Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 50, 2011, Pages 20066-20071

  Glanville, Jacob ^a   Kuo, Tracy C ^a   Von Büdingen, H Christian ^b   Guey, Lin ^a   Berka, Jan ^a   Sundar, Purnima D ^a   Huerta, Gabriella ^a   Mehta, Gautam R ^a   Oksenberg, Jorge R ^b,c   Hauser, Stephen L ^b,c   Cox, David R ^a   Rajpal, Arvind ^a   Pons, Jaume ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Heritable variation; Next generation sequencing; V gene

Indexed keywords

ANTIBODY; B LYMPHOCYTE RECEPTOR;

ARTICLE; AUTOIMMUNITY; CELL THERAPY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GENE FREQUENCY; GENE SEQUENCE; GENETIC VARIABILITY; GERM LINE; HEREDITY; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; LYMPHOMA; MONOZYGOTIC TWINS; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; VIRUS INFECTION;

ANTIBODIES; GENETIC VARIATION; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOSUPPRESSIVE AGENTS; INHERITANCE PATTERNS; LYMPHOCYTE DEPLETION; TWINS; V(D)J RECOMBINATION;

EID: 84055181361     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1107498108     Document Type: Article

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