Estimating Hypermutation Rates from Clonal Tree Data

Journal of Immunology

Volumn 171, Issue 9, 2003, Pages 4639-4649

  Kleinstein, Steven H ^a,e   Louzoun, Yoram ^b,c   Shlomchik, Mark J ^d  

^a Princeton University   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c BAR ILAN UNIVERSITY   (Israel)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; HAPTEN ANTIBODY;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CLONE; IMMUNE RESPONSE; LETHAL MUTANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; TECHNIQUE;

EID: 0142149019     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.9.4639     Document Type: Article

References (32)

1. Celada, F., and P. E. Seiden. 1996. Affinity maturation and hypermutation in a simulation of the humoral immune response. Eur. J. Immunol. 26:1350.
2. Shlomchik, M. J., P. Watts, M. G. Weigert, and S. Litwin. 1998. "Clone": a Monte-Carlo computer simulation of B cell clonal expansion, somatic mutation and antigen-driven selection. Curr. Top. Microbiol. Immunol. 229:173.
3. Kleinstein, S. H., and J. P. Singh. 2001. Toward quantitative simulation of germinal center dynamics: biological and modeling insights from experimental validation. J. Theor. Biol. 211:253.
4. Wabl, M., P. D. Burrows, A. von Gabain, and C. Steinberg. 1985. Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line. Proc. Natl. Acad. Sci. USA 82:479.
5. Wabl, M., H. M. Jack, J. Meyer, G. Beck-Engeser. R. C. von Borstel, and C. M. Steinberg. 1987. Measurements of mutation rates in B lymphocytes. Immunol. Rev. 96:91.
6. Sale, J. E., and M. S. Neuberger. 1998. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 9:859.
7. Martin, A., P. D. Bardwell, C. J. Woo. M. Fan, M. J. Shulman, and M. D. Scharff. 2002. Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature 415:802.
8. McKean, D., K. Huppi, M. Bell, L. Staudt, W. Gerhard, and M. Weigert. 1984. Generation of antibody diversity in the immune response of BALB/c mice to influenza hemagglutinin. Proc. Natl. Acad. Sci. USA 81:3180.
9. Sablitzky, F., G. Wildner, and K. Rajewsky. 1985. Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. EMBO J. 4:345.
10. Zhang, J., I. C. M. MacLennan, Y.-J. Liu, and P. Lane. 1988. Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones? Immunol. Lett. 18:297.
11. Shlomchik, M. J., A. Marshak-Rothstein, C. B. Wolfowicz, T. L. Rothstein, and M. G. Weigert. 1987. The role of clonal selection and somatic mutation in autoimmunity. Nature 328:805.
12. Jacob, J., and G. Kelsoe. 1992. In situ studies of the primary response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:679.
13. William, J., C. Euler, S. Christensen, and M. J. Shlomchik, 2002. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 297:2066.
14. Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. 1991. Intraclonal generation of antibody mutants in germinal centres. Nature 354:389.
15. H sequences in developing splenic germinal centers of immunuzed rabbits. J. Immunol. 162:3984.
16. Vora, K. A., K. Tumas-Brundage, and T. Manser. 1999. Contrasting the in situ behavior of a memory B cell clone during primary and secondary immune responses. J. Immunol. 163:4315.
17. Papavasiliou, F. N., and D. G. Schatz. 2000. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature 408:216.
18. Shlomchik, M. J., S. Litwin, and M. Weigert. 1990. The influence of somatic mutation on clonal expansion. In Proceedings of the Seventh International Congress of Immunology. Prog. Immunol. VII:415.
19. Lam, K. P., R. Kuhn, and K. Rajewsky. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90:1073.
20. Muramatsu, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553.
21. Kanzler, H., R. Kuppers, M. L. Hansmann, and K. Rajewsky. 1996. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J. Exp. Med. 184:1495.
22. Goossens, T., U. Klein, and R. Kuppers. 1998. Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc. Natl. Acad. Sci. USA 95:2463.
23. Pasqualucci, L., A. Migliazza, N. Fracchiolia, C. William, A. Neri, L. Baldini, R. S. Chaganti, U. Klein, R. Kuppers, K. Rajewsky, and R. Dalla-Favera. 1998. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. USA 95:11816.
24. Lentz, V. M., and T. Manser. 2001. Cutting edge: germinal centers can be induced in the absence of T cells. J. Immunol. 167:15.
25. Toellner, K. M., W. E. Jenkinson, D. R. Taylor, M. Khan, D. M. Sze, D. M. Sansom, C. G. Vinuesa, and I. C. MacLennan. 2002. Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers. J. Exp. Med. 195:383.
26. Du Pasquier, L., M. Wilson, A. S. Greenberg, and M. F. Flajnik. 1998. Somatic mutation in ectothermic vertebrates: musings on selection and origins. Curr. Top. Microbiol. Immunol. 229:199.
27. Diaz, M., A. S. Greenberg, and M. F. Flajnik. 1998. Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers. Proc. Natl. Acad. Sci. USA 95:14343.
28. Diaz, M., and M. F. Flajnik. 1998. Evolution of somatic hypermutation and gene conversion in adaptive immunity. Immunol. Rev. 162:13.
29. Schroder, A. E., A. Greiner, C. Seyfert, and C. Berek. 1996. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 93:221.
30. Kepler, T. B., and A. S. Perelson. 1993. Somatic hypermutation in B cells: an optimal control treatment. J. Theor. Biol. 164:37.
31. Kepler, T. B., and A. S. Perelson. 1995. Modeling and optimization of populations subject to time-dependent mutation. Proc. Natl. Acad. Sci. USA 92:8219.
32. Press, W. H., S. A. Teukolsky, W. T. Vetterling, and B. P. Flannery. 1992. Numerical Recipes in C. Cambridge University Press, Cambridge.