Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery

Nature Biotechnology

Volumn 32, Issue 4, 2014, Pages 356-363

  Lee, E Chiang ^a   Liang, Qi ^a   Ali, Hanif ^a   Bayliss, Luke ^a   Beasley, Alastair ^a   Bloomfield Gerdes, Tara ^a   Bonoli, Laura ^a   Brown, Richard ^a   Campbell, Jamie ^a   Carpenter, Adam ^a   Chalk, Sara ^a   Davis, Alison ^a   England, Nick ^a   Fane Dremucheva, Alla ^a   Franz, Bettina ^a   Germaschewski, Volker ^a   Holmes, Helen ^a   Holmes, Steve ^a   Kirby, Ian ^a   Kosmac, Miha ^a   Legent, Anais ^a   Lui, Hui ^a   Manin, Anais ^a   O'Leary, Siobhan ^a   Paterson, Jemima ^a   Sciarrillo, Rocco ^a   Speak, Anneliese ^b   Spensberger, Dominik ^a   Tuffery, Laura ^a   Waddell, Nikole ^a   Wang, Wei ^b   Wells, Sophie ^a   Wong, Vivian ^a   Wood, Andrew ^a   Owen, Michael J ^a   Friedrich, Glenn A ^a   Bradley, Allan ^b   more..

^a Kymab Ltd   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPES; GENES; IMMUNIZATION; MAMMALS;

COMPLEMENTARITY-DETERMINING REGION 3; EMBRYONIC STEM CELLS; HUMAN IMMUNOGLOBULIN; HUMAN MONOCLONAL ANTIBODIES; SOMATIC HYPERMUTATION; TECHNICAL LIMITATIONS; THERAPEUTIC ANTIBODIES; TRANSGENIC TECHNOLOGY;

ANTIBODIES;

CD40 LIGAND; HEMOLYSIN; HUMAN IMMUNOGLOBULIN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN M; MINOR HISTOCOMPATIBILITY ANTIGEN; MONOCLONAL ANTIBODY; OVALBUMIN; IMMUNOGLOBULIN VARIABLE REGION;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ARTICLE; B LYMPHOCYTE; BACTERIAL ARTIFICIAL CHROMOSOME; CELL MATURATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENE CLUSTER; GENE EXPRESSION; GENE INSERTION; GENETIC ENGINEERING; GENETIC MANIPULATION; HAPLOTYPE; HEAVY CHAIN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOGLOBULIN CONSTANT REGION; LIGHT CHAIN; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MOUSE STRAIN; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STAPHYLOCOCCUS AUREUS; TRANSGENE; TRANSGENIC MOUSE; TRANSIENT EXPRESSION; VDJ RECOMBINATION; AMINO ACID SEQUENCE; ANIMAL; FEMALE; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MALE; MOLECULAR GENETICS; PHYSIOLOGY; PROCEDURES;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; B-LYMPHOCYTES; CHROMOSOMES, ARTIFICIAL, BACTERIAL; FEMALE; GENETIC ENGINEERING; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; TRANSGENES;

EID: 84900869380     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2825     Document Type: Article

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