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Volumn 8, Issue 3, 2013, Pages

Identification of Small Molecule Activators of BMP Signaling

Author keywords

[No Author keywords available]

Indexed keywords

4' HYDROXYCHALCONE; APIGENIN; BONE MORPHOGENETIC PROTEIN; DIOSMETIN; FLAVONOID; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; ISOLIQUIRITIGENIN; LUCIFERASE; SMAD PROTEIN; SMAD1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84875092554     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059045     Document Type: Article
Times cited : (61)

References (54)
  • 1
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • Canalis E, Economides AN, Gazzerro E, (2003) Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 24: 218-235.
    • (2003) Endocr Rev , vol.24 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 3
    • 71449108623 scopus 로고    scopus 로고
    • Bone morphogenetic proteins (BMPs): from morphogens to metabologens
    • Reddi AH, Reddi A, (2009) Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev 20: 341-342.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 341-342
    • Reddi, A.H.1    Reddi, A.2
  • 4
    • 0033200373 scopus 로고    scopus 로고
    • BMP signalling in early Xenopus development
    • Dale L, Jones CM, (1999) BMP signalling in early Xenopus development. Bioessays 21: 751-760.
    • (1999) Bioessays , vol.21 , pp. 751-760
    • Dale, L.1    Jones, C.M.2
  • 5
    • 58149239733 scopus 로고    scopus 로고
    • Roles of TGF-beta family signaling in stem cell renewal and differentiation
    • Watabe T, Miyazono K, (2009) Roles of TGF-beta family signaling in stem cell renewal and differentiation. Cell Res 19: 103-115.
    • (2009) Cell Res , vol.19 , pp. 103-115
    • Watabe, T.1    Miyazono, K.2
  • 7
    • 0028332818 scopus 로고
    • Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
    • ten Dijke P, Yamashita H, Sampath TK, Reddi AH, Estevez M, et al. (1994) Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem 269: 16985-16988.
    • (1994) J Biol Chem , vol.269 , pp. 16985-16988
    • ten Dijke, P.1    Yamashita, H.2    Sampath, T.K.3    Reddi, A.H.4    Estevez, M.5
  • 8
    • 0028142801 scopus 로고
    • Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells
    • Koenig BB, Cook JS, Wolsing DH, Ting J, Tiesman JP, et al. (1994) Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol Cell Biol 14: 5961-5974.
    • (1994) Mol Cell Biol , vol.14 , pp. 5961-5974
    • Koenig, B.B.1    Cook, J.S.2    Wolsing, D.H.3    Ting, J.4    Tiesman, J.P.5
  • 9
    • 0029117276 scopus 로고
    • Cloning and characterization of a human type II receptor for bone morphogenetic proteins
    • Rosenzweig BL, Imamura T, Okadome T, Cox GN, Yamashita H, et al. (1995) Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci U S A 92: 7632-7636.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 7632-7636
    • Rosenzweig, B.L.1    Imamura, T.2    Okadome, T.3    Cox, G.N.4    Yamashita, H.5
  • 10
    • 0036682542 scopus 로고    scopus 로고
    • From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction
    • Moustakas A, Heldin CH, (2002) From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction. Genes Dev 16: 1867-1871.
    • (2002) Genes Dev , vol.16 , pp. 1867-1871
    • Moustakas, A.1    Heldin, C.H.2
  • 11
    • 0030667930 scopus 로고    scopus 로고
    • Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase
    • Chen Y, Bhushan A, Vale W, (1997) Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase. Proc Natl Acad Sci U S A 94: 12938-12943.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 12938-12943
    • Chen, Y.1    Bhushan, A.2    Vale, W.3
  • 12
    • 0029892494 scopus 로고    scopus 로고
    • MADR1, a MAD-related protein that functions in BMP2 signaling pathways
    • Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, et al. (1996) MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85: 489-500.
    • (1996) Cell , vol.85 , pp. 489-500
    • Hoodless, P.A.1    Haerry, T.2    Abdollah, S.3    Stapleton, M.4    O'Connor, M.B.5
  • 13
    • 3543041812 scopus 로고    scopus 로고
    • Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells
    • Peng Y, Kang Q, Luo Q, Jiang W, Si W, et al. (2004) Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. J Biol Chem 279: 32941-32949.
    • (2004) J Biol Chem , vol.279 , pp. 32941-32949
    • Peng, Y.1    Kang, Q.2    Luo, Q.3    Jiang, W.4    Si, W.5
  • 15
    • 77955883062 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling: implications in urology
    • Jeong J, Kang DI, Lee GT, Kim IY, (2010) Bone morphogenetic protein signaling: implications in urology. Korean J Urol 51: 511-517.
    • (2010) Korean J Urol , vol.51 , pp. 511-517
    • Jeong, J.1    Kang, D.I.2    Lee, G.T.3    Kim, I.Y.4
  • 17
    • 78951494764 scopus 로고    scopus 로고
    • Brain tumors: from childhood through adolescence into adulthood
    • Kieran MW, Walker D, Frappaz D, Prados M, (2010) Brain tumors: from childhood through adolescence into adulthood. J Clin Oncol 28: 4783-4789.
    • (2010) J Clin Oncol , vol.28 , pp. 4783-4789
    • Kieran, M.W.1    Walker, D.2    Frappaz, D.3    Prados, M.4
  • 19
    • 33646362581 scopus 로고    scopus 로고
    • Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    • Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, et al. (2006) Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 24: 1924-1931.
    • (2006) J Clin Oncol , vol.24 , pp. 1924-1931
    • Thompson, M.C.1    Fuller, C.2    Hogg, T.L.3    Dalton, J.4    Finkelstein, D.5
  • 20
    • 4043147087 scopus 로고    scopus 로고
    • Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling
    • Rios I, Alvarez-Rodriguez R, Marti E, Pons S, (2004) Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling. Development 131: 3159-3168.
    • (2004) Development , vol.131 , pp. 3159-3168
    • Rios, I.1    Alvarez-Rodriguez, R.2    Marti, E.3    Pons, S.4
  • 21
    • 41149130332 scopus 로고    scopus 로고
    • Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development
    • Zhao H, Ayrault O, Zindy F, Kim JH, Roussel MF, (2008) Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes Dev 22: 722-727.
    • (2008) Genes Dev , vol.22 , pp. 722-727
    • Zhao, H.1    Ayrault, O.2    Zindy, F.3    Kim, J.H.4    Roussel, M.F.5
  • 22
    • 71549138077 scopus 로고    scopus 로고
    • Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma
    • Flora A, Klisch TJ, Schuster G, Zoghbi HY, (2009) Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science 326: 1424-1427.
    • (2009) Science , vol.326 , pp. 1424-1427
    • Flora, A.1    Klisch, T.J.2    Schuster, G.3    Zoghbi, H.Y.4
  • 23
    • 40149091426 scopus 로고    scopus 로고
    • Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
    • Kimura H, Ng JM, Curran T, (2008) Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell 13: 249-260.
    • (2008) Cancer Cell , vol.13 , pp. 249-260
    • Kimura, H.1    Ng, J.M.2    Curran, T.3
  • 24
    • 70350496540 scopus 로고    scopus 로고
    • Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
    • Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, et al. (2009) Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326: 572-574.
    • (2009) Science , vol.326 , pp. 572-574
    • Yauch, R.L.1    Dijkgraaf, G.J.2    Alicke, B.3    Januario, T.4    Ahn, C.P.5
  • 25
    • 65849212897 scopus 로고    scopus 로고
    • Mesenchymal stem cell and gene therapies for spinal fusion
    • discussion 391-382
    • Gottfried ON, Dailey AT, (2008) Mesenchymal stem cell and gene therapies for spinal fusion. Neurosurgery 63 pp. 380-391 discussion 391-382.
    • (2008) Neurosurgery 63 , pp. 380-391
    • Gottfried, O.N.1    Dailey, A.T.2
  • 26
    • 37249010753 scopus 로고    scopus 로고
    • Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    • Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, et al. (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 4: 33-41.
    • (2008) Nat Chem Biol , vol.4 , pp. 33-41
    • Yu, P.B.1    Hong, C.C.2    Sachidanandan, C.3    Babitt, J.L.4    Deng, D.Y.5
  • 27
    • 27744450224 scopus 로고    scopus 로고
    • The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
    • Uziel T, Zindy F, Xie S, Lee Y, Forget A, et al. (2005) The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev 19: 2656-2667.
    • (2005) Genes Dev , vol.19 , pp. 2656-2667
    • Uziel, T.1    Zindy, F.2    Xie, S.3    Lee, Y.4    Forget, A.5
  • 28
    • 84875097725 scopus 로고    scopus 로고
    • Accessed 2013 Febrary 13
    • http://www.sigmaaldrich.com/catalog/product/sigma/lo1280?lang=en®ion=US.Accessed 2013 Febrary 13.
  • 29
    • 0033780376 scopus 로고    scopus 로고
    • Effective targeted gene 'knockdown' in zebrafish
    • Nasevicius A, Ekker SC, (2000) Effective targeted gene 'knockdown' in zebrafish. Nat Genet 26: 216-220.
    • (2000) Nat Genet , vol.26 , pp. 216-220
    • Nasevicius, A.1    Ekker, S.C.2
  • 30
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: bottleneck in brain drug development
    • Pardridge WM, (2005) The blood-brain barrier: bottleneck in brain drug development. NeuroRx. 2: 3-14.
    • (2005) NeuroRx. , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 31
    • 77649131474 scopus 로고    scopus 로고
    • Complications associated with the use of bone morphogenetic protein in pediatric patients
    • Oetgen ME, Richards BS, (2010) Complications associated with the use of bone morphogenetic protein in pediatric patients. J Pediatr Orthop 30: 192-198.
    • (2010) J Pediatr Orthop , vol.30 , pp. 192-198
    • Oetgen, M.E.1    Richards, B.S.2
  • 32
    • 0037085441 scopus 로고    scopus 로고
    • Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
    • Korchynskyi O, ten Dijke P, (2002) Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem 277: 4883-4891.
    • (2002) J Biol Chem , vol.277 , pp. 4883-4891
    • Korchynskyi, O.1    ten Dijke, P.2
  • 33
    • 0032145569 scopus 로고    scopus 로고
    • Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
    • Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, et al. (1998) Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 12: 2424-2433.
    • (1998) Genes Dev , vol.12 , pp. 2424-2433
    • Zindy, F.1    Eischen, C.M.2    Randle, D.H.3    Kamijo, T.4    Cleveland, J.L.5
  • 34
    • 0033003760 scopus 로고    scopus 로고
    • A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays
    • Zhang JH, Chung TD, Oldenburg KR, (1999) A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen 4: 67-73.
    • (1999) J Biomol Screen , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 35
    • 50249087534 scopus 로고    scopus 로고
    • Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells
    • Mirzoeva S, Kim ND, Chiu K, Franzen CA, Bergan RC, et al. (2008) Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. Mol Carcinog 47: 686-700.
    • (2008) Mol Carcinog , vol.47 , pp. 686-700
    • Mirzoeva, S.1    Kim, N.D.2    Chiu, K.3    Franzen, C.A.4    Bergan, R.C.5
  • 36
    • 0029946420 scopus 로고    scopus 로고
    • Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin
    • Makita H, Tanaka T, Fujitsuka H, Tatematsu N, Satoh K, et al. (1996) Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin. Cancer Res 56: 4904-4909.
    • (1996) Cancer Res , vol.56 , pp. 4904-4909
    • Makita, H.1    Tanaka, T.2    Fujitsuka, H.3    Tatematsu, N.4    Satoh, K.5
  • 37
    • 57749091536 scopus 로고    scopus 로고
    • Bioactivation of the phytoestrogen diosmetin by CYP1 cytochromes P450
    • Androutsopoulos V, Wilsher N, Arroo RR, Potter GA, (2009) Bioactivation of the phytoestrogen diosmetin by CYP1 cytochromes P450. Cancer Lett 274: 54-60.
    • (2009) Cancer Lett , vol.274 , pp. 54-60
    • Androutsopoulos, V.1    Wilsher, N.2    Arroo, R.R.3    Potter, G.A.4
  • 39
    • 0037085287 scopus 로고    scopus 로고
    • The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways
    • Nohe A, Hassel S, Ehrlich M, Neubauer F, Sebald W, et al. (2002) The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem 277: 5330-5338.
    • (2002) J Biol Chem , vol.277 , pp. 5330-5338
    • Nohe, A.1    Hassel, S.2    Ehrlich, M.3    Neubauer, F.4    Sebald, W.5
  • 40
    • 70349481110 scopus 로고    scopus 로고
    • Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes
    • Shin GC, Kim C, Lee JM, Cho WS, Lee SG, et al. (2009) Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. Chem Biol Interact 182: 29-36.
    • (2009) Chem Biol Interact , vol.182 , pp. 29-36
    • Shin, G.C.1    Kim, C.2    Lee, J.M.3    Cho, W.S.4    Lee, S.G.5
  • 41
    • 0032981308 scopus 로고    scopus 로고
    • Pathogenesis of joint damage in rheumatoid arthritis
    • Bresnihan B, (1999) Pathogenesis of joint damage in rheumatoid arthritis. J Rheumatol 26: 717-719.
    • (1999) J Rheumatol , vol.26 , pp. 717-719
    • Bresnihan, B.1
  • 42
    • 77955172689 scopus 로고    scopus 로고
    • Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo
    • Yang J, Li X, Al-Lamki RS, Southwood M, Zhao J, et al. (2010) Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. Circ Res 107: 252-262.
    • (2010) Circ Res , vol.107 , pp. 252-262
    • Yang, J.1    Li, X.2    Al-Lamki, R.S.3    Southwood, M.4    Zhao, J.5
  • 43
    • 0017759258 scopus 로고
    • Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
    • Yaffe D, Saxel O, (1977) Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature 270: 725-727.
    • (1977) Nature , vol.270 , pp. 725-727
    • Yaffe, D.1    Saxel, O.2
  • 45
    • 24144458202 scopus 로고    scopus 로고
    • Differential effect of BMP4 on NIH/3T3 and C2C12 cells: implications for endochondral bone formation
    • Li G, Peng H, Corsi K, Usas A, Olshanski A, et al. (2005) Differential effect of BMP4 on NIH/3T3 and C2C12 cells: implications for endochondral bone formation. J Bone Miner Res 20: 1611-1623.
    • (2005) J Bone Miner Res , vol.20 , pp. 1611-1623
    • Li, G.1    Peng, H.2    Corsi, K.3    Usas, A.4    Olshanski, A.5
  • 47
    • 0024389202 scopus 로고
    • Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin
    • Vukicevic S, Luyten FP, Reddi AH, (1989) Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin. Proc Natl Acad Sci U S A 86: 8793-8797.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 8793-8797
    • Vukicevic, S.1    Luyten, F.P.2    Reddi, A.H.3
  • 48
    • 0031939744 scopus 로고    scopus 로고
    • Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
    • Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR, et al. (1998) Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem 273: 1872-1879.
    • (1998) J Biol Chem , vol.273 , pp. 1872-1879
    • Nishimura, R.1    Kato, Y.2    Chen, D.3    Harris, S.E.4    Mundy, G.R.5
  • 49
    • 77449108244 scopus 로고    scopus 로고
    • In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors
    • Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, et al. (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol 5: 245-253.
    • (2010) ACS Chem Biol , vol.5 , pp. 245-253
    • Hao, J.1    Ho, J.N.2    Lewis, J.A.3    Karim, K.A.4    Daniels, R.N.5
  • 50
    • 0034898429 scopus 로고    scopus 로고
    • Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations
    • Lele Z, Bakkers J, Hammerschmidt M, (2001) Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations. Genesis 30: 190-194.
    • (2001) Genesis , vol.30 , pp. 190-194
    • Lele, Z.1    Bakkers, J.2    Hammerschmidt, M.3
  • 51
    • 0030990981 scopus 로고    scopus 로고
    • Loss of cerebum function ventralizes the zebrafish embryo
    • Fisher S, Amacher SL, Halpern ME, (1997) Loss of cerebum function ventralizes the zebrafish embryo. Development 124: 1301-1311.
    • (1997) Development , vol.124 , pp. 1301-1311
    • Fisher, S.1    Amacher, S.L.2    Halpern, M.E.3
  • 52
    • 12344269338 scopus 로고    scopus 로고
    • Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning
    • Little SC, Mullins MC, (2004) Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Development 131: 5825-5835.
    • (2004) Development , vol.131 , pp. 5825-5835
    • Little, S.C.1    Mullins, M.C.2
  • 53
    • 33747329861 scopus 로고    scopus 로고
    • Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling
    • Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, et al. (2006) Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. J Biol Chem 281: 22471-22484.
    • (2006) J Biol Chem , vol.281 , pp. 22471-22484
    • Cooper, B.J.1    Key, B.2    Carter, A.3    Angel, N.Z.4    Hart, D.N.5
  • 54
    • 70449366408 scopus 로고    scopus 로고
    • The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization
    • Shen Q, Little SC, Xu M, Haupt J, Ast C, et al. (2009) The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J Clin Invest 119: 3462-3472.
    • (2009) J Clin Invest , vol.119 , pp. 3462-3472
    • Shen, Q.1    Little, S.C.2    Xu, M.3    Haupt, J.4    Ast, C.5


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