Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

Neuropharmacology

Volumn 60, Issue 6, 2011, Pages 982-990

  Rammes, Gerhard ^a,b   Hasenjäger, Anne ^c   Sroka Saidi, Kamila ^c   Deussing, Jan M ^b   Parsons, Chris G ^c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^c MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

Alzheimer's disease; Amyloid beta; LTP; Memantine; MPEP; Ro 25 6981

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; AMYLOID BETA PROTEIN[1-42]; MEMANTINE; METABOTROPIC RECEPTOR 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; RO 25 698; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; DRUG EFFICACY; DRUG RECEPTOR BINDING; EXCITOTOXICITY; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; MOUSE; NEUROMODULATION; NEUROPHARMACOLOGY; NEWBORN; NONHUMAN; OLIGOMERIZATION; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN FUNCTION;

AMYLOID BETA-PEPTIDES; ANIMALS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MEMANTINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; PHENOLS; PIPERIDINES; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

EID: 79952454330     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.01.051     Document Type: Article

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