Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue

Cancer Immunology, Immunotherapy

Volumn 62, Issue 9, 2013, Pages 1453-1461

  Sherwood, Anna M ^a   Emerson, Ryan O ^a   Scherer, Dominique ^b   Habermann, Nina ^b   Buck, Katharina ^b   Staffa, Jürgen ^b   Desmarais, Cindy ^a   Halama, Niels ^b,c   Jaeger, Dirk ^b,c   Schirmacher, Peter ^d   Herpel, Esther ^d   Kloor, Matthias ^c   Ulrich, Alexis ^d   Schneider, Martin ^d   Ulrich, Cornelia M ^b,e   Robins, Harlan ^e  

^a ADAPTIVE BIOTECHNOLOGIES   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^e Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Colorectal cancer; Immune repertoire sequencing; T cell receptor ; Tumor infiltrating lymphocytes

Indexed keywords

T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADAPTIVE IMMUNITY; ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; CD3+ T LYMPHOCYTE; CELL CLONING; CELL DENSITY; CLINICAL ARTICLE; COLORECTAL TUMOR; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKOCYTE COUNT; MALE; MICROSATELLITE INSTABILITY; ONCOGENE; ONCOGENE TCRBJ; ONCOGENE TCRBV; PRIORITY JOURNAL; SEQUENCE ANALYSIS; T LYMPHOCYTE SUBPOPULATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY;

ADULT; AGED; COHORT STUDIES; COLORECTAL NEOPLASMS; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTESTINAL MUCOSA; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 84883466251     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1446-2     Document Type: Article

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