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Volumn 35, Issue 12, 2014, Pages 581-590

Characterizing immune repertoires by high throughput sequencing: Strategies and applications

Author keywords

Antibody diversity; High throughput sequencing; Immune profiling; Immune repertoires; Immunoglobulin diversity; T cell receptor diversity

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN; LYMPHOCYTE ANTIGEN RECEPTOR; NUCLEOTIDE; T LYMPHOCYTE RECEPTOR;

EID: 84916207039     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2014.09.004     Document Type: Review
Times cited : (132)

References (103)
  • 1
    • 79953164038 scopus 로고    scopus 로고
    • Recombination centres and the orchestration of V(D)J recombination
    • Schatz D.G., Ji Y. Recombination centres and the orchestration of V(D)J recombination. Nat. Rev. Immunol. 2011, 11:251-263.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 251-263
    • Schatz, D.G.1    Ji, Y.2
  • 3
    • 39049145798 scopus 로고    scopus 로고
    • Immunoglobulin somatic hypermutation
    • Teng G., Papavasiliou F.N. Immunoglobulin somatic hypermutation. Annu. Rev. Genet. 2007, 41:107-120.
    • (2007) Annu. Rev. Genet. , vol.41 , pp. 107-120
    • Teng, G.1    Papavasiliou, F.N.2
  • 4
    • 84893411589 scopus 로고    scopus 로고
    • Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair
    • Matthews A.J., et al. Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair. Adv. Immunol. 2014, 122:1-57.
    • (2014) Adv. Immunol. , vol.122 , pp. 1-57
    • Matthews, A.J.1
  • 5
    • 0033615678 scopus 로고    scopus 로고
    • A direct estimate of the human T cell receptor diversity
    • Arstila T.P., et al. A direct estimate of the human T cell receptor diversity. Science 1999, 286:958-961.
    • (1999) Science , vol.286 , pp. 958-961
    • Arstila, T.P.1
  • 6
    • 84890413048 scopus 로고    scopus 로고
    • The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis
    • Six A., et al. The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis. Front. Immunol. 2013, 4:413.
    • (2013) Front. Immunol. , vol.4 , pp. 413
    • Six, A.1
  • 7
    • 80052942203 scopus 로고    scopus 로고
    • Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
    • Wu X., et al. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science 2011, 333:1593-1602.
    • (2011) Science , vol.333 , pp. 1593-1602
    • Wu, X.1
  • 8
    • 63849131879 scopus 로고    scopus 로고
    • Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
    • Scheid J.F., et al. Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature 2009, 458:636-640.
    • (2009) Nature , vol.458 , pp. 636-640
    • Scheid, J.F.1
  • 9
    • 80052531336 scopus 로고    scopus 로고
    • Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses
    • Mouquet H., et al. Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses. PLoS ONE 2011, 6:e24078.
    • (2011) PLoS ONE , vol.6 , pp. e24078
    • Mouquet, H.1
  • 10
    • 0032006979 scopus 로고    scopus 로고
    • Nonsense surveillance in lymphocytes?
    • Li S., Wilkinson M. Nonsense surveillance in lymphocytes?. Immunity 1998, 8:135-141.
    • (1998) Immunity , vol.8 , pp. 135-141
    • Li, S.1    Wilkinson, M.2
  • 11
    • 84904263671 scopus 로고    scopus 로고
    • Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements
    • Jackson K.J.L., et al. Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements. Cell Host Microbe 2014, 16:105-114.
    • (2014) Cell Host Microbe , vol.16 , pp. 105-114
    • Jackson, K.J.L.1
  • 12
    • 77954601328 scopus 로고    scopus 로고
    • Measurement and clinical monitoring of human lymphocyte clonality by massively parallel V-D-J pyrosequencing
    • Boyd S.D., et al. Measurement and clinical monitoring of human lymphocyte clonality by massively parallel V-D-J pyrosequencing. Sci. Transl. Med. 2009, 1:1-8.
    • (2009) Sci. Transl. Med. , vol.1 , pp. 1-8
    • Boyd, S.D.1
  • 13
    • 84892778834 scopus 로고    scopus 로고
    • Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires
    • Wang C., et al. Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. J. Immunol. 2014, 192:603-611.
    • (2014) J. Immunol. , vol.192 , pp. 603-611
    • Wang, C.1
  • 14
    • 84879109338 scopus 로고    scopus 로고
    • Convergent antibody signatures in human dengue
    • Parameswaran P., et al. Convergent antibody signatures in human dengue. Cell Host Microbe 2013, 13:691-700.
    • (2013) Cell Host Microbe , vol.13 , pp. 691-700
    • Parameswaran, P.1
  • 15
    • 1842273974 scopus 로고
    • MRNA stability varies during B lymphocyte differentiation
    • Jack H., Wabi M. mRNA stability varies during B lymphocyte differentiation. EMBO J. 1988, 7:1041-1046.
    • (1988) EMBO J. , vol.7 , pp. 1041-1046
    • Jack, H.1    Wabi, M.2
  • 16
    • 0023717487 scopus 로고
    • Lymphokine mRNA and T cell multireceptor mRNA of the Ig super gene family are reciprocally modulated during human T cell activation
    • Paillard F., et al. Lymphokine mRNA and T cell multireceptor mRNA of the Ig super gene family are reciprocally modulated during human T cell activation. Eur. J. Immunol. 1988, 18:1643-1646.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 1643-1646
    • Paillard, F.1
  • 17
    • 9144265458 scopus 로고    scopus 로고
    • Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936
    • Van Dongen J.J.M., et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003, 17:2257-2317.
    • (2003) Leukemia , vol.17 , pp. 2257-2317
    • Van Dongen, J.J.M.1
  • 18
    • 77950541195 scopus 로고    scopus 로고
    • Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells
    • Robins H.S., et al. Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells. Blood 2009, 114:4099-4107.
    • (2009) Blood , vol.114 , pp. 4099-4107
    • Robins, H.S.1
  • 19
    • 79960100655 scopus 로고    scopus 로고
    • Deep sequencing of the human TCRγ and TCRβ repertoires suggests that TCRβ rearranges after αβ and γδ T cell commitment
    • Sherwood A.M., et al. Deep sequencing of the human TCRγ and TCRβ repertoires suggests that TCRβ rearranges after αβ and γδ T cell commitment. Sci. Transl. Med. 2011, 3:1-7.
    • (2011) Sci. Transl. Med. , vol.3 , pp. 1-7
    • Sherwood, A.M.1
  • 20
    • 84866177970 scopus 로고    scopus 로고
    • Shaping of human germline IgH repertoires revealed by deep sequencing
    • Larimore K., et al. Shaping of human germline IgH repertoires revealed by deep sequencing. J. Immunol. 2012, 189:3221-3230.
    • (2012) J. Immunol. , vol.189 , pp. 3221-3230
    • Larimore, K.1
  • 21
    • 76549090763 scopus 로고    scopus 로고
    • High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets
    • Wang C., et al. High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:1518-1523.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 1518-1523
    • Wang, C.1
  • 22
    • 84882432416 scopus 로고    scopus 로고
    • Genetic measurement of memory B-cell recall using antibody repertoire sequencing
    • Vollmers C., et al. Genetic measurement of memory B-cell recall using antibody repertoire sequencing. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:13463-13468.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 13463-13468
    • Vollmers, C.1
  • 23
    • 84862961025 scopus 로고    scopus 로고
    • High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment
    • Logan A.C., et al. High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:21194-21199.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 21194-21199
    • Logan, A.C.1
  • 24
    • 70349750487 scopus 로고    scopus 로고
    • Cloning and expression of murine Ig genes from single B cells
    • Tiller T., et al. Cloning and expression of murine Ig genes from single B cells. J. Immunol. Methods 2009, 350:183-193.
    • (2009) J. Immunol. Methods , vol.350 , pp. 183-193
    • Tiller, T.1
  • 25
    • 84900860392 scopus 로고    scopus 로고
    • Using synthetic templates to design an unbiased multiplex PCR assay
    • Carlson C.S., et al. Using synthetic templates to design an unbiased multiplex PCR assay. Nat. Commun. 2013, 4:1-9.
    • (2013) Nat. Commun. , vol.4 , pp. 1-9
    • Carlson, C.S.1
  • 26
    • 70349648171 scopus 로고    scopus 로고
    • Profiling the T-cell receptor β-chain repertoire by massively parallel sequencing
    • Freeman J.D., et al. Profiling the T-cell receptor β-chain repertoire by massively parallel sequencing. Genome Res. 2009, 19:1817-1824.
    • (2009) Genome Res. , vol.19 , pp. 1817-1824
    • Freeman, J.D.1
  • 27
    • 79955554975 scopus 로고    scopus 로고
    • Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes
    • Warren R.L., et al. Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes. Genome Res. 2011, 21:790-797.
    • (2011) Genome Res. , vol.21 , pp. 790-797
    • Warren, R.L.1
  • 28
    • 84892159495 scopus 로고    scopus 로고
    • Preparing unbiased T-cell receptor and antibody cDNA libraries for the deep next generation sequencing profiling
    • Mamedov I.Z., et al. Preparing unbiased T-cell receptor and antibody cDNA libraries for the deep next generation sequencing profiling. Front. Immunol. 2013, 4:1-10.
    • (2013) Front. Immunol. , vol.4 , pp. 1-10
    • Mamedov, I.Z.1
  • 29
    • 84900869380 scopus 로고    scopus 로고
    • Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery
    • Lee E-C., et al. Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery. Nat. Biotechnol. 2014, 32:356-363.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 356-363
    • Lee, E.-C.1
  • 30
    • 0033559113 scopus 로고    scopus 로고
    • Amplification of cDNA ends based on template-switching effect and step-out PCR
    • Matz M., et al. Amplification of cDNA ends based on template-switching effect and step-out PCR. Nucleic Acids Res. 1999, 27:1558-1560.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 1558-1560
    • Matz, M.1
  • 31
    • 0037087319 scopus 로고    scopus 로고
    • A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape
    • Douek D.C., et al. A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape. J. Immunol. 2002, 168:3099-3104.
    • (2002) J. Immunol. , vol.168 , pp. 3099-3104
    • Douek, D.C.1
  • 32
    • 84868154295 scopus 로고    scopus 로고
    • Next generation sequencing for TCR repertoire profiling: platform-specific features and correction algorithms
    • Bolotin D., et al. Next generation sequencing for TCR repertoire profiling: platform-specific features and correction algorithms. Eur. J. Immunol. 2012, 42:3073-3083.
    • (2012) Eur. J. Immunol. , vol.42 , pp. 3073-3083
    • Bolotin, D.1
  • 33
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies - the next generation
    • Metzker M.L. Sequencing technologies - the next generation. Nat. Rev. Genet. 2010, 11:31-46.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 31-46
    • Metzker, M.L.1
  • 34
    • 84876933570 scopus 로고    scopus 로고
    • Shining a light on dark sequencing: characterising errors in Ion Torrent PGM data
    • Bragg L.M., et al. Shining a light on dark sequencing: characterising errors in Ion Torrent PGM data. PLoS Comput. Biol. 2013, 9:e1003031.
    • (2013) PLoS Comput. Biol. , vol.9 , pp. e1003031
    • Bragg, L.M.1
  • 35
    • 84864518203 scopus 로고    scopus 로고
    • Pacific biosciences sequencing technology for genotyping and variation discovery in human data
    • Carneiro M.O., et al. Pacific biosciences sequencing technology for genotyping and variation discovery in human data. BMC Genomics 2012, 13:1-7.
    • (2012) BMC Genomics , vol.13 , pp. 1-7
    • Carneiro, M.O.1
  • 36
    • 84860756398 scopus 로고    scopus 로고
    • Performance comparison of benchtop high-throughput sequencing platforms
    • Loman N.J., et al. Performance comparison of benchtop high-throughput sequencing platforms. Nat. Biotechnol. 2012, 30:434-439.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 434-439
    • Loman, N.J.1
  • 37
    • 84877827603 scopus 로고    scopus 로고
    • DNA sequencing - spanning the generations
    • McGinn S., Gut I.G. DNA sequencing - spanning the generations. N. Biotechnol. 2013, 30:366-372.
    • (2013) N. Biotechnol. , vol.30 , pp. 366-372
    • McGinn, S.1    Gut, I.G.2
  • 38
    • 84903741407 scopus 로고    scopus 로고
    • PRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires
    • Vander Heiden J.A., et al. pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics 2014, 30:1930-1932.
    • (2014) Bioinformatics , vol.30 , pp. 1930-1932
    • Vander Heiden, J.A.1
  • 39
    • 84901857468 scopus 로고    scopus 로고
    • Towards error-free profiling of immune repertoires
    • Shugay M., et al. Towards error-free profiling of immune repertoires. Nat. Methods 2014, 11:653-655.
    • (2014) Nat. Methods , vol.11 , pp. 653-655
    • Shugay, M.1
  • 40
    • 84897530472 scopus 로고    scopus 로고
    • Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling
    • Britanova O.V., et al. Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling. J. Immunol. 2014, 192:2689-2698.
    • (2014) J. Immunol. , vol.192 , pp. 2689-2698
    • Britanova, O.V.1
  • 41
    • 65649122270 scopus 로고    scopus 로고
    • High-throughput sequencing of the zebrafish antibody repertoire
    • Weinstein J., et al. High-throughput sequencing of the zebrafish antibody repertoire. Science 2009, 324:807-810.
    • (2009) Science , vol.324 , pp. 807-810
    • Weinstein, J.1
  • 42
    • 84865631443 scopus 로고    scopus 로고
    • High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals
    • Briney B.S., et al. High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals. Genes Immun. 2012, 13:469-473.
    • (2012) Genes Immun. , vol.13 , pp. 469-473
    • Briney, B.S.1
  • 43
    • 77956460339 scopus 로고    scopus 로고
    • + T cell receptor repertoire
    • + T cell receptor repertoire. Sci. Transl. Med. 2010, 2:1-9.
    • (2010) Sci. Transl. Med. , vol.2 , pp. 1-9
    • Robins, H.S.1
  • 44
    • 84892142348 scopus 로고    scopus 로고
    • Mother and child T cell receptor repertoires: deep profiling study
    • Putintseva E.V., et al. Mother and child T cell receptor repertoires: deep profiling study. Front. Immunol. 2013, 4:1-13.
    • (2013) Front. Immunol. , vol.4 , pp. 1-13
    • Putintseva, E.V.1
  • 45
    • 84893710050 scopus 로고    scopus 로고
    • Human memory T cells: generation, compartmentalization and homeostasis
    • Farber D.L., et al. Human memory T cells: generation, compartmentalization and homeostasis. Nat. Rev. Immunol. 2014, 14:24-35.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 24-35
    • Farber, D.L.1
  • 46
    • 84903535340 scopus 로고    scopus 로고
    • Tissue-specific expressed antibody variable gene repertoires
    • Briney B.S., et al. Tissue-specific expressed antibody variable gene repertoires. PLoS ONE 2014, 9:e100839.
    • (2014) PLoS ONE , vol.9 , pp. e100839
    • Briney, B.S.1
  • 47
    • 77953632929 scopus 로고    scopus 로고
    • Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements
    • Boyd S.D., et al. Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements. J. Immunol. 2010, 184:6986-6992.
    • (2010) J. Immunol. , vol.184 , pp. 6986-6992
    • Boyd, S.D.1
  • 48
    • 84055181361 scopus 로고    scopus 로고
    • Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation
    • Glanville J., et al. Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:20066-20071.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 20066-20071
    • Glanville, J.1
  • 49
    • 79961160227 scopus 로고    scopus 로고
    • High-resolution description of antibody heavy-chain repertoires in humans
    • Arnaout R., et al. High-resolution description of antibody heavy-chain repertoires in humans. PLoS ONE 2011, 6:e22365.
    • (2011) PLoS ONE , vol.6 , pp. e22365
    • Arnaout, R.1
  • 50
    • 84899102474 scopus 로고    scopus 로고
    • Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing
    • Zvyagin I.V., et al. Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:5980-5985.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 5980-5985
    • Zvyagin, I.V.1
  • 51
    • 84892163383 scopus 로고    scopus 로고
    • Huge overlap of individual TCRβ repertoires
    • Shugay M., et al. Huge overlap of individual TCRβ repertoires. Front. Immunol. 2013, 4:1-3.
    • (2013) Front. Immunol. , vol.4 , pp. 1-3
    • Shugay, M.1
  • 52
    • 79955022207 scopus 로고    scopus 로고
    • A mechanism for TCR sharing between T cell subsets and individuals revealed by pyrosequencing
    • Venturi V., et al. A mechanism for TCR sharing between T cell subsets and individuals revealed by pyrosequencing. J. Immunol. 2011, 186:4285-4294.
    • (2011) J. Immunol. , vol.186 , pp. 4285-4294
    • Venturi, V.1
  • 53
    • 84865412764 scopus 로고    scopus 로고
    • Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution
    • Mehr R., et al. Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution. Immunol. Lett. 2012, 148:11-22.
    • (2012) Immunol. Lett. , vol.148 , pp. 11-22
    • Mehr, R.1
  • 54
    • 84867095375 scopus 로고    scopus 로고
    • Statistical inference of the generation probability of T-cell receptors from sequence repertoires
    • Murugan A., et al. Statistical inference of the generation probability of T-cell receptors from sequence repertoires. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:16161-16166.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 16161-16166
    • Murugan, A.1
  • 55
    • 84878316328 scopus 로고    scopus 로고
    • The gracefully aging immune system
    • Boraschi D., et al. The gracefully aging immune system. Sci. Transl. Med. 2013, 5:1-9.
    • (2013) Sci. Transl. Med. , vol.5 , pp. 1-9
    • Boraschi, D.1
  • 56
    • 84875905994 scopus 로고    scopus 로고
    • Diagnostic applications of high-throughput DNA sequencing
    • Boyd S.D. Diagnostic applications of high-throughput DNA sequencing. Annu. Rev. Pathol. 2013, 8:381-410.
    • (2013) Annu. Rev. Pathol. , vol.8 , pp. 381-410
    • Boyd, S.D.1
  • 57
    • 84874092680 scopus 로고    scopus 로고
    • Lineage structure of the human antibody repertoire in response to influenza vaccination
    • Jiang N., et al. Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci. Transl. Med. 2013, 5:1-9.
    • (2013) Sci. Transl. Med. , vol.5 , pp. 1-9
    • Jiang, N.1
  • 58
    • 84874095196 scopus 로고    scopus 로고
    • Age-related changes in human peripheral blood IGH repertoire following vaccination
    • Wu Y-C.B., et al. Age-related changes in human peripheral blood IGH repertoire following vaccination. Front. Immunol. 2012, 3:1-12.
    • (2012) Front. Immunol. , vol.3 , pp. 1-12
    • Wu, Y.-C.B.1
  • 59
    • 81155152466 scopus 로고    scopus 로고
    • Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages
    • Ademokun A., et al. Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages. Aging Cell 2011, 10:922-930.
    • (2011) Aging Cell , vol.10 , pp. 922-930
    • Ademokun, A.1
  • 60
    • 84875228084 scopus 로고    scopus 로고
    • Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation
    • Van Heijst J.W.J., et al. Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. Nat. Med. 2013, 19:372-377.
    • (2013) Nat. Med. , vol.19 , pp. 372-377
    • Van Heijst, J.W.J.1
  • 61
    • 84896775850 scopus 로고    scopus 로고
    • T cell repertoire following autologous stem cell transplantation for multiple sclerosis
    • Muraro P.A., et al. T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J. Clin. Invest. 2014, 124:1168-1172.
    • (2014) J. Clin. Invest. , vol.124 , pp. 1168-1172
    • Muraro, P.A.1
  • 62
    • 79953292499 scopus 로고    scopus 로고
    • Quantitative tracking of T cell clones after haematopoietic stem cell transplantation
    • Mamedov I.Z., et al. Quantitative tracking of T cell clones after haematopoietic stem cell transplantation. EMBO Mol. Med. 2011, 3:201-207.
    • (2011) EMBO Mol. Med. , vol.3 , pp. 201-207
    • Mamedov, I.Z.1
  • 63
    • 80055118908 scopus 로고    scopus 로고
    • Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated
    • Liao H-X., et al. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J. Exp. Med. 2011, 208:2237-2249.
    • (2011) J. Exp. Med. , vol.208 , pp. 2237-2249
    • Liao, H.-X.1
  • 64
    • 84887167328 scopus 로고    scopus 로고
    • High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer
    • Emerson R.O., et al. High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer. J. Pathol. 2013, 231:433-440.
    • (2013) J. Pathol. , vol.231 , pp. 433-440
    • Emerson, R.O.1
  • 65
    • 84887511784 scopus 로고    scopus 로고
    • Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas
    • Gerlinger M., et al. Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas. J. Pathol. 2013, 231:424-432.
    • (2013) J. Pathol. , vol.231 , pp. 424-432
    • Gerlinger, M.1
  • 66
    • 84883466251 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue
    • Sherwood A.M., et al. Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue. Cancer Immunol. Immunother. 2013, 62:1453-1461.
    • (2013) Cancer Immunol. Immunother. , vol.62 , pp. 1453-1461
    • Sherwood, A.M.1
  • 67
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp S., et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med. 2013, 368:1509-1518.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1509-1518
    • Grupp, S.1
  • 68
    • 84905490286 scopus 로고    scopus 로고
    • Detection of minimal residual disease in patients with B lymphoblastic leukemia by high-throughput sequencing of IGH
    • Wu D., et al. Detection of minimal residual disease in patients with B lymphoblastic leukemia by high-throughput sequencing of IGH. Clin. Cancer Res. 2014, 20:4540-4548.
    • (2014) Clin. Cancer Res. , vol.20 , pp. 4540-4548
    • Wu, D.1
  • 69
    • 84861120541 scopus 로고    scopus 로고
    • High-throughput sequencing detects minimal residual disease in acute T lymphoblastic leukemia
    • Wu D., et al. High-throughput sequencing detects minimal residual disease in acute T lymphoblastic leukemia. Sci. Transl. Med. 2012, 4:1-7.
    • (2012) Sci. Transl. Med. , vol.4 , pp. 1-7
    • Wu, D.1
  • 70
    • 84891685285 scopus 로고    scopus 로고
    • Minimal residual disease monitoring with high-throughput sequencing of T cell receptors in cutaneous T cell lymphoma
    • Weng W-K., et al. Minimal residual disease monitoring with high-throughput sequencing of T cell receptors in cutaneous T cell lymphoma. Sci. Transl. Med. 2013, 5:1-9.
    • (2013) Sci. Transl. Med. , vol.5 , pp. 1-9
    • Weng, W.-K.1
  • 71
    • 84869826772 scopus 로고    scopus 로고
    • Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia
    • Gawad C., et al. Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia. Blood 2012, 120:4407-4417.
    • (2012) Blood , vol.120 , pp. 4407-4417
    • Gawad, C.1
  • 72
    • 84895454215 scopus 로고    scopus 로고
    • Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity
    • Doorenspleet M.E., et al. Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity. Ann. Rheum. Dis. 2014, 73:756-762.
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 756-762
    • Doorenspleet, M.E.1
  • 73
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996, 381:751-758.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 74
    • 0026502380 scopus 로고
    • Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics
    • Jorgensen J., et al. Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 1992, 355:224-230.
    • (1992) Nature , vol.355 , pp. 224-230
    • Jorgensen, J.1
  • 75
    • 77956688921 scopus 로고    scopus 로고
    • Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells
    • Reddy S.T., et al. Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nat. Biotechnol. 2010, 28:965-969.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 965-969
    • Reddy, S.T.1
  • 76
    • 84873605796 scopus 로고    scopus 로고
    • High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire
    • DeKosky B.J., et al. High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat. Biotechnol. 2013, 31:166-169.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 166-169
    • DeKosky, B.J.1
  • 77
    • 84881640374 scopus 로고    scopus 로고
    • Pairing of T-cell receptor chains via emulsion PCR
    • Turchaninova M., et al. Pairing of T-cell receptor chains via emulsion PCR. Eur. J. Immunol. 2013, 43:2507-2515.
    • (2013) Eur. J. Immunol. , vol.43 , pp. 2507-2515
    • Turchaninova, M.1
  • 78
    • 84893623221 scopus 로고    scopus 로고
    • Single-cell based high-throughput sequencing of full-length immunoglobulin heavy and light chain genes
    • Busse C.E., et al. Single-cell based high-throughput sequencing of full-length immunoglobulin heavy and light chain genes. Eur. J. Immunol. 2014, 44:597-603.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 597-603
    • Busse, C.E.1
  • 79
    • 84893831480 scopus 로고    scopus 로고
    • The promise and challenge of high-throughput sequencing of the antibody repertoire
    • Georgiou G., et al. The promise and challenge of high-throughput sequencing of the antibody repertoire. Nat. Biotechnol. 2014, 32:158-168.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 158-168
    • Georgiou, G.1
  • 80
    • 84903993800 scopus 로고    scopus 로고
    • Linking T-cell receptor sequence to functional phenotype at the single-cell level
    • Han A., et al. Linking T-cell receptor sequence to functional phenotype at the single-cell level. Nat. Biotechnol. 2014, 32:684-692.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 684-692
    • Han, A.1
  • 81
    • 84860381828 scopus 로고    scopus 로고
    • A proteomics approach for the identification and cloning of monoclonal antibodies from serum
    • Cheung W.C., et al. A proteomics approach for the identification and cloning of monoclonal antibodies from serum. Nat. Biotechnol. 2012, 30:447-452.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 447-452
    • Cheung, W.C.1
  • 82
    • 84869438827 scopus 로고    scopus 로고
    • Proteomics-directed cloning of circulating antiviral human monoclonal antibodies
    • Sato S., et al. Proteomics-directed cloning of circulating antiviral human monoclonal antibodies. Nat. Biotechnol. 2012, 30:1039-1043.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 1039-1043
    • Sato, S.1
  • 83
    • 84893840611 scopus 로고    scopus 로고
    • Identification and characterization of the constituent human serum antibodies elicited by vaccination
    • Lavinder J.J., et al. Identification and characterization of the constituent human serum antibodies elicited by vaccination. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:2259-2264.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 2259-2264
    • Lavinder, J.J.1
  • 84
    • 84901295133 scopus 로고    scopus 로고
    • Deconstructing the peptide-MHC specificity of T cell recognition
    • Birnbaum M.E., et al. Deconstructing the peptide-MHC specificity of T cell recognition. Cell 2014, 157:1073-1087.
    • (2014) Cell , vol.157 , pp. 1073-1087
    • Birnbaum, M.E.1
  • 85
    • 84893716395 scopus 로고    scopus 로고
    • + T cell specificity
    • + T cell specificity. J. Immunol. Methods 2013, 403:72-78.
    • (2013) J. Immunol. Methods , vol.403 , pp. 72-78
    • Pan, X.1
  • 86
    • 84883563447 scopus 로고    scopus 로고
    • IgBLAST: an immunoglobulin variable domain sequence analysis tool
    • Ye J., et al. IgBLAST: an immunoglobulin variable domain sequence analysis tool. Nucleic Acids Res. 2013, 41:W34-W40.
    • (2013) Nucleic Acids Res. , vol.41 , pp. W34-W40
    • Ye, J.1
  • 87
    • 84867834056 scopus 로고    scopus 로고
    • ® web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis for NGS high throughput and deep sequencing
    • ® web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis for NGS high throughput and deep sequencing. Immunome Res. 2012, 8:1-15.
    • (2012) Immunome Res. , vol.8 , pp. 1-15
    • Alamyar, E.1
  • 88
    • 48449094247 scopus 로고    scopus 로고
    • IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
    • Brochet X., et al. IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 2008, 36:W503-W508.
    • (2008) Nucleic Acids Res. , vol.36 , pp. W503-W508
    • Brochet, X.1
  • 89
    • 34547840205 scopus 로고    scopus 로고
    • IHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences
    • Gaëta B., et al. iHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences. Bioinformatics 2007, 23:1580-1587.
    • (2007) Bioinformatics , vol.23 , pp. 1580-1587
    • Gaëta, B.1
  • 90
    • 77951949737 scopus 로고    scopus 로고
    • SoDA2: a hidden Markov model approach for identification of immunoglobulin rearrangements
    • Munshaw S., Kepler T.B. SoDA2: a hidden Markov model approach for identification of immunoglobulin rearrangements. Bioinformatics 2010, 26:867-872.
    • (2010) Bioinformatics , vol.26 , pp. 867-872
    • Munshaw, S.1    Kepler, T.B.2
  • 91
    • 33748744694 scopus 로고    scopus 로고
    • No evidence for the use of DIR, D-D fusions, chromosome 15 open reading frames or VH replacement in the peripheral repertoire was found on application of an improved algorithm, JointML, to 6329 human immunoglobulin H rearrangements
    • Ohm-Laursen L., et al. No evidence for the use of DIR, D-D fusions, chromosome 15 open reading frames or VH replacement in the peripheral repertoire was found on application of an improved algorithm, JointML, to 6329 human immunoglobulin H rearrangements. Immunology 2006, 119:265-277.
    • (2006) Immunology , vol.119 , pp. 265-277
    • Ohm-Laursen, L.1
  • 92
    • 57649176319 scopus 로고    scopus 로고
    • Ab-origin: an enhanced tool to identify the sourcing gene segments in germline for rearranged antibodies
    • Wang X., et al. Ab-origin: an enhanced tool to identify the sourcing gene segments in germline for rearranged antibodies. BMC Bioinformatics 2008, 9:1-9.
    • (2008) BMC Bioinformatics , vol.9 , pp. 1-9
    • Wang, X.1
  • 93
    • 2442717677 scopus 로고    scopus 로고
    • Characterization of the human Ig heavy chain antigen binding complementarity determining region 3 using a newly developed software algorithm, JOINSOLVER
    • Souto-Carneiro M.M., et al. Characterization of the human Ig heavy chain antigen binding complementarity determining region 3 using a newly developed software algorithm, JOINSOLVER. J. Immunol. 2004, 172:6790-6802.
    • (2004) J. Immunol. , vol.172 , pp. 6790-6802
    • Souto-Carneiro, M.M.1
  • 94
    • 13444301423 scopus 로고    scopus 로고
    • VBASE2, an integrative V gene database
    • Retter I., et al. VBASE2, an integrative V gene database. Nucleic Acids Res. 2005, 33:D671-D674.
    • (2005) Nucleic Acids Res. , vol.33 , pp. D671-D674
    • Retter, I.1
  • 95
    • 84883462993 scopus 로고    scopus 로고
    • MiTCR: software for T-cell receptor sequencing data analysis
    • Bolotin D., et al. MiTCR: software for T-cell receptor sequencing data analysis. Nat. Methods 2013, 10:813-814.
    • (2013) Nat. Methods , vol.10 , pp. 813-814
    • Bolotin, D.1
  • 96
    • 33947316710 scopus 로고    scopus 로고
    • Methods for comparing the diversity of samples of the T cell receptor repertoire
    • Venturi V., et al. Methods for comparing the diversity of samples of the T cell receptor repertoire. J. Immunol. Methods 2007, 321:182-195.
    • (2007) J. Immunol. Methods , vol.321 , pp. 182-195
    • Venturi, V.1
  • 97
    • 77957266497 scopus 로고    scopus 로고
    • Clustering-based identification of clonally-related immunoglobulin gene sequence sets
    • Chen Z., et al. Clustering-based identification of clonally-related immunoglobulin gene sequence sets. Immunome Res. 2010, 6:1-7.
    • (2010) Immunome Res. , vol.6 , pp. 1-7
    • Chen, Z.1
  • 98
    • 0142149019 scopus 로고    scopus 로고
    • Estimating hypermutation rates from clonal tree data
    • Kleinstein S.H., et al. Estimating hypermutation rates from clonal tree data. J. Immunol. 2003, 171:4639-4649.
    • (2003) J. Immunol. , vol.171 , pp. 4639-4649
    • Kleinstein, S.H.1
  • 99
    • 50949103123 scopus 로고    scopus 로고
    • IgTree: creating immunoglobulin variable region gene lineage trees
    • Barak M., et al. IgTree: creating immunoglobulin variable region gene lineage trees. J. Immunol. Methods 2008, 338:67-74.
    • (2008) J. Immunol. Methods , vol.338 , pp. 67-74
    • Barak, M.1
  • 100
    • 84888251984 scopus 로고    scopus 로고
    • The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
    • Sok D., et al. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS Pathog. 2013, 9:e1003754.
    • (2013) PLoS Pathog. , vol.9 , pp. e1003754
    • Sok, D.1
  • 101
    • 84866933098 scopus 로고    scopus 로고
    • Quantifying selection in high-throughput immunoglobulin sequencing data sets
    • Yaari G., et al. Quantifying selection in high-throughput immunoglobulin sequencing data sets. Nucleic Acids Res. 2012, 40:e134.
    • (2012) Nucleic Acids Res. , vol.40 , pp. e134
    • Yaari, G.1
  • 102
    • 73349126428 scopus 로고    scopus 로고
    • Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells
    • Anderson S.M., et al. Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells. J. Immunol. 2009, 183:7314-7325.
    • (2009) J. Immunol. , vol.183 , pp. 7314-7325
    • Anderson, S.M.1
  • 103
    • 84893392457 scopus 로고    scopus 로고
    • Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences
    • Uduman M., et al. Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences. J. Immunol. 2014, 192:867-874.
    • (2014) J. Immunol. , vol.192 , pp. 867-874
    • Uduman, M.1


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