Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression

Journal of Geriatric Psychiatry and Neurology

Volumn 18, Issue 4, 2005, Pages 218-223

  Mortimer, James A ^a   Borenstein, Amy R ^a   Gosche, Karen M ^b   Snowdon, David A ^c  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b NeuroImaging Research   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer's disease; Biomarkers; Prevention

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E4; BIOLOGICAL MARKER;

ALZHEIMER DISEASE; BRAIN ATROPHY; BRAIN FUNCTION; BRAIN SIZE; COGNITION; COGNITIVE DEFECT; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; EARLY DIAGNOSIS; EDUCATION; GENETIC RISK; HERITABILITY; HIGH RISK PATIENT; HIPPOCAMPUS; HUMAN; NEUROPATHOLOGY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SENSITIVITY AND SPECIFICITY; TASK PERFORMANCE;

AGED; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; BRAIN; COGNITION DISORDERS; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC ERRORS; EDUCATIONAL STATUS; FALSE NEGATIVE REACTIONS; HUMANS; LINGUISTICS; RISK FACTORS; SENSITIVITY AND SPECIFICITY;

EID: 28444448358     PISSN: 08919887     EISSN: None     Source Type: Journal    
DOI: 10.1177/0891988705281869     Document Type: Conference Paper

References (61)

1. Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 1997; 18:351-357.
2. LaRue A, Jarvik LF. Cognitive function and prediction of dementia in old age. Int J Aging Hum Dev 1987; 25:79-89.
3. Linn R, Wolf P, Bachman D, Knoefel J. The "preclinical phase" of probable Alzheimer's disease: a 13-year prospective study of the Framingham cohort. Arch Neurol 1995; 52:485-490.
4. Elias MF, Beiser A, Wolf P, et al. The preclinical phase of Alzheimer's disease: a 22-year prospective study of the Framingham cohort. Arch Neurol 2000; 57:808-813.
5. Kawas CH, Corrada MM, Brookmeyer R, et al. Visual memory predicts Alzheimer's disease more than a decade before diagnosis. Neurology 2003; 60:1089-1093.
6. Snowdon DA, Kemper SJ, Mortimer JA, et al. Linguistic ability in early life and cognitive function and Alzheimer's disease in late life: Findings from the Nun Study. JAMA 1996; 275:528-532 .
7. Ashford JW, Mortimer JA. Non-familial Alzheimer's disease is mainly due to genetic factors. J Alzheimers Dis 2002; 4:169-177.
8. Gatz M, Pedersen NL, Berg S, et al. Heritability of Alzheimer's disease: the study of dementia in Swedish twins. J Gerontol A Biol Sci Med Sci 1997; 52A:M117-M125.
9. Bergem AL, Engedal K, Kringlen E. The role of heredity in late-onset Alzheimer disease and vascular dementia. A twin study. Arch Gen Psychiatry 1997; 54:264-270.
10. Polvikoski T, Sulkava R, Haltia M, et al. Apolipoprotein E, dementia and cortical deposition of β-amyloid protein. N Engl J Med 1995; 333:1242-1247.
11. Ghebremedhin E, Schultz C, Thai DR. Gender and age modify the association between APOE and AD-related neuropathology. Neurology 2001; 56:1696-1701.
12. Raber J, Huang Y, Ashford JW. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging 2004; 25:641-650.
13. Mortimer JA, Markesbery WR, Snowdon DA. Apolipoprotein E-e4 as a risk factor for Alzheimer and non-Alzheimer's dementias: findings from the Nun Study. Neurobiol Aging 2000; 21: S32-S33.
14. Crystal H, Dickson D, Fuld P, et al. Clinico-pathologic studies in dementia: non-demented subjects with pathologically-confirmed Alzheimer's disease. Neurology 1988; 38:1682-1687.
15. Katzman R, Terry R, DeTeresa R, et al. Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 1988; 23:138-144.
16. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 2001; 357:169-175.
17. Snowdon DA, Greiner LH, Mortimer JA, et al. Brain infarction and the clinical expression of Alzheimer disease. JAMA 1997; 277:813-817.
18. Dartigues JF, Gagnon M, Michel P, et al. The Paquid research program on the epidemiology of dementia. Methods and initial results. Rev Neurol 1991; 147:225-230.
19. Bowirrat A, Friedland RP, Farrer L, et al. Genetic and environmental risk factors for Alzheimer's disease in Israeli Arabs. J Mol Neurosci 2002; 19:239-245.
20. Callahan CM, Hall KS, Hui SL, et al. Relationship of age, education, and occupation with dementia among a community-based sample of African-Americans. Arch Neurol 1996; 53:134-140.
21. Chibnall JT, Eastwood R. Postsecondary education and dementia risk in older Jesuit priests. Int Psychogeriatr 1998; 10:359-368.
22. De Ronchi D, Fratiglioni L, Rucci P, et al. The effect of education of dementia occurrence in an Italian population with middle to high socioeconomic status. Neurology 1998; 50:1231-1238.
23. Haan MN, Mungas DM, Gonzalez HM, et al. Prevalence of dementia in older Latinos: the influence of type 2 diabetes mellitus, stroke and genetic factors. J Am Geriatr Soc 2003; 51:169-177.
24. Hall K, Gureje O, Gao S, et al. Risk factors and Alzheimer's disease: a comparative study of two communities. Aust N Z J Psychiatry 1998; 32:698-706.
25. Kokmen E, Beard CM, O'Brien PC, Kurland LT. Educational attainment and Alzheimer's disease: reassessment of the Rochester, Minnesota data (1975-1984). Neurology 1993; 43:A317.
26. Ott A, Breteler MM, van Harskamp F, et al. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. BMJ 1995; 310:970-973.
27. Precipe M, Casini AR, Ferretti C, et al. Prevalence of dementia in an elderly rural population: effects of age, sex, and education. J Neurol Neurosurg Psychiatry 1996; 60:628-633.
28. Ravaglia G, Forti P, Maioli F, et al. Education, occupation, and prevalence of dementia: findings from the Conselice study. Dement Geriatr Cogn Disord 2002; 14:90-100.
29. Schmand B, Smit J, Lindeboom J, et al. Low education is a genuine risk factor for accelerated memory decline and dementia. J Clin Epidemiol 1997; 50:1025-1033.
30. Zhang MY, Katzman R, Salmon D, et al. The prevalence of dementia and Alzheimer's disease in Shanghai, China: impact of age, gender, and education. Ann Neurol 1990; 27:428-437.
31. Di Carlo A, Baldereschi M, Amaducci L, et al. Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study. J Am Geriatr Soc 2002; 50:41-48.
32. Evans DA, Hebert LE, Beckett LA, et al. Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons. Arch Neurol 1997; 54:1399-1405.
33. Fratiglioni L, Viitanen M, von Strauss E, et al. Very old women at highest risk of dementia and Alzheimer's disease: incidence data from the Kungshomen Project, Stockholm. Neurology 1997; 48:132-138.
34. Karp A, Kareholt I, Qiu C, et al. Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease. Am J Epidemiol 2004; 159:175-183.
35. Launer LJ, Andersen K, Dewey ME, et al. Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. Neurology 1999; 52:78-84.
36. Letenneur L, Gilleron V, Commenges D, et al. Are sex and educational level independent predictors of dementia and Alzheimer's disease? Incidence data from the PAQUID project. J Neurol Neurosurg Psychiatry 1999; 66:177-183.
37. Lindsay J, Laurin D, Verreault R, et al. Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 2002; 156:445-453.
38. Ott A, van Rossum CTM, van Harskamp F, et al. Education and the incidence of dementia in a large population-based study: The Rotterdam Study. Neurology 1999; 52:663-666.
39. Stern Y, Gurland B, Tatemichi TK, et al. Influence of education and occupation on the incidence of Alzheimer's disease. JAMA 1994; 271:1004-1010.
40. Wilson RS, Bennett DA, Bienias JL, et al. Cognitive activity and incident AD in a population-based sample of older persons. Neurology 2002; 59:1910-1914.
41. Zhang M, Katzman R, Yu E, et al. A preliminary analysis of incidence of dementia in Shanghai, China. Psychiatry Clin Neurosci 1998; 52:8291-8294.
42. Beard CM, Kokmen E, Offord KP, Kurland LT. Lack of association between Alzheimer's disease and education, occupation, marital status, or living arrangement. Neurology 1992; 42:2063-2068.
43. Cobb JL, Wolf PA, Au R, et al. The effect of education on the incidence of dementia and Alzheimer's disease in the Framingham Study. Neurology 1995; 45:1707-1712.
44. Graves AB, Larson EB, Edland SD, et al. Prevalence of dementia and its subtypes in the Japanese American population of King County, Washington state. The Kame Project. Am J Epidemiol 1996; 144:760-771.
45. Dobbing K, Sands J. Quantitative growth and development of the human brain. Arch Dis Child 1973; 49:757-767.
46. Mori E, Hirono N, Yamashita H, et al. Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer's disease. Am J Psychiatry 1997; 154:18-24.
47. Schofield PW, Mosesson RE, Stern Y, Mayeux R. The age at onset of Alzheimer's disease and an intracranial area measurement. A relationship. Arch Neurol 1995; 52:95-98.
48. Wolf H, Julin P, Gertz HJ, et al. Intracranial volume in mild cognitive impairment, Alzheimer's disease and vascular dementia: evidence for brain reserve? Int J Geriatr Psychiatry 2004; 19:995-1007.
49. Graves AB, Mortimer JA, Larson EB, et al. Head circumference as a measure of cognitive reserve: association with severity of impairment in Alzheimer's disease. Br J Psychiatry 1996; 169:86-92.
50. Reynolds MD, Johnson JM, Dodge HH, et al. Small head size is related to low Mini-Mental State Examination scores in a community sample of nondemented older adults. Neurology 1999; 53:228-229.
51. Schofield PW, Logroscino G, Andrews HF, et al. An association between head circumference and Alzheimer's disease in a population-based study of aging and dementia. Neurology 1997; 49:30-37.
52. Borenstein-Graves A, Mortimer JA, Bowen JD, et al. Head circumference and incident Alzheimer's disease: modification by apolipoprotein E. Neurology 2001; 57:1453-1460.
53. Edland SD, Xu Y, Plevak M, et al. Total intracranial volume: normative values and lack of association with Alzheimer's disease. Neurology 2002; 59:272-274.
54. Jenkins R, Fox NC, Rossor AM, et al. Intracranial volume and Alzheimer's disease: evidence against the cerebral reserve hypothesis. Arch Neurol 2000; 57:220-224.
55. Teng EL, Hasegawa K, Homma A, et al. The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiologic studies of dementia. Int Psychogeriatr 1994; 6:45-56.
56. Mortimer JA, Snowdon DA, Markesbery WR. Head circumference, education and risk of dementia: findings from the Nun Study. J Clin Exp Neuropsychol 2003; 5:671-679.
57. Bennett DA, Wilson RS, Schneider JA, et al. Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology 2003; 60:1909-1915.
58. Riley KP, Snowdon DA, Markesbery WR. Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol 2002; 51:567-577.
59. Gosche KM, Mortimer JA, Smith CD, et al. An automated technique for measuring hippocampal volumes from MR imaging studies. AJNR 2001; 22:1686-1689.
60. Jack CR, Dickson DW, Parisi JE, et al. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology 2002; 58:750-757.
61. Gosche KM, Mortimer JA, Smith CD, et al. Hippocampal volume as an index of Alzheimer neuropathology. Findings from the Nun Study. Neurology 2002; 58:1476-1482.