., Whalen J. D., Braunstein S., Robbins P. D., Evans C. H., A gene therapy approach to accelerating bone healing. Evaluation of gene expression in a New Zealand white rabbit model. Knee Surgery, Sports Traumatology, Arthroscopy 1999 7 3 197 202 2-s2.0-0032618428
39. Schmidmaier G., Wildemann B., Cromme F., Kandziora F., Haas N. P., Raschke M., Bone morphogenetic protein-2 coating of titanium implants increases biomechanical strength and accelerates bone remodeling in fracture treatment: a biomechanical and histological study in rats. Bone 2002 30 6 816 822 2-s2.0-0036274231 10.1016/S8756-3282(02)00740-8 (Pubitemid 34616007)